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Items: 1 to 50 of 67

1.

Orally available Mn porphyrins with superoxide dismutase and catalase activities.

Rosenthal RA, Huffman KD, Fisette LW, Damphousse CA, Callaway WB, Malfroy B, Doctrow SR.

J Biol Inorg Chem. 2009 Aug;14(6):979-91. doi: 10.1007/s00775-009-0550-4. Epub 2009 Jun 6.

2.

Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species.

Tocco G, Illigens BM, Malfroy B, Benichou G.

Cell Immunol. 2006 Jun;241(2):59-65. Epub 2006 Sep 12.

PMID:
16970930
3.

Oxidative neuropathology and putative chemical entities for Alzheimer's disease: neuroprotective effects of salen-manganese catalytic anti-oxidants.

Rupniak HT, Joy KA, Atkin C, Brown G, Barnes JC, Doctrow SR, Malfroy B, Wong T, Anderson IK, Molloy CR, Mills GI, Soden P.

Neurotox Res. 2000;2(2-3):167-78.

PMID:
16787839
4.

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.

Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8526-31. Epub 2003 Jun 18.

5.

Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.

Doctrow SR, Huffman K, Marcus CB, Tocco G, Malfroy E, Adinolfi CA, Kruk H, Baker K, Lazarowych N, Mascarenhas J, Malfroy B.

J Med Chem. 2002 Sep 26;45(20):4549-58.

PMID:
12238934
6.

Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics.

Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B.

J Neurosci. 2001 Nov 1;21(21):8348-53.

7.

Oxidative signalling and inflammatory pathways in Alzheimer's disease.

Anderson I, Adinolfi C, Doctrow S, Huffman K, Joy KA, Malfroy B, Soden P, Rupniak HT, Barnes JC.

Biochem Soc Symp. 2001;(67):141-9.

PMID:
11447830
8.

6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics.

Giblin GM, Box PC, Campbell IB, Hancock AP, Roomans S, Mills GI, Molloy C, Tranter GE, Walker AL, Doctrow SR, Huffman K, Malfroy B.

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1367-70.

PMID:
11378356
9.

Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model.

Jung C, Rong Y, Doctrow S, Baudry M, Malfroy B, Xu Z.

Neurosci Lett. 2001 May 25;304(3):157-60.

PMID:
11343826
10.

Extension of life-span with superoxide dismutase/catalase mimetics.

Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ.

Science. 2000 Sep 1;289(5484):1567-9.

11.
12.

Role of oxidant stress and iron delocalization in acidosis-induced intestinal epithelial hyperpermeability.

Gonzalez PK, Doctrow SR, Malfroy B, Fink MP.

Shock. 1997 Aug;8(2):108-14.

PMID:
9261900
13.

Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites.

Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G.

Cell Immunol. 1997 Apr 10;177(1):62-8.

PMID:
9140096
14.

A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication.

Cruikshank WW, Doctrow SR, Falvo MS, Huffman K, Maciaszek J, Viglianti G, Raina J, Kornfeld H, Malfroy B.

J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Mar 1;14(3):193-203.

PMID:
9117450
15.

Vasodilatory effects of a salen-manganese complex with potent oxyradical scavenger activities.

Barandier C, Boucher F, Malfroy B, de Leiris J.

J Vasc Res. 1997 Jan-Feb;34(1):49-57.

PMID:
9075825
16.

Salen-manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy.

Doctrow SR, Huffman K, Marcus CB, Musleh W, Bruce A, Baudry M, Malfroy B.

Adv Pharmacol. 1997;38:247-69. Review. No abstract available.

PMID:
8895812
17.

EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage.

Gianello P, Saliez A, Bufkens X, Pettinger R, Misseleyn D, Hori S, Malfroy B.

Transplantation. 1996 Dec 15;62(11):1664-6.

PMID:
8970624
18.

EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated iron-overloaded rat heart from functional and structural damage induced by ischemia/reperfusion.

Pucheu S, Boucher F, Sulpice T, Tresallet N, Bonhomme Y, Malfroy B, de Leiris J.

Cardiovasc Drugs Ther. 1996 Jul;10(3):331-9.

PMID:
8877076
19.
20.

Free radicals in reperfusion-induced arrhythmias: study with EUK 8, a novel nonprotein catalytic antioxidant.

Tanguy S, Boucher FR, Malfroy B, de Leiris JG.

Free Radic Biol Med. 1996;21(7):945-54.

PMID:
8937880
21.

Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury.

Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP.

Shock. 1996;6 Suppl 1:S23-6. Review.

PMID:
8828094
22.

EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine.

Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP.

J Pharmacol Exp Ther. 1995 Nov;275(2):798-806.

PMID:
7473169
23.
24.

The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells.

Doctrow SR, Abelleira SM, Curry LA, Heller-Harrison R, Kozarich JW, Malfroy B, McCarroll LA, Morgan KG, Morrow AR, Musso GF, et al.

J Pharmacol Exp Ther. 1994 Oct;271(1):229-37.

PMID:
7965719
25.

Effects of EUK-8, a synthetic catalytic superoxide scavenger, on hypoxia- and acidosis-induced damage in hippocampal slices.

Musleh W, Bruce A, Malfroy B, Baudry M.

Neuropharmacology. 1994 Jul;33(7):929-34.

PMID:
7969813
26.

Salen-manganese complexes are superoxide dismutase-mimics.

Baudry M, Etienne S, Bruce A, Palucki M, Jacobsen E, Malfroy B.

Biochem Biophys Res Commun. 1993 Apr 30;192(2):964-8.

PMID:
8484797
27.

Drug delivery to the brain using an anti-transferrin receptor antibody.

Friden PM, Walus L, Taylor M, Musso GF, Abelleira SA, Malfroy B, Tehrani F, Eckman JB 3rd, Morrow AR, Starzyk RM.

NIDA Res Monogr. 1992;120:202-17. Review. No abstract available.

PMID:
1501686
28.

Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

Friden PM, Walus LR, Musso GF, Taylor MA, Malfroy B, Starzyk RM.

Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4771-5.

30.

Substance P contracts the human iris sphincter: possible modulation by endogenous enkephalinase.

Anderson JA, Malfroy B, Richard NR, Kullerstrand L, Lucas C, Binder PS.

Regul Pept. 1990 Jun;29(1):49-58.

PMID:
1697082
31.

Recombinant enkephalinase effectively inhibits substance P-induced miosis in the rabbit eye cup model.

Anderson JA, Hernandez E, Duzman E, Malfroy B.

Curr Eye Res. 1990 Jun;9(6):543-7.

PMID:
1696872
32.

Characterization of endopeptidase 3.4.24.11 ("enkephalinase") activity in human plasma and cerebrospinal fluid.

Spillantini MG, Sicuteri F, Salmon S, Malfroy B.

Biochem Pharmacol. 1990 Apr 15;39(8):1353-6.

PMID:
2322317
33.

Administration of recombinant enkephalinase (neutral endopeptidase) prevents capsaicin-induced miosis in the rabbit eye in vivo.

Malfroy B, Liggitt D, McCabe J, Baughman R, Kado-Fong H, Mulholland K, Bridenbaugh R, Anderson J.

J Pharmacol Exp Ther. 1990 Feb;252(2):462-5.

PMID:
1690290
34.

Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs.

Kohrogi H, Nadel JA, Malfroy B, Gorman C, Bridenbaugh R, Patton JS, Borson DB.

J Clin Invest. 1989 Sep;84(3):781-6.

35.

Localization of enkephalinase mRNA in rat brain by in situ hybridization: comparison with immunohistochemical localization of the protein.

Wilcox JN, Pollard H, Moreau J, Schwartz JC, Malfroy B.

Neuropeptides. 1989 Aug-Sep;14(2):77-83.

PMID:
2812291
36.
37.

Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation.

Perianin A, Snyderman R, Malfroy B.

Biochem Biophys Res Commun. 1989 Jun 15;161(2):520-4.

PMID:
2472137
38.

Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases.

Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz JC, Hellmiss R.

Biochem Biophys Res Commun. 1989 May 30;161(1):236-41.

PMID:
2567164
39.

Expression of enzymatically active enkephalinase (neutral endopeptidase) in mammalian cells.

Gorman CM, Gies D, Schofield PR, Kado-Fong H, Malfroy B.

J Cell Biochem. 1989 Mar;39(3):277-84.

PMID:
2708459
40.
41.

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

Malfroy B, Kuang WJ, Seeburg PH, Mason AJ, Schofield PR.

FEBS Lett. 1988 Feb 29;229(1):206-10.

43.

Molecular cloning and amino acid sequence of rat enkephalinase.

Malfroy B, Schofield PR, Kuang WJ, Seeburg PH, Mason AJ, Henzel WJ.

Biochem Biophys Res Commun. 1987 Apr 14;144(1):59-66.

PMID:
3555489
44.

New substrates for enkephalinase (neutral endopeptidase) based on fluorescence energy transfer.

Malfroy B, Burnier J.

Biochem Biophys Res Commun. 1987 Feb 27;143(1):58-66.

PMID:
3548727
45.

Brain-specific gene expression.

Milner RJ, Lai C, Lenoir D, Nave K, Bakhit C, Malfroy B.

Biochem Soc Symp. 1986;52:107-17.

PMID:
3579967
47.

Brain-specific polypeptide 1B236 exists in multiple molecular forms.

Malfroy B, Bakhit C, Bloom FE, Sutcliffe JG, Milner RJ.

Proc Natl Acad Sci U S A. 1985 Apr;82(7):2009-13.

48.

Enkephalin metabolism and its inhibition.

Gros C, Giros B, Llorens C, Malfroy B, Pollard H, Pachot I, Schwartz JC, Mazie JC.

Biochem Soc Trans. 1985 Feb;13(1):47-50. No abstract available.

PMID:
2860040
49.
50.

[Use of opiate receptor antagonists and peptidase inhibitors for studying central morphinomimetic peptidergic systems].

Malfroy B.

Ann Endocrinol (Paris). 1983;44(5):335-7. French. No abstract available.

PMID:
6326657

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