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Items: 1 to 50 of 88

1.

The Genomic Landscape of Centromeres in Cancers.

Saha AK, Mourad M, Kaplan MH, Chefetz I, Malek SN, Buckanovich R, Markovitz DM, Contreras-Galindo R.

Sci Rep. 2019 Aug 2;9(1):11259. doi: 10.1038/s41598-019-47757-6.

2.

Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR.

Wang F, Gatica D, Ying ZX, Peterson LF, Kim P, Bernard D, Saiya-Cork K, Wang S, Kaminski MS, Chang AE, Phillips T, Klionsky DJ, Malek SN.

J Clin Invest. 2019 Mar 4;130:1626-1640. doi: 10.1172/JCI98288. eCollection 2019 Mar 4.

3.

Gene Disruption Using CRISPR-Cas9 Technology.

Hu N, Malek SN.

Methods Mol Biol. 2019;1881:201-209. doi: 10.1007/978-1-4939-8876-1_16.

PMID:
30350208
4.

CRISPR/Cas9-Based Gene Dropout Screens.

Wu K, Malek SN.

Methods Mol Biol. 2019;1881:185-200. doi: 10.1007/978-1-4939-8876-1_15.

PMID:
30350207
5.

Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action.

Jaudan A, Sharma S, Malek SNA, Dixit A.

PLoS One. 2018 Feb 8;13(2):e0191523. doi: 10.1371/journal.pone.0191523. eCollection 2018.

6.

Ultrasensitive mutation detection identifies rare residual cells causing acute myelogenous leukemia relapse.

Parkin B, Londoño-Joshi A, Kang Q, Tewari M, Rhim AD, Malek SN.

J Clin Invest. 2017 Sep 1;127(9):3484-3495. doi: 10.1172/JCI91964. Epub 2017 Aug 21.

7.

Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.

Suhaimi SA, Hong SL, Abdul Malek SN.

Pharmacogn Mag. 2017 Jul;13(Suppl 2):S179-S188. doi: 10.4103/pm.pm_432_16. Epub 2017 Jul 11.

8.

6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells.

Seow SLS, Hong SL, Lee GS, Malek SNA, Sabaratnam V.

BMC Complement Altern Med. 2017 Jun 24;17(1):334. doi: 10.1186/s12906-017-1837-6.

9.

Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity, and Blood Compatibility.

Foo YY, Periasamy V, Kiew LV, Kumar GG, Malek SNA.

Nanomaterials (Basel). 2017 May 27;7(6). pii: E123. doi: 10.3390/nano7060123.

10.
11.

Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.

Ying ZX, Jin M, Peterson LF, Bernard D, Saiya-Cork K, Yildiz M, Wang S, Kaminski MS, Chang AE, Klionsky DJ, Malek SN.

Clin Cancer Res. 2016 Nov 1;22(21):5383-5393. Epub 2016 Jun 7.

12.

Chalepin: isolated from Ruta angustifolia L. Pers induces mitochondrial mediated apoptosis in lung carcinoma cells.

Richardson JS, Sethi G, Lee GS, Malek SN.

BMC Complement Altern Med. 2016 Oct 12;16(1):389.

13.

Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.

Boice M, Salloum D, Mourcin F, Sanghvi V, Amin R, Oricchio E, Jiang M, Mottok A, Denis-Lagache N, Ciriello G, Tam W, Teruya-Feldstein J, de Stanchina E, Chan WC, Malek SN, Ennishi D, Brentjens RJ, Gascoyne RD, Cogné M, Tarte K, Wendel HG.

Cell. 2016 Oct 6;167(2):405-418.e13. doi: 10.1016/j.cell.2016.08.032. Epub 2016 Sep 29.

14.

Identification and in vitro Evaluation of Lipids from Sclerotia of Lignosus rhinocerotis for Antioxidant and Anti-neuroinflammatory Activities.

Nallathamby N, Serm LG, Raman J, Malek SNA, Vidyadaran S, Naidu M, Kuppusamy UR, Sabaratnama V.

Nat Prod Commun. 2016 Oct;11(10):1485-1490.

PMID:
30549604
15.

Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia.

Amin NA, Balasubramanian S, Saiya-Cork K, Shedden K, Hu N, Malek SN.

Clin Cancer Res. 2017 Feb 15;23(4):1049-1059. doi: 10.1158/1078-0432.CCR-15-2921. Epub 2016 Aug 17.

16.

A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia.

Amin NA, Seymour E, Saiya-Cork K, Parkin B, Shedden K, Malek SN.

Clin Cancer Res. 2016 Sep 1;22(17):4525-35. doi: 10.1158/1078-0432.CCR-15-3103. Epub 2016 Apr 8.

17.

Gene mutations in chronic lymphocytic leukemia.

Amin NA, Malek SN.

Semin Oncol. 2016 Apr;43(2):215-21. doi: 10.1053/j.seminoncol.2016.02.002. Epub 2016 Feb 6. Review.

PMID:
27040699
18.

Non-aqueous extracts of Curcuma mangga rhizomes induced cell death in human colorectal adenocarcinoma cell line (HT29) via induction of apoptosis and cell cycle arrest at G0/G1 phase.

Hong GW, Hong SL, Lee GS, Yaacob H, Malek SN.

Asian Pac J Trop Med. 2016 Jan;9(1):8-18. doi: 10.1016/j.apjtm.2015.12.003. Epub 2015 Dec 19.

19.

Xanthohumol induces apoptosis and S phase cell cycle arrest in A549 non-small cell lung cancer cells.

Yong WK, Ho YF, Malek SN.

Pharmacogn Mag. 2015 Oct;11(Suppl 2):S275-83. doi: 10.4103/0973-1296.166069.

20.

Exploring the interaction between the antiallergic drug, tranilast and human serum albumin: Insights from calorimetric, spectroscopic and modeling studies.

Tayyab S, Zaroog MS, Feroz SR, Mohamad SB, Malek SN.

Int J Pharm. 2015 Aug 1;491(1-2):352-8. doi: 10.1016/j.ijpharm.2015.06.042. Epub 2015 Jun 30.

PMID:
26142245
21.

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.

He S, Malik B, Borkin D, Miao H, Shukla S, Kempinska K, Purohit T, Wang J, Chen L, Parkin B, Malek SN, Danet-Desnoyers G, Muntean AG, Cierpicki T, Grembecka J.

Leukemia. 2016 Feb;30(2):508-13. doi: 10.1038/leu.2015.144. Epub 2015 Jun 18. No abstract available.

22.

Supramolecular interaction of 6-shogaol, a therapeutic agent of Zingiber officinale with human serum albumin as elucidated by spectroscopic, calorimetric and molecular docking methods.

Feroz SR, Mohamad SB, Lee GS, Malek SN, Tayyab S.

Phytomedicine. 2015 Jun 1;22(6):621-30. doi: 10.1016/j.phymed.2015.03.016. Epub 2015 Apr 9.

PMID:
26055127
23.

A Quantum Chemical and Statistical Study of Cytotoxic Activity of Compounds Isolated from Curcuma zedoaria.

Hamdi OA, Anouar el H, Shilpi JA, Trabolsy ZB, Zain SB, Zakaria NS, Zulkefeli M, Weber JF, Malek SN, Rahman SN, Awang K.

Int J Mol Sci. 2015 Apr 27;16(5):9450-68. doi: 10.3390/ijms16059450.

24.

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.

Peterson LF, Sun H, Liu Y, Potu H, Kandarpa M, Ermann M, Courtney SM, Young M, Showalter HD, Sun D, Jakubowiak A, Malek SN, Talpaz M, Donato NJ.

Blood. 2015 Jun 4;125(23):3588-97. doi: 10.1182/blood-2014-10-605584. Epub 2015 Mar 26.

PMID:
25814533
25.
26.

Integrated genomic profiling, therapy response, and survival in adult acute myelogenous leukemia.

Parkin B, Ouillette P, Yildiz M, Saiya-Cork K, Shedden K, Malek SN.

Clin Cancer Res. 2015 May 1;21(9):2045-56. doi: 10.1158/1078-0432.CCR-14-0921. Epub 2015 Feb 4.

27.

A comparative analysis on the binding characteristics of various mammalian albumins towards a multitherapeutic agent, pinostrobin.

Feroz SR, Sumi RA, Malek SN, Tayyab S.

Exp Anim. 2015;64(2):101-8. doi: 10.1538/expanim.14-0053. Epub 2014 Dec 16.

28.

Activating STAT6 mutations in follicular lymphoma.

Yildiz M, Li H, Bernard D, Amin NA, Ouillette P, Jones S, Saiya-Cork K, Parkin B, Jacobi K, Shedden K, Wang S, Chang AE, Kaminski MS, Malek SN.

Blood. 2015 Jan 22;125(4):668-79. doi: 10.1182/blood-2014-06-582650. Epub 2014 Nov 26.

29.

Cytotoxic activity of Alpinia murdochii Ridl.: A mountain ginger species from Peninsular Malaysia.

Sim KS, Ibrahim H, Malek SN, Syamsir DR, Awang K.

Pharmacogn Mag. 2014 Jan;10(37):70-2. doi: 10.4103/0973-1296.126666.

30.

Induction of apoptosis of 2,4',6-trihydroxybenzophenone in HT-29 colon carcinoma cell line.

Lay MM, Karsani SA, Malek SN.

Biomed Res Int. 2014;2014:468157. doi: 10.1155/2014/468157. Epub 2014 Jan 22.

31.

Lipid constituents of the edible mushroom, Pleurotus giganteus demonstrate anti-Candida activity.

Phan CW, Lee GS, Macreadie IG, Malek SN, Pamela D, Sabaratnam V.

Nat Prod Commun. 2013 Dec;8(12):1763-5.

PMID:
24555294
32.

Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.

Palomba ML, Piersanti K, Ziegler CG, Decker H, Cotari JW, Bantilan K, Rijo I, Gardner JR, Heaney M, Bemis D, Balderas R, Malek SN, Seymour E, Zelenetz AD, van den Brink MR, Altan-Bonnet G.

PLoS One. 2014 Jan 29;9(1):e79987. doi: 10.1371/journal.pone.0079987. eCollection 2014.

33.
34.

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.

Li H, Kaminski MS, Li Y, Yildiz M, Ouillette P, Jones S, Fox H, Jacobi K, Saiya-Cork K, Bixby D, Lebovic D, Roulston D, Shedden K, Sabel M, Marentette L, Cimmino V, Chang AE, Malek SN.

Blood. 2014 Mar 6;123(10):1487-98. doi: 10.1182/blood-2013-05-500264. Epub 2014 Jan 16.

35.

Genetics of follicular lymphoma transformation.

Pasqualucci L, Khiabanian H, Fangazio M, Vasishtha M, Messina M, Holmes AB, Ouillette P, Trifonov V, Rossi D, Tabbò F, Ponzoni M, Chadburn A, Murty VV, Bhagat G, Gaidano G, Inghirami G, Malek SN, Rabadan R, Dalla-Favera R.

Cell Rep. 2014 Jan 16;6(1):130-40. doi: 10.1016/j.celrep.2013.12.027. Epub 2014 Jan 2.

36.

Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.

Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN.

Int J Med Mushrooms. 2013;15(6):539-54.

PMID:
24266378
37.

AMP-activated protein kinase mediates insulin-like and lipo-mobilising effects of β-glucan-rich polysaccharides isolated from Pleurotus sajor-caju (Fr.), Singer mushroom, in 3T3-L1 cells.

Kanagasabapathy G, Chua KH, Malek SN, Vikineswary S, Kuppusamy UR.

Food Chem. 2014 Feb 15;145:198-204. doi: 10.1016/j.foodchem.2013.08.051. Epub 2013 Aug 21.

PMID:
24128468
38.

Probing the interaction of a therapeutic flavonoid, pinostrobin with human serum albumin: multiple spectroscopic and molecular modeling investigations.

Feroz SR, Mohamad SB, Bakri ZS, Malek SN, Tayyab S.

PLoS One. 2013 Oct 8;8(10):e76067. doi: 10.1371/journal.pone.0076067. eCollection 2013.

39.

Antioxidant potential, cytotoxic activity and total phenolic content of Alpinia pahangensis rhizomes.

Phang CW, Malek SN, Ibrahim H.

BMC Complement Altern Med. 2013 Oct 1;13:243. doi: 10.1186/1472-6882-13-243.

40.

Beta-Glucan-Rich Extract from Pleurotus sajor-caju (Fr.) Singer Prevents Obesity and Oxidative Stress in C57BL/6J Mice Fed on a High-Fat Diet.

Kanagasabapathy G, Malek SN, Mahmood AA, Chua KH, Vikineswary S, Kuppusamy UR.

Evid Based Complement Alternat Med. 2013;2013:185259. doi: 10.1155/2013/185259. Epub 2013 May 7.

41.

Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia.

Ouillette P, Saiya-Cork K, Seymour E, Li C, Shedden K, Malek SN.

Clin Cancer Res. 2013 Jun 1;19(11):2893-904. doi: 10.1158/1078-0432.CCR-13-0138. Epub 2013 Apr 25.

42.
43.

New fusion transcripts identified in normal karyotype acute myeloid leukemia.

Wen H, Li Y, Malek SN, Kim YC, Xu J, Chen P, Xiao F, Huang X, Zhou X, Xuan Z, Mankala S, Hou G, Rowley JD, Zhang MQ, Wang SM.

PLoS One. 2012;7(12):e51203. doi: 10.1371/journal.pone.0051203. Epub 2012 Dec 12.

44.

Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia.

Parkin B, Ouillette P, Li Y, Keller J, Lam C, Roulston D, Li C, Shedden K, Malek SN.

Blood. 2013 Jan 10;121(2):369-77. doi: 10.1182/blood-2012-04-427039. Epub 2012 Nov 21.

45.
46.

Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.

Ouillette P, Li J, Shaknovich R, Li Y, Melnick A, Shedden K, Malek SN.

Genes Chromosomes Cancer. 2012 Dec;51(12):1125-32. doi: 10.1002/gcc.21997. Epub 2012 Sep 6.

47.

Multispectroscopic and molecular modeling approach to investigate the interaction of flavokawain B with human serum albumin.

Feroz SR, Mohamad SB, Bujang N, Malek SN, Tayyab S.

J Agric Food Chem. 2012 Jun 13;60(23):5899-908. doi: 10.1021/jf301139h. Epub 2012 Jun 4.

PMID:
22624666
48.

Characteristics of chronic lymphocytic leukemia with somatically acquired mutations in NOTCH1 exon 34.

Shedden K, Li Y, Ouillette P, Malek SN.

Leukemia. 2012 May;26(5):1108-10. doi: 10.1038/leu.2011.361. Epub 2011 Dec 20. No abstract available.

49.

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.

Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, Malek SN, Powell S, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N.

Hum Mutat. 2012 Jan;33(1):100-3. doi: 10.1002/humu.21633. Epub 2011 Nov 23.

50.

Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.

Li M, Collins R, Jiao Y, Ouillette P, Bixby D, Erba H, Vogelstein B, Kinzler KW, Papadopoulos N, Malek SN.

Blood. 2011 Nov 24;118(22):5914-7. doi: 10.1182/blood-2011-05-356204. Epub 2011 Oct 11.

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