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Items: 27


The Resting Potential and K+ Currents in Primary Human Articular Chondrocytes.

Maleckar MM, Clark RB, Votta B, Giles WR.

Front Physiol. 2018 Sep 4;9:974. doi: 10.3389/fphys.2018.00974. eCollection 2018.


Label-free prediction of three-dimensional fluorescence images from transmitted-light microscopy.

Ounkomol C, Seshamani S, Maleckar MM, Collman F, Johnson GR.

Nat Methods. 2018 Nov;15(11):917-920. doi: 10.1038/s41592-018-0111-2. Epub 2018 Sep 17.


A computational framework for testing arrhythmia marker sensitivities to model parameters in functionally calibrated populations of atrial cells.

Vagos MR, Arevalo H, de Oliveira BL, Sundnes J, Maleckar MM.

Chaos. 2017 Sep;27(9):093941. doi: 10.1063/1.4999476.


Inverse estimation of cardiac activation times via gradient-based optimization.

Kallhovd S, Maleckar MM, Rognes ME.

Int J Numer Method Biomed Eng. 2018 Feb;34(2). doi: 10.1002/cnm.2919. Epub 2017 Aug 23.


Importance of material parameters and strain energy function on the wall stresses in the left ventricle.

Behdadfar S, Navarro L, Sundnes J, Maleckar MM, Avril S.

Comput Methods Biomech Biomed Engin. 2017 Aug;20(11):1223-1232. doi: 10.1080/10255842.2017.1347160. Epub 2017 Jul 4.


Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling.

Maleckar MM, Edwards AG, Louch WE, Lines GT.

Clin Med Insights Cardiol. 2017 Apr 12;11:1179546817698602. doi: 10.1177/1179546817698602. eCollection 2017.


Ventricular Microanatomy, Arrhythmias, and the Electrochemical Driving Force for Na+: Is There a Need for Flipped Learning?

Belardinelli L, Maleckar MM, Giles WR.

Circ Arrhythm Electrophysiol. 2017 Feb;10(2):e004955. doi: 10.1161/CIRCEP.117.004955. No abstract available. Erratum in: Circ Arrhythm Electrophysiol. 2017 Mar;10 (3):.


Refractoriness in human atria: Time and voltage dependence of sodium channel availability.

Skibsbye L, Jespersen T, Christ T, Maleckar MM, van den Brink J, Tavi P, Koivumäki JT.

J Mol Cell Cardiol. 2016 Dec;101:26-34. doi: 10.1016/j.yjmcc.2016.10.009. Epub 2016 Oct 20.


Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.

Grandi E, Maleckar MM.

Pharmacol Ther. 2016 Dec;168:126-142. doi: 10.1016/j.pharmthera.2016.09.012. Epub 2016 Sep 6. Review.


Simple T-Wave Metrics May Better Predict Early Ischemia as Compared to ST Segment.

Lines GT, de Oliveira BL, Skavhaug O, Maleckar MM.

IEEE Trans Biomed Eng. 2017 Jun;64(6):1305-1309. doi: 10.1109/TBME.2016.2600198. Epub 2016 Aug 25.


NS5806 partially restores action potential duration but fails to ameliorate calcium transient dysfunction in a computational model of canine heart failure.

Maleckar MM, Lines GT, Koivumäki JT, Cordeiro JM, Calloe K.

Europace. 2014 Nov;16 Suppl 4:iv46-iv55. doi: 10.1093/europace/euu252.


Na(+) current expression in human atrial myofibroblasts: identity and functional roles.

Koivumäki JT, Clark RB, Belke D, Kondo C, Fedak PW, Maleckar MM, Giles WR.

Front Physiol. 2014 Aug 7;5:275. doi: 10.3389/fphys.2014.00275. eCollection 2014.


Variable t-tubule organization and Ca2+ homeostasis across the atria.

Frisk M, Koivumäki JT, Norseng PA, Maleckar MM, Sejersted OM, Louch WE.

Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H609-20. doi: 10.1152/ajpheart.00295.2014. Epub 2014 Jun 20.


In silico screening of the key cellular remodeling targets in chronic atrial fibrillation.

Koivumäki JT, Seemann G, Maleckar MM, Tavi P.

PLoS Comput Biol. 2014 May 22;10(5):e1003620. doi: 10.1371/journal.pcbi.1003620. eCollection 2014 May.


Benchmarking electrophysiological models of human atrial myocytes.

Wilhelms M, Hettmann H, Maleckar MM, Koivumäki JT, Dössel O, Seemann G.

Front Physiol. 2013 Jan 4;3:487. doi: 10.3389/fphys.2012.00487. eCollection 2012.


Ca(2+) entry through TRP-C channels regulates fibroblast biology in chronic atrial fibrillation.

Rose RA, Belke DD, Maleckar MM, Giles WR.

Circulation. 2012 Oct 23;126(17):2039-41. doi: 10.1161/CIRCULATIONAHA.112.138065. No abstract available.


Slow Calcium-Depolarization-Calcium waves may initiate fast local depolarization waves in ventricular tissue.

Tveito A, Lines GT, Edwards AG, Maleckar MM, Michailova A, Hake J, McCulloch A.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):295-304. doi: 10.1016/j.pbiomolbio.2012.07.005. Epub 2012 Jul 24.


Note on a possible proarrhythmic property of antiarrhythmic drugs aimed at improving gap-junction coupling.

Tveito A, Lines GT, Maleckar MM.

Biophys J. 2012 Jan 18;102(2):231-7. doi: 10.1016/j.bpj.2011.11.4015.


Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density.

McDowell KS, Arevalo HJ, Maleckar MM, Trayanova NA.

Biophys J. 2011 Sep 21;101(6):1307-15. doi: 10.1016/j.bpj.2011.08.009. Epub 2011 Sep 20.


Unstable eigenmodes are possible drivers for cardiac arrhythmias.

Tveito A, Lines G, Skavhaug O, Maleckar MM.

J R Soc Interface. 2011 Aug 7;8(61):1212-6. doi: 10.1098/rsif.2011.0152. Epub 2011 May 13.


Existence of excitation waves for a collection of cardiomyocytes electrically coupled to fibroblasts.

Tveito A, Lines G, Artebrant R, Skavhaug O, Maleckar MM.

Math Biosci. 2011 Apr;230(2):79-86. doi: 10.1016/j.mbs.2011.01.004. Epub 2011 Feb 4.


Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization.

Maleckar MM, Greenstein JL, Giles WR, Trayanova NA.

Biophys J. 2009 Oct 21;97(8):2179-90. doi: 10.1016/j.bpj.2009.07.054.


K+ current changes account for the rate dependence of the action potential in the human atrial myocyte.

Maleckar MM, Greenstein JL, Giles WR, Trayanova NA.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1398-410. doi: 10.1152/ajpheart.00411.2009. Epub 2009 Jul 24.


Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.

Maleckar MM, Greenstein JL, Trayanova NA, Giles WR.

Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):161-70. doi: 10.1016/j.pbiomolbio.2009.01.010. Epub 2009 Jan 30.


Polarity reversal lowers activation time during diastolic field stimulation of the rabbit ventricles: insights into mechanisms.

Maleckar MM, Woods MC, Sidorov VY, Holcomb MR, Mashburn DN, Wikswo JP, Trayanova NA.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1626-33. doi: 10.1152/ajpheart.00706.2008. Epub 2008 Aug 15.


Cardiac defibrillation and the role of mechanoelectric feedback in postshock arrhythmogenesis.

Gurev V, Maleckar MM, Trayanova NA.

Ann N Y Acad Sci. 2006 Oct;1080:320-33.


Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerability.

Bourn DW, Maleckar MM, Rodriguez B, Trayanova NA.

Philos Trans A Math Phys Eng Sci. 2006 Jun 15;364(1843):1333-48.


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