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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E.

Mol Cell. 2016 Oct 20;64(2):431. doi: 10.1016/j.molcel.2016.10.005. No abstract available.


An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E.

Mol Cell. 2016 Aug 4;63(3):485-97. doi: 10.1016/j.molcel.2016.06.010. Epub 2016 Jul 14. Erratum in: Mol Cell. 2016 Oct 20;64(2):431.


Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea.

Carlucci L, Zhou E, Malashkevich VN, Almo SC, Mundorff EC.

Protein Sci. 2016 Apr;25(4):877-86. doi: 10.1002/pro.2895. Epub 2016 Feb 21.


Molecular Basis of Spectral Diversity in Near-Infrared Phytochrome-Based Fluorescent Proteins.

Shcherbakova DM, Baloban M, Pletnev S, Malashkevich VN, Xiao H, Dauter Z, Verkhusha VV.

Chem Biol. 2015 Nov 19;22(11):1540-1551. doi: 10.1016/j.chembiol.2015.10.007.


Analysis of the Structure and Function of FOX-4 Cephamycinase.

Lefurgy ST, Malashkevich VN, Aguilan JT, Nieves E, Mundorff EC, Biju B, Noel MA, Toro R, Baiwir D, Papp-Wallace KM, Almo SC, Frere JM, Bou G, Bonomo RA.

Antimicrob Agents Chemother. 2015 Nov 2;60(2):717-28. doi: 10.1128/AAC.01887-15. Print 2016 Feb.


A switch from parallel to antiparallel strand orientation in a coiled-coil X-ray structure via two core hydrophobic mutations.

Malashkevich VN, Higgins CD, Almo SC, Lai JR.

Biopolymers. 2015 May;104(3):178-85. doi: 10.1002/bip.22631.


Photoswitchable red fluorescent protein with a large Stokes shift.

Piatkevich KD, English BP, Malashkevich VN, Xiao H, Almo SC, Singer RH, Verkhusha VV.

Chem Biol. 2014 Oct 23;21(10):1402-1414. doi: 10.1016/j.chembiol.2014.08.010. Epub 2014 Sep 18.


Orange fluorescent proteins: structural studies of LSSmOrange, PSmOrange and PSmOrange2.

Pletnev S, Shcherbakova DM, Subach OM, Pletneva NV, Malashkevich VN, Almo SC, Dauter Z, Verkhusha VV.

PLoS One. 2014 Jun 24;9(6):e99136. doi: 10.1371/journal.pone.0099136. eCollection 2014.


Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.

Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, Almo SC, Glasner ME.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8535-40. doi: 10.1073/pnas.1318703111. Epub 2014 May 28.


Influence of a heptad repeat stutter on the pH-dependent conformational behavior of the central coiled-coil from influenza hemagglutinin HA2.

Higgins CD, Malashkevich VN, Almo SC, Lai JR.

Proteins. 2014 Sep;82(9):2220-8. doi: 10.1002/prot.24585. Epub 2014 May 6.


An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates.

Padlan CS, Malashkevich VN, Almo SC, Levy M, Brenowitz M, Girvin ME.

RNA. 2014 Apr;20(4):447-61. doi: 10.1261/rna.043034.113. Epub 2014 Feb 25.


Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species.

Koellhoffer JF, Dai Z, Malashkevich VN, Stenglein MD, Liu Y, Toro R, S Harrison J, Chandran K, DeRisi JL, Almo SC, Lai JR.

J Mol Biol. 2014 Apr 3;426(7):1452-68. doi: 10.1016/j.jmb.2013.12.009. Epub 2013 Dec 12.


X-ray crystal structure of bovine 3 Glu-osteocalcin.

Malashkevich VN, Almo SC, Dowd TL.

Biochemistry. 2013 Nov 26;52(47):8387-92. doi: 10.1021/bi4010254. Epub 2013 Nov 12.


Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.

Daughtry KD, Huang H, Malashkevich V, Patskovsky Y, Liu W, Ramagopal U, Sauder JM, Burley SK, Almo SC, Dunaway-Mariano D, Allen KN.

Biochemistry. 2013 Aug 13;52(32):5372-86. doi: 10.1021/bi400659k. Epub 2013 Jul 29.


Extended Stokes shift in fluorescent proteins: chromophore-protein interactions in a near-infrared TagRFP675 variant.

Piatkevich KD, Malashkevich VN, Morozova KS, Nemkovich NA, Almo SC, Verkhusha VV.

Sci Rep. 2013;3:1847. doi: 10.1038/srep01847.


Crystal structure of the Marburg virus GP2 core domain in its postfusion conformation.

Koellhoffer JF, Malashkevich VN, Harrison JS, Toro R, Bhosle RC, Chandran K, Almo SC, Lai JR.

Biochemistry. 2012 Oct 2;51(39):7665-75. doi: 10.1021/bi300976m. Epub 2012 Sep 19.


Structure and catalytic mechanism of LigI: insight into the amidohydrolase enzymes of cog3618 and lignin degradation.

Hobbs ME, Malashkevich V, Williams HJ, Xu C, Sauder JM, Burley SK, Almo SC, Raushel FM.

Biochemistry. 2012 Apr 24;51(16):3497-507. doi: 10.1021/bi300307b. Epub 2012 Apr 9.


Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide.

Roche CJ, Malashkevich V, Balazs TC, Dantsker D, Chen Q, Moreira J, Almo SC, Friedman JM, Hirsch RE.

J Biol Chem. 2011 Jul 1;286(26):23452-66. doi: 10.1074/jbc.M110.183186. Epub 2011 Apr 29.


Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding.

Magalhães ML, Czekster CM, Guan R, Malashkevich VN, Almo SC, Levy M.

Protein Sci. 2011 Jul;20(7):1145-54. doi: 10.1002/pro.642. Epub 2011 May 12.


Engineering ESPT pathways based on structural analysis of LSSmKate red fluorescent proteins with large Stokes shift.

Piatkevich KD, Malashkevich VN, Almo SC, Verkhusha VV.

J Am Chem Soc. 2010 Aug 11;132(31):10762-70. doi: 10.1021/ja101974k.


Phenothiazines inhibit S100A4 function by inducing protein oligomerization.

Malashkevich VN, Dulyaninova NG, Ramagopal UA, Liriano MA, Varney KM, Knight D, Brenowitz M, Weber DJ, Almo SC, Bresnick AR.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10. doi: 10.1073/pnas.0913660107. Epub 2010 Apr 26.


Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins.

Subach OM, Malashkevich VN, Zencheck WD, Morozova KS, Piatkevich KD, Almo SC, Verkhusha VV.

Chem Biol. 2010 Apr 23;17(4):333-41. doi: 10.1016/j.chembiol.2010.03.005.


Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.

Brims DR, Qian J, Jarchum I, Mikesh L, Palmieri E, Ramagopal UA, Malashkevich VN, Chaparro RJ, Lund T, Hattori M, Shabanowitz J, Hunt DF, Nathenson SG, Almo SC, Dilorenzo TP.

Int Immunol. 2010 Mar;22(3):191-203. doi: 10.1093/intimm/dxp127. Epub 2010 Jan 21.


Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states.

Subach FV, Malashkevich VN, Zencheck WD, Xiao H, Filonov GS, Almo SC, Verkhusha VV.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21097-102. doi: 10.1073/pnas.0909204106. Epub 2009 Nov 23.


Analysis of coiled-coil interactions between core proteins of the spindle pole body.

Zizlsperger N, Malashkevich VN, Pillay S, Keating AE.

Biochemistry. 2008 Nov 11;47(45):11858-68. doi: 10.1021/bi801378z. Epub 2008 Oct 14.


Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA.

Malashkevich VN, Varney KM, Garrett SC, Wilder PT, Knight D, Charpentier TH, Ramagopal UA, Almo SC, Weber DJ, Bresnick AR.

Biochemistry. 2008 May 6;47(18):5111-26. doi: 10.1021/bi702537s. Epub 2008 Apr 15.


Structural genomics of protein phosphatases.

Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK.

J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. Review.


Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.

Chattopadhyay K, Ramagopal UA, Mukhopadhaya A, Malashkevich VN, Dilorenzo TP, Brenowitz M, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19452-7. Epub 2007 Nov 26.


Structure of CD84 provides insight into SLAM family function.

Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10583-8. Epub 2007 Jun 11.


Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase.

Kim J, Malashkevich V, Roday S, Lisbin M, Schramm VL, Almo SC.

Biochemistry. 2006 May 23;45(20):6407-16.


Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation.

Dulyaninova NG, Malashkevich VN, Almo SC, Bresnick AR.

Biochemistry. 2005 May 10;44(18):6867-76.


Short constrained peptides that inhibit HIV-1 entry.

Sia SK, Carr PA, Cochran AG, Malashkevich VN, Kim PS.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14664-9. Epub 2002 Nov 4.


Structure of the Bcr-Abl oncoprotein oligomerization domain.

Zhao X, Ghaffari S, Lodish H, Malashkevich VN, Kim PS.

Nat Struct Biol. 2002 Feb;9(2):117-20.


Side-chain repacking calculations for predicting structures and stabilities of heterodimeric coiled coils.

Keating AE, Malashkevich VN, Tidor B, Kim PS.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14825-30.


Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.

Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN.

Nat Struct Biol. 2001 Nov;8(11):963-7.


The trimer-of-hairpins motif in membrane fusion: Visna virus.

Malashkevich VN, Singh M, Kim PS.

Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8502-6. Epub 2001 Jul 10.


Buried polar residues in coiled-coil interfaces.

Akey DL, Malashkevich VN, Kim PS.

Biochemistry. 2001 May 29;40(21):6352-60.


Structural characterization of the human respiratory syncytial virus fusion protein core.

Zhao X, Singh M, Malashkevich VN, Kim PS.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14172-7.


Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.

Meier M, Bider MD, Malashkevich VN, Spiess M, Burkhard P.

J Mol Biol. 2000 Jul 21;300(4):857-65.


Crystal structures of dialkylglycine decarboxylase inhibitor complexes.

Malashkevich VN, Strop P, Keller JW, Jansonius JN, Toney MD.

J Mol Biol. 1999 Nov 19;294(1):193-200.


Conversion of aspartate aminotransferase into an L-aspartate beta-decarboxylase by a triple active-site mutation.

Graber R, Kasper P, Malashkevich VN, Strop P, Gehring H, Jansonius JN, Christen P.

J Biol Chem. 1999 Oct 29;274(44):31203-8.


Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.

Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS.

Cell. 1999 Oct 1;99(1):103-15.


Preliminary X-ray analysis of a new crystal form of recombinant pig kidney DOPA decarboxylase.

Malashkevich VN, Burkhard P, Dominici P, Moore PS, Borri Voltattorni C, Jansonius JN.

Acta Crystallogr D Biol Crystallogr. 1999 Feb;55(Pt 2):568-70.


Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution.

Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7.


Functional and structural analysis of cis-proline mutants of Escherichia coli aspartate aminotransferase.

Birolo L, Malashkevich VN, Capitani G, De Luca F, Moretta A, Jansonius JN, Marino G.

Biochemistry. 1999 Jan 19;38(3):905-13.


Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues.

Eckert DM, Malashkevich VN, Kim PS.

J Mol Biol. 1998 Dec 11;284(4):859-65.


Crystallization and preliminary X-ray analysis of the beta-isoform of glutamate decarboxylase from Escherichia coli.

Malashkevich VN, De Biase D, Markovic-Housley Z, Schlunegger MP, Bossa F, Jansonius JN.

Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1020-2.


The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel?

Malashkevich VN, Kammerer RA, Efimov VP, Schulthess T, Engel J.

Science. 1996 Nov 1;274(5288):761-5.


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