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Comparative Incidences and Biological Outcomes for Thymoma in Various Rat Strains in National Toxicology Program Studies.

Moore RR, Nagai H, Miller RA, Hardisty JF, Allison N, Shockley KR, Malarkey DE.

Toxicol Pathol. 2019 Aug 8:192623319863119. doi: 10.1177/0192623319863119. [Epub ahead of print]


Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program.

Janardhan KS, Venkannagari P, Jensen H, Hoenerhoff MJ, Herbert RA, Malarkey DE, Sills RC, Pandiri AR.

Toxicol Pathol. 2019 Jul;47(5):577-584. doi: 10.1177/0192623319845838. Epub 2019 May 7.


NTP Research Report on Baseline Characteristics of Diversity Outbred (J:DO) Mice Relevant to Toxicology Studies: Research Report 6 [Internet].

Harrill AH, Borghoff S, Zorrilla L, Blystone C, Kissling GE, Malarkey D, Shockley K, Travlos G, DeVito MJ.

Durham (NC): National Toxicology Program; 2018 Jun.


Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies.

Jackson-Humbles DN, Seely JC, Herbert RA, Malarkey DE, McIntyre BS, Foster PM, Dixon D.

Toxicol Pathol. 2018 Jun;46(4):421-430. doi: 10.1177/0192623318772487. Epub 2018 Apr 29.


Comparative inhalation toxicity of ethyltoluene isomers in rats and mice.

Roberts GK, Willson CJ, Olivera DS, Malarkey DE, Morgan DL.

Inhal Toxicol. 2017 Oct - Dec;29(12-14):577-585. doi: 10.1080/08958378.2018.1430190. Epub 2018 Jan 29.


NTP/NIEHS Global Contributions to Toxicologic Pathology.

Sills R, Brix A, Cesta M, Churchill SR, Cora MC, Dixon D, Dykstra M, Flake G, Herbert R, Kovi R, Janardhan K, King-Herbert A, Malarkey D, Pandiri A, Travlos G, Willson C, Elmore SA.

Toxicol Pathol. 2017 Dec;45(8):1035-1038. doi: 10.1177/0192623317740326. Epub 2017 Nov 16.


Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice.

Hart-Unger S, Arao Y, Hamilton KJ, Lierz SL, Malarkey DE, Hewitt SC, Freemark M, Korach KS.

Int J Obes (Lond). 2017 Jun;41(6):945-954. doi: 10.1038/ijo.2017.50. Epub 2017 Feb 21.


Proceedings of the 2016 National Toxicology Program Satellite Symposium.

Elmore SA, Chen VS, Hayes-Bouknight S, Hoane JS, Janardhan K, Kooistra LH, Nolte T, Szabo KA, Willson GA, Wolf JC, Malarkey DE.

Toxicol Pathol. 2017 Jan;45(1):11-51. doi: 10.1177/0192623316672074. Epub 2016 Nov 11.


Proceedings of the 2015 National Toxicology Program Satellite Symposium.

Elmore SA, Farman CA, Hailey JR, Kovi RC, Malarkey DE, Morrison JP, Neel J, Pesavento PA, Porter BF, Szabo KA, Teixeira LB, Quist EM.

Toxicol Pathol. 2016 Jun;44(4):502-35. doi: 10.1177/0192623316631844. Epub 2016 Apr 12.


Utilizing Whole Slide Images for Pathology Peer Review and Working Groups.

Malarkey DE, Willson GA, Willson CJ, Adams ET, Olson GR, Witt WM, Elmore SA, Hardisty JF, Boyle MC, Crabbs TA, Miller RA.

Toxicol Pathol. 2015 Dec;43(8):1149-57. doi: 10.1177/0192623315605933. Epub 2015 Oct 27.


Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.

Bhusari S, Pandiri AR, Nagai H, Wang Y, Foley J, Hong HH, Ton TV, DeVito M, Shockley KR, Peddada SD, Gerrish KE, Malarkey DE, Hooth MJ, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Dec;43(8):1114-26. doi: 10.1177/0192623315599853. Epub 2015 Aug 18.


Comparative pathology of canine soft tissue sarcomas: possible models of human non-rhabdomyosarcoma soft tissue sarcomas.

Milovancev M, Hauck M, Keller C, Stranahan LW, Mansoor A, Malarkey DE.

J Comp Pathol. 2015 Jan;152(1):22-7. doi: 10.1016/j.jcpa.2014.09.005. Epub 2014 Nov 27.


The course of toxicity in the pregnant mouse after exposure to the cyanobacterial toxin cylindrospermopsin: clinical effects, serum chemistries, hematology, and histopathology.

Chernoff N, Rogers EH, Zehr RD, Gage MI, Travlos GS, Malarkey DE, Brix A, Schmid JE, Hill D.

J Toxicol Environ Health A. 2014;77(17):1040-60. doi: 10.1080/15287394.2014.919838.


Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease.

Wahlang B, Song M, Beier JI, Cameron Falkner K, Al-Eryani L, Clair HB, Prough RA, Osborne TS, Malarkey DE, Christopher States J, Cave MC.

Toxicol Appl Pharmacol. 2014 Sep 15;279(3):380-90. doi: 10.1016/j.taap.2014.06.019. Epub 2014 Jul 3.


Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

Surh I, Rao DB, Cesta MF, Hébert CD, Mann JF, Cunny H, Kissling GE, Malarkey D, Chhabra RS.

Food Chem Toxicol. 2014 Apr;66:254-61. doi: 10.1016/j.fct.2014.01.048. Epub 2014 Feb 3.


The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource.

Cesta MF, Malarkey DE, Herbert RA, Brix A, Hamlin MH 2nd, Singletary E, Sills RC, Bucher JR, Birnbaum LS.

Toxicol Pathol. 2014;42(2):458-60. doi: 10.1177/0192623313517304.


Proceedings of the 2013 National Toxicology Program Satellite Symposium.

Elmore SA, Boyle MC, Boyle MH, Cora MC, Crabbs TA, Cummings CA, Gruebbel MM, Johnson CL, Malarkey DE, McInnes EF, Nolte T, Shackelford CC, Ward JM.

Toxicol Pathol. 2014 Jan;42(1):12-44. doi: 10.1177/0192623313508020. Epub 2013 Dec 13.


Perinatal toxicity and carcinogenicity studies of styrene-acrylonitrile trimer, a ground water contaminant.

Behl M, Elmore SA, Malarkey DE, Hejtmancik MR, Gerken DK, Chhabra RS.

Toxicology. 2013 Dec 6;314(1):84-94. doi: 10.1016/j.tox.2013.09.006. Epub 2013 Sep 20.


Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene.

Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth MJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014;42(3):555-64. doi: 10.1177/0192623313491169. Epub 2013 May 23.


Cardiac structure and function in female carriers of a canine model of Duchenne muscular dystrophy.

Kane AM, DeFrancesco TC, Boyle MC, Malarkey DE, Ritchey JW, Atkins CE, Cullen JM, Kornegay JN, Keene BW.

Res Vet Sci. 2013 Jun;94(3):610-7. doi: 10.1016/j.rvsc.2012.09.027. Epub 2012 Dec 8.


Evaluation of expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiosarcomas and hemangiomas in mice.

Kakiuchi-Kiyota S, Crabbs TA, Arnold LL, Pennington KL, Cook JC, Malarkey DE, Cohen SM.

Toxicol Pathol. 2013 Jul;41(5):709-21. doi: 10.1177/0192623312464309. Epub 2012 Nov 2.


Comparative histomorphological review of rat and human hepatocellular proliferative lesions.

Thoolen B, Ten Kate FJ, van Diest PJ, Malarkey DE, Elmore SA, Maronpot RR.

J Toxicol Pathol. 2012 Sep;25(3):189-99. doi: 10.1293/tox.25.189. Epub 2012 Oct 1.


Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes--conclusions from the 3rd International ESTP Expert Workshop.

Hall AP, Elcombe CR, Foster JR, Harada T, Kaufmann W, Knippel A, Küttler K, Malarkey DE, Maronpot RR, Nishikawa A, Nolte T, Schulte A, Strauss V, York MJ.

Toxicol Pathol. 2012 Oct;40(7):971-94. Epub 2012 Jun 21. Review.


Testing an aflatoxin B1 gene signature in rat archival tissues.

Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR.

Chem Res Toxicol. 2012 May 21;25(5):1132-44. doi: 10.1021/tx3000945. Epub 2012 May 4.


Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage.

Boyle MC, Crabbs TA, Wyde ME, Painter JT, Hill GD, Malarkey DE, Lieuallen WG, Nyska A.

Toxicol Pathol. 2012 Jun;40(4):561-76. doi: 10.1177/0192623311436178. Epub 2012 Feb 9.


Immunohistochemical features of 3,3',4,4'-tetrachloroazobenzene-induced rat gingival lesions.

Ramot Y, Vered M, Malarkey DE, Hooth MJ, Painter JT, Dayan D, Clayton N, Masinde T, Nyska A.

Toxicol Pathol. 2012 Jun;40(4):577-92. doi: 10.1177/0192623311436185. Epub 2012 Feb 7.


Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.

Ellis JM, Paul DS, Depetrillo MA, Singh BP, Malarkey DE, Coleman RA.

Toxicol Pathol. 2012 Apr;40(3):513-21. doi: 10.1177/0192623311432298. Epub 2012 Jan 3.


Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.

Pandiri AR, Sills RC, Hoenerhoff MJ, Peddada SD, Ton TV, Hong HH, Flake GP, Malarkey DE, Olson GR, Pogribny IP, Walker NJ, Boudreau MD.

Toxicol Pathol. 2011 Dec;39(7):1065-74. doi: 10.1177/0192623311422081. Epub 2011 Sep 21.


Morphologic aspects of rodent cardiotoxicity in a retrospective evaluation of National Toxicology Program studies.

Jokinen MP, Lieuallen WG, Boyle MC, Johnson CL, Malarkey DE, Nyska A.

Toxicol Pathol. 2011 Aug;39(5):850-60. doi: 10.1177/0192623311413788. Epub 2011 Jul 11.


Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice.

Chan PC, Peckham JC, Malarkey DE, Kissling GE, Travlos GS, Fu PP.

Am J Chin Med. 2011;39(4):779-88.


Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice.

Blystone CR, Elmore SA, Witt KL, Malarkey DE, Foster PM.

Food Chem Toxicol. 2011 Sep;49(9):2116-24. doi: 10.1016/j.fct.2011.05.026. Epub 2011 May 30.


Histopathological evaluation of the nervous system in National Toxicology Program rodent studies: a modified approach.

Rao DB, Little PB, Malarkey DE, Herbert RA, Sills RC.

Toxicol Pathol. 2011 Apr;39(3):463-70. doi: 10.1177/0192623311401044. Epub 2011 Mar 23.


Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system.

Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey DE, Kaufmann W, Küttler K, Deschl U, Nakae D, Gregson R, Vinlove MP, Brix AE, Singh B, Belpoggi F, Ward JM.

Toxicol Pathol. 2010 Dec;38(7 Suppl):5S-81S. doi: 10.1177/0192623310386499. Review.


Proceedings of the 2010 National Toxicology Program Satellite Symposium.

Adams ET, Auerbach S, Blackshear PE, Bradley A, Gruebbel MM, Little PB, Malarkey D, Maronpot R, McKay JS, Miller RA, Moore RR, Morrison JP, Nyska A, Ramot Y, Rao D, Suttie A, Wells MY, Willson GA, Elmore SA.

Toxicol Pathol. 2011 Jan;39(1):240-66. doi: 10.1177/0192623310391680. Epub 2010 Dec 21.


Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin.

Chernoff N, Rogers EH, Zehr RD, Gage MI, Malarkey DE, Bradfield CA, Liu Y, Schmid JE, Jaskot RH, Richards JH, Wood CR, Rosen MB.

J Appl Toxicol. 2011 Apr;31(3):242-54. doi: 10.1002/jat.1586. Epub 2010 Oct 8.


Fourteen-week toxicity study of green tea extract in rats and mice.

Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A.

Toxicol Pathol. 2010 Dec;38(7):1070-84. doi: 10.1177/0192623310382437. Epub 2010 Sep 30.


Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats.

Stanko JP, Enoch RR, Rayner JL, Davis CC, Wolf DC, Malarkey DE, Fenton SE.

Reprod Toxicol. 2010 Dec;30(4):540-9. doi: 10.1016/j.reprotox.2010.07.006. Epub 2010 Aug 19. Erratum in: Reprod Toxicol. 2011 Jul;32(1):146-7.


Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB).

Singh BP, Nyska A, Kissling GE, Lieuallen W, Johansson SL, Malarkey DE, Hooth MJ.

Toxicol Pathol. 2010 Apr;38(3):372-81. doi: 10.1177/0192623310362708. Epub 2010 Mar 16.


Chemical carcinogenesis of the gastrointestinal tract in rodents: an overview with emphasis on NTP carcinogenesis bioassays.

Chandra SA, Nolan MW, Malarkey DE.

Toxicol Pathol. 2010 Jan;38(1):188-97. doi: 10.1177/0192623309356452. Epub 2009 Dec 17. Review.


Proceedings of the 2009 National Toxicology Program Satellite Symposium.

Bach U, Hailey JR, Hill GD, Kaufmann W, Latimer KS, Malarkey DE, Maronpot RM, Miller RA, Moore RR, Morrison JP, Nolte T, Rinke M, Rittinghausen S, Suttie AW, Travlos GS, Vahle JL, Willson GA, Elmore SA.

Toxicol Pathol. 2010 Jan;38(1):9-36. doi: 10.1177/0192623309354111. Epub 2009 Dec 15.


The pivotal role of electron microscopic evaluation in investigation of the cardiotoxicity of bis(2-chloroethoxy)methane in rats and mice.

Nyska A, Cunningham M, Snell M, Malarkey D, Sutton D, Dunnick J.

Toxicol Pathol. 2009 Dec;37(7):873-7. doi: 10.1177/0192623309347908.


Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed to 3,3',4,4'-tetrachloroazobenzene for 2 years.

Ramot Y, Nyska A, Lieuallen W, Maly A, Flake G, Kissling GE, Brix A, Malarkey DE, Hooth MJ.

Toxicology. 2009 Nov 9;265(1-2):1-9. doi: 10.1016/j.tox.2009.08.017. Epub 2009 Sep 6.


Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice.

Hoffler U, Hobbie K, Wilson R, Bai R, Rahman A, Malarkey D, Travlos G, Ghanayem BI.

Endocrine. 2009 Oct;36(2):311-25. doi: 10.1007/s12020-009-9224-9. Epub 2009 Aug 11.


No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days.

Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L.

Environ Mol Mutagen. 2010 Jan;51(1):80-8. doi: 10.1002/em.20515.


Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance.

Cohen SM, Storer RD, Criswell KA, Doerrer NG, Dellarco VL, Pegg DG, Wojcinski ZW, Malarkey DE, Jacobs AC, Klaunig JE, Swenberg JA, Cook JC.

Toxicol Sci. 2009 Sep;111(1):4-18. doi: 10.1093/toxsci/kfp131. Epub 2009 Jun 12. Review.


Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.

Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Abdo KM, Malarkey DE, Hooth MJ.

Environ Health Perspect. 2009 May;117(5):716-22. doi: 10.1289/ehp.0800208. Epub 2008 Dec 31.


Expression of epidermal growth factor receptor and vascular endothelial growth factor in malignant canine epithelial nasal tumours.

Shiomitsu K, Johnson CL, Malarkey DE, Pruitt AF, Thrall DE.

Vet Comp Oncol. 2009 Jun;7(2):106-14. doi: 10.1111/j.1476-5829.2009.00178.x.


Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years.

Stout MD, Nyska A, Collins BJ, Witt KL, Kissling GE, Malarkey DE, Hooth MJ.

Food Chem Toxicol. 2009 Apr;47(4):729-33. doi: 10.1016/j.fct.2009.01.006. Epub 2009 Jan 8.


Bilateral nocardial endophthalmitis in a prothonotary warbler (Protonotaria citrea).

Reynolds TL, Barnes HJ, Wolfe B, Lu L, Camp DM, Malarkey DE.

Vet Pathol. 2009 Jan;46(1):120-3. doi: 10.1354/vp.46-1-120.


Epibulbar melanoma in a foal.

McMullen RJ, Clode AB, Pandiri AK, Malarkey DE, Michau TM, Gilger BC.

Vet Ophthalmol. 2008 Sep;11 Suppl 1:44-50. doi: 10.1111/j.1463-5224.2008.00637.x.

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