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Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells.

Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S.

Cancer Immunol Res. 2019 Sep 12. doi: 10.1158/2326-6066.CIR-18-0934. [Epub ahead of print]


Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome.

Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S.

Nat Commun. 2019 Sep 2;10(1):3931. doi: 10.1038/s41467-019-11947-7.


Single-center experience suggests donor lymphocyte infusion may promote long-term survival in children with high-risk acute lymphoblastic leukemia.

Liberio N, Robinson H, Nugent M, Simpson P, Margolis DA, Malarkannan S, Keever-Taylor C, Thakar MS.

Pediatr Blood Cancer. 2019 Jul 31:e27950. doi: 10.1002/pbc.27950. [Epub ahead of print]


Immune-Checkpoint Protein VISTA Regulates Antitumor Immunity by Controlling Myeloid Cell-Mediated Inflammation and Immunosuppression.

Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta HM, Miller HE, Olson M, Rajasekaran K, Ernstoff MS, Wang D, Malarkannan S, Wang L.

Cancer Immunol Res. 2019 Sep;7(9):1497-1510. doi: 10.1158/2326-6066.CIR-18-0489. Epub 2019 Jul 24.


Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression.

Reimer M Jr, Pulakanti K, Shi L, Abel A, Liang M, Malarkannan S, Rao S.

BMC Dev Biol. 2019 Jul 8;19(1):16. doi: 10.1186/s12861-019-0196-6.


IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection.

Kumar P, Rajasekaran K, Nanbakhsh A, Gorski J, Thakar MS, Malarkannan S.

Sci Rep. 2019 Mar 21;9(1):4984. doi: 10.1038/s41598-019-41478-6.


Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells.

Luo X, Chen J, Schroeder JA, Allen KP, Baumgartner CK, Malarkannan S, Hu J, Williams CB, Shi Q.

Front Immunol. 2018 Sep 6;9:1950. doi: 10.3389/fimmu.2018.01950. eCollection 2018.


Natural Killer Cells: Development, Maturation, and Clinical Utilization.

Abel AM, Yang C, Thakar MS, Malarkannan S.

Front Immunol. 2018 Aug 13;9:1869. doi: 10.3389/fimmu.2018.01869. eCollection 2018. Review.


Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance.

Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ.

Immunohorizons. 2018 Apr 1;2(4):107-118. doi: 10.4049/immunohorizons.1700055.


IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.

Abel AM, Tiwari AA, Gerbec ZJ, Siebert JR, Yang C, Schloemer NJ, Dixon KJ, Thakar MS, Malarkannan S.

Front Immunol. 2018 May 28;9:1168. doi: 10.3389/fimmu.2018.01168. eCollection 2018.


mTORC1 and mTORC2 differentially promote natural killer cell development.

Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S.

Elife. 2018 May 29;7. pii: e35619. doi: 10.7554/eLife.35619.


Author Correction: Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.

Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L.

Sci Rep. 2018 Mar 1;8(1):4054. doi: 10.1038/s41598-018-22151-w.


Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection.

Jang Y, Gerbec ZJ, Won T, Choi B, Podsiad A, B Moore B, Malarkannan S, Laouar Y.

J Immunol. 2018 Mar 15;200(6):1982-1987. doi: 10.4049/jimmunol.1701676. Epub 2018 Feb 9.


The structure, expression, and multifaceted role of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation.

Xu W, Hiếu T, Malarkannan S, Wang L.

Cell Mol Immunol. 2018 May;15(5):438-446. doi: 10.1038/cmi.2017.148. Epub 2018 Jan 29. Review.


Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells.

Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S.

J Vis Exp. 2018 Jan 15;(131). doi: 10.3791/55063.


Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.

Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L.

Sci Rep. 2017 May 3;7(1):1485. doi: 10.1038/s41598-017-01411-1. Erratum in: Sci Rep. 2018 Mar 1;8(1):4054.


The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.

Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S.

Leukemia. 2017 Mar;31(3):712-719. doi: 10.1038/leu.2016.240. Epub 2016 Aug 24.


Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy.

Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S.

Front Immunol. 2016 May 12;7:176. doi: 10.3389/fimmu.2016.00176. eCollection 2016. Review.


The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells.

Gerbec ZJ, Thakar MS, Malarkannan S.

Front Immunol. 2015 Sep 16;6:472. doi: 10.3389/fimmu.2015.00472. eCollection 2015. Review.


TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.

Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ.

J Leukoc Biol. 2015 Nov;98(5):703-12. doi: 10.1189/jlb.2HIMA1214-578R. Epub 2015 Jul 7.


IQGAP1: insights into the function of a molecular puppeteer.

Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S.

Mol Immunol. 2015 Jun;65(2):336-49. doi: 10.1016/j.molimm.2015.02.012. Epub 2015 Feb 28. Review.


Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner.

Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S.

Exp Hematol. 2015 Jan;43(1):53-64.e1-8. doi: 10.1016/j.exphem.2014.09.004. Epub 2014 Sep 20.


Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.

Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA.

PLoS One. 2014 Jun 10;9(6):e99486. doi: 10.1371/journal.pone.0099486. eCollection 2014.


Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.

Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S.

Nat Immunol. 2013 Nov;14(11):1127-36. doi: 10.1038/ni.2708. Epub 2013 Sep 15. Erratum in: Nat Immunol. 2014 Feb;15(2):205.


IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration.

Kumar P, Rajasekaran K, Palmer JM, Thakar MS, Malarkannan S.

J Cancer. 2013;4(1):57-65. doi: 10.7150/jca.5048. Epub 2012 Dec 25.


Clinical relevance of natural killer cells following hematopoietic stem cell transplantation.

Palmer JM, Rajasekaran K, Thakar MS, Malarkannan S.

J Cancer. 2013;4(1):25-35. doi: 10.7150/jca.5049. Epub 2012 Dec 5.


IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection.

Kumar P, Thakar MS, Ouyang W, Malarkannan S.

Mucosal Immunol. 2013 Jan;6(1):69-82. doi: 10.1038/mi.2012.49. Epub 2012 Jun 27.


IQGAP1: a regulator of intracellular spacetime relativity.

Malarkannan S, Awasthi A, Rajasekaran K, Kumar P, Schuldt KM, Bartoszek A, Manoharan N, Goldner NK, Umhoefer CM, Thakar MS.

J Immunol. 2012 Mar 1;188(5):2057-63. doi: 10.4049/jimmunol.1102439. Review.


High-throughput detection method for influenza virus.

Kumar P, Bartoszek AE, Moran TM, Gorski J, Bhattacharyya S, Navidad JF, Thakar MS, Malarkannan S.

J Vis Exp. 2012 Feb 4;(60). pii: 3623. doi: 10.3791/3623.


Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.

Kwun J, Malarkannan S, Burlingham WJ, Knechtle SJ.

J Immunol. 2011 Oct 15;187(8):3997-4006. doi: 10.4049/jimmunol.1003918. Epub 2011 Sep 7.


Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.

Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, Kim TW, Li X, Thakar MS, Zhang J, Malarkannan S.

J Biol Chem. 2011 Sep 9;286(36):31213-24. doi: 10.1074/jbc.M111.261917. Epub 2011 Jul 19.


Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells.

Rajasekaran K, Xiong V, Fong L, Gorski J, Malarkannan S.

PLoS One. 2010 Sep 9;5(9). pii: e12635. doi: 10.1371/journal.pone.0012635.


Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.

Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S.

J Exp Med. 2010 Aug 30;207(9):1923-38. doi: 10.1084/jem.20100040. Epub 2010 Aug 23.


Evasion of natural killer cells by influenza virus.

Guo H, Kumar P, Malarkannan S.

J Leukoc Biol. 2011 Feb;89(2):189-94. doi: 10.1189/jlb.0610319. Epub 2010 Aug 3. Review.


The functional impairment of natural killer cells during influenza virus infection.

Guo H, Kumar P, Moran TM, Garcia-Sastre A, Zhou Y, Malarkannan S.

Immunol Cell Biol. 2009 Nov-Dec;87(8):579-89. doi: 10.1038/icb.2009.60. Epub 2009 Sep 1.


Murine NKG2D ligands: "double, double toil and trouble".

Samarakoon A, Chu H, Malarkannan S.

Mol Immunol. 2009 Mar;46(6):1011-9. doi: 10.1016/j.molimm.2008.09.035. Epub 2008 Dec 10. Review.


The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.

Guo H, Samarakoon A, Vanhaesebroeck B, Malarkannan S.

J Exp Med. 2008 Sep 29;205(10):2419-35. doi: 10.1084/jem.20072327. Epub 2008 Sep 22.


Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5.

Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H.

Blood. 2008 Dec 15;112(13):4905-14. doi: 10.1182/blood-2008-03-146555. Epub 2008 Sep 16.


Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity.

Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S.

J Immunol. 2008 Sep 1;181(5):3373-83.


Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells.

Awasthi A, Samarakoon A, Dai X, Wen R, Wang D, Malarkannan S.

Genes Immun. 2008 Sep;9(6):522-35. doi: 10.1038/gene.2008.45. Epub 2008 Jun 12.


Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation.

Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D.

J Immunol. 2007 Sep 15;179(6):3752-62.


Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells.

Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D, Malarkannan S.

J Immunol. 2006 Oct 15;177(8):5365-76.


The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions.

Malarkannan S.

Semin Immunol. 2006 Jun;18(3):186-92. Review.


Unanticipated antigens: translation initiation at CUG with leucine.

Schwab SR, Shugart JA, Horng T, Malarkannan S, Shastri N.

PLoS Biol. 2004 Nov;2(11):e366. Epub 2004 Oct 26.


NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors.

Regunathan J, Chen Y, Wang D, Malarkannan S.

Blood. 2005 Jan 1;105(1):233-40. Epub 2004 Aug 24.


A single nucleotide polymorphism in the Emp3 gene defines the H4 minor histocompatibility antigen.

Luedtke B, Pooler LM, Choi EY, Tranchita AM, Reinbold CJ, Brown AC, Shaffer DJ, Roopenian DC, Malarkannan S.

Immunogenetics. 2003 Aug;55(5):284-95. Epub 2003 Jul 4.


Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease.

Choi EY, Christianson GJ, Yoshimura Y, Jung N, Sproule TJ, Malarkannan S, Joyce S, Roopenian DC.

Blood. 2002 Dec 15;100(13):4259-65. Epub 2002 Aug 22.


Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others.

Choi EY, Yoshimura Y, Christianson GJ, Sproule TJ, Malarkannan S, Shastri N, Joyce S, Roopenian DC.

J Immunol. 2001 Apr 1;166(7):4370-9.


Generation of antigen-specific, lacZ-inducible T-cell hybrids.

Malarkannan S, Mendoza LM, Shastri N.

Methods Mol Biol. 2001;156:265-72. No abstract available.


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