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High detection rate of osteoporosis with screening of a general hospitalized population: a 6-year study in 6406 patients in a university hospital setting.

Malaise O, Detroz M, Leroy M, Leonori L, Seidel L, Malaise MG.

BMC Musculoskelet Disord. 2020 Feb 10;21(1):90. doi: 10.1186/s12891-020-3116-9.


Glycosylation deficiency of lipopolysaccharide-binding protein and corticosteroid-binding globulin associated with activity and response to treatment for rheumatoid arthritis.

Ciregia F, Baiwir D, Cobraiville G, Dewael T, Mazzucchelli G, Badot V, Di Romana S, Sidiras P, Sokolova T, Durez P, Malaise MG, de Seny D.

J Transl Med. 2020 Jan 6;18(1):8. doi: 10.1186/s12967-019-02188-9.


Did Osteoblastic Cell Therapy Improve the Prognosis of Pre-fracture Osteonecrosis of the Femoral Head? A Randomized, Controlled Trial.

Hauzeur JP, Lechanteur C, Baudoux E, De Maertelaer V, Pather S, Katz R, Malaise M, Ino J, Beguin Y.

Clin Orthop Relat Res. 2019 Dec 26. doi: 10.1097/CORR.0000000000001107. [Epub ahead of print]


Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets.

Guiot J, Struman I, Louis E, Louis R, Malaise M, Njock MS.

J Clin Med. 2019 Aug 29;8(9). pii: E1345. doi: 10.3390/jcm8091345. Review.


Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis.

Nys G, Cobraiville G, Servais AC, Malaise MG, de Seny D, Fillet M.

Talanta. 2019 Nov 1;204:507-517. doi: 10.1016/j.talanta.2019.06.044. Epub 2019 Jun 11.


Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study.

Henrotin Y, Malaise M, Wittoek R, de Vlam K, Brasseur JP, Luyten FP, Jiangang Q, Van den Berghe M, Uhoda R, Bentin J, De Vroey T, Erpicum L, Donneau AF, Dierckxsens Y.

Arthritis Res Ther. 2019 Jul 27;21(1):179. doi: 10.1186/s13075-019-1960-5.


Biomarkers in systemic sclerosis-associated interstitial lung disease: review of the literature.

Bonhomme O, André B, Gester F, de Seny D, Moermans C, Struman I, Louis R, Malaise M, Guiot J.

Rheumatology (Oxford). 2019 Sep 1;58(9):1534-1546. doi: 10.1093/rheumatology/kez230.


Hyaluronan derivative HYMOVIS® increases cartilage volume and type ii collagen turnover in osteoarhritic knee: data from MOKHA study.

Henrotin Y, Bannuru R, Malaise M, Ea HK, Confavreux C, Bentin J, Urbin-Choffray D, Conrozier T, Brasseur JP, Thomas P, Hick AC, Marinello A, Giordan N, Richette P.

BMC Musculoskelet Disord. 2019 Jun 18;20(1):293. doi: 10.1186/s12891-019-2667-0.


15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts.

Vaamonde-Garcia C, Malaise O, Charlier E, Deroyer C, Neuville S, Gillet P, Kurth W, Meijide-Failde R, Malaise MG, de Seny D.

Biochem Pharmacol. 2019 Jul;165:66-78. doi: 10.1016/j.bcp.2019.03.039. Epub 2019 Mar 29.


Chondrocyte dedifferentiation and osteoarthritis (OA).

Charlier E, Deroyer C, Ciregia F, Malaise O, Neuville S, Plener Z, Malaise M, de Seny D.

Biochem Pharmacol. 2019 Jul;165:49-65. doi: 10.1016/j.bcp.2019.02.036. Epub 2019 Mar 7. Review.


CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes.

Deroyer C, Charlier E, Neuville S, Malaise O, Gillet P, Kurth W, Chariot A, Malaise M, de Seny D.

Cell Death Dis. 2019 Feb 4;10(2):103. doi: 10.1038/s41419-019-1377-8.


Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death.

Relic B, Charlier E, Deroyer C, Malaise O, Crine Y, Neuville S, Gillet P, de Seny D, Malaise MG.

Oncotarget. 2018 Nov 9;9(88):35830-35843. doi: 10.18632/oncotarget.26295. eCollection 2018 Nov 9.


18F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab.

Fosse P, Kaiser MJ, Namur G, de Seny D, Malaise MG, Hustinx R.

Eur J Hybrid Imaging. 2018;2(1):6. doi: 10.1186/s41824-017-0022-y. Epub 2018 Feb 5.


Inefficacy of autologous bone marrow concentrate in stage three osteonecrosis: a randomized controlled double-blind trial.

Hauzeur JP, De Maertelaer V, Baudoux E, Malaise M, Beguin Y, Gangji V.

Int Orthop. 2018 Jul;42(7):1429-1435. doi: 10.1007/s00264-017-3650-8. Epub 2017 Oct 7.


Efficacy of golimumab in Belgian patients with active rheumatoid arthritis despite treatment with non-biologic disease-modifying anti-rheumatic drugs: sub-analysis of the GO-MORE study.

Durez P, Vanthuyne M, Soyfoo MS, Hoffman I, Malaise M, Geusens P.

Acta Clin Belg. 2017 Dec;72(6):424-428. doi: 10.1080/17843286.2017.1314079. Epub 2017 Apr 21.


Validation of a new method by nano-liquid chromatography on chip tandem mass spectrometry for combined quantitation of C3f and the V65 vitronectin fragment as biomarkers of diagnosis and severity of osteoarthritis.

Cobraiville G, Fillet M, Sharif M, Ourradi K, Nys G, Malaise MG, de Seny D.

Talanta. 2017 Jul 1;169:170-180. doi: 10.1016/j.talanta.2017.03.078. Epub 2017 Mar 28.


OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages.

Quesada-Calvo F, Massot C, Bertrand V, Longuespée R, Blétard N, Somja J, Mazzucchelli G, Smargiasso N, Baiwir D, De Pauw-Gillet MC, Delvenne P, Malaise M, Coimbra Marques C, Polus M, De Pauw E, Meuwis MA, Louis E.

Clin Proteomics. 2017 Mar 24;14:9. doi: 10.1186/s12014-017-9143-3. eCollection 2017.


Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis.

Charlier E, Relic B, Deroyer C, Malaise O, Neuville S, Collée J, Malaise MG, De Seny D.

Int J Mol Sci. 2016 Dec 20;17(12). pii: E2146. doi: 10.3390/ijms17122146. Review.


Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts.

Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, Gillet P, Louis E, Malaise MG, de Seny D.

Arthritis Res Ther. 2016 Oct 4;18(1):219.


Biomarkers of inflammation and innate immunity in atrophic nonunion fracture.

de Seny D, Cobraiville G, Leprince P, Fillet M, Collin C, Mathieu M, Hauzeur JP, Gangji V, Malaise MG.

J Transl Med. 2016 Sep 6;14:258. doi: 10.1186/s12967-016-1019-1.


BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death.

Relic B, Charlier E, Deroyer C, Malaise O, Neuville S, Desoroux A, Gillet P, de Seny D, Malaise MG.

Oncotarget. 2016 Apr 26;7(17):23370-82. doi: 10.18632/oncotarget.8042.


A prospective cohort study of the clinical presentation of non-traumatic osteonecrosis of the femoral head: spine and knee symptoms as clinical presentation of hip osteonecrosis.

Hauzeur JP, Malaise M, de Maertelaer V.

Int Orthop. 2016 Jul;40(7):1347-51. doi: 10.1007/s00264-015-3079-x. Epub 2016 Jan 5.


Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and β-catenin activation.

Charlier E, Malaise O, Zeddou M, Neuville S, Cobraiville G, Deroyer C, Sanchez C, Gillet P, Kurth W, de Seny D, Relic B, Malaise MG.

Osteoarthritis Cartilage. 2016 Feb;24(2):315-24. doi: 10.1016/j.joca.2015.08.002. Epub 2015 Aug 28.


¹⁸F-FPRGD₂ PET/CT imaging of musculoskeletal disorders.

Withofs N, Charlier E, Simoni P, Alvarez-Miezentseva V, Mievis F, Giacomelli F, Mella C, Gambhir SS, Malaise O, de Seny D, Malaise M, Hustinx R.

Ann Nucl Med. 2015 Dec;29(10):839-47. doi: 10.1007/s12149-015-1011-5. Epub 2015 Aug 8.


Use of Tomosynthesis for Detection of Bone Erosions of the Foot in Patients With Established Rheumatoid Arthritis: Comparison With Radiography and CT.

Simoni P, Gérard L, Kaiser MJ, Ribbens C, Rinkin C, Malaise O, Malaise M.

AJR Am J Roentgenol. 2015 Aug;205(2):364-70. doi: 10.2214/AJR.14.14120.


Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties.

de Seny D, Cobraiville G, Charlier E, Neuville S, Lutteri L, Le Goff C, Malaise D, Malaise O, Chapelle JP, Relic B, Malaise MG.

PLoS One. 2015 Apr 7;10(4):e0122904. doi: 10.1371/journal.pone.0122904. eCollection 2015.


Selective glucocorticoid receptor modulator compound A, in contrast to prednisolone, does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts.

Malaise O, Relic B, Quesada-Calvo F, Charlier E, Zeddou M, Neuville S, Gillet P, Louis E, de Seny D, Malaise MG.

Rheumatology (Oxford). 2015 Jun;54(6):1087-92. doi: 10.1093/rheumatology/keu428. Epub 2014 Nov 10.


Comparison of two FFPE preparation methods using label-free shotgun proteomics: Application to tissues of diverticulitis patients.

Quesada-Calvo F, Bertrand V, Longuespée R, Delga A, Mazzucchelli G, Smargiasso N, Baiwir D, Delvenne P, Malaise M, De Pauw-Gillet MC, De Pauw E, Louis E, Meuwis MA.

J Proteomics. 2015 Jan 1;112:250-61. doi: 10.1016/j.jprot.2014.08.013. Epub 2014 Sep 10.


Umbilical cord fibroblasts: Could they be considered as mesenchymal stem cells?

Zeddou M, Relic B, Malaise MG.

World J Stem Cells. 2014 Jul 26;6(3):367-70. doi: 10.4252/wjsc.v6.i3.367. Review.


Comprehensive plasma profiling for the characterization of graft-versus-host disease biomarkers.

De Bock M, Beguin Y, Leprince P, Willems E, Baron F, Deroyer C, Seidel L, Cavalier E, de Seny D, Malaise M, Gothot A, Merville MP, Fillet M.

Talanta. 2014 Jul;125:265-75. doi: 10.1016/j.talanta.2014.03.017. Epub 2014 Mar 18.


The apoptosis of osteoblasts and osteocytes in femoral head osteonecrosis: its specificity and its distribution.

Mutijima E, De Maertelaer V, Deprez M, Malaise M, Hauzeur JP.

Clin Rheumatol. 2014 Dec;33(12):1791-5. doi: 10.1007/s10067-014-2607-1. Epub 2014 Apr 15.


[Two spondylodiscitis due to a contamination by Brucella melitensis in a mother and daughter back from holidays].

Malaise O, Libon F, Bricmaan J, von Frenckell C, Simoni P, Léonard P, Malaise M.

Rev Med Suisse. 2014 Jan 22;10(414):197-200. French.


KLRG1+ NK cells protect T-bet-deficient mice from pulmonary metastatic colorectal carcinoma.

Malaisé M, Rovira J, Renner P, Eggenhofer E, Sabet-Baktach M, Lantow M, Lang SA, Koehl GE, Farkas SA, Loss M, Agha A, Campistol JM, Schlitt HJ, Geissler EK, Kroemer A.

J Immunol. 2014 Feb 15;192(4):1954-61. doi: 10.4049/jimmunol.1300876. Epub 2014 Jan 10.


["Synthesis 2014" Scientific research: in addition to the rest!].

Malaise MG.

Rev Med Liege. 2014;69 Spec No:1-2. French. No abstract available.


Double deficiency for RORγt and T-bet drives Th2-mediated allograft rejection in mice.

Sabet-Baktach M, Eggenhofer E, Rovira J, Renner P, Lantow M, Farkas SA, Malaisé M, Edtinger K, Shaotang Z, Koehl GE, Dahlke MH, Schlitt HJ, Geissler EK, Kroemer A.

J Immunol. 2013 Oct 15;191(8):4440-6. doi: 10.4049/jimmunol.1301741. Epub 2013 Sep 20.


[Clinical case of the month. A rare case of arthritis and fever].

Rinkin C, Van Durme C, Fautrel B, Malaise M.

Rev Med Liege. 2013 Jul-Aug;68(7-8):423-7. French.


[The management of systemic lupus erythematosus with biological therapies].

Malaise O, von Frenckell C, André B, Malaise MG.

Rev Med Suisse. 2013 Aug 28;9(395):1507-11. French.


Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties.

de Seny D, Cobraiville G, Charlier E, Neuville S, Esser N, Malaise D, Malaise O, Calvo FQ, Relic B, Malaise MG.

PLoS One. 2013 Jun 12;8(6):e66769. doi: 10.1371/journal.pone.0066769. Print 2013.


[Early referral of first line patients suspected of axial spondyloarthritis: the Belgian results of the RADAR study].

Bentin J, Van Praet L, Malaise M, François D, Mielants H.

Rev Med Liege. 2012 Dec;67(12):649-54. French.


(111)Indium-oxine labelling for evaluating the homing process of autologous osteoblasts implanted percutaneously in atrophic nonunion fractures.

Hauzeur JP, Bernard C, Egrise D, Kurth W, Van Cauwenberge H, Lechanteur C, Gillet P, Beguin Y, Malaise M, Hustinx R.

Int Orthop. 2013 Jan;37(1):131-6. doi: 10.1007/s00264-012-1719-y. Epub 2012 Nov 25.


[Rhupus: when rheumatoid arthritis meets lupus].

Malaise O, Halleux S, von Frenckell C, Lutteri L, Chapelle JP, Malaise MG.

Rev Med Liege. 2012 Sep;67(9):475-84. French.


[Genetic and environmental interactions on the development of rheumatoid arthritis].

Malaise O, von Frenckell C, Malaise MG.

Rev Med Liege. 2012 May-Jun;67(5-6):305-13. Review. French.


[Targeted therapy in inflammatory disease: cytokines].

von Frenckell C, Malaise MG.

Rev Med Liege. 2012;67 Spec No:22-8. French.


["Synthèse 2012". Targeted treatments. Hopes and deceptions].

Malaise M.

Rev Med Liege. 2012;67 Spec No:1. French. No abstract available.


[Image of the month. Tophaceous gout of the forefoot ].

Malaise O, Malaise M, Simoni P.

Rev Med Liege. 2012 Apr;67(4):165-6. French. No abstract available.


Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells.

Zeddou M, Relic B, Malaise O, Charlier E, Desoroux A, Beguin Y, de Seny D, Malaise MG.

Stem Cells Dev. 2012 Jul 20;21(11):1948-55. doi: 10.1089/scd.2011.0321. Epub 2011 Dec 23.


Stable and reproducible engraftment of primary adult and pediatric acute myeloid leukemia in NSG mice.

Malaisé M, Neumeier M, Botteron C, Döhner K, Reinhardt D, Schlegelberger B, Göhring G, Gruhn B, Debatin KM, Corbacioglu S.

Leukemia. 2011 Oct;25(10):1635-9. doi: 10.1038/leu.2011.121. Epub 2011 Jun 7. No abstract available.


Assessment of long-term safety and efficacy of etanercept in a 5-year extension study in patients with rheumatoid arthritis.

Klareskog L, Gaubitz M, Rodríguez-Valverde V, Malaise M, Dougados M, Wajdula J; Etanercept Study 301 Investigators.

Clin Exp Rheumatol. 2011 Mar-Apr;29(2):238-47. Epub 2011 Apr 19.


Discovery and biochemical characterisation of four novel biomarkers for osteoarthritis.

de Seny D, Sharif M, Fillet M, Cobraiville G, Meuwis MA, Marée R, Hauzeur JP, Wehenkel L, Louis E, Merville MP, Kirwan J, Ribbens C, Malaise M.

Ann Rheum Dis. 2011 Jun;70(6):1144-52. doi: 10.1136/ard.2010.135541. Epub 2011 Feb 28.


[Summary of 2010. From the technical to the clinical].

Malaise MG.

Rev Med Liege. 2010;65 Spec no.:1-2. French. No abstract available.

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