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Items: 26


Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response.

Alonso H, Parra J, Malaga W, Payros D, Liu CF, Berrone C, Robert C, Meunier E, Burlet-Schiltz O, Rivière M, Guilhot C.

Sci Rep. 2017 Aug 11;7(1):7913. doi: 10.1038/s41598-017-08489-7.


ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.

Augenstreich J, Arbues A, Simeone R, Haanappel E, Wegener A, Sayes F, Le Chevalier F, Chalut C, Malaga W, Guilhot C, Brosch R, Astarie-Dequeker C.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12726. Epub 2017 Feb 15.


Trisaccharides of Phenolic Glycolipids Confer Advantages to Pathogenic Mycobacteria through Manipulation of Host-Cell Pattern-Recognition Receptors.

Arbués A, Malaga W, Constant P, Guilhot C, Prandi J, Astarie-Dequeker C.

ACS Chem Biol. 2016 Oct 21;11(10):2865-2875. Epub 2016 Sep 2.


pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence.

Boritsch EC, Frigui W, Cascioferro A, Malaga W, Etienne G, Laval F, Pawlik A, Le Chevalier F, Orgeur M, Ma L, Bouchier C, Stinear TP, Supply P, Majlessi L, Daffé M, Guilhot C, Brosch R.

Nat Microbiol. 2016 Jan 27;1:15019. doi: 10.1038/nmicrobiol.2015.19.


The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria.

Gavalda S, Bardou F, Laval F, Bon C, Malaga W, Chalut C, Guilhot C, Mourey L, Daffé M, Quémard A.

Chem Biol. 2014 Dec 18;21(12):1660-9. doi: 10.1016/j.chembiol.2014.10.011. Epub 2014 Nov 26.


Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator.

Gonzalo-Asensio J, Malaga W, Pawlik A, Astarie-Dequeker C, Passemar C, Moreau F, Laval F, Daffé M, Martin C, Brosch R, Guilhot C.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11491-6. doi: 10.1073/pnas.1406693111. Epub 2014 Jul 21.


The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

Solans L, Gonzalo-Asensio J, Sala C, Benjak A, Uplekar S, Rougemont J, Guilhot C, Malaga W, Martín C, Cole ST.

PLoS Pathog. 2014 May 29;10(5):e1004183. doi: 10.1371/journal.ppat.1004183. eCollection 2014 May.


Reversible lipid accumulation and associated division arrest of Mycobacterium avium in lipoprotein-induced foamy macrophages may resemble key events during latency and reactivation of tuberculosis.

Caire-Brändli I, Papadopoulos A, Malaga W, Marais D, Canaan S, Thilo L, de Chastellier C.

Infect Immun. 2014 Feb;82(2):476-90. doi: 10.1128/IAI.01196-13. Epub 2013 Nov 25.


Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions.

Passemar C, Arbués A, Malaga W, Mercier I, Moreau F, Lepourry L, Neyrolles O, Guilhot C, Astarie-Dequeker C.

Cell Microbiol. 2014 Feb;16(2):195-213. doi: 10.1111/cmi.12214. Epub 2013 Oct 16.


Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials.

Arbues A, Aguilo JI, Gonzalo-Asensio J, Marinova D, Uranga S, Puentes E, Fernandez C, Parra A, Cardona PJ, Vilaplana C, Ausina V, Williams A, Clark S, Malaga W, Guilhot C, Gicquel B, Martin C.

Vaccine. 2013 Oct 1;31(42):4867-73. doi: 10.1016/j.vaccine.2013.07.051. Epub 2013 Aug 17.


Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis.

Liu CF, Tonini L, Malaga W, Beau M, Stella A, Bouyssié D, Jackson MC, Nigou J, Puzo G, Guilhot C, Burlet-Schiltz O, Rivière M.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6560-5. doi: 10.1073/pnas.1219704110. Epub 2013 Apr 2.


Functional characterisation of three o-methyltransferases involved in the biosynthesis of phenolglycolipids in Mycobacterium tuberculosis.

Simeone R, Huet G, Constant P, Malaga W, Lemassu A, Laval F, Daffé M, Guilhot C, Chalut C.

PLoS One. 2013;8(3):e58954. doi: 10.1371/journal.pone.0058954. Epub 2013 Mar 11.


Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.

Bergeret F, Gavalda S, Chalut C, Malaga W, Quémard A, Pedelacq JD, Daffé M, Guilhot C, Mourey L, Bon C.

J Biol Chem. 2012 Sep 28;287(40):33675-90. Epub 2012 Jul 23.


Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1.

Manca C, Peixoto B, Malaga W, Guilhot C, Kaplan G.

J Interferon Cytokine Res. 2012 Jan;32(1):27-33. doi: 10.1089/jir.2011.0044. Epub 2011 Oct 7.


Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.

Krishnan N, Malaga W, Constant P, Caws M, Tran TH, Salmons J, Nguyen TN, Nguyen DB, Daffé M, Young DB, Robertson BD, Guilhot C, Thwaites GE.

PLoS One. 2011;6(9):e23870. doi: 10.1371/journal.pone.0023870. Epub 2011 Sep 8.


Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.

Tabouret G, Astarie-Dequeker C, Demangel C, Malaga W, Constant P, Ray A, Honoré N, Bello NF, Perez E, Daffé M, Guilhot C.

PLoS Pathog. 2010 Oct 21;6(10):e1001159. doi: 10.1371/journal.ppat.1001159.


Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.

Siméone R, Léger M, Constant P, Malaga W, Marrakchi H, Daffé M, Guilhot C, Chalut C.

FEBS J. 2010 Jun;277(12):2715-25. doi: 10.1111/j.1742-464X.2010.07688.x.


A lipid profile typifies the Beijing strains of Mycobacterium tuberculosis: identification of a mutation responsible for a modification of the structures of phthiocerol dimycocerosates and phenolic glycolipids.

Huet G, Constant P, Malaga W, Lanéelle MA, Kremer K, van Soolingen D, Daffé M, Guilhot C.

J Biol Chem. 2009 Oct 2;284(40):27101-13. doi: 10.1074/jbc.M109.041939. Epub 2009 Aug 2.


Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.

Astarie-Dequeker C, Le Guyader L, Malaga W, Seaphanh FK, Chalut C, Lopez A, Guilhot C.

PLoS Pathog. 2009 Feb;5(2):e1000289. doi: 10.1371/journal.ppat.1000289. Epub 2009 Feb 6.


Identification of the polyketide synthase involved in the biosynthesis of the surface-exposed lipooligosaccharides in mycobacteria.

Etienne G, Malaga W, Laval F, Lemassu A, Guilhot C, Daffé M.

J Bacteriol. 2009 Apr;191(8):2613-21. doi: 10.1128/JB.01235-08. Epub 2009 Jan 30.


The use of temperature-sensitive plasmids in mycobacteria.

Portevin D, Malaga W, Guilhot C.

Methods Mol Biol. 2009;465:229-42. doi: 10.1007/978-1-59745-207-6_15.


Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex.

Malaga W, Constant P, Euphrasie D, Cataldi A, Daffé M, Reyrat JM, Guilhot C.

J Biol Chem. 2008 May 30;283(22):15177-84. doi: 10.1074/jbc.M710275200. Epub 2008 Apr 4.


The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions.

Veyron-Churlet R, Bigot S, Guerrini O, Verdoux S, Malaga W, Daffé M, Zerbib D.

J Mol Biol. 2005 Nov 4;353(4):847-58. Epub 2005 Sep 23.


Production of unmarked mutations in mycobacteria using site-specific recombination.

Malaga W, Perez E, Guilhot C.

FEMS Microbiol Lett. 2003 Feb 28;219(2):261-8.

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