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Items: 19

1.

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.

Winters M, DuHadaway JB, Pham KN, Lewis-Ballester A, Badir S, Wai J, Sheikh E, Yeh SR, Prendergast GC, Muller AJ, Malachowski WP.

Eur J Med Chem. 2018 Nov 14;162:455-464. doi: 10.1016/j.ejmech.2018.11.010. [Epub ahead of print]

PMID:
30469041
2.

Proton Spin-Lattice Relaxation in Organic Molecular Solids: Polymorphism and the Dependence on Sample Preparation.

Beckmann PA, Ford J, Malachowski WP, McGhie AR, Moore CE, Rheingold AL, Sloan GJ, Szewczyk ST.

Chemphyschem. 2018 Sep 18;19(18):2423-2436. doi: 10.1002/cphc.201800237. Epub 2018 Jun 28.

PMID:
29956438
3.

Catalytic Enantioselective Birch-Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters.

Krasley AT, Malachowski WP, Terz HM, Tran Tien S.

Org Lett. 2018 Apr 6;20(7):1740-1743. doi: 10.1021/acs.orglett.8b00196. Epub 2018 Mar 21.

PMID:
29561159
4.

Discovery of IDO1 Inhibitors: From Bench to Bedside.

Prendergast GC, Malachowski WP, DuHadaway JB, Muller AJ.

Cancer Res. 2017 Dec 15;77(24):6795-6811. doi: 10.1158/0008-5472.CAN-17-2285. Review.

5.

Monitoring a simple hydrolysis process in an organic solid by observing methyl group rotation.

Beckmann PA, Bohen JM, Ford J, Malachowski WP, Mallory CW, Mallory FB, McGhie AR, Rheingold AL, Sloan GJ, Szewczyk ST, Wang X, Wheeler KA.

Solid State Nucl Magn Reson. 2017 Sep;85-86:1-11. doi: 10.1016/j.ssnmr.2017.01.004. Epub 2017 Jan 29.

PMID:
28260612
6.

O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.

Malachowski WP, Winters M, DuHadaway JB, Lewis-Ballester A, Badir S, Wai J, Rahman M, Sheikh E, LaLonde JM, Yeh SR, Prendergast GC, Muller AJ.

Eur J Med Chem. 2016 Jan 27;108:564-576. doi: 10.1016/j.ejmech.2015.12.028. Epub 2015 Dec 17.

7.

The enantioselective construction of tetracyclic diterpene skeletons with Friedel-Crafts alkylation and palladium-catalyzed cycloalkenylation reactions.

Burke SJ, Malachowski WP, Mehta SK, Appenteng R.

Org Biomol Chem. 2015 Mar 7;13(9):2726-44. doi: 10.1039/c4ob02489c.

8.
9.

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1.

Flick HE, Lalonde JM, Malachowski WP, Muller AJ.

Int J Tryptophan Res. 2013 Aug 19;6:35-45. doi: 10.4137/IJTR.S12094. eCollection 2013.

10.

Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.

Kumar S, Jaller D, Patel B, LaLonde JM, DuHadaway JB, Malachowski WP, Prendergast GC, Muller AJ.

J Med Chem. 2008 Aug 28;51(16):4968-77. doi: 10.1021/jm800512z. Epub 2008 Jul 30.

11.

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

Kumar S, Malachowski WP, DuHadaway JB, LaLonde JM, Carroll PJ, Jaller D, Metz R, Prendergast GC, Muller AJ.

J Med Chem. 2008 Mar 27;51(6):1706-18. doi: 10.1021/jm7014155. Epub 2008 Mar 5. Erratum in: J Med Chem. 2008 Nov 27;51(22):7325.

12.

A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase.

Banerjee T, Duhadaway JB, Gaspari P, Sutanto-Ward E, Munn DH, Mellor AL, Malachowski WP, Prendergast GC, Muller AJ.

Oncogene. 2008 May 1;27(20):2851-7. Epub 2007 Nov 19.

PMID:
18026137
13.

The enantioselective synthesis of (-)-lycoramine with the Birch-Cope sequence.

Malachowski WP, Paul T, Phounsavath S.

J Org Chem. 2007 Aug 31;72(18):6792-6. Epub 2007 Aug 4.

PMID:
17676911
14.

Exploration of the enantioselective Birch-Cope sequence for the synthesis of carbocyclic quaternary stereocenters.

Paul T, Malachowski WP, Lee J.

J Org Chem. 2007 Feb 2;72(3):930-7. Erratum in: J Org Chem. 2007 Jun 22;72(13):5024.

PMID:
17253813
16.

Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

Gaspari P, Banerjee T, Malachowski WP, Muller AJ, Prendergast GC, DuHadaway J, Bennett S, Donovan AM.

J Med Chem. 2006 Jan 26;49(2):684-92.

17.

Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors.

Muller AJ, Malachowski WP, Prendergast GC.

Expert Opin Ther Targets. 2005 Aug;9(4):831-49. Review.

PMID:
16083346
18.

The synthesis of azapeptidomimetic beta-lactam molecules as potential protease inhibitors.

Malachowski WP, Tie C, Wang K, Broadrup RL.

J Org Chem. 2002 Dec 13;67(25):8962-9.

PMID:
12467415
19.

Nature of the rate-determining steps of the reaction catalyzed by the Yersinia protein-tyrosine phosphatase.

Zhang ZY, Malachowski WP, Van Etten RL, Dixon JE.

J Biol Chem. 1994 Mar 18;269(11):8140-5.

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