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Items: 38

1.

Novel mitochondrial transition pore inhibitor N-methyl-4-isoleucine cyclosporin is a new therapeutic option in acute pancreatitis.

Tóth E, Maléth J, Závogyán N, Fanczal J, Grassalkovich A, Erdős R, Pallagi P, Horváth G, Tretter L, Bálint ER, Rakonczay Z Jr, Venglovecz V, Hegyi P.

J Physiol. 2019 Oct 20. doi: 10.1113/JP278517. [Epub ahead of print]

PMID:
31631343
2.

Failure in the compensatory mechanism in red blood cells due to sustained smoking during pregnancy.

Chakraborty P, Dugmonits KN, Végh AG, Hollandi R, Horváth P, Maléth J, Hegyi P, Németh G, Hermesz E.

Chem Biol Interact. 2019 Nov 1;313:108821. doi: 10.1016/j.cbi.2019.108821. Epub 2019 Sep 13.

PMID:
31525342
3.

Ca2+ Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis.

Son A, Ahuja M, Schwartz DM, Varga A, Swaim W, Kang N, Maleth J, Shin DM, Muallem S.

Gastroenterology. 2019 Sep 4. pii: S0016-5085(19)41299-7. doi: 10.1053/j.gastro.2019.08.042. [Epub ahead of print]

PMID:
31493399
4.

Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis.

Bakondi E, Singh SB, Hajnády Z, Nagy-Pénzes M, Regdon Z, Kovács K, Hegedűs C, Madácsy T, Maléth J, Hegyi P, Demény MÁ, Nagy T, Kéki S, Szabó É, Virág L.

Int J Mol Sci. 2019 Sep 3;20(17). pii: E4308. doi: 10.3390/ijms20174308.

5.

Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion.

Molnár R, Madácsy T, Varga Á, Németh M, Katona X, Görög M, Molnár B, Fanczal J, Rakonczay Z Jr, Hegyi P, Pallagi P, Maléth J.

Lab Invest. 2019 Aug 13. doi: 10.1038/s41374-019-0300-3. [Epub ahead of print]

PMID:
31409889
6.

Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment.

Jha A, Chung WY, Vachel L, Maleth J, Lake S, Zhang G, Ahuja M, Muallem S.

EMBO J. 2019 Jun 17;38(12). pii: e101452. doi: 10.15252/embj.2018101452. Epub 2019 May 6.

PMID:
31061173
7.

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas.

Madácsy T, Pallagi P, Maleth J.

Front Physiol. 2018 Dec 20;9:1585. doi: 10.3389/fphys.2018.01585. eCollection 2018. Review.

8.

Bidirectional Relationship Between Reduced Blood pH and Acute Pancreatitis: A Translational Study of Their Noxious Combination.

Rumbus Z, Toth E, Poto L, Vincze A, Veres G, Czako L, Olah E, Marta K, Miko A, Rakonczay Z Jr, Balla Z, Kaszaki J, Foldesi I, Maleth J, Hegyi P, Garami A.

Front Physiol. 2018 Oct 1;9:1360. doi: 10.3389/fphys.2018.01360. eCollection 2018.

9.

Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease.

Hegyi P, Maléth J, Walters JR, Hofmann AF, Keely SJ.

Physiol Rev. 2018 Oct 1;98(4):1983-2023. doi: 10.1152/physrev.00054.2017. Review.

10.

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis.

Balázs A, Balla Z, Kui B, Maléth J, Rakonczay Z Jr, Duerr J, Zhou-Suckow Z, Schatterny J, Sendler M, Mayerle J, Kühn JP, Tiszlavicz L, Mall MA, Hegyi P.

Front Physiol. 2018 May 29;9:632. doi: 10.3389/fphys.2018.00632. eCollection 2018.

11.

Microtubule organization in presynaptic boutons relies on the formin DAAM.

Migh E, Götz T, Földi I, Szikora S, Gombos R, Darula Z, Medzihradszky KF, Maléth J, Hegyi P, Sigrist S, Mihály J.

Development. 2018 Mar 16;145(6). pii: dev158519. doi: 10.1242/dev.158519.

12.

The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones.

Szikora S, Földi I, Tóth K, Migh E, Vig A, Bugyi B, Maléth J, Hegyi P, Kaltenecker P, Sanchez-Soriano N, Mihály J.

J Cell Sci. 2017 Aug 1;130(15):2506-2519. doi: 10.1242/jcs.203455. Epub 2017 Jun 12.

13.

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger.

Szentesi A, Tóth E, Bálint E, Fanczal J, Madácsy T, Laczkó D, Ignáth I, Balázs A, Pallagi P, Maléth J, Rakonczay Z Jr, Kui B, Illés D, Márta K, Blaskó Á, Demcsák A, Párniczky A, Pár G, Gódi S, Mosztbacher D, Szücs Á, Halász A, Izbéki F, Farkas N, Hegyi P; Hungarian Pancreatic Study Group.

PLoS One. 2016 Oct 24;11(10):e0165244. doi: 10.1371/journal.pone.0165244. eCollection 2016.

14.

Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview.

Maléth J, Hegyi P.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150425. doi: 10.1098/rstb.2015.0425. Review.

15.

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.

Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Tóth M, Uc A, Gray MA, Rakonczay Z Jr, Maléth J.

Rev Physiol Biochem Pharmacol. 2016;170:37-66. doi: 10.1007/112_2015_5002. Review.

16.

A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury.

Katona M, Hegyi P, Kui B, Balla Z, Rakonczay Z Jr, Rázga Z, Tiszlavicz L, Maléth J, Venglovecz V.

Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G193-204. doi: 10.1152/ajpgi.00317.2015. Epub 2015 Nov 25.

17.

Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

Balázs A, Ruffert C, Hegyi E, Hritz I, Czakó L, Takács T, Szepes Z, Németh BC, Gervain J, Izbéki F, Halász A, Kelemen D, Szmola R, Novák J, Crai S, Illés A, Vincze Á, Molnár Z, Varga M, Bod B, Farkas G Jr, Sümegi J, Szepes A, Dubravcsik Z, Lásztity N, Párniczky A, Hamvas J, Andorka C, Veres G, Szentkereszty Z, Rakonczay Z Jr, Maléth J, Sahin-Tóth M, Rosendahl J, Hegyi P; Hungarian Pancreatic Study Group.

Pancreatology. 2015 Sep-Oct;15(5):508-513. doi: 10.1016/j.pan.2015.08.008. Epub 2015 Sep 1.

PMID:
26372434
18.

Breakdown of bioenergetics evoked by mitochondrial damage in acute pancreatitis: Mechanisms and consequences.

Maléth J, Hegyi P, Rakonczay Z Jr, Venglovecz V.

Pancreatology. 2015 Jul;15(4 Suppl):S18-22. doi: 10.1016/j.pan.2015.06.002. Epub 2015 Jun 30. Review.

PMID:
26162756
19.

Pancreatic epithelial fluid and bicarbonate secretion is significantly elevated in the absence of peripheral serotonin.

Maléth J, Madácsy T, Pallagi P, Balázs A, Venglovecz V, Rakonczay Z Jr, Hegyi P.

Gut. 2015 Sep;64(9):1497-8. doi: 10.1136/gutjnl-2015-309776. Epub 2015 Jun 11. No abstract available.

PMID:
26069275
20.

The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.

Cao X, Choi S, Maléth JJ, Park S, Ahuja M, Muallem S.

Cell Calcium. 2015 Oct;58(4):342-8. doi: 10.1016/j.ceca.2015.03.003. Epub 2015 Mar 18. Review.

21.
22.

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P.

Gastroenterology. 2015 Feb;148(2):427-39.e16. doi: 10.1053/j.gastro.2014.11.002. Epub 2014 Nov 7.

23.

Bile acids inhibit Na⁺/H⁺ exchanger and Cl⁻/HCO₃⁻ exchanger activities via cellular energy breakdown and Ca²⁺ overload in human colonic crypts.

Pallagi-Kunstár É, Farkas K, Maléth J, Rakonczay Z Jr, Nagy F, Molnár T, Szepes Z, Venglovecz V, Lonovics J, Rázga Z, Wittmann T, Hegyi P.

Pflugers Arch. 2015 Jun;467(6):1277-90. Epub 2015 Jul 13.

PMID:
25015415
24.

The TRPCs-STIM1-Orai interaction.

Choi S, Maleth J, Jha A, Lee KP, Kim MS, So I, Ahuja M, Muallem S.

Handb Exp Pharmacol. 2014;223:1035-54. doi: 10.1007/978-3-319-05161-1_13. Review.

PMID:
24961979
25.

Spatiotemporally limited BDNF and GDNF overexpression rescues motoneurons destined to die and induces elongative axon growth.

Pajenda G, Hercher D, Márton G, Pajer K, Feichtinger GA, Maléth J, Redl H, Nógrádi A.

Exp Neurol. 2014 Nov;261:367-76. doi: 10.1016/j.expneurol.2014.05.019. Epub 2014 May 27.

PMID:
24873730
26.

cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.

Ahuja M, Jha A, Maléth J, Park S, Muallem S.

Cell Calcium. 2014 Jun;55(6):385-93. doi: 10.1016/j.ceca.2014.01.006. Epub 2014 Feb 7. Review.

27.

Calcium signaling in pancreatic ductal epithelial cells: an old friend and a nasty enemy.

Maléth J, Hegyi P.

Cell Calcium. 2014 Jun;55(6):337-45. doi: 10.1016/j.ceca.2014.02.004. Epub 2014 Feb 15. Review.

PMID:
24602604
28.

The role of pancreatic ductal secretion in protection against acute pancreatitis in mice*.

Pallagi P, Balla Z, Singh AK, Dósa S, Iványi B, Kukor Z, Tóth A, Riederer B, Liu Y, Engelhardt R, Jármay K, Szabó A, Janovszky A, Perides G, Venglovecz V, Maléth J, Wittmann T, Takács T, Gray MA, Gácser A, Hegyi P, Seidler U, Rakonczay Z Jr.

Crit Care Med. 2014 Mar;42(3):e177-88. doi: 10.1097/CCM.0000000000000101.

PMID:
24368347
29.

Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation.

Judák L, Hegyi P, Rakonczay Z Jr, Maléth J, Gray MA, Venglovecz V.

Pflugers Arch. 2014 Mar;466(3):549-62. doi: 10.1007/s00424-013-1333-x. Epub 2013 Aug 16.

PMID:
23948742
30.

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.

Kemény LV, Schnúr A, Czepán M, Rakonczay Z Jr, Gál E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maléth J, Judák L, Németh IB, Szabó K, Almássy J, Virág L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varró A, Hegyi P.

Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15;305(8):G552-63. doi: 10.1152/ajpgi.00394.2012. Epub 2013 Aug 1.

31.

Intraductal acidosis in acute biliary pancreatitis.

Takács T, Rosztóczy A, Maléth J, Rakonczay Z Jr, Hegyi P.

Pancreatology. 2013 Jul-Aug;13(4):333-5. doi: 10.1016/j.pan.2013.05.011. Epub 2013 Jun 10.

PMID:
23890129
32.

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function.

Jha A, Ahuja M, Maléth J, Moreno CM, Yuan JP, Kim MS, Muallem S.

J Cell Biol. 2013 Jul 8;202(1):71-9. doi: 10.1083/jcb.201301148. Epub 2013 Jul 1.

33.

[Long-term proton pump inhibitor therapy and osteoporosis. Is there a real danger?].

Maléth J, Hegyi P.

Orv Hetil. 2013 Jun 30;154(26):1005-9. doi: 10.1556/OH.2013.29656. Review. Hungarian.

PMID:
23800385
34.

Central role of mitochondrial injury in the pathogenesis of acute pancreatitis.

Maléth J, Rakonczay Z Jr, Venglovecz V, Dolman NJ, Hegyi P.

Acta Physiol (Oxf). 2013 Feb;207(2):226-35. doi: 10.1111/apha.12037. Epub 2012 Dec 11. Review.

PMID:
23167280
35.

Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.

Pallagi P, Venglovecz V, Rakonczay Z Jr, Borka K, Korompay A, Ozsvári B, Judák L, Sahin-Tóth M, Geisz A, Schnúr A, Maléth J, Takács T, Gray MA, Argent BE, Mayerle J, Lerch MM, Wittmann T, Hegyi P.

Gastroenterology. 2011 Dec;141(6):2228-2239.e6. doi: 10.1053/j.gastro.2011.08.039. Epub 2011 Sep 3.

36.

Pancreatic ductal bicarbonate secretion: challenge of the acinar Acid load.

Hegyi P, Maléth J, Venglovecz V, Rakonczay Z Jr.

Front Physiol. 2011 Jul 14;2:36. doi: 10.3389/fphys.2011.00036. eCollection 2011.

37.

Galanin, a potent inhibitor of pancreatic bicarbonate secretion, is involved in the induction and progression of cerulein-induced experimental acute pancreatitis.

Hegyi P, Venglovecz V, Pallagi P, Maléth J, Takács T, Rakonczay Z Jr.

Pancreas. 2011 Jan;40(1):155-6; author reply 156-7. doi: 10.1097/MPA.0b013e3181eabe78. No abstract available.

PMID:
21160373
38.

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells.

Maléth J, Venglovecz V, Rázga Z, Tiszlavicz L, Rakonczay Z Jr, Hegyi P.

Gut. 2011 Jan;60(1):136-8. doi: 10.1136/gut.2009.192153. Epub 2010 Aug 23. No abstract available.

PMID:
20732916

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