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Items: 1 to 50 of 112

1.

A nuclease-polymerase chain reaction enables amplification of probes used for capture-based DNA target enrichment.

Leong KW, Yu F, Adalsteinsson VA, Reed S, Gydush G, Ladas I, Li J, Tantisira KG, Makrigiorgos GM.

Nucleic Acids Res. 2019 Dec 16;47(22):e147. doi: 10.1093/nar/gkz870.

PMID:
31598677
2.
3.

Extreme PCR Meets High-Speed Melting: A Step Closer to Molecular Diagnostics "While You Wait".

Makrigiorgos GM.

Clin Chem. 2019 Feb;65(2):217-219. doi: 10.1373/clinchem.2018.298356. Epub 2018 Dec 10. No abstract available.

PMID:
30530717
4.

Denaturation-Enhanced Droplet Digital PCR for Liquid Biopsies.

Fitarelli-Kiehl M, Yu F, Ashtaputre R, Leong KW, Ladas I, Supplee J, Paweletz C, Mitra D, Schoenfeld JD, Parangi S, Makrigiorgos GM.

Clin Chem. 2018 Dec;64(12):1762-1771. doi: 10.1373/clinchem.2018.293845. Epub 2018 Oct 1.

5.

Fast Temperature-Gradient COLD PCR for the enrichment of the paternally inherited SNPs in cell free fetal DNA; an application to non-invasive prenatal diagnosis of β-thalassaemia.

Byrou S, Makrigiorgos GM, Christofides A, Kallikas I, Papasavva T, Kleanthous M.

PLoS One. 2018 Jul 25;13(7):e0200348. doi: 10.1371/journal.pone.0200348. eCollection 2018.

6.

Determining optimal eluter design by modeling physical dose enhancement in brachytherapy.

Guthier CV, D'Amico AV, King MT, Nguyen PL, Orio PF, Sridhar S, Makrigiorgos GM, Cormack RA.

Med Phys. 2018 Jun 15. doi: 10.1002/mp.13051. [Epub ahead of print]

PMID:
29905964
7.

Enhanced detection of microsatellite instability using pre-PCR elimination of wild-type DNA homo-polymers in tissue and liquid biopsies.

Ladas I, Yu F, Leong KW, Fitarelli-Kiehl M, Song C, Ashtaputre R, Kulke M, Mamon H, Makrigiorgos GM.

Nucleic Acids Res. 2018 Jul 6;46(12):e74. doi: 10.1093/nar/gky251.

8.

Multiplexed Elimination of Wild-Type DNA and High-Resolution Melting Prior to Targeted Resequencing of Liquid Biopsies.

Ladas I, Fitarelli-Kiehl M, Song C, Adalsteinsson VA, Parsons HA, Lin NU, Wagle N, Makrigiorgos GM.

Clin Chem. 2017 Oct;63(10):1605-1613. doi: 10.1373/clinchem.2017.272849. Epub 2017 Jul 5.

9.

Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation.

van de Ven AL, Tangutoori S, Baldwin P, Qiao J, Gharagouzloo C, Seitzer N, Clohessy JG, Makrigiorgos GM, Cormack R, Pandolfi PP, Sridhar S.

Mol Cancer Ther. 2017 Jul;16(7):1279-1289. doi: 10.1158/1535-7163.MCT-16-0740. Epub 2017 May 12.

10.

Methylation-sensitive enrichment of minor DNA alleles using a double-strand DNA-specific nuclease.

Liu Y, Song C, Ladas I, Fitarelli-Kiehl M, Makrigiorgos GM.

Nucleic Acids Res. 2017 Apr 7;45(6):e39. doi: 10.1093/nar/gkw1166.

11.

Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment.

Song C, Liu Y, Fontana R, Makrigiorgos A, Mamon H, Kulke MH, Makrigiorgos GM.

Nucleic Acids Res. 2016 Nov 2;44(19):e146. Epub 2016 Jul 18.

12.

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.

Herter-Sprie GS, Koyama S, Korideck H, Hai J, Deng J, Li YY, Buczkowski KA, Grant AK, Ullas S, Rhee K, Cavanaugh JD, Neupane NP, Christensen CL, Herter JM, Makrigiorgos GM, Hodi FS, Freeman GJ, Dranoff G, Hammerman PS, Kimmelman AC, Wong KK.

JCI Insight. 2016 Jun 16;1(9):e87415. doi: 10.1172/jci.insight.87415.

13.

Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy.

Detappe A, Kunjachan S, Sancey L, Motto-Ros V, Biancur D, Drane P, Guieze R, Makrigiorgos GM, Tillement O, Langer R, Berbeco R.

J Control Release. 2016 Sep 28;238:103-113. doi: 10.1016/j.jconrel.2016.07.021. Epub 2016 Jul 14.

PMID:
27423325
14.

Closing the Cancer Divide Through Ubuntu: Information and Communication Technology-Powered Models for Global Radiation Oncology.

Ngwa W, Ngoma T, Zietman A, Mayr N, Elzawawy A, Winningham TA, Balogun O, Enwerem-Bromson N, Ntizimira C, Olopade OI, Oluwole D, Odedina F, Williams M, Flanigan J, Asana L, Ngwa K, Avery S, Pollard JM, Roland T, Funwi-gabga N, Mbarika V, Hardenbergh P, Winkfield K, Pipman Y, Stefan C, Ngoma M, Mohammed S, Katz M, Erno S, Moni J, Fitzgerald T, Tonlaar N, Efstathiou J, Gierga D, Ayo C, Knaul F, Gospodarowicz M, Makrigiorgos GM, Nguyen PL.

Int J Radiat Oncol Biol Phys. 2016 Mar 1;94(3):440-9. doi: 10.1016/j.ijrobp.2015.10.063. Epub 2015 Nov 6. No abstract available.

15.

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.

Duquette M, Sadow PM, Husain A, Sims JN, Antonello ZA, Fischer AH, Song C, Castellanos-Rizaldos E, Makrigiorgos GM, Kurebayashi J, Nose V, Van Hummelen P, Bronson RT, Vinco M, Giordano TJ, Dias-Santagata D, Pandolfi PP, Nucera C.

Oncotarget. 2015 Dec 15;6(40):42445-67. doi: 10.18632/oncotarget.6442.

16.

Kilovoltage radiosurgery with gold nanoparticles for neovascular age-related macular degeneration (AMD): a Monte Carlo evaluation.

Brivio D, Zygmanski P, Arnoldussen M, Hanlon J, Chell E, Sajo E, Makrigiorgos GM, Ngwa W.

Phys Med Biol. 2015 Dec 21;60(24):9203-13. doi: 10.1088/0031-9155/60/24/9203. Epub 2015 Nov 18.

17.

DMSO Increases Mutation Scanning Detection Sensitivity of High-Resolution Melting in Clinical Samples.

Song C, Castellanos-Rizaldos E, Bejar R, Ebert BL, Makrigiorgos GM.

Clin Chem. 2015 Nov;61(11):1354-62. doi: 10.1373/clinchem.2015.245357. Epub 2015 Oct 2.

18.

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.

Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Motto-Ros V, Sancey L, Sridhar S, Makrigiorgos GM, Berbeco RI.

Nano Lett. 2015 Nov 11;15(11):7488-96. doi: 10.1021/acs.nanolett.5b03073. Epub 2015 Oct 6.

19.

Enhanced ratio of signals enables digital mutation scanning for rare allele detection.

Castellanos-Rizaldos E, Paweletz C, Song C, Oxnard GR, Mamon H, Jänne PA, Makrigiorgos GM.

J Mol Diagn. 2015 May;17(3):284-92. doi: 10.1016/j.jmoldx.2014.12.003. Epub 2015 Mar 13.

20.

Nanoparticle-aided Radiotherapy for Retinoblastoma and Choroidal Melanoma.

Altundal Y, Sajo E, Makrigiorgos GM, Berbeco RI, Ngwa W.

IFMBE Proc. 2015;51:907-910. doi: 10.1007/978-3-319-19387-8_221.

21.

Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters.

Sinha N, Cifter G, Sajo E, Kumar R, Sridhar S, Nguyen PL, Cormack RA, Makrigiorgos GM, Ngwa W.

Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):385-92. doi: 10.1016/j.ijrobp.2014.10.001. Epub 2014 Dec 5.

22.

Targeted radiotherapy with gold nanoparticles: current status and future perspectives.

Ngwa W, Kumar R, Sridhar S, Korideck H, Zygmanski P, Cormack RA, Berbeco R, Makrigiorgos GM.

Nanomedicine (Lond). 2014 May;9(7):1063-82. doi: 10.2217/nnm.14.55. Review.

23.

Enriching mutant sequences by modulating the denaturation time during PCR.

Murphy DM, Castellanos-Rizaldos E, Makrigiorgos GM.

Clin Chem. 2014 Jul;60(7):1014-6. doi: 10.1373/clinchem.2014.221465. Epub 2014 May 5. No abstract available.

24.

COLD-PCR amplification of bisulfite-converted DNA allows the enrichment and sequencing of rare un-methylated genomic regions.

Castellanos-Rizaldos E, Milbury CA, Karatza E, Chen CC, Makrigiorgos GM, Merewood A.

PLoS One. 2014 Apr 11;9(4):e94103. doi: 10.1371/journal.pone.0094103. eCollection 2014.

25.

Third generation gold nanoplatform optimized for radiation therapy.

Kumar R, Korideck H, Ngwa W, Berbeco RI, Makrigiorgos GM, Sridhar S.

Transl Cancer Res. 2013 Aug;2(4). doi: 10.3978/j.issn.2218-676X.2013.07.02.

26.

COLD-PCR enriches low-level variant DNA sequences and increases the sensitivity of genetic testing.

Castellanos-Rizaldos E, Milbury CA, Guha M, Makrigiorgos GM.

Methods Mol Biol. 2014;1102:623-39. doi: 10.1007/978-1-62703-727-3_33.

PMID:
24259002
27.

DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation.

Guha M, Castellanos-Rizaldos E, Makrigiorgos GM.

PLoS One. 2013 Jun 21;8(6):e67782. doi: 10.1371/journal.pone.0067782. Print 2013.

28.

Differential strand separation at critical temperature: a minimally disruptive enrichment method for low-abundance unknown DNA mutations.

Guha M, Castellanos-Rizaldos E, Liu P, Mamon H, Makrigiorgos GM.

Nucleic Acids Res. 2013 Feb 1;41(3):e50. doi: 10.1093/nar/gks1250. Epub 2012 Dec 20.

29.

Enrichment of mutations in multiple DNA sequences using COLD-PCR in emulsion.

Castellanos-Rizaldos E, Milbury CA, Makrigiorgos GM.

PLoS One. 2012;7(12):e51362. doi: 10.1371/journal.pone.0051362. Epub 2012 Dec 6.

30.

DNA damage enhancement from gold nanoparticles for clinical MV photon beams.

Berbeco RI, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, Johnson S, Price BD, Kimmelman A, Makrigiorgos GM.

Radiat Res. 2012 Dec;178(6):604-8. doi: 10.1667/RR3001.1. Epub 2012 Nov 13.

31.

In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds.

Ngwa W, Korideck H, Kassis AI, Kumar R, Sridhar S, Makrigiorgos GM, Cormack RA.

Nanomedicine. 2013 Jan;9(1):25-7. doi: 10.1016/j.nano.2012.09.001. Epub 2012 Oct 2.

32.

Gold nanoparticle enhancement of stereotactic radiosurgery for neovascular age-related macular degeneration.

Ngwa W, Makrigiorgos GM, Berbeco RI.

Phys Med Biol. 2012 Oct 21;57(20):6371-80. doi: 10.1088/0031-9155/57/20/6371. Epub 2012 Sep 21.

PMID:
22995994
33.

Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment.

Castellanos-Rizaldos E, Liu P, Milbury CA, Guha M, Brisci A, Cremonesi L, Ferrari M, Mamon H, Makrigiorgos GM.

Clin Chem. 2012 Jul;58(7):1130-8. doi: 10.1373/clinchem.2012.183095. Epub 2012 May 15.

34.

A multipurpose quality assurance phantom for the small animal radiation research platform (SARRP).

Ngwa W, Tsiamas P, Zygmanski P, Makrigiorgos GM, Berbeco RI.

Phys Med Biol. 2012 May 7;57(9):2575-86. doi: 10.1088/0031-9155/57/9/2575. Epub 2012 Apr 11.

PMID:
22491061
35.

Gold nanoparticle-aided brachytherapy with vascular dose painting: estimation of dose enhancement to the tumor endothelial cell nucleus.

Ngwa W, Makrigiorgos GM, Berbeco RI.

Med Phys. 2012 Jan;39(1):392-8. doi: 10.1118/1.3671905.

PMID:
22225308
36.

COLD-PCR enrichment of rare cancer mutations prior to targeted amplicon resequencing.

Milbury CA, Correll M, Quackenbush J, Rubio R, Makrigiorgos GM.

Clin Chem. 2012 Mar;58(3):580-9. doi: 10.1373/clinchem.2011.176198. Epub 2011 Dec 21.

37.

MOSFET assessment of radiation dose delivered to mice using the Small Animal Radiation Research Platform (SARRP).

Ngwa W, Korideck H, Chin LM, Makrigiorgos GM, Berbeco RI.

Radiat Res. 2011 Dec;176(6):816-20. Epub 2011 Sep 30.

PMID:
21962005
38.

Rapid and sensitive detection of KRAS mutation after fast-COLD-PCR enrichment and high-resolution melting analysis.

Song C, Milbury CA, Li J, Liu P, Zhao M, Makrigiorgos GM.

Diagn Mol Pathol. 2011 Jun;20(2):81-9. doi: 10.1097/PDM.0b013e3181fde92f.

PMID:
21532494
39.

COLD-PCR: improving the sensitivity of molecular diagnostics assays.

Milbury CA, Li J, Liu P, Makrigiorgos GM.

Expert Rev Mol Diagn. 2011 Mar;11(2):159-69. doi: 10.1586/erm.10.115.

40.

Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content.

Milbury CA, Chen CC, Mamon H, Liu P, Santagata S, Makrigiorgos GM.

J Mol Diagn. 2011 Mar;13(2):220-32. doi: 10.1016/j.jmoldx.2010.10.008.

41.
42.

Localized dose enhancement to tumor blood vessel endothelial cells via megavoltage X-rays and targeted gold nanoparticles: new potential for external beam radiotherapy.

Berbeco RI, Ngwa W, Makrigiorgos GM.

Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):270-6. doi: 10.1016/j.ijrobp.2010.10.022. Epub 2010 Dec 14.

PMID:
21163591
43.

Full COLD-PCR protocol for noninvasive prenatal diagnosis of genetic diseases.

Galbiati S, Brisci A, Lalatta F, Seia M, Makrigiorgos GM, Ferrari M, Cremonesi L.

Clin Chem. 2011 Jan;57(1):136-8. doi: 10.1373/clinchem.2010.155671. Epub 2010 Oct 25. No abstract available.

44.

Applying gold nanoparticles as tumor-vascular disrupting agents during brachytherapy: estimation of endothelial dose enhancement.

Ngwa W, Makrigiorgos GM, Berbeco RI.

Phys Med Biol. 2010 Nov 7;55(21):6533-48. doi: 10.1088/0031-9155/55/21/013. Epub 2010 Oct 19.

PMID:
20959684
45.

Ice-COLD-PCR enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations.

Milbury CA, Li J, Makrigiorgos GM.

Nucleic Acids Res. 2011 Jan;39(1):e2. doi: 10.1093/nar/gkq899. Epub 2010 Oct 11.

46.

Radiosensitizer-eluting nanocoatings on gold fiducials for biological in-situ image-guided radio therapy (BIS-IGRT).

Nagesha DK, Tada DB, Stambaugh CK, Gultepe E, Jost E, Levy CO, Cormack R, Makrigiorgos GM, Sridhar S.

Phys Med Biol. 2010 Oct 21;55(20):6039-52. doi: 10.1088/0031-9155/55/20/001. Epub 2010 Sep 21.

PMID:
20858923
47.

s-RT-MELT: a novel technology for mutation screening.

Li J, Makrigiorgos GM.

Methods Mol Biol. 2010;653:207-19. doi: 10.1007/978-1-60761-759-4_12. Review.

PMID:
20721745
48.

Solid-tumor radionuclide therapy dosimetry: new paradigms in view of tumor microenvironment and angiogenesis.

Zhu X, Palmer MR, Makrigiorgos GM, Kassis AI.

Med Phys. 2010 Jun;37(6):2974-84.

49.

Methylation-specific loop-mediated isothermal amplification for detecting hypermethylated DNA in simplex and multiplex formats.

Zerilli F, Bonanno C, Shehi E, Amicarelli G, Adlerstein D, Makrigiorgos GM.

Clin Chem. 2010 Aug;56(8):1287-96. doi: 10.1373/clinchem.2010.143545. Epub 2010 Jun 15.

50.

Chitosan film containing poly(D,L-lactic-co-glycolic acid) nanoparticles: a platform for localized dual-drug release.

Tada DB, Singh S, Nagesha D, Jost E, Levy CO, Gultepe E, Cormack R, Makrigiorgos GM, Sridhar S.

Pharm Res. 2010 Aug;27(8):1738-45. doi: 10.1007/s11095-010-0176-9. Epub 2010 Jun 3.

PMID:
20521086

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