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Mouse cytomegalovirus m153 protein stabilizes expression of the inhibitory NKR-P1B ligand, Clr-b.

Aguilar OA, Sampaio IS, Rahim MMA, Samaniego JD, Tilahun ME, Krishnamoorthy M, Popović B, Babić M, Krmpotić A, Treanor B, Margulies DH, Allan DSJ, Makrigiannis AP, Jonjić S, Carlyle JR.

J Virol. 2019 Oct 9. pii: JVI.01220-19. doi: 10.1128/JVI.01220-19. [Epub ahead of print]


NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.

Abou-Samra E, Hickey Z, Aguilar OA, Scur M, Mahmoud AB, Pyatibrat S, Tu MM, Francispillai J, Mortha A, Carlyle JR, Rahim MMA, Makrigiannis AP.

Cell Mol Immunol. 2018 Oct 1. doi: 10.1038/s41423-018-0169-x. [Epub ahead of print]


Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses.

Wight A, Mahmoud AB, Scur M, Tu MM, Rahim MMA, Sad S, Makrigiannis AP.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11579-11584. doi: 10.1073/pnas.1722374115. Epub 2018 Sep 24.


The ITIM Domain-Containing NK Receptor Ly49Q Impacts Pulmonary Infection by Mediating Neutrophil Functions.

Margraf A, Volmering S, Skupski J, Van Marck V, Makrigiannis AP, Block H, Zarbock A.

J Immunol. 2018 Jun 15;200(12):4085-4093. doi: 10.4049/jimmunol.1701084. Epub 2018 Apr 30.


Immunosurveillance and Immunoediting of Breast Cancer via Class I MHC Receptors.

Tu MM, Rahim MMA, Sayed C, Mahmoud AB, Makrigiannis AP.

Cancer Immunol Res. 2017 Nov;5(11):1016-1028. doi: 10.1158/2326-6066.CIR-17-0056. Epub 2017 Sep 18.


A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family.

Aguilar OA, Berry R, Rahim MMA, Reichel JJ, Popović B, Tanaka M, Fu Z, Balaji GR, Lau TNH, Tu MM, Kirkham CL, Mahmoud AB, Mesci A, Krmpotić A, Allan DSJ, Makrigiannis AP, Jonjić S, Rossjohn J, Carlyle JR.

Cell. 2017 Mar 23;169(1):58-71.e14. doi: 10.1016/j.cell.2017.03.002.


NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine.

Alkayyal AA, Tai LH, Kennedy MA, de Souza CT, Zhang J, Lefebvre C, Sahi S, Ananth AA, Mahmoud AB, Makrigiannis AP, Cron GO, Macdonald B, Marginean EC, Stojdl DF, Bell JC, Auer RC.

Cancer Immunol Res. 2017 Mar;5(3):211-221. doi: 10.1158/2326-6066.CIR-16-0162. Epub 2017 Feb 3.


Correction: Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.

Mahmoud AB, Tu MM, Wight A, Zein HS, Rahim MM, Lee SH, Sekhon HS, Brown EG, Makrigiannis AP.

PLoS Pathog. 2016 Nov 4;12(11):e1006021. doi: 10.1371/journal.ppat.1006021. eCollection 2016 Nov. Erratum in: PLoS Pathog. 2016 Dec 16;12 (12 ):e1006105.


Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection.

Rahim MM, Wight A, Mahmoud AB, Aguilar OA, Lee SH, Vidal SM, Carlyle JR, Makrigiannis AP.

J Immunol. 2016 Sep 15;197(6):2325-37. doi: 10.4049/jimmunol.1600776. Epub 2016 Aug 10.


Licensed and Unlicensed NK Cells: Differential Roles in Cancer and Viral Control.

Tu MM, Mahmoud AB, Makrigiannis AP.

Front Immunol. 2016 May 2;7:166. doi: 10.3389/fimmu.2016.00166. eCollection 2016. Review.


Nucleosome Presence at AML-1 Binding Sites Inversely Correlates with Ly49 Expression: Revelations from an Informatics Analysis of Nucleosomes and Immune Cell Transcription Factors.

Wight A, Yang D, Ioshikhes I, Makrigiannis AP.

PLoS Comput Biol. 2016 Apr 28;12(4):e1004894. doi: 10.1371/journal.pcbi.1004894. eCollection 2016 Apr.


Ly49 knockdown in mice results in aberrant uterine crypt formation and impaired blastocyst implantation.

Leon L, Felker AM, Kay VR, Tu MM, Makrigiannis AP, Croy BA.

Placenta. 2016 Mar;39:147-50. doi: 10.1016/j.placenta.2016.01.013. Epub 2016 Jan 26.


Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.

Mahmoud AB, Tu MM, Wight A, Zein HS, Rahim MM, Lee SH, Sekhon HS, Brown EG, Makrigiannis AP.

PLoS Pathog. 2016 Feb 29;12(2):e1005446. doi: 10.1371/journal.ppat.1005446. eCollection 2016 Feb. Erratum in: PLoS Pathog. 2016 Nov 4;12 (11):e1006021.


Endothelial Gata5 transcription factor regulates blood pressure.

Messaoudi S, He Y, Gutsol A, Wight A, Hébert RL, Vilmundarson RO, Makrigiannis AP, Chalmers J, Hamet P, Tremblay J, McPherson R, Stewart AFR, Touyz RM, Nemer M.

Nat Commun. 2015 Nov 30;6:8835. doi: 10.1038/ncomms9835.


Ly49 receptors: evolution, genetic diversity, and impact on immunity.

Rahim MM, Makrigiannis AP.

Immunol Rev. 2015 Sep;267(1):137-47. doi: 10.1111/imr.12318. Review.


Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.

Chen P, Aguilar OA, Rahim MM, Allan DS, Fine JH, Kirkham CL, Ma J, Tanaka M, Tu MM, Wight A, Kartsogiannis V, Gillespie MT, Makrigiannis AP, Carlyle JR.

J Immunol. 2015 Mar 15;194(6):2909-18. doi: 10.4049/jimmunol.1401523. Epub 2015 Feb 13.


The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.

Rahim MM, Chen P, Mottashed AN, Mahmoud AB, Thomas MJ, Zhu Q, Brooks CG, Kartsogiannis V, Gillespie MT, Carlyle JR, Makrigiannis AP.

Blood. 2015 Apr 2;125(14):2217-27. doi: 10.1182/blood-2014-02-556142. Epub 2015 Jan 22.


Impaired NK-cell education diminishes resistance to murine CMV infection.

Wei H, Nash WT, Makrigiannis AP, Brown MG.

Eur J Immunol. 2014 Nov;44(11):3273-82. doi: 10.1002/eji.201444800. Epub 2014 Oct 1.


Ly49 receptors activate angiogenic mouse DBA⁺ uterine natural killer cells.

Lima PD, Tu MM, Rahim MM, Peng AR, Croy BA, Makrigiannis AP.

Cell Mol Immunol. 2014 Sep;11(5):467-76. doi: 10.1038/cmi.2014.44. Epub 2014 Jun 23.


Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells.

Tu MM, Mahmoud AB, Wight A, Mottashed A, Bélanger S, Rahim MM, Abou-Samra E, Makrigiannis AP.

Cancer Res. 2014 Jul 15;74(14):3684-94. doi: 10.1158/0008-5472.CAN-13-3021. Epub 2014 May 6.


The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy.

Klingel K, Fabritius C, Sauter M, Göldner K, Stauch D, Kandolf R, Ettischer N, Gahlen S, Schönberger T, Ebner S, Makrigiannis AP, Bélanger S, Diefenbach A, Polić B, Pratschke J, Kotsch K.

J Pathol. 2014 Oct;234(2):164-77. doi: 10.1002/path.4369. Epub 2014 Aug 6.


Ly49 receptors: innate and adaptive immune paradigms.

Rahim MM, Tu MM, Mahmoud AB, Wight A, Abou-Samra E, Lima PD, Makrigiannis AP.

Front Immunol. 2014 Apr 2;5:145. doi: 10.3389/fimmu.2014.00145. eCollection 2014. Review.


Maraba MG1 virus enhances natural killer cell function via conventional dendritic cells to reduce postoperative metastatic disease.

Zhang J, Tai LH, Ilkow CS, Alkayyal AA, Ananth AA, de Souza CT, Wang J, Sahi S, Ly L, Lefebvre C, Falls TJ, Stephenson KB, Mahmoud AB, Makrigiannis AP, Lichty BD, Bell JC, Stojdl DF, Auer RC.

Mol Ther. 2014 Jul;22(7):1320-1332. doi: 10.1038/mt.2014.60. Epub 2014 Apr 3.


Optimized tetramer analysis reveals Ly49 promiscuity for MHC ligands.

McFall E, Tu MM, Al-Khattabi N, Tai LH, St-Laurent AS, Tzankova V, Hall CW, Belanger S, Troke AD, Wight A, Mahmoud AB, Zein HS, Rahim MM, Carlyle JR, Makrigiannis AP.

J Immunol. 2013 Dec 1;191(11):5722-9. doi: 10.4049/jimmunol.1300726. Epub 2013 Oct 23.


Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells.

Tai LH, Zhang J, Scott KJ, de Souza CT, Alkayyal AA, Ananth AA, Sahi S, Adair RA, Mahmoud AB, Sad S, Bell JC, Makrigiannis AP, Melcher AA, Auer RC.

Clin Cancer Res. 2013 Sep 15;19(18):5104-15. doi: 10.1158/1078-0432.CCR-13-0246. Epub 2013 Jul 23.


Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.

Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, Makrigiannis AP.

J Immunol. 2013 Apr 15;190(8):3994-4004. doi: 10.4049/jimmunol.1200873. Epub 2013 Mar 11.


Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.

Zhang Q, Rahim MM, Allan DS, Tu MM, Belanger S, Abou-Samra E, Ma J, Sekhon HS, Fairhead T, Zein HS, Carlyle JR, Anderson SK, Makrigiannis AP.

PLoS One. 2012;7(12):e50561. doi: 10.1371/journal.pone.0050561. Epub 2012 Dec 4.


Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells.

Tai LH, de Souza CT, Bélanger S, Ly L, Alkayyal AA, Zhang J, Rintoul JL, Ananth AA, Lam T, Breitbach CJ, Falls TJ, Kirn DH, Bell JC, Makrigiannis AP, Auer RA.

Cancer Res. 2013 Jan 1;73(1):97-107. doi: 10.1158/0008-5472.CAN-12-1993. Epub 2012 Oct 22.


Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice.

Bélanger S, Tu MM, Rahim MM, Mahmoud AB, Patel R, Tai LH, Troke AD, Wilhelm BT, Landry JR, Zhu Q, Tung KS, Raulet DH, Makrigiannis AP.

Blood. 2012 Jul 19;120(3):592-602. doi: 10.1182/blood-2012-02-408732. Epub 2012 Jun 1. Erratum in: Blood. 2013 Oct 3;122(14):2525.


Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands.

Heyward CY, Patel R, Mace EM, Grier JT, Guan H, Makrigiannis AP, Orange JS, Ricciardi RP.

Immunol Lett. 2012 May 30;144(1-2):16-23. doi: 10.1016/j.imlet.2012.03.001. Epub 2012 Mar 14.


Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals conservation of genomic organization and functional receptor-ligand interactions despite significant allelic polymorphism.

Chen P, Bélanger S, Aguilar OA, Zhang Q, St-Laurent A, Rahim MM, Makrigiannis AP, Carlyle JR.

Immunogenetics. 2011 Oct;63(10):627-40. doi: 10.1007/s00251-011-0542-8. Epub 2011 Jun 11.


Effect of Ly49 haplotype variance on NK cell function and education.

Patel R, Bélanger S, Tai LH, Troke AD, Makrigiannis AP.

J Immunol. 2010 Oct 15;185(8):4783-92. doi: 10.4049/jimmunol.1001287. Epub 2010 Sep 20.


MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus.

Xie X, Stadnisky MD, Coats ER, Ahmed Rahim MM, Lundgren A, Xu W, Makrigiannis AP, Brown MG.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8754-9. doi: 10.1073/pnas.0913126107. Epub 2010 Apr 26.


Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.

Hayashi M, Nakashima T, Kodama T, Makrigiannis AP, Toyama-Sorimachi N, Takayanagi H.

Biochem Biophys Res Commun. 2010 Mar 12;393(3):432-8. doi: 10.1016/j.bbrc.2010.02.013. Epub 2010 Feb 12.


The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.

Sasawatari S, Yoshizaki M, Taya C, Tazawa A, Furuyama-Tanaka K, Yonekawa H, Dohi T, Makrigiannis AP, Sasazuki T, Inaba K, Toyama-Sorimachi N.

Immunity. 2010 Feb 26;32(2):200-13. doi: 10.1016/j.immuni.2010.01.012. Epub 2010 Feb 11.


Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.

Yoshizaki M, Tazawa A, Kasumi E, Sasawatari S, Itoh K, Dohi T, Sasazuki T, Inaba K, Makrigiannis AP, Toyama-Sorimachi N.

Blood. 2009 Aug 20;114(8):1518-27. doi: 10.1182/blood-2008-12-192344. Epub 2009 Jun 15.


Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.

Tai LH, Goulet ML, Belanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, Makrigiannis AP.

J Exp Med. 2008 Dec 22;205(13):3187-99. doi: 10.1084/jem.20080718. Epub 2008 Dec 15.


Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.

Fodil-Cornu N, Lee SH, Belanger S, Makrigiannis AP, Biron CA, Buller RM, Vidal SM.

J Immunol. 2008 Nov 1;181(9):6394-405.


The evolution of NK cell diversity.

Makrigiannis AP, Parham P.

Semin Immunol. 2008 Dec;20(6):309-10. doi: 10.1016/j.smim.2008.09.004. Epub 2008 Oct 19. No abstract available.


Evolution of the Ly49 and Nkrp1 recognition systems.

Carlyle JR, Mesci A, Fine JH, Chen P, Bélanger S, Tai LH, Makrigiannis AP.

Semin Immunol. 2008 Dec;20(6):321-30. doi: 10.1016/j.smim.2008.05.004. Epub 2008 Jul 2. Review.


Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome.

Belanger S, Tai LH, Anderson SK, Makrigiannis AP.

Genes Immun. 2008 Sep;9(6):509-21. doi: 10.1038/gene.2008.43. Epub 2008 Jun 5.


Translational control of the innate immune response through IRF-7.

Colina R, Costa-Mattioli M, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N.

Nature. 2008 Mar 20;452(7185):323-8. doi: 10.1038/nature06730. Epub 2008 Feb 13.


Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.

Tai LH, Goulet ML, Belanger S, Troke AD, St-Laurent AG, Mesci A, Toyama-Sorimachi N, Carlyle JR, Makrigiannis AP.

Mol Immunol. 2007 Apr;44(10):2638-46. Epub 2007 Jan 22.


NKR-P1 biology: from prototype to missing self.

Mesci A, Ljutic B, Makrigiannis AP, Carlyle JR.

Immunol Res. 2006;35(1-2):13-26. Review.


Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells.

Carlyle JR, Mesci A, Ljutic B, Belanger S, Tai LH, Rousselle E, Troke AD, Proteau MF, Makrigiannis AP.

J Immunol. 2006 Jun 15;176(12):7511-24.


Complete elucidation of a minimal class I MHC natural killer cell receptor haplotype.

Anderson SK, Dewar K, Goulet ML, Leveque G, Makrigiannis AP.

Genes Immun. 2005 Sep;6(6):481-92.


Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection.

Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM.

Nat Genet. 2005 Jun;37(6):593-9. Epub 2005 May 15.


Direct sequence comparison of two divergent class I MHC natural killer cell receptor haplotypes.

Makrigiannis AP, Patel D, Goulet ML, Dewar K, Anderson SK.

Genes Immun. 2005 Mar;6(2):71-83.


Mapping of the BALB/c Ly49 cluster defines a minimal natural killer cell receptor gene repertoire.

Proteau MF, Rousselle E, Makrigiannis AP.

Genomics. 2004 Oct;84(4):669-77.


Independent control of Ly49g alleles: implications for NK cell repertoire selection and tumor cell killing.

Makrigiannis AP, Rousselle E, Anderson SK.

J Immunol. 2004 Feb 1;172(3):1414-25.

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