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Items: 1 to 50 of 85


Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex.

Wang Y, Palmfeldt J, Gregersen N, Makhov AM, Conway JF, Wang M, McCalley SP, Basu S, Alharbi H, St Croix C, Calderon MJ, Watkins S, Vockley J.

J Biol Chem. 2019 Aug 16;294(33):12380-12391. doi: 10.1074/jbc.RA119.008680. Epub 2019 Jun 24.


High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16.

Guan J, Bywaters SM, Brendle SA, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S.

Viruses. 2017 Dec 6;9(12). pii: E374. doi: 10.3390/v9120374.


Cryo-EM maps reveal five-fold channel structures and their modification by gatekeeper mutations in the parvovirus minute virus of mice (MVM) capsid.

Subramanian S, Organtini LJ, Grossman A, Domeier PP, Cifuente JO, Makhov AM, Conway JF, D'Abramo A Jr, Cotmore SF, Tattersall P, Hafenstein S.

Virology. 2017 Oct;510:216-223. doi: 10.1016/j.virol.2017.07.015. Epub 2017 Jul 24.


Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.

Abdullah LH, Evans JR, Wang TT, Ford AA, Makhov AM, Nguyen K, Coakley RD, Griffith JD, Davis CW, Ballard ST, Kesimer M.

JCI Insight. 2017 Mar 23;2(6):e89752. doi: 10.1172/jci.insight.89752.


Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site.

Guan J, Bywaters SM, Brendle SA, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S.

Structure. 2017 Feb 7;25(2):253-263. doi: 10.1016/j.str.2016.12.001. Epub 2017 Jan 5.


Honey Bee Deformed Wing Virus Structures Reveal that Conformational Changes Accompany Genome Release.

Organtini LJ, Shingler KL, Ashley RE, Capaldi EA, Durrani K, Dryden KA, Makhov AM, Conway JF, Pizzorno MC, Hafenstein S.

J Virol. 2017 Jan 3;91(2). pii: e01795-16. doi: 10.1128/JVI.01795-16. Print 2017 Jan 15.


The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs.

Lee H, Shingler KL, Organtini LJ, Ashley RE, Makhov AM, Conway JF, Hafenstein S.

Sci Adv. 2016 Aug 24;2(8):e1501929. doi: 10.1126/sciadv.1501929. eCollection 2016 Aug.


Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus.

Organtini LJ, Lee H, Iketani S, Huang K, Ashley RE, Makhov AM, Conway JF, Parrish CR, Hafenstein S.

J Virol. 2016 Oct 14;90(21):9733-9742. doi: 10.1128/JVI.01112-16. Print 2016 Nov 1.


Transmission electron microscopy for the evaluation and optimization of crystal growth.

Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G.

Acta Crystallogr D Struct Biol. 2016 May;72(Pt 5):603-15. doi: 10.1107/S2059798316001546. Epub 2016 Apr 26.


Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery.

Huet A, Makhov AM, Huffman JB, Vos M, Homa FL, Conway JF.

Nat Struct Mol Biol. 2016 Jun;23(6):531-9. doi: 10.1038/nsmb.3212. Epub 2016 Apr 25.


Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization.

Guan J, Bywaters SM, Brendle SA, Lee H, Ashley RE, Makhov AM, Conway JF, Christensen ND, Hafenstein S.

Virology. 2015 Sep;483:253-63. doi: 10.1016/j.virol.2015.04.016. Epub 2015 May 19.


The enterovirus 71 procapsid binds neutralizing antibodies and rescues virus infection in vitro.

Shingler KL, Cifuente JO, Ashley RE, Makhov AM, Conway JF, Hafenstein S.

J Virol. 2015 Feb;89(3):1900-8. doi: 10.1128/JVI.03098-14. Epub 2014 Nov 26.


A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.

Lee H, Brendle SA, Bywaters SM, Guan J, Ashley RE, Yoder JD, Makhov AM, Conway JF, Christensen ND, Hafenstein S.

J Virol. 2015 Jan 15;89(2):1428-38. doi: 10.1128/JVI.02898-14. Epub 2014 Nov 12.


Transmission electron microscopy as a tool for nanocrystal characterization pre- and post-injector.

Stevenson HP, DePonte DP, Makhov AM, Conway JF, Zeldin OB, Boutet S, Calero G, Cohen AE.

Philos Trans R Soc Lond B Biol Sci. 2014 Jul 17;369(1647):20130322. doi: 10.1098/rstb.2013.0322.


Use of transmission electron microscopy to identify nanocrystals of challenging protein targets.

Stevenson HP, Makhov AM, Calero M, Edwards AL, Zeldin OB, Mathews II, Lin G, Barnes CO, Santamaria H, Ross TM, Soltis SM, Khosla C, Nagarajan V, Conway JF, Cohen AE, Calero G.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8470-5. doi: 10.1073/pnas.1400240111. Epub 2014 May 28.


Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle.

Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD.

J Virol. 2014 May;88(10):5755-65. doi: 10.1128/JVI.00299-14. Epub 2014 Mar 12.


Open-channel structures of the human glycine receptor α1 full-length transmembrane domain.

Mowrey DD, Cui T, Jia Y, Ma D, Makhov AM, Zhang P, Tang P, Xu Y.

Structure. 2013 Oct 8;21(10):1897-904. doi: 10.1016/j.str.2013.07.014. Epub 2013 Aug 29.


A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody.

Lee H, Cifuente JO, Ashley RE, Conway JF, Makhov AM, Tano Y, Shimizu H, Nishimura Y, Hafenstein S.

J Virol. 2013 Nov;87(21):11363-70. doi: 10.1128/JVI.01926-13. Epub 2013 Aug 14.


Structure of the pseudorabies virus capsid: comparison with herpes simplex virus type 1 and differential binding of essential minor proteins.

Homa FL, Huffman JB, Toropova K, Lopez HR, Makhov AM, Conway JF.

J Mol Biol. 2013 Sep 23;425(18):3415-28. doi: 10.1016/j.jmb.2013.06.034. Epub 2013 Jul 1.


Structures of the procapsid and mature virion of enterovirus 71 strain 1095.

Cifuente JO, Lee H, Yoder JD, Shingler KL, Carnegie MS, Yoder JL, Ashley RE, Makhov AM, Conway JF, Hafenstein S.

J Virol. 2013 Jul;87(13):7637-45. doi: 10.1128/JVI.03519-12. Epub 2013 May 1.


Details of ssDNA annealing revealed by an HSV-1 ICP8-ssDNA binary complex.

Tolun G, Makhov AM, Ludtke SJ, Griffith JD.

Nucleic Acids Res. 2013 Jun;41(11):5927-37. doi: 10.1093/nar/gkt266. Epub 2013 Apr 19.


Characterization of spherulites as a lipidic carrier for low and high molecular weight agents.

Zhang P, Huang Y, Makhov AM, Gao X, Zhang P, Li S.

Pharm Res. 2013 Jun;30(6):1525-35. doi: 10.1007/s11095-013-0990-y. Epub 2013 Apr 12.


The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoEM study of picornavirus uncoating.

Shingler KL, Yoder JL, Carnegie MS, Ashley RE, Makhov AM, Conway JF, Hafenstein S.

PLoS Pathog. 2013 Mar;9(3):e1003240. doi: 10.1371/journal.ppat.1003240. Epub 2013 Mar 21. Erratum in: PLoS Pathog. 2013 Sep;9(9). doi: 10.1371/annotation/e92d19e0-996a-4bfa-afdd-20dce770ed75.


Nanoassembly of surfactants with interfacial drug-interactive motifs as tailor-designed drug carriers.

Gao X, Huang Y, Makhov AM, Epperly M, Lu J, Grab S, Zhang P, Rohan L, Xie XQ, Wipf P, Greenberger J, Li S.

Mol Pharm. 2013 Jan 7;10(1):187-98. doi: 10.1021/mp300319m. Epub 2012 Dec 17.


An intramolecular salt bridge drives the soluble domain of GTP-bound atlastin into the postfusion conformation.

Morin-Leisk J, Saini SG, Meng X, Makhov AM, Zhang P, Lee TH.

J Cell Biol. 2011 Nov 14;195(4):605-15. doi: 10.1083/jcb.201105006. Epub 2011 Nov 7.


Disulfide bond formation contributes to herpes simplex virus capsid stability and retention of pentons.

Szczepaniak R, Nellissery J, Jadwin JA, Makhov AM, Kosinski A, Conway JF, Weller SK.

J Virol. 2011 Sep;85(17):8625-34. doi: 10.1128/JVI.00214-11. Epub 2011 Jun 22.


The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.

Ahn J, Novince Z, Concel J, Byeon CH, Makhov AM, Byeon IJ, Zhang P, Gronenborn AM.

Biochemistry. 2011 Mar 1;50(8):1359-67. doi: 10.1021/bi101749s. Epub 2011 Jan 31.


Unpacking a gel-forming mucin: a view of MUC5B organization after granular release.

Kesimer M, Makhov AM, Griffith JD, Verdugo P, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L15-22. doi: 10.1152/ajplung.00194.2009. Epub 2009 Sep 25.


Structural and biophysical characterization of the proteins interacting with the herpes simplex virus 1 origin of replication.

Manolaridis I, Mumtsidu E, Konarev P, Makhov AM, Fullerton SW, Sinz A, Kalkhof S, McGeehan JE, Cary PD, Griffith JD, Svergun D, Kneale GG, Tucker PA.

J Biol Chem. 2009 Jun 12;284(24):16343-53. doi: 10.1074/jbc.M806134200. Epub 2009 Mar 27.


The bipolar filaments formed by herpes simplex virus type 1 SSB/recombination protein (ICP8) suggest a mechanism for DNA annealing.

Makhov AM, Sen A, Yu X, Simon MN, Griffith JD, Egelman EH.

J Mol Biol. 2009 Feb 20;386(2):273-9. doi: 10.1016/j.jmb.2008.12.059. Epub 2008 Dec 31.


Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.

Cai L, Makhov AM, Schafer DA, Bear JE.

Cell. 2008 Sep 5;134(5):828-42. doi: 10.1016/j.cell.2008.06.054.


Structural features of the single-stranded DNA-binding protein of Epstein-Barr virus.

Mumtsidu E, Makhov AM, Konarev PV, Svergun DI, Griffith JD, Tucker PA.

J Struct Biol. 2008 Feb;161(2):172-87. Epub 2007 Nov 1.


Structural features of the Bluetongue virus NS2 protein.

Mumtsidu E, Makhov AM, Roessle M, Bathke A, Tucker PA.

J Struct Biol. 2007 Nov;160(2):157-67. Epub 2007 Aug 17.


F-actin binding is essential for coronin 1B function in vivo.

Cai L, Makhov AM, Bear JE.

J Cell Sci. 2007 May 15;120(Pt 10):1779-90. Epub 2007 Apr 24.


Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers.

Nossal NG, Makhov AM, Chastain PD 2nd, Jones CE, Griffith JD.

J Biol Chem. 2007 Jan 12;282(2):1098-108. Epub 2006 Nov 13.


Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP.

Ji Y, Gu J, Makhov AM, Griffith JD, Mitchell BS.

J Biol Chem. 2006 Jan 6;281(1):206-12. Epub 2005 Oct 21.


t-Loops in yeast mitochondria.

Tomaska L, Makhov AM, Griffith JD, Nosek J.

Mitochondrion. 2002 May;1(5):455-9.


Amplification of telomeric arrays via rolling-circle mechanism.

Nosek J, Rycovska A, Makhov AM, Griffith JD, Tomaska L.

J Biol Chem. 2005 Mar 18;280(11):10840-5. Epub 2005 Jan 18.


Two-dimensional crystallization of herpes simplex virus type 1 single-stranded DNA-binding protein, ICP8, on a lipid monolayer.

Makhov AM, Taylor DW, Griffith JD.

Biochim Biophys Acta. 2004 Sep 1;1701(1-2):101-8.


The Epstein-Barr virus polymerase accessory factor BMRF1 adopts a ring-shaped structure as visualized by electron microscopy.

Makhov AM, Subramanian D, Holley-Guthrie E, Kenney SC, Griffith JD.

J Biol Chem. 2004 Sep 24;279(39):40358-61. Epub 2004 Jul 30.


Architecture of the replication complex and DNA loops at the fork generated by the bacteriophage t4 proteins.

Chastain PD 2nd, Makhov AM, Nossal NG, Griffith J.

J Biol Chem. 2003 Jun 6;278(23):21276-85. Epub 2003 Mar 20.


Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: visualization of a specific preunwinding complex.

Makhov AM, Lee SS, Lehman IR, Griffith JD.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):898-903. Epub 2003 Jan 24.


Hairpin formation in Friedreich's ataxia triplet repeat expansion.

Heidenfelder BL, Makhov AM, Topal MD.

J Biol Chem. 2003 Jan 24;278(4):2425-31. Epub 2002 Nov 18.


Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein.

Lin BY, Makhov AM, Griffith JD, Broker TR, Chow LT.

Mol Cell Biol. 2002 Sep;22(18):6592-604.


Preferential binding of ATR protein to UV-damaged DNA.

Unsal-Kaçmaz K, Makhov AM, Griffith JD, Sancar A.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6673-8.


Electron microscopic analysis supports a dual role for the mitochondrial telomere-binding protein of Candida parapsilosis.

Tomaska L, Makhov AM, Nosek J, Kucejova B, Griffith JD.

J Mol Biol. 2001 Jan 5;305(1):61-9.


Analysis of the Okazaki fragment distributions along single long DNAs replicated by the bacteriophage T4 proteins.

Chastain PD 2nd, Makhov AM, Nossal NG, Griffith JD.

Mol Cell. 2000 Oct;6(4):803-14.


Extragenomic double-stranded DNA circles in yeast with linear mitochondrial genomes: potential involvement in telomere maintenance.

Tomaska L, Nosek J, Makhov AM, Pastorakova A, Griffith JD.

Nucleic Acids Res. 2000 Nov 15;28(22):4479-87.


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