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Items: 20


Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu SS.

J Mol Biol. 2019 Mar 15;431(6):1160-1171. doi: 10.1016/j.jmb.2019.02.007. Epub 2019 Feb 11.


Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10.

Zhang W, Sartori MA, Makhnevych T, Federowicz KE, Dong X, Liu L, Nim S, Dong A, Yang J, Li Y, Haddad D, Ernst A, Heerding D, Tong Y, Moffat J, Sidhu SS.

J Mol Biol. 2017 Nov 10;429(22):3546-3560. doi: 10.1016/j.jmb.2017.05.025. Epub 2017 Jun 3.


Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex.

Kakihara Y, Makhnevych T, Zhao L, Tang W, Houry WA.

Genome Biol. 2014 Jul 25;15(7):404. doi: 10.1186/s13059-014-0404-4.


A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.

Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M, Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA, Andrews B, Boone C, Moffat J.

Mol Syst Biol. 2013 Oct 8;9:696. doi: 10.1038/msb.2013.54.


The control of spindle length by Hsp70 and Hsp110 molecular chaperones.

Makhnevych T, Houry WA.

FEBS Lett. 2013 Apr 17;587(8):1067-72. doi: 10.1016/j.febslet.2013.02.018. Epub 2013 Feb 19. Review.


Hsp110 is required for spindle length control.

Makhnevych T, Wong P, Pogoutse O, Vizeacoumar FJ, Greenblatt JF, Emili A, Houry WA.

J Cell Biol. 2012 Aug 20;198(4):623-36. doi: 10.1083/jcb.201111105.


Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90.

Jiménez B, Ugwu F, Zhao R, Ortí L, Makhnevych T, Pineda-Lucena A, Houry WA.

J Biol Chem. 2012 Feb 17;287(8):5698-709. doi: 10.1074/jbc.M111.287458. Epub 2011 Dec 16.


The role of Hsp90 in protein complex assembly.

Makhnevych T, Houry WA.

Biochim Biophys Acta. 2012 Mar;1823(3):674-82. doi: 10.1016/j.bbamcr.2011.09.001. Epub 2011 Sep 16. Review.


The TFIIH subunit Tfb3 regulates cullin neddylation.

Rabut G, Le Dez G, Verma R, Makhnevych T, Knebel A, Kurz T, Boone C, Deshaies RJ, Peter M.

Mol Cell. 2011 Aug 5;43(3):488-95. doi: 10.1016/j.molcel.2011.05.032.


Lumenal interactions in nuclear pore complex assembly and stability.

Yewdell WT, Colombi P, Makhnevych T, Lusk CP.

Mol Biol Cell. 2011 Apr 15;22(8):1375-88. doi: 10.1091/mbc.E10-06-0554. Epub 2011 Feb 23.


A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration.

Sydorskyy Y, Srikumar T, Jeram SM, Wheaton S, Vizeacoumar FJ, Makhnevych T, Chong YT, Gingras AC, Raught B.

Mol Cell Biol. 2010 Sep;30(18):4452-62. doi: 10.1128/MCB.00335-10. Epub 2010 Jul 20.


The genetic landscape of a cell.

Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ, Boone C.

Science. 2010 Jan 22;327(5964):425-31. doi: 10.1126/science.1180823.


Global map of SUMO function revealed by protein-protein interaction and genetic networks.

Makhnevych T, Sydorskyy Y, Xin X, Srikumar T, Vizeacoumar FJ, Jeram SM, Li Z, Bahr S, Andrews BJ, Boone C, Raught B.

Mol Cell. 2009 Jan 16;33(1):124-35. doi: 10.1016/j.molcel.2008.12.025.


Nup53p is a target of two mitotic kinases, Cdk1p and Hrr25p.

Lusk CP, Waller DD, Makhnevych T, Dienemann A, Whiteway M, Thomas DY, Wozniak RW.

Traffic. 2007 Jun;8(6):647-60. Epub 2007 Apr 25.


The role of karyopherins in the regulated sumoylation of septins.

Makhnevych T, Ptak C, Lusk CP, Aitchison JD, Wozniak RW.

J Cell Biol. 2007 Apr 9;177(1):39-49. Epub 2007 Apr 2.


Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein.

Sydorskyy Y, Dilworth DJ, Halloran B, Yi EC, Makhnevych T, Wozniak RW, Aitchison JD.

Biochem J. 2005 Jun 15;388(Pt 3):819-26.


New ways to skin a kap: mechanisms for controlling nuclear transport.

Lusk CP, Makhnevych T, Wozniak RW.

Biochem Cell Biol. 2004 Dec;82(6):618-25. Review.


Cell cycle regulated transport controlled by alterations in the nuclear pore complex.

Makhnevych T, Lusk CP, Anderson AM, Aitchison JD, Wozniak RW.

Cell. 2003 Dec 26;115(7):813-23.


Karyopherins in nuclear pore biogenesis: a role for Kap121p in the assembly of Nup53p into nuclear pore complexes.

Lusk CP, Makhnevych T, Marelli M, Aitchison JD, Wozniak RW.

J Cell Biol. 2002 Oct 28;159(2):267-78. Epub 2002 Oct 28.


[Features of the inhibition of catalase activity by 3-amino-1,2,4-triazole in erythrocytes and liver of rats with streptozotocin diabetes].

Oliiarnyk OD, Velykyĭ MM, Makhnevych TR.

Ukr Biokhim Zh (1999). 1999 Jan-Feb;71(1):77-82. Russian.


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