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Items: 11


DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP.

Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT.

Sci Adv. 2020 Jan 8;6(2):eaay0922. doi: 10.1126/sciadv.aay0922. eCollection 2020 Jan.


Sae2/CtIP prevents R-loop accumulation in eukaryotic cells.

Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT.

Elife. 2018 Dec 7;7. pii: e42733. doi: 10.7554/eLife.42733.


ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.

Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27.


CtIP: A DNA damage response protein at the intersection of DNA metabolism.

Makharashvili N, Paull TT.

DNA Repair (Amst). 2015 Aug;32:75-81. doi: 10.1016/j.dnarep.2015.04.016. Epub 2015 May 2. Review.


Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.

Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M.

J Cell Biol. 2014 Sep 29;206(7):877-94. doi: 10.1083/jcb.201401146.


Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.

Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT.

Mol Cell. 2014 Jun 19;54(6):1022-33. doi: 10.1016/j.molcel.2014.04.011. Epub 2014 May 15.


Household income and poor treatment outcome among patients with tuberculosis in Georgia: a cohort study.

Djibuti M, Mirvelashvili E, Makharashvili N, Magee MJ.

BMC Public Health. 2014 Jan 29;14:88. doi: 10.1186/1471-2458-14-88.


Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.

Fu Q, Chow J, Bernstein KA, Makharashvili N, Arora S, Lee CF, Person MD, Rothstein R, Paull TT.

Mol Cell Biol. 2014 Mar;34(5):778-93. doi: 10.1128/MCB.00963-13. Epub 2013 Dec 16. Erratum in: Mol Cell Biol. 2014 Nov 15;34(22):4213.


RecR-mediated modulation of RecF dimer specificity for single- and double-stranded DNA.

Makharashvili N, Mi T, Koroleva O, Korolev S.

J Biol Chem. 2009 Jan 16;284(3):1425-34. doi: 10.1074/jbc.M806378200. Epub 2008 Nov 17.


Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function.

Koroleva O, Makharashvili N, Courcelle CT, Courcelle J, Korolev S.

EMBO J. 2007 Feb 7;26(3):867-77. Epub 2007 Jan 25.


A novel structure of DNA repair protein RecO from Deinococcus radiodurans.

Makharashvili N, Koroleva O, Bera S, Grandgenett DP, Korolev S.

Structure. 2004 Oct;12(10):1881-9.

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