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Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells.

Chinchar E, Makey KL, Gibson J, Chen F, Cole SA, Megason GC, Vijayakumar S, Miele L, Gu JW.

Vasc Cell. 2014 Jun 1;6:12. doi: 10.1186/2045-824X-6-12. eCollection 2014.


EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression.

Gu JW, Makey KL, Tucker KB, Chinchar E, Mao X, Pei I, Thomas EY, Miele L.

Vasc Cell. 2013 May 2;5(1):9. doi: 10.1186/2045-824X-5-9.


Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women.

Makey KL, Patterson SG, Robinson J, Loftin M, Waddell DE, Miele L, Chinchar E, Huang M, Smith AD, Weber M, Gu JW.

Eur J Cancer Prev. 2013 Jan;22(1):83-9. doi: 10.1097/CEJ.0b013e328353ed81.


Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice.

Gu JW, Young E, Patterson SG, Makey KL, Wells J, Huang M, Tucker KB, Miele L.

Cancer Biol Ther. 2011 May 15;11(10):910-7. Epub 2011 May 15.

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