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Chaperone activation and client binding of a 2-cysteine peroxiredoxin.

Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U.

Nat Commun. 2019 Feb 8;10(1):659. doi: 10.1038/s41467-019-08565-8.


Phase variation of Opa proteins of Neisseria meningitidis and the effects of bacterial transformation.

Sadarangani M, Hoe CJ, Makepeace K, van der Ley P, Pollard AJ.

J Biosci. 2016 Mar;41(1):13-9.


Protein unfolding as a switch from self-recognition to high-affinity client binding.

Groitl B, Horowitz S, Makepeace KAT, Petrotchenko EV, Borchers CH, Reichmann D, Bardwell JCA, Jakob U.

Nat Commun. 2016 Jan 20;7:10357. doi: 10.1038/ncomms10357.


Comprehensive identification of disulfide bonds using non-specific proteinase K digestion and CID-cleavable crosslinking analysis methodology for Orbitrap LC/ESI-MS/MS data.

Makepeace KA, Serpa JJ, Petrotchenko EV, Borchers CH.

Methods. 2015 Nov 1;89:74-8. doi: 10.1016/j.ymeth.2015.02.021. Epub 2015 Mar 6.


Structure of EspB from the ESX-1 type VII secretion system and insights into its export mechanism.

Solomonson M, Setiaputra D, Makepeace KAT, Lameignere E, Petrotchenko EV, Conrady DG, Bergeron JR, Vuckovic M, DiMaio F, Borchers CH, Yip CK, Strynadka NCJ.

Structure. 2015 Mar 3;23(3):571-583. doi: 10.1016/j.str.2015.01.002. Epub 2015 Feb 12.


Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: a comparison in mice.

Mehta OH, Norheim G, Hoe JC, Rollier CS, Nagaputra JC, Makepeace K, Saleem M, Chan H, Ferguson DJ, Jones C, Sadarangani M, Hood DW, Feavers I, Derrick JP, Pollard AJ, Moxon ER.

PLoS One. 2014 Dec 29;9(12):e115713. doi: 10.1371/journal.pone.0115713. eCollection 2014.


DXMSMS Match Program for Automated Analysis of LC-MS/MS Data Obtained Using Isotopically Coded CID-Cleavable Cross-Linking Reagents.

Petrotchenko EV, Makepeace KA, Borchers CH.

Curr Protoc Bioinformatics. 2014 Dec 12;48:8.18.1-19. doi: 10.1002/0471250953.bi0818s48.


Isotopically-coded short-range hetero-bifunctional photo-reactive crosslinkers for studying protein structure.

Brodie NI, Makepeace KA, Petrotchenko EV, Borchers CH.

J Proteomics. 2015 Apr 6;118:12-20. doi: 10.1016/j.jprot.2014.08.012. Epub 2014 Sep 2.


(14)N(15)N DXMSMS Match program for the automated analysis of LC/ESI-MS/MS crosslinking data from experiments using (15)N metabolically labeled proteins.

Petrotchenko EV, Serpa JJ, Makepeace KA, Brodie NI, Borchers CH.

J Proteomics. 2014 Sep 23;109:104-10. doi: 10.1016/j.jprot.2014.06.014. Epub 2014 Jun 25.


Analysis of protein structure by cross-linking combined with mass spectrometry.

Petrotchenko EV, Makepeace KA, Serpa JJ, Borchers CH.

Methods Mol Biol. 2014;1156:447-63. doi: 10.1007/978-1-4939-0685-7_30.


Super Spy variants implicate flexibility in chaperone action.

Quan S, Wang L, Petrotchenko EV, Makepeace KA, Horowitz S, Yang J, Zhang Y, Borchers CH, Bardwell JC.

Elife. 2014;3:e01584. doi: 10.7554/eLife.01584. Epub 2014 Feb 4.


Using isotopically-coded hydrogen peroxide as a surface modification reagent for the structural characterization of prion protein aggregates.

Serpa JJ, Makepeace KA, Borchers TH, Wishart DS, Petrotchenko EV, Borchers CH.

J Proteomics. 2014 Apr 4;100:160-6. doi: 10.1016/j.jprot.2013.11.020. Epub 2013 Dec 3.


Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41.

Tonkin ML, Arredondo SA, Loveless BC, Serpa JJ, Makepeace KA, Sundar N, Petrotchenko EV, Miller LH, Grigg ME, Boulanger MJ.

J Biol Chem. 2013 May 3;288(18):12805-17. doi: 10.1074/jbc.M113.455667. Epub 2013 Mar 19.


Construction of Opa-positive and Opa-negative strains of Neisseria meningitidis to evaluate a novel meningococcal vaccine.

Sadarangani M, Hoe JC, Callaghan MJ, Jones C, Chan H, Makepeace K, Daniels-Treffandier H, Deadman ME, Bayliss C, Feavers I, van der Ley P, Pollard AJ.

PLoS One. 2012;7(12):e51045. doi: 10.1371/journal.pone.0051045. Epub 2012 Dec 12.


Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia.

Mukhopadhyay S, Plüddemann A, Hoe JC, Williams KJ, Varin A, Makepeace K, Aknin ML, Bowdish DM, Smale ST, Barclay AN, Gordon S.

Cell Host Microbe. 2010 Sep 16;8(3):236-47. doi: 10.1016/j.chom.2010.08.005.


Genes required for the synthesis of heptose-containing oligosaccharide outer core extensions in Haemophilus influenzae lipopolysaccharide.

Hood DW, Deadman ME, Engskog MK, Vitiazeva V, Makepeace K, Schweda EK, Moxon R.

Microbiology. 2010 Nov;156(Pt 11):3421-31. doi: 10.1099/mic.0.041780-0. Epub 2010 Aug 5.


Sialic acid mediated transcriptional modulation of a highly conserved sialometabolism gene cluster in Haemophilus influenzae and its effect on virulence.

Jenkins GA, Figueira M, Kumar GA, Sweetman WA, Makepeace K, Pelton SI, Moxon R, Hood DW.

BMC Microbiol. 2010 Feb 16;10:48. doi: 10.1186/1471-2180-10-48.


Kinetics of the natural, humoral immune response to Salmonella enterica serovar Typhi in Kathmandu, Nepal.

Pulickal AS, Gautam S, Clutterbuck EA, Thorson S, Basynat B, Adhikari N, Makepeace K, Rijpkema S, Borrow R, Farrar JJ, Pollard AJ.

Clin Vaccine Immunol. 2009 Oct;16(10):1413-9. doi: 10.1128/CVI.00245-09. Epub 2009 Aug 26.


Lex2B, a phase-variable glycosyltransferase, adds either a glucose or a galactose to Haemophilus influenzae lipopolysaccharide.

Deadman ME, Hermant P, Engskog M, Makepeace K, Moxon ER, Schweda EK, Hood DW.

Infect Immun. 2009 Jun;77(6):2376-84. doi: 10.1128/IAI.01446-08. Epub 2009 Mar 16.


The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia.

Plüddemann A, Hoe JC, Makepeace K, Moxon ER, Gordon S.

PLoS Pathog. 2009 Feb;5(2):e1000297. doi: 10.1371/journal.ppat.1000297. Epub 2009 Feb 13.


Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.

Jäkel A, Plested JS, Hoe JC, Makepeace K, Gidney MA, Lacelle S, St Michael F, Cox AD, Richards JC, Moxon ER.

Vaccine. 2008 Dec 2;26(51):6655-63. doi: 10.1016/j.vaccine.2008.09.041.


Neisseria meningitidis escape from the bactericidal activity of a monoclonal antibody is mediated by phase variation of lgtG and enhanced by a mutator phenotype.

Bayliss CD, Hoe JC, Makepeace K, Martin P, Hood DW, Moxon ER.

Infect Immun. 2008 Nov;76(11):5038-48. doi: 10.1128/IAI.00395-08. Epub 2008 Aug 11.


Duplicate copies of lic1 direct the addition of multiple phosphocholine residues in the lipopolysaccharide of Haemophilus influenzae.

Fox KL, Li J, Schweda EK, Vitiazeva V, Makepeace K, Jennings MP, Moxon ER, Hood DW.

Infect Immun. 2008 Feb;76(2):588-600. Epub 2007 Nov 5.


Identification of a bifunctional lipopolysaccharide sialyltransferase in Haemophilus influenzae: incorporation of disialic acid.

Fox KL, Cox AD, Gilbert M, Wakarchuk WW, Li J, Makepeace K, Richards JC, Moxon ER, Hood DW.

J Biol Chem. 2006 Dec 29;281(52):40024-32. Epub 2006 Oct 27.


Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay.

Peiser L, Makepeace K, Plüddemann A, Savino S, Wright JC, Pizza M, Rappuoli R, Moxon ER, Gordon S.

Infect Immun. 2006 Sep;74(9):5191-9.


Digalactoside expression in the lipopolysaccharide of Haemophilus influenzae and its role in intravascular survival.

Griffin R, Bayliss CD, Herbert MA, Cox AD, Makepeace K, Richards JC, Hood DW, Moxon ER.

Infect Immun. 2005 Oct;73(10):7022-6.


Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits.

Cox AD, Zou W, Gidney MA, Lacelle S, Plested JS, Makepeace K, Wright JC, Coull PA, Moxon ER, Richards JC.

Vaccine. 2005 Oct 17;23(43):5045-54.


Microsatellite instability regulates transcription factor binding and gene expression.

Martin P, Makepeace K, Hill SA, Hood DW, Moxon ER.

Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3800-4. Epub 2005 Feb 22.


Biosynthesis of cryptic lipopolysaccharide glycoforms in Haemophilus influenzae involves a mechanism similar to that required for O-antigen synthesis.

Hood DW, Randle G, Cox AD, Makepeace K, Li J, Schweda EK, Richards JC, Moxon ER.

J Bacteriol. 2004 Nov;186(21):7429-39.


lpt6, a gene required for addition of phosphoethanolamine to inner-core lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae.

Wright JC, Hood DW, Randle GA, Makepeace K, Cox AD, Li J, Chalmers R, Richards JC, Moxon ER.

J Bacteriol. 2004 Oct;186(20):6970-82.


Three genes, lgtF, lic2C and lpsA, have a primary role in determining the pattern of oligosaccharide extension from the inner core of Haemophilus influenzae LPS.

Hood DW, Deadman ME, Cox AD, Makepeace K, Martin A, Richards JC, Moxon ER.

Microbiology. 2004 Jul;150(Pt 7):2089-97.


Development, characterization, and functional activity of a panel of specific monoclonal antibodies to inner core lipopolysaccharide epitopes in Neisseria meningitidis.

Gidney MA, Plested JS, Lacelle S, Coull PA, Wright JC, Makepeace K, Brisson JR, Cox AD, Moxon ER, Richards JC.

Infect Immun. 2004 Jan;72(1):559-69.


The role of lex2 in lipopolysaccharide biosynthesis in Haemophilus influenzae strains RM7004 and RM153.

Griffin R, Cox AD, Makepeace K, Richards JC, Moxon ER, Hood DW.

Microbiology. 2003 Nov;149(Pt 11):3165-75.


Highly conserved Neisseria meningitidis inner-core lipopolysaccharide epitope confers protection against experimental meningococcal bacteremia.

Plested JS, Harris SL, Wright JC, Coull PA, Makepeace K, Gidney MA, Brisson JR, Richards JC, Granoff DM, Moxon ER.

J Infect Dis. 2003 Apr 15;187(8):1223-34. Epub 2003 Apr 2.


The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses.

Peiser L, De Winther MP, Makepeace K, Hollinshead M, Coull P, Plested J, Kodama T, Moxon ER, Gordon S.

Infect Immun. 2002 Oct;70(10):5346-54.


Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae.

Cox AD, Hood DW, Martin A, Makepeace KM, Deadman ME, Li J, Brisson JR, Moxon ER, Richards JC.

Eur J Biochem. 2002 Aug;269(16):4009-19. Erratum in: Eur J Biochem 2002 Sep;269(17):4384.


Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide.

Tang CM, Stroud D, Mackinnon F, Makepeace K, Plested J, Moxon ER, Chalmers R.

Gene. 2002 Feb 6;284(1-2):133-40.


Functional opsonic activity of human serum antibodies to inner core lipopolysaccharide (galE) of serogroup B meningococci measured by flow cytometry.

Plested JS, Ferry BL, Coull PA, Makepeace K, Lehmann AK, MacKinnon FG, Griffiths HG, Herbert MA, Richards JC, Moxon ER.

Infect Immun. 2001 May;69(5):3203-13.


Identification of a lipopolysaccharide alpha-2,3-sialyltransferase from Haemophilus influenzae.

Hood DW, Cox AD, Gilbert M, Makepeace K, Walsh S, Deadman ME, Cody A, Martin A, Månsson M, Schweda EK, Brisson JR, Richards JC, Moxon ER, Wakarchuk WW.

Mol Microbiol. 2001 Jan;39(2):341-50.


Conservation and accessibility of an inner core lipopolysaccharide epitope of Neisseria meningitidis.

Plested JS, Makepeace K, Jennings MP, Gidney MA, Lacelle S, Brisson J, Cox AD, Martin A, Bird AG, Tang CM, Mackinnon FM, Richards JC, Moxon ER.

Infect Immun. 1999 Oct;67(10):5417-26.


Sialic acid in the lipopolysaccharide of Haemophilus influenzae: strain distribution, influence on serum resistance and structural characterization.

Hood DW, Makepeace K, Deadman ME, Rest RF, Thibault P, Martin A, Richards JC, Moxon ER.

Mol Microbiol. 1999 Aug;33(4):679-92.


Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae.

Virji M, Makepeace K, Ferguson DJ, Watt SM.

Mol Microbiol. 1996 Dec;22(5):941-50.


The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae.

Virji M, Watt SM, Barker S, Makepeace K, Doyonnas R.

Mol Microbiol. 1996 Dec;22(5):929-39.


Pathogenic mechanisms of Neisseria meningitidis.

Virji M, Makepeace K, Peak IR, Ferguson DJ, Moxon ER.

Ann N Y Acad Sci. 1996 Oct 25;797:273-6. No abstract available.


Posttranslational modifications of meningococcal pili. Identification of a common trisaccharide substitution on variant pilins of strain C311.

Virji M, Stimson E, Makepeace K, Dell A, Morris HR, Payne G, Saunders JR, Moxon ER.

Ann N Y Acad Sci. 1996 Oct 25;797:53-64.


Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides.

Virji M, Makepeace K, Peak IRA, Ferguson DJP, Jennings MP, Moxon ER.

Mol Microbiol. 1995 Nov;18(4):741-754. doi: 10.1111/j.1365-2958.1995.mmi_18040741.x.


Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides.

Virji M, Makepeace K, Peak IR, Ferguson DJ, Jennings MP, Moxon ER.

Mol Microbiol. 1995 Nov;18(4):741-54.


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