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Items: 44


Rickettsia buchneri, symbiont of the deer tick Ixodes scapularis, can colonise the salivary glands of its host.

Al-Khafaji AM, Armstrong SD, Varotto Boccazzi I, Gaiarsa S, Sinha A, Li Z, Sassera D, Carlow CKS, Epis S, Makepeace BL.

Ticks Tick Borne Dis. 2019 Sep 9:101299. doi: 10.1016/j.ttbdis.2019.101299. [Epub ahead of print]


Characterisation of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite.

Rose C, Praulins G, Armstrong SD, Casas-Sanchez A, Davis J, Molyneux G, Yunta C, Stead Z, Prescott M, Perally S, Rutter A, Makepeace BL, La Course EJ, Acosta-Serrano A.

Parasitology. 2019 Jun 13:1-27. doi: 10.1017/S0031182019000763. [Epub ahead of print] No abstract available.


Genomes of trombidid mites reveal novel predicted allergens and laterally transferred genes associated with secondary metabolism.

Dong X, Chaisiri K, Xia D, Armstrong SD, Fang Y, Donnelly MJ, Kadowaki T, McGarry JW, Darby AC, Makepeace BL.

Gigascience. 2018 Dec 1;7(12). doi: 10.1093/gigascience/giy127.


Meeting the challenge of tick-borne disease control: A proposal for 1000 Ixodes genomes.

Murgia MV, Bell-Sakyi L, de la Fuente J, Kurtti TJ, Makepeace BL, Mans B, McCoy KD, Munderloh U, Plantard O, Rispe C, Valle MR, Tabor A, Thangamani S, Thimmapuram J, Hill CA.

Ticks Tick Borne Dis. 2019 Jan;10(1):213-218. doi: 10.1016/j.ttbdis.2018.08.009. Epub 2018 Aug 24. No abstract available.


Multi-locus sequence typing of Ixodes ricinus and its symbiont Candidatus Midichloria mitochondrii across Europe reveals evidence of local co-cladogenesis in Scotland.

Al-Khafaji AM, Clegg SR, Pinder AC, Luu L, Hansford KM, Seelig F, Dinnis RE, Margos G, Medlock JM, Feil EJ, Darby AC, McGarry JW, Gilbert L, Plantard O, Sassera D, Makepeace BL.

Ticks Tick Borne Dis. 2019 Jan;10(1):52-62. doi: 10.1016/j.ttbdis.2018.08.016. Epub 2018 Aug 31.


The Tick Cell Biobank: A global resource for in vitro research on ticks, other arthropods and the pathogens they transmit.

Bell-Sakyi L, Darby A, Baylis M, Makepeace BL.

Ticks Tick Borne Dis. 2018 Jul;9(5):1364-1371. doi: 10.1016/j.ttbdis.2018.05.015. Epub 2018 May 31. Review.


Autofluorescence microscopy for paired-matched morphological and molecular identification of individual chigger mites (Acari: Trombiculidae), the vectors of scrub typhus.

Kumlert R, Chaisiri K, Anantatat T, Stekolnikov AA, Morand S, Prasartvit A, Makepeace BL, Sungvornyothin S, Paris DH.

PLoS One. 2018 Mar 1;13(3):e0193163. doi: 10.1371/journal.pone.0193163. eCollection 2018.


Onchocerca volvulus: The Road from Basic Biology to a Vaccine.

Lustigman S, Makepeace BL, Klei TR, Babayan SA, Hotez P, Abraham D, Bottazzi ME.

Trends Parasitol. 2018 Jan;34(1):64-79. doi: 10.1016/ Epub 2017 Sep 22. Review.


Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host.

Wewer V, Makepeace BL, Tanya VN, Peisker H, Pfarr K, Hoerauf A, Dörmann P.

Int J Parasitol. 2017 Dec;47(14):903-912. doi: 10.1016/j.ijpara.2017.06.001. Epub 2017 Jul 23.


Whence river blindness? The domestication of mammals and host-parasite co-evolution in the nematode genus Onchocerca.

Lefoulon E, Giannelli A, Makepeace BL, Mutafchiev Y, Townson S, Uni S, Verocai GG, Otranto D, Martin C.

Int J Parasitol. 2017 Jul;47(8):457-470. doi: 10.1016/j.ijpara.2016.12.009. Epub 2017 Mar 24.


Draft genome of the honey bee ectoparasitic mite, Tropilaelaps mercedesae, is shaped by the parasitic life history.

Dong X, Armstrong SD, Xia D, Makepeace BL, Darby AC, Kadowaki T.

Gigascience. 2017 Mar 1;6(3):1-17. doi: 10.1093/gigascience/gix008.


The potential role of Wolbachia in controlling the transmission of emerging human arboviral infections.

Kamtchum-Tatuene J, Makepeace BL, Benjamin L, Baylis M, Solomon T.

Curr Opin Infect Dis. 2017 Feb;30(1):108-116. doi: 10.1097/QCO.0000000000000342. Review.


25 Years of the Onchocerca ochengi Model.

Makepeace BL, Tanya VN.

Trends Parasitol. 2016 Dec;32(12):966-978. doi: 10.1016/ Epub 2016 Sep 21. Review.


Stage-specific Proteomes from Onchocerca ochengi, Sister Species of the Human River Blindness Parasite, Uncover Adaptations to a Nodular Lifestyle.

Armstrong SD, Xia D, Bah GS, Krishna R, Ngangyung HF, LaCourse EJ, McSorley HJ, Kengne-Ouafo JA, Chounna-Ndongmo PW, Wanji S, Enyong PA, Taylor DW, Blaxter ML, Wastling JM, Tanya VN, Makepeace BL.

Mol Cell Proteomics. 2016 Aug;15(8):2554-75. doi: 10.1074/mcp.M115.055640. Epub 2016 May 25.


Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts.

Lefoulon E, Bain O, Makepeace BL, d'Haese C, Uni S, Martin C, Gavotte L.

PeerJ. 2016 Mar 28;4:e1840. doi: 10.7717/peerj.1840. eCollection 2016.


A Revised Checklist of Chigger Mites (Acari: Trombiculidae) From Thailand, with the Description of Three New Species.

Chaisiri K, Stekolnikov AA, Makepeace BL, Morand S.

J Med Entomol. 2016 Mar;53(2):321-42.


Supergroup C Wolbachia, mutualist symbionts of filarial nematodes, have a distinct genome structure.

Comandatore F, Cordaux R, Bandi C, Blaxter M, Darby A, Makepeace BL, Montagna M, Sassera D.

Open Biol. 2015 Dec;5(12):150099. doi: 10.1098/rsob.150099.


Immunotherapy with mutated onchocystatin fails to enhance the efficacy of a sub-lethal oxytetracycline regimen against Onchocerca ochengi.

Bah GS, Tanya VN, Makepeace BL.

Vet Parasitol. 2015 Aug 15;212(1-2):25-34. doi: 10.1016/j.vetpar.2015.06.005. Epub 2015 Jun 12.


The case for vaccine development in the strategy to eradicate river blindness (onchocerciasis) from Africa.

Makepeace BL, Babayan SA, Lustigman S, Taylor DW.

Expert Rev Vaccines. 2015;14(9):1163-5. doi: 10.1586/14760584.2015.1059281. Epub 2015 Jun 19.


Symbiosis in an overlooked microcosm: a systematic review of the bacterial flora of mites.

Chaisiri K, McGarry JW, Morand S, Makepeace BL.

Parasitology. 2015 Aug;142(9):1152-62. doi: 10.1017/S0031182015000530. Epub 2015 May 25.


The Onchocerciasis Vaccine for Africa--TOVA--Initiative.

Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S.

PLoS Negl Trop Dis. 2015 Jan 29;9(1):e0003422. doi: 10.1371/journal.pntd.0003422. eCollection 2015 Jan. No abstract available.


Extracellular Onchocerca-derived small RNAs in host nodules and blood.

Quintana JF, Makepeace BL, Babayan SA, Ivens A, Pfarr KM, Blaxter M, Debrah A, Wanji S, Ngangyung HF, Bah GS, Tanya VN, Taylor DW, Hoerauf A, Buck AH.

Parasit Vectors. 2015 Jan 27;8:58. doi: 10.1186/s13071-015-0656-1.


Iron necessity: the secret of Wolbachia's success?

Gill AC, Darby AC, Makepeace BL.

PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3224. doi: 10.1371/journal.pntd.0003224. eCollection 2014 Oct. Review.


A simple isothermal DNA amplification method to screen black flies for Onchocerca volvulus infection.

Alhassan A, Makepeace BL, LaCourse EJ, Osei-Atweneboana MY, Carlow CK.

PLoS One. 2014 Oct 9;9(10):e108927. doi: 10.1371/journal.pone.0108927. eCollection 2014. Erratum in: PLoS One. 2015;10(2):e0118323.


Comparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites.

Armstrong SD, Babayan SA, Lhermitte-Vallarino N, Gray N, Xia D, Martin C, Kumar S, Taylor DW, Blaxter ML, Wastling JM, Makepeace BL.

Mol Cell Proteomics. 2014 Oct;13(10):2527-44. doi: 10.1074/mcp.M114.038539. Epub 2014 Jun 23.


Efficacy of three-week oxytetracycline or rifampin monotherapy compared with a combination regimen against the filarial nematode Onchocerca ochengi.

Bah GS, Ward EL, Srivastava A, Trees AJ, Tanya VN, Makepeace BL.

Antimicrob Agents Chemother. 2014;58(2):801-10. doi: 10.1128/AAC.01995-13. Epub 2013 Nov 18.


Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress.

Darby AC, Gill AC, Armstrong SD, Hartley CS, Xia D, Wastling JM, Makepeace BL.

ISME J. 2014 Apr;8(4):925-37. doi: 10.1038/ismej.2013.192. Epub 2013 Oct 24.


Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis.

Darby AC, Armstrong SD, Bah GS, Kaur G, Hughes MA, Kay SM, Koldkjær P, Rainbow L, Radford AD, Blaxter ML, Tanya VN, Trees AJ, Cordaux R, Wastling JM, Makepeace BL.

Genome Res. 2012 Dec;22(12):2467-77. doi: 10.1101/gr.138420.112. Epub 2012 Aug 23.


Granulocytes in helminth infection -- who is calling the shots?

Makepeace BL, Martin C, Turner JD, Specht S.

Curr Med Chem. 2012;19(10):1567-86. Review.


A worm's best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi.

Hansen RD, Trees AJ, Bah GS, Hetzel U, Martin C, Bain O, Tanya VN, Makepeace BL.

Proc Biol Sci. 2011 Aug 7;278(1716):2293-302. doi: 10.1098/rspb.2010.2367. Epub 2010 Dec 22.


Onchocerca armillata contains the endosymbiotic bacterium Wolbachia and elicits a limited inflammatory response.

Neary JM, Trees AJ, Ekale DD, Tanya VN, Hetzel U, Makepeace BL.

Vet Parasitol. 2010 Dec 15;174(3-4):267-76. doi: 10.1016/j.vetpar.2010.08.031. Epub 2010 Sep 17.


Immunisation with a multivalent, subunit vaccine reduces patent infection in a natural bovine model of onchocerciasis during intense field exposure.

Makepeace BL, Jensen SA, Laney SJ, Nfon CK, Njongmeta LM, Tanya VN, Williams SA, Bianco AE, Trees AJ.

PLoS Negl Trop Dis. 2009 Nov 10;3(11):e544. doi: 10.1371/journal.pntd.0000544.


UMF-078: A modified flubendazole with potent macrofilaricidal activity against Onchocerca ochengi in African cattle.

Dec Bronsvoort BM, Makepeace BL, Renz A, Tanya VN, Fleckenstein L, Ekale D, Trees AJ.

Parasit Vectors. 2008 Jun 20;1(1):18. doi: 10.1186/1756-3305-1-18.


Of mice, cattle, and humans: the immunology and treatment of river blindness.

Allen JE, Adjei O, Bain O, Hoerauf A, Hoffmann WH, Makepeace BL, Schulz-Key H, Tanya VN, Trees AJ, Wanji S, Taylor DW.

PLoS Negl Trop Dis. 2008 Apr 30;2(4):e217. doi: 10.1371/journal.pntd.0000217. Review.


Lack of resistance after re-exposure of cattle cured of Onchocerca ochengi infection with oxytetracycline.

Nfon CK, Makepeace BL, Njongmeta LM, Tanya VN, Trees AJ.

Am J Trop Med Hyg. 2007 Jan;76(1):67-72.


Eosinophils contribute to killing of adult Onchocerca ochengi within onchocercomata following elimination of Wolbachia.

Nfon CK, Makepeace BL, Njongmeta LM, Tanya VN, Bain O, Trees AJ.

Microbes Infect. 2006 Oct;8(12-13):2698-705. Epub 2006 Aug 22.


In a bovine model of onchocerciasis, protective immunity exists naturally, is absent in drug-cured hosts, and is induced by vaccination.

Tchakouté VL, Graham SP, Jensen SA, Makepeace BL, Nfon CK, Njongmeta LM, Lustigman S, Enyong PA, Tanya VN, Bianco AE, Trees AJ.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5971-6. Epub 2006 Apr 3.


Rate of elimination of Wolbachia pipientis by doxycycline in vitro increases following drug withdrawal.

Makepeace BL, Rodgers L, Trees AJ.

Antimicrob Agents Chemother. 2006 Mar;50(3):922-7.


Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species).

Gilbert J, Nfon CK, Makepeace BL, Njongmeta LM, Hastings IM, Pfarr KM, Renz A, Tanya VN, Trees AJ.

J Infect Dis. 2005 Oct 15;192(8):1483-93. Epub 2005 Sep 14.


Wolbachia variability and host effects on crossing type in Culex mosquitoes.

Sinkins SP, Walker T, Lynd AR, Steven AR, Makepeace BL, Godfray HC, Parkhill J.

Nature. 2005 Jul 14;436(7048):257-60.


Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor (TLR)4 and TLR2 signalling.

Humphries HE, Triantafilou M, Makepeace BL, Heckels JE, Triantafilou K, Christodoulides M.

Cell Microbiol. 2005 Mar;7(3):415-30.


Cattle protected from onchocerciasis by ivermectin are highly susceptible to infection after drug withdrawal.

Njongmeta LM, Nfon CK, Gilbert J, Makepeace BL, Tanya VN, Trees AJ.

Int J Parasitol. 2004 Aug;34(9):1069-74.


Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines.

Christodoulides M, Makepeace BL, Partridge KA, Kaur D, Fowler MI, Weller RO, Heckels JE.

Infect Immun. 2002 Aug;70(8):4035-44.


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