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Items: 1 to 50 of 559

1.

The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances.

Regalado EL, Haidar Ahmad IA, Bennett R, D'Atri V, Makarov AA, Humphrey GR, Mangion I, Guillarme D.

Acc Chem Res. 2019 Jun 14. doi: 10.1021/acs.accounts.9b00068. [Epub ahead of print]

PMID:
31198042
2.

Interstitial clustering in metallic systems as a source for the formation of the icosahedral matrix and defects in the glassy state.

Konchakov R, Makarov A, Kobelev N, Glezer A, Wilde G, Khonik VA.

J Phys Condens Matter. 2019 Jun 13. doi: 10.1088/1361-648X/ab29d4. [Epub ahead of print]

PMID:
31195372
3.

Quantitative and Qualitative Characterization of Phagocytic Activity of Macrophages of Bone Marrow and Fetal Origin.

Lokhonina AV, Makarov AV, Elchaninov AV, Arutyunyan IV, Shmakova TV, Grinberg MV, Usman NY, Surovtsev VV, Chernikov VP, Fatkhudinov TK.

Bull Exp Biol Med. 2019 Jun 10. doi: 10.1007/s10517-019-04481-5. [Epub ahead of print]

PMID:
31183654
4.

Preparation and Testing of Cells Expressing Fluorescent Proteins for Intravital Imaging of Tumor Microenvironment.

Vodopyanov SS, Kunin MA, Garanina AS, Grinenko NF, Vlasova KY, Mel'nikov PA, Chekhonin VP, Sukhinich KK, Makarov AV, Naumenko VA, Abakumov MA, Majouga AG.

Bull Exp Biol Med. 2019 Jun 10. doi: 10.1007/s10517-019-04475-3. [Epub ahead of print]

PMID:
31183645
5.

Evaluation of MALDI-TOF/TOF Mass Spectrometry Approach for Quantitative Determination of Aspartate Residue Isomerization in the Amyloid-β Peptide.

Pekov SI, Ivanov DG, Bugrova AE, Indeykina MI, Zakharova NV, Popov IA, Kononikhin AS, Kozin SA, Makarov AA, Nikolaev EN.

J Am Soc Mass Spectrom. 2019 May 9. doi: 10.1007/s13361-019-02199-2. [Epub ahead of print]

PMID:
31073890
6.

High-Resolution Differential Ion Mobility Separations/Orbitrap Mass Spectrometry without Buffer Gas Limitations.

Baird MA, Shliaha PV, Anderson GA, Moskovets E, Laiko V, Makarov AA, Jensen ON, Shvartsburg AA.

Anal Chem. 2019 May 21;91(10):6918-6925. doi: 10.1021/acs.analchem.9b01309. Epub 2019 May 9.

PMID:
31034203
7.

Activated Macrophages of Monocytic Origin Predominantly Express Proinflammatory Cytokine Genes, Whereas Kupffer Cells Predominantly Express Anti-Inflammatory Cytokine Genes.

Lokhonina A, Elchaninov A, Fatkhudinov T, Makarov A, Arutyunyan I, Grinberg M, Glinkina V, Surovtsev V, Bolshakova G, Goldshtein D, Sukhikh G.

Biomed Res Int. 2019 Mar 5;2019:3912142. doi: 10.1155/2019/3912142. eCollection 2019.

8.

[Influence of the Donor of Hydrogen Sulfide GYY4137 on the Activation of Human Neutrophils by E. coli Lipopolysaccharides].

Petrushanko IY, Melnikova EV, Yurinskaya MM, Vinokurov MG, Suslikov AV, Mitkevich VA, Makarov AA.

Mol Biol (Mosk). 2019 Jan-Feb;53(1):101-108. doi: 10.1134/S0026898419010130. Russian.

9.

Glutathione-related substances maintain cardiomyocyte contractile function in hypoxic conditions.

Poluektov YM, Petrushanko IY, Undrovinas NA, Lakunina VA, Khapchaev AY, Kapelko VI, Abramov AA, Lakomkin VL, Novikov MS, Shirinsky VP, Mitkevich VA, Makarov AA.

Sci Rep. 2019 Mar 19;9(1):4872. doi: 10.1038/s41598-019-41266-2.

10.

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances.

Haidar Ahmad IA, Chen W, Halsey HM, Klapars A, Limanto J, Pirrone GF, Nowak T, Bennett R, Hartman R, Makarov AA, Mangion I, Regalado EL.

Analyst. 2019 Apr 23;144(9):2872-2880. doi: 10.1039/c8an02499e.

PMID:
30830135
11.

Evaluation of global conformational changes in peptides and proteins following purification by supercritical fluid chromatography.

Schiavone NM, Bennett R, Hicks MB, Pirrone GF, Regalado EL, Mangion I, Makarov AA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 15;1110-1111:94-100. doi: 10.1016/j.jchromb.2019.02.012. Epub 2019 Feb 13.

PMID:
30785083
12.

Use of MALDI-MS with solid-state hydrogen deuterium exchange for semi-automated assessment of peptide and protein physical stability in lyophilized solids.

Kabaria SR, Mangion I, Makarov AA, Pirrone GF.

Anal Chim Acta. 2019 Apr 25;1054:114-121. doi: 10.1016/j.aca.2018.12.034. Epub 2019 Jan 9.

PMID:
30712581
13.

Surface-Induced Dissociation of Noncovalent Protein Complexes in an Extended Mass Range Orbitrap Mass Spectrometer.

VanAernum ZL, Gilbert JD, Belov ME, Makarov AA, Horning SR, Wysocki VH.

Anal Chem. 2019 Mar 5;91(5):3611-3618. doi: 10.1021/acs.analchem.8b05605. Epub 2019 Feb 12.

PMID:
30688442
14.

Na,K-ATPase α-subunit conformation determines glutathionylation efficiency.

Poluektov YM, Dergousova EA, Lopina OD, Mitkevich VA, Makarov AA, Petrushanko IY.

Biochem Biophys Res Commun. 2019 Feb 26;510(1):86-90. doi: 10.1016/j.bbrc.2019.01.052. Epub 2019 Jan 17.

PMID:
30661791
15.

[The Effect of Beta-Amyloid Peptides and Main Stress Protein HSP70 on Human SH-SY5Y Neuroblastoma Proteome].

Rezvykh AP, Yurinskaya MM, Vinokurov MG, Krasnov GS, Mitkevich VA, Makarov AA, Evgen'ev MB, Zatsepina OG.

Mol Biol (Mosk). 2018 Nov-Dec;52(6):1082-1092. doi: 10.1134/S0026898418060150. Russian.

16.

Pelvic Electric Potential as a Marker of Autonomic Dysfunctions and Risk Factor of Neurogenic Arrhythmias in Humans.

Nikitin SS, Kirpatovskii VI, Moiseev SV, Gavrilov IY, Kabanova IV, Makarov AD, Revenko SV.

Bull Exp Biol Med. 2019 Jan;166(3):404-408. doi: 10.1007/s10517-019-04360-z. Epub 2019 Jan 9.

PMID:
30627894
17.

Combination of circular dichroism spectroscopy and size-exclusion chromatography coupled with HDX-MS for studying global conformational structures of peptides in solution.

Schiavone NM, Pirrone GF, Guetschow ED, Mangion I, Makarov AA.

Talanta. 2019 Mar 1;194:177-182. doi: 10.1016/j.talanta.2018.09.077. Epub 2018 Sep 25.

PMID:
30609519
18.

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins.

Kafader JO, Melani RD, Senko MW, Makarov AA, Kelleher NL, Compton PD.

Anal Chem. 2019 Feb 19;91(4):2776-2783. doi: 10.1021/acs.analchem.8b04519. Epub 2019 Jan 29.

PMID:
30609364
19.

IVR Dynamics of Vibrational Levels of the ν1 Mode in (CF3)2C═C═O Molecules Excited by Resonant IR Femtosecond Radiation.

Laptev VB, Kompanets VO, Pigulsky SV, Makarov AA, Mishakov GV, Serebryakov DV, Sharkov AV, Chekalin SV, Ryabov EA.

J Phys Chem A. 2019 Jan 31;123(4):771-779. doi: 10.1021/acs.jpca.8b11095. Epub 2019 Jan 16.

PMID:
30605333
20.

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances.

Tsay FR, Haidar Ahmad IA, Henderson D, Schiavone N, Liu Z, Makarov AA, Mangion I, Regalado EL.

J Chromatogr A. 2019 Feb 22;1587:129-135. doi: 10.1016/j.chroma.2018.12.018. Epub 2018 Dec 11.

PMID:
30591245
21.

Anti-amyloid Therapy of Alzheimer's Disease: Current State and Prospects.

Kozin SA, Barykin EP, Mitkevich VA, Makarov AA.

Biochemistry (Mosc). 2018 Sep;83(9):1057-1067. doi: 10.1134/S0006297918090079. Review.

22.

pKa measurements for the SAMPL6 prediction challenge for a set of kinase inhibitor-like fragments.

Işık M, Levorse D, Rustenburg AS, Ndukwe IE, Wang H, Wang X, Reibarkh M, Martin GE, Makarov AA, Mobley DL, Rhodes T, Chodera JD.

J Comput Aided Mol Des. 2018 Oct;32(10):1117-1138. doi: 10.1007/s10822-018-0168-0. Epub 2018 Nov 7.

PMID:
30406372
23.

Umbilical cord-derived mesenchymal stromal/stem cells enhance recovery of surgically induced skeletal muscle ischemia in a rat model.

Arutyunyan I, Fatkhudinov T, Elchaninov A, Vasyukova O, Makarov A, Usman N, Kananykhina E, Lokhonina A, Goldshtein D, Bolshakova G, Sukhikh G.

Histol Histopathol. 2019 May;34(5):513-523. doi: 10.14670/HH-18-057. Epub 2018 Nov 6.

PMID:
30398287
24.

Intramolecular Palladium-Catalyzed Oxidative Amination of Furans: Synthesis of Functionalized Indoles.

Makarov AS, Uchuskin MG, Gevorgyan V.

J Org Chem. 2018 Nov 16;83(22):14010-14021. doi: 10.1021/acs.joc.8b02470. Epub 2018 Oct 29.

PMID:
30346172
25.

Neurotoxic Effects of Aβ6-42 Peptides Mimicking Putative Products Formed by the Angiotensin Converting Enzyme.

Medvedev AE, Radko SP, Yurinskaya MM, Vinokurov MG, Buneeva OA, Kopylov AT, Kozin SA, Mitkevich VA, Makarov AA.

J Alzheimers Dis. 2018;66(1):263-270. doi: 10.3233/JAD-180500.

PMID:
30282362
26.

Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution.

Kelstrup CD, Aizikov K, Batth TS, Kreutzman A, Grinfeld D, Lange O, Mourad D, Makarov AA, Olsen JV.

J Proteome Res. 2018 Nov 2;17(11):4008-4016. doi: 10.1021/acs.jproteome.8b00381. Epub 2018 Sep 28.

27.

Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition.

Barykin EP, Petrushanko IY, Kozin SA, Telegin GB, Chernov AS, Lopina OD, Radko SP, Mitkevich VA, Makarov AA.

Front Mol Neurosci. 2018 Aug 29;11:302. doi: 10.3389/fnmol.2018.00302. eCollection 2018.

28.

Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer's Disease.

Kozin SA, Barykin EP, Telegin GB, Chernov AS, Adzhubei AA, Radko SP, Mitkevich VA, Makarov AA.

Front Neurosci. 2018 Aug 23;12:518. doi: 10.3389/fnins.2018.00518. eCollection 2018.

29.

Glutathionylation of Na,K-ATPase Alpha-Subunit Alters Enzyme Conformation and Sensitivity to Trypsinolysis.

Dergousova EA, Poluektov YM, Klimanova EA, Petrushanko IY, Mitkevich VA, Makarov AA, Lopina OD.

Biochemistry (Mosc). 2018 Aug;83(8):969-981. doi: 10.1134/S0006297918080084.

30.

Sequencing Grade Tandem Mass Spectrometry for Top-Down Proteomics Using Hybrid Electron Capture Dissociation Methods in a Benchtop Orbitrap Mass Spectrometer.

Shaw JB, Malhan N, Vasil'ev YV, Lopez NI, Makarov A, Beckman JS, Voinov VG.

Anal Chem. 2018 Sep 18;90(18):10819-10827. doi: 10.1021/acs.analchem.8b01901. Epub 2018 Aug 30.

PMID:
30118589
31.

High-sensitive absorption measurement in transparent isotropic dielectrics with time-resolved photothermal common-path interferometry.

Vlasova KV, Makarov AI, Andreev NF, Konstantinov AY.

Appl Opt. 2018 Aug 1;57(22):6318-6328. doi: 10.1364/AO.57.006318.

PMID:
30117860
32.

[Enalaprilat Inhibits Zinc-Dependent Oligomerization of Metal-Binding Domain of Amyloid-beta Isoforms and Protects Human Neuroblastoma Cells from Toxic Action of these Isoforms].

Kozin SA, Polshakov VI, Mezentsev YV, Ivanov AS, Zhokhov SS, Yurinskaya MM, Vinokurov MG, Makarov AA, Mitkevich VA.

Mol Biol (Mosk). 2018 Jul-Aug;52(4):683-691. doi: 10.1134/S0026898418040109. Russian.

33.

Evaluation of resorbable polydioxanone and polyglycolic acid meshes in a rat model of ventral hernia repair.

Fatkhudinov T, Tsedik L, Arutyunyan I, Lokhonina A, Makarov A, Korshunov A, Elchaninov A, Kananykhina E, Vasyukova O, Usman N, Uvarova E, Chuprynin V, Eremina I, Degtyarev D, Sukhikh G.

J Biomed Mater Res B Appl Biomater. 2019 Apr;107(3):652-663. doi: 10.1002/jbm.b.34158. Epub 2018 Aug 9.

PMID:
30091512
34.

An Orbitrap-based laser desorption/ablation mass spectrometer designed for spaceflight.

Arevalo R Jr, Selliez L, Briois C, Carrasco N, Thirkell L, Cherville B, Colin F, Gaubicher B, Farcy B, Li X, Makarov A.

Rapid Commun Mass Spectrom. 2018 Nov 15;32(21):1875-1886. doi: 10.1002/rcm.8244.

PMID:
30048021
35.

Modelling interaction between HIV-1 Nef and calnexin.

Adzhubei AA, Anashkina AA, Tkachev YV, Kravatsky YV, Pushkarsky T, Kulkarni A, Makarov AA, Bukrinsky MI.

AIDS. 2018 Sep 24;32(15):2103-2111. doi: 10.1097/QAD.0000000000001951.

PMID:
30005006
36.

Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats.

Elchaninov AV, Fatkhudinov TK, Usman NY, Kananykhina EY, Arutyunyan IV, Makarov AV, Lokhonina AV, Eremina IZ, Surovtsev VV, Goldshtein DV, Bolshakova GB, Glinkina VV, Sukhikh GT.

BMC Immunol. 2018 Jul 9;19(1):23. doi: 10.1186/s12865-018-0260-1.

37.

Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.

van de Waterbeemd M, Tamara S, Fort KL, Damoc E, Franc V, Bieri P, Itten M, Makarov A, Ban N, Heck AJR.

Nat Commun. 2018 Jun 27;9(1):2493. doi: 10.1038/s41467-018-04853-x.

38.

Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats.

El'chaninov AV, Fatkhudinov TK, Arutyunyan IV, Makarov AV, Usman NY, Mikhailova LP, Lokhonina AV, Botchey VM, Glinkina VV, Bol'shakova GB.

Bull Exp Biol Med. 2018 May;165(1):136-141. doi: 10.1007/s10517-018-4115-9. Epub 2018 May 24.

PMID:
29796817
39.

[Enhancement of Na,K-ATPase Activity as a Result of Removal of Redox Modifications from Cysteine Residues of the al Subunit: the Effect of Reducing Agents].

Dergousova EA, Petrushanko IY, Klimanova EA, Mitkevich VA, Ziganshin RH, Lopina OD, Makarov AA.

Mol Biol (Mosk). 2018 Mar-Apr;52(2):289-293. doi: 10.7868/S002689841802012X. Russian.

40.

Heparin Modulates the Kinetics of Zinc-Induced Aggregation of Amyloid-β Peptides.

Radko SP, Khmeleva SA, Mantsyzov AB, Kiseleva YY, Mitkevich VA, Kozin SA, Makarov AA.

J Alzheimers Dis. 2018;63(2):539-550. doi: 10.3233/JAD-171120.

PMID:
29630553
41.

Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer.

Sanders JD, Grinfeld D, Aizikov K, Makarov A, Holden DD, Brodbelt JS.

Anal Chem. 2018 May 1;90(9):5896-5902. doi: 10.1021/acs.analchem.8b00724. Epub 2018 Apr 18.

PMID:
29608288
42.

Visualizing and studying frictional heating effects in reversed-phase liquid chromatography using infrared thermal imaging.

Makarov AA, Mann BF, Regalado EL, Pirrone GF, Sun C, Sun S, Nowak T, Wang H, Mangion I.

Anal Chim Acta. 2018 Aug 14;1018:1-6. doi: 10.1016/j.aca.2018.02.061. Epub 2018 Mar 9.

PMID:
29605126
43.

Patterns of sensitization to inhalant and food allergens among pediatric patients from the Moscow region (Russian Federation).

Voloshin S, Smoldovskaya O, Feyzkhanova G, Arefieva A, Pavlushkina L, Filatova T, Butvilovskaya V, Filippova M, Lysov Y, Shcherbo S, Makarov A, Rubina A, Zasedatelev A.

PLoS One. 2018 Mar 22;13(3):e0194775. doi: 10.1371/journal.pone.0194775. eCollection 2018.

44.

Multipotent stromal cells stimulate liver regeneration by influencing the macrophage polarization in rat.

Elchaninov A, Fatkhudinov T, Usman N, Arutyunyan I, Makarov A, Lokhonina A, Eremina I, Surovtsev V, Goldshtein D, Bolshakova G, Glinkina V, Sukhikh G.

World J Hepatol. 2018 Feb 27;10(2):287-296. doi: 10.4254/wjh.v10.i2.287.

45.

Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.

Pirrone GF, Mathew RM, Makarov AA, Bernardoni F, Klapars A, Hartman R, Limanto J, Regalado EL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:42-49. doi: 10.1016/j.jchromb.2018.02.006. Epub 2018 Feb 8.

PMID:
29477066
46.

Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation.

Zatsepina OG, Kechko OI, Mitkevich VA, Kozin SA, Yurinskaya MM, Vinokurov MG, Serebryakova MV, Rezvykh AP, Evgen'ev MB, Makarov AA.

Sci Rep. 2018 Feb 23;8(1):3518. doi: 10.1038/s41598-018-21815-x.

47.

Macrocyclic glycopeptide chiral selectors bonded to core-shell particles enables enantiopurity analysis of the entire verubecestat synthetic route.

Barhate CL, Lopez DA, Makarov AA, Bu X, Morris WJ, Lekhal A, Hartman R, Armstrong DW, Regalado EL.

J Chromatogr A. 2018 Mar 2;1539:87-92. doi: 10.1016/j.chroma.2018.01.042. Epub 2018 Jan 31.

PMID:
29397980
48.

N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease.

Kugaevskaya EV, Veselovsky AV, Indeykina MI, Solovyeva NI, Zharkova MS, Popov IA, Nikolaev EN, Mantsyzov AB, Makarov AA, Kozin SA.

Sci Rep. 2018 Jan 10;8(1):298. doi: 10.1038/s41598-017-18567-5.

49.

Application of MALDI-TOF/TOF-MS for relative quantitation of α- and β-Asp7 isoforms of amyloid-β peptide.

Pekov S, Indeykina M, Popov I, Kononikhin A, Bocharov K, Kozin SA, Makarov AA, Nikolaev E.

Eur J Mass Spectrom (Chichester). 2018 Feb;24(1):141-144. doi: 10.1177/1469066717730544. Epub 2017 Sep 8.

PMID:
29232976
50.

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes.

Fort KL, van de Waterbeemd M, Boll D, Reinhardt-Szyba M, Belov ME, Sasaki E, Zschoche R, Hilvert D, Makarov AA, Heck AJR.

Analyst. 2017 Dec 18;143(1):100-105. doi: 10.1039/c7an01629h.

PMID:
29138777

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