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Items: 1 to 50 of 979

1.

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.

Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C.

Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201819473. doi: 10.1073/pnas.1819473116. [Epub ahead of print]

PMID:
30770442
2.

Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors.

Gorrini C, Mak TW.

Cancer Cell. 2019 Feb 11;35(2):161-163. doi: 10.1016/j.ccell.2019.01.017.

PMID:
30753819
3.

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW.

Science. 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072.

PMID:
30733420
4.

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.

Kubli SP, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, Jafari SM, Snow B, Jones L, Palomero L, Thu KL, Cassetta L, Soong D, Berger T, Ramachandran P, Baniasadi SP, Duncan G, Lindzen M, Yarden Y, Herranz C, Lazaro C, Chu MF, Haight J, Tinto P, Silvester J, Cescon DW, Petit A, Pettersson S, Pollard JW, Mak TW, Pujana MA, Cappello P, Gorrini C.

Proc Natl Acad Sci U S A. 2019 Feb 7. pii: 201815126. doi: 10.1073/pnas.1815126116. [Epub ahead of print]

PMID:
30733286
5.

Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.

Nishio M, Miyachi Y, Otani J, Tane S, Omori H, Ueda F, Togashi H, Sasaki T, Mak TW, Nakao K, Fujita Y, Nishina H, Maehama T, Suzuki A.

FASEB J. 2019 Jan 14:fj201802005R. doi: 10.1096/fj.201802005R. [Epub ahead of print]

PMID:
30640535
6.

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Tarnawski L, Reardon C, Caravaca AS, Rosas-Ballina M, Tusche MW, Drake AR, Hudson LK, Hanes WM, Li JH, Parrish WR, Ojamaa K, Al-Abed Y, Faltys M, Pavlov VA, Andersson U, Chavan SS, Levine YA, Mak TW, Tracey KJ, Olofsson PS.

Front Immunol. 2018 Nov 27;9:2648. doi: 10.3389/fimmu.2018.02648. eCollection 2018.

7.

Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism.

Leca J, Berger T, Mak TW.

Cell Metab. 2018 Dec 4;28(6):811-813. doi: 10.1016/j.cmet.2018.11.011.

PMID:
30517895
8.

Localisation of Colorectal Polyps by Convolutional Neural Network Features Learnt from White Light and Narrow Band Endoscopic Images of Multiple Databases.

Zheng Y, Zhang R, Yu R, Jiang Y, Mak TWC, Wong SH, Lau JYW, Poon CCY.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4142-4145. doi: 10.1109/EMBC.2018.8513337.

PMID:
30441267
9.

The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism.

Elliott MJ, Jerzak KJ, Cockburn JG, Safikhani Z, Gwynne WD, Hassell JA, Bane A, Silvester J, Thu KL, Haibe-Kains B, Mak TW, Cescon DW.

Sci Rep. 2018 Nov 8;8(1):16562. doi: 10.1038/s41598-018-34348-0.

10.

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.

Li L, Li L, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W, Yang X, Jiang P.

Nat Commun. 2018 Nov 8;9(1):4683. doi: 10.1038/s41467-018-07127-8.

11.

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.

Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31.

12.

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition.

Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10810-E10811. doi: 10.1073/pnas.1813967115. Epub 2018 Oct 30. No abstract available.

PMID:
30377273
13.

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY.

Cell Stem Cell. 2018 Dec 6;23(6):882-897.e11. doi: 10.1016/j.stem.2018.09.016. Epub 2018 Oct 18.

PMID:
30344100
14.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.

Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15.

PMID:
30323273
15.

Gelsemium poisoning mediated by the non-toxic plant Cassytha filiformis parasitizing Gelsemium elegans.

Cheung WL, Law CY, Lee HCH, Tang CO, Lam YH, Ng SW, Chan SS, Chow TC, Pang KS, Mak TWL.

Toxicon. 2018 Nov;154:42-49. doi: 10.1016/j.toxicon.2018.09.009. Epub 2018 Sep 28.

PMID:
30273705
16.

Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration.

Rebalka IA, Monaco CMF, Varah NE, Berger T, D'souza DM, Zhou S, Mak TW, Hawke TJ.

Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C714-C721. doi: 10.1152/ajpcell.00195.2017. Epub 2018 Sep 26.

PMID:
30257107
17.

Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.

Tang MHY, Chong YK, Chan CY, Ching CK, Lai CK, Li YK, Mak TWL.

Forensic Sci Int. 2018 Sep;290:238-243. doi: 10.1016/j.forsciint.2018.07.014. Epub 2018 Jul 24.

PMID:
30081327
18.

Targeting the cell cycle in breast cancer: towards the next phase.

Thu KL, Soria-Bretones I, Mak TW, Cescon DW.

Cell Cycle. 2018;17(15):1871-1885. doi: 10.1080/15384101.2018.1502567. Epub 2018 Sep 11.

PMID:
30078354
19.

RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer.

Pan Y, Tong JHM, Lung RWM, Kang W, Kwan JSH, Chak WP, Tin KY, Chung LY, Wu F, Ng SSM, Mak TWC, Yu J, Lo KW, Chan AWH, To KF.

Mol Cancer. 2018 Jul 23;17(1):102. doi: 10.1186/s12943-018-0853-6.

20.

Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.

Pan Y, Cheung ST, Tong JHM, Tin KY, Kang W, Lung RWM, Wu F, Li H, Ng SSM, Mak TWC, To KF, Chan AWH.

J Transl Med. 2018 Jun 4;16(1):150. doi: 10.1186/s12967-018-1530-7.

21.

Fighting Fire with Fire in Cancer.

Berger T, Saunders ME, Mak TW.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.

22.

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.

Haxaire C, Hakobyan N, Pannellini T, Carballo C, McIlwain D, Mak TW, Rodeo S, Acharya S, Li D, Szymonifka J, Song X, Monette S, Srivastava A, Salmon JE, Blobel CP.

Blood. 2018 Sep 6;132(10):1064-1074. doi: 10.1182/blood-2017-12-820571. Epub 2018 May 18.

PMID:
29776906
23.

Immunization Elicits Antigen-Specific Antibody Sequestration in Dorsal Root Ganglia Sensory Neurons.

Gunasekaran M, Chatterjee PK, Shih A, Imperato GH, Addorisio M, Kumar G, Lee A, Graf JF, Meyer D, Marino M, Puleo C, Ashe J, Cox MA, Mak TW, Bouton C, Sherry B, Diamond B, Andersson U, Coleman TR, Metz CN, Tracey KJ, Chavan SS.

Front Immunol. 2018 Apr 16;9:638. doi: 10.3389/fimmu.2018.00638. eCollection 2018.

24.

Retrospective Study of the Characteristics of Anticoagulant-Type Rodenticide Poisoning in Hong Kong.

Ng WY, Ching CK, Chong YK, Ng SW, Cheung WL, Mak TWL.

J Med Toxicol. 2018 Sep;14(3):218-228. doi: 10.1007/s13181-018-0660-x. Epub 2018 Apr 23.

PMID:
29687220
25.

Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.

Li J, Lee Y, Li Y, Jiang Y, Lu H, Zang W, Zhao X, Liu L, Chen Y, Tan H, Yang Z, Zhang MQ, Mak TW, Ni L, Dong C.

Immunity. 2018 Apr 17;48(4):773-786.e5. doi: 10.1016/j.immuni.2018.03.018. Epub 2018 Apr 3.

PMID:
29625896
26.

Evaluation of three rapid oral fluid test devices on the screening of multiple drugs of abuse including ketamine.

Tang MHY, Ching CK, Poon S, Chan SSS, Ng WY, Lam M, Wong CK, Pao R, Lau A, Mak TWL.

Forensic Sci Int. 2018 May;286:113-120. doi: 10.1016/j.forsciint.2018.03.004. Epub 2018 Mar 12.

PMID:
29574346
27.

Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.

Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.

Development. 2018 Mar 16;145(6). pii: dev159244. doi: 10.1242/dev.159244.

28.

A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism.

Capulli M, Ponzetti M, Maurizi A, Gemini-Piperni S, Berger T, Mak TW, Teti A, Rucci N.

J Bone Miner Res. 2018 Jun;33(6):1141-1153. doi: 10.1002/jbmr.3406. Epub 2018 Mar 24.

PMID:
29444358
29.

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.

Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1913-1918. doi: 10.1073/pnas.1719760115. Epub 2018 Feb 6.

30.

Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.

Thu KL, Silvester J, Elliott MJ, Ba-Alawi W, Duncan MH, Elia AC, Mer AS, Smirnov P, Safikhani Z, Haibe-Kains B, Mak TW, Cescon DW.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1570-E1577. doi: 10.1073/pnas.1719577115. Epub 2018 Jan 29.

31.

Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes.

Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1576-1581. doi: 10.1073/pnas.1720570115. Epub 2018 Jan 29.

32.

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.

Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE.

J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5.

33.

Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro.

Safikhani Z, Smirnov P, Thu KL, Silvester J, El-Hachem N, Quevedo R, Lupien M, Mak TW, Cescon D, Haibe-Kains B.

Nat Commun. 2018 Jan 9;9(1):166. doi: 10.1038/s41467-017-02136-5.

34.

Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.

Hauck L, Stanley-Hasnain S, Fung A, Grothe D, Rao V, Mak TW, Billia F.

PLoS One. 2017 Dec 21;12(12):e0189861. doi: 10.1371/journal.pone.0189861. eCollection 2017.

35.

Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas.

Lemonnier F, Poullot E, Dupuy A, Couronné L, Martin N, Scourzic L, Fataccioli V, Bruneau J, Cairns RA, Mak TW, Bernard OA, de Leval L, Gaulard P.

Haematologica. 2018 Mar;103(3):e115-e118. doi: 10.3324/haematol.2017.167973. Epub 2017 Dec 14. No abstract available.

36.

Lipocalin-2 in Fructose-Induced Fatty Liver Disease.

Lambertz J, Berger T, Mak TW, van Helden J, Weiskirchen R.

Front Physiol. 2017 Nov 28;8:964. doi: 10.3389/fphys.2017.00964. eCollection 2017.

37.

2-oxo-PCE: ketamine analogue on the streets.

Chong YK, Tang MH, Chan CL, Li YK, Ching CK, Mak TW.

Hong Kong Med J. 2017 Dec;23(6):665-6. doi: 10.12809/hkmj177089. No abstract available.

PMID:
29226843
38.

Pillars Article: Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function. Science. 1997. 275: 540-543.

Mittrücker HW, Matsuyama T, Grossman A, Kündig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW.

J Immunol. 2017 Dec 1;199(11):3717-3720. No abstract available.

39.

Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA.

J Virol. 2018 Jan 17;92(3). pii: e01637-17. doi: 10.1128/JVI.01637-17. Print 2018 Feb 1.

40.

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS.

J Immunol. 2017 Dec 15;199(12):4056-4065. doi: 10.4049/jimmunol.1600396. Epub 2017 Nov 6.

41.

Gene isoforms as expression-based biomarkers predictive of drug response in vitro.

Safikhani Z, Smirnov P, Thu KL, Silvester J, El-Hachem N, Quevedo R, Lupien M, Mak TW, Cescon D, Haibe-Kains B.

Nat Commun. 2017 Oct 24;8(1):1126. doi: 10.1038/s41467-017-01153-8. Erratum in: Nat Commun. 2018 Jan 9;9(1):166.

42.

Adulteration of proprietary Chinese medicines and health products with undeclared drugs: experience of a tertiary toxicology laboratory in Hong Kong.

Ching CK, Chen SPL, Lee HHC, Lam YH, Ng SW, Chen ML, Tang MHY, Chan SSS, Ng CWY, Cheung JWL, Chan TYC, Lau NKC, Chong YK, Mak TWL.

Br J Clin Pharmacol. 2018 Jan;84(1):172-178. doi: 10.1111/bcp.13420. Epub 2017 Oct 4.

43.

Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling.

Sintsova A, Guo CX, Sarantis H, Mak TW, Glogauer M, Gray-Owen SD.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12788. Epub 2017 Oct 9.

PMID:
28886618
44.

Check point inhibitors as therapies for infectious diseases.

Cox MA, Nechanitzky R, Mak TW.

Curr Opin Immunol. 2017 Oct;48:61-67. doi: 10.1016/j.coi.2017.07.016. Epub 2017 Aug 31. Review.

PMID:
28865357
45.

Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.

Szymiczek A, Carbone M, Pastorino S, Napolitano A, Tanji M, Minaai M, Pagano I, Mason JM, Pass HI, Bray MR, Mak TW, Yang H.

Oncogene. 2017 Nov 16;36(46):6501-6507. doi: 10.1038/onc.2017.266. Epub 2017 Jul 31.

46.

p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs.

Stanley-Hasnain S, Hauck L, Grothe D, Aschar-Sobbi R, Beca S, Butany J, Backx PH, Mak TW, Billia F.

Cell Cycle. 2017;16(17):1585-1600. doi: 10.1080/15384101.2017.1346758. Epub 2017 Jul 26.

47.

The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.

Urriola-Muñoz P, Li X, Maretzky T, McIlwain DR, Mak TW, Reyes JG, Blobel CP, Moreno RD.

J Cell Physiol. 2018 Mar;233(3):2247-2256. doi: 10.1002/jcp.26097. Epub 2017 Aug 25.

PMID:
28703301
48.

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.

Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M, Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong ZJ, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C.

Cell Res. 2017 Aug;27(8):1034-1045. doi: 10.1038/cr.2017.90. Epub 2017 Jul 7.

49.

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.

Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, Wang Y, Xu A, Sweeney G.

Am J Transl Res. 2017 Jun 15;9(6):2723-2735. eCollection 2017.

50.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D.

Immunity. 2017 Jun 20;46(6):1089-1090. doi: 10.1016/j.immuni.2017.06.009. No abstract available.

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