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Items: 1 to 50 of 1007

1.

ANP32B Deficiency Protects Mice From Lethal Influenza A Virus Challenge by Dampening the Host Immune Response.

Beck S, Zickler M, Pinho Dos Reis V, Günther T, Grundhoff A, Reilly PT, Mak TW, Stanelle-Bertram S, Gabriel G.

Front Immunol. 2020 Mar 13;11:450. doi: 10.3389/fimmu.2020.00450. eCollection 2020.

2.

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.

Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D.

Cell Metab. 2020 Mar 16. pii: S1550-4131(20)30119-4. doi: 10.1016/j.cmet.2020.03.004. [Epub ahead of print]

PMID:
32213345
3.

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.

Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak TW, Nakao K, Nakagawa T, Maehama T, Suzuki A.

Sci Adv. 2020 Mar 18;6(12):eaay3324. doi: 10.1126/sciadv.aay3324. eCollection 2020 Mar.

4.

Receptor tyrosine kinase fusions act as a significant alternative driver of the serrated pathway in colorectal cancer development.

Chan AW, Pan Y, Tong JH, Lung RW, Kwan JS, Chow C, Tin EK, Chung LY, Li H, Wong SS, Chau SL, Chan YY, Mak TW, Ng SS, To KF.

J Pathol. 2020 Mar 11. doi: 10.1002/path.5418. [Epub ahead of print]

PMID:
32162306
5.

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas.

Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW.

Cancer Cell. 2020 Mar 16;37(3):308-323.e12. doi: 10.1016/j.ccell.2020.02.002. Epub 2020 Mar 5.

6.

NK Cells Regulate CD8+ T Cell Mediated Autoimmunity.

Lang PA, Crome SQ, Xu HC, Lang KS, Chapatte L, Deenick EK, Grusdat M, Pandyra AA, Pozdeev VI, Wang R, Holderried TAW, Cantor H, Diefenbach A, Elford AR, McIlwain DR, Recher M, Häussinger D, Mak TW, Ohashi PS.

Front Cell Infect Microbiol. 2020 Feb 13;10:36. doi: 10.3389/fcimb.2020.00036. eCollection 2020.

7.

Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains.

Tang B, Li X, Maretzky T, Perez-Aguilar JM, McIlwain D, Xie Y, Zheng Y, Mak TW, Weinstein H, Blobel CP.

FASEB J. 2020 Apr;34(4):4956-4969. doi: 10.1096/fj.201902649R. Epub 2020 Feb 26.

PMID:
32103528
8.

Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas.

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Lupien M, Mak TW, Khokha R.

Nat Genet. 2020 Apr;52(4):464. doi: 10.1038/s41588-020-0589-2.

PMID:
32094913
9.

Simultaneous detection of 24 oral antidiabetic drugs and their metabolites in urine by liquid chromatography-tandem mass spectrometry.

Lam YH, Leung MT, Ching CK, Mak TWL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Mar 15;1141:122020. doi: 10.1016/j.jchromb.2020.122020. Epub 2020 Feb 3.

PMID:
32062369
10.

ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).

Weskamp G, Tüshaus J, Li D, Feederle R, Maretzky T, Swendemann S, Falck-Pedersen E, McIlwain DR, Mak TW, Salmon JE, Lichtenthaler SF, Blobel CP.

J Biol Chem. 2020 Mar 27;295(13):4350-4358. doi: 10.1074/jbc.RA119.011136. Epub 2020 Feb 14.

PMID:
32060096
11.

Superwarfarin (Long-Acting Anticoagulant Rodenticides) Poisoning: from Pathophysiology to Laboratory-Guided Clinical Management.

Chong YK, Mak TW.

Clin Biochem Rev. 2019 Nov;40(4):175-185. doi: 10.33176/AACB-19-00029. Review.

12.

Opposing effects of NPM1wt and NPM1c mutants on AKT signaling in AML.

Ren Z, Shrestha M, Sakamoto T, Melkman T, Meng L, Cairns RA, Zacksenhaus E, Mak TW, Stambolic V, Minden MD, Wang JA.

Leukemia. 2020 Apr;34(4):1172-1176. doi: 10.1038/s41375-019-0621-7. Epub 2019 Nov 14. No abstract available.

PMID:
31728055
13.

Beyond neurotransmission: acetylcholine in immunity and inflammation.

Cox MA, Bassi C, Saunders ME, Nechanitzky R, Morgado-Palacin I, Zheng C, Mak TW.

J Intern Med. 2020 Feb;287(2):120-133. doi: 10.1111/joim.13006. Epub 2019 Dec 3. Review.

PMID:
31710126
14.

iRhom2 inhibits bile duct obstruction-induced liver fibrosis.

Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA.

Sci Signal. 2019 Oct 29;12(605). pii: eaax1194. doi: 10.1126/scisignal.aax1194.

PMID:
31662486
15.

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration.

Ghosh S, Padmanabhan A, Vaidya T, Watson AM, Bhutto IA, Hose S, Shang P, Stepicheva N, Yazdankhah M, Weiss J, Das M, Gopikrishna S, Aishwarya, Yadav N, Berger T, Mak TW, Xia S, Qian J, Lutty GA, Jayagopal A, Zigler JS Jr, Sethu S, Handa JT, Watkins SC, Ghosh A, Sinha D.

Commun Biol. 2019 Sep 20;2:348. doi: 10.1038/s42003-019-0588-y. eCollection 2019.

16.

Author Correction: Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.

Kubli SP, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, Cox M, Han S, Nechanitzky R, Nechanitzky D, Snow BE, Jones L, Li WY, Haight J, Wakeham A, Bray MR, Mak TW.

Nat Commun. 2019 Sep 3;10(1):4069. doi: 10.1038/s41467-019-12106-8.

17.

Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation.

Melino G, Cecconi F, Pelicci PG, Mak TW, Bernassola F.

Mol Oncol. 2019 Oct;13(10):2033-2048. doi: 10.1002/1878-0261.12567. Epub 2019 Sep 5. Review.

18.

Lysergic acid diethylamide-associated intoxication in Hong Kong: a case series.

Li C, Tang MHY, Chong YK, Chan TYC, Mak TWL.

Hong Kong Med J. 2019 Aug;25(4):323-325. doi: 10.12809/hkmj197942. No abstract available.

19.

Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy.

Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM, Kurie JM, Villalobos P, Lu W, Behrens C, Mino B, Solis LM, Silvester J, Thu KL, Cescon DW, Rodriguez-Canales J, Wistuba II, Mak TW, Liu X, Dmitrovsky E.

Mol Cancer Ther. 2019 Oct;18(10):1775-1786. doi: 10.1158/1535-7163.MCT-18-0864. Epub 2019 Jul 29.

PMID:
31358662
20.

Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.

Veitch ZW, Cescon DW, Denny T, Yonemoto LM, Fletcher G, Brokx R, Sampson P, Li SW, Pugh TJ, Bruce J, Bray MR, Slamon DJ, Mak TW, Wainberg ZA, Bedard PL.

Br J Cancer. 2019 Aug;121(4):318-324. doi: 10.1038/s41416-019-0517-3. Epub 2019 Jul 15.

PMID:
31303643
21.

Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.

Kubli SP, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, Cox M, Han S, Nechanitzky R, Nechanitzky D, Snow BE, Jones L, Li WY, Haight J, Wakeham A, Bray MR, Mak TW.

Nat Commun. 2019 Jun 18;10(1):2678. doi: 10.1038/s41467-019-10619-w. Erratum in: Nat Commun. 2019 Sep 3;10(1):4069.

22.
23.

MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.

Kato W, Nishio M, To Y, Togashi H, Mak TW, Takada H, Ohga S, Maehama T, Suzuki A.

Genes Cells. 2019 Jul;24(7):485-495. doi: 10.1111/gtc.12704. Epub 2019 May 24.

24.

Role for polo-like kinase 4 in mediation of cytokinesis.

Press MF, Xie B, Davenport S, Zhou Y, Guzman R, Nolan GP, O'Brien N, Palazzolo M, Mak TW, Brugge JS, Slamon DJ.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11309-11318. doi: 10.1073/pnas.1818820116. Epub 2019 May 16.

25.

Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation.

Araos P, Prado C, Lozano M, Figueroa S, Espinoza A, Berger T, Mak TW, Jaisser F, Pacheco R, Michea L, Amador CA.

J Hypertens. 2019 Jul;37(7):1482-1492. doi: 10.1097/HJH.0000000000002067.

PMID:
31033725
26.

Ketamine analogues multiplying in Hong Kong.

Li C, Lai CK, Tang MHY, Chan CCK, Chong YK, Mak TWL.

Hong Kong Med J. 2019 Apr;25(2):169. doi: 10.12809/hkmj197863. No abstract available.

PMID:
30971512
27.

Poisoning by toxic plants in Hong Kong: a 15-year review.

Ng WY, Hung LY, Lam YH, Chan SS, Pang KS, Chong YK, Ching CK, Mak TWL.

Hong Kong Med J. 2019 Apr;25(2):102-112. doi: 10.12809/hkmj187745. Epub 2019 Apr 10.

28.

HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression.

Patel N, Wang J, Shiozawa K, Jones KB, Zhang Y, Prokop JW, Davenport GG, Nihira NT, Hao Z, Wong D, Brandsmeier L, Meadows SK, Sampaio AV, Werff RV, Endo M, Capecchi MR, McNagny KM, Mak TW, Nielsen TO, Underhill TM, Myers RM, Kondo T, Su L.

iScience. 2019 Mar 29;13:43-54. doi: 10.1016/j.isci.2019.02.008. Epub 2019 Feb 15.

29.

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1.

Roux C, Jafari SM, Shinde R, Duncan G, Cescon DW, Silvester J, Chu MF, Hodgson K, Berger T, Wakeham A, Palomero L, Garcia-Valero M, Pujana MA, Mak TW, McGaha TL, Cappello P, Gorrini C.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4326-4335. doi: 10.1073/pnas.1819473116. Epub 2019 Feb 15.

30.

Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors.

Gorrini C, Mak TW.

Cancer Cell. 2019 Feb 11;35(2):161-163. doi: 10.1016/j.ccell.2019.01.017.

31.

Choline acetyltransferase-expressing T cells are required to control chronic viral infection.

Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW.

Science. 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072.

PMID:
30733420
32.

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.

Kubli SP, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, Jafari SM, Snow B, Jones L, Palomero L, Thu KL, Cassetta L, Soong D, Berger T, Ramachandran P, Baniasadi SP, Duncan G, Lindzen M, Yarden Y, Herranz C, Lazaro C, Chu MF, Haight J, Tinto P, Silvester J, Cescon DW, Petit A, Pettersson S, Pollard JW, Mak TW, Pujana MA, Cappello P, Gorrini C.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3604-3613. doi: 10.1073/pnas.1815126116. Epub 2019 Feb 7.

33.

Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.

Nishio M, Miyachi Y, Otani J, Tane S, Omori H, Ueda F, Togashi H, Sasaki T, Mak TW, Nakao K, Fujita Y, Nishina H, Maehama T, Suzuki A.

FASEB J. 2019 Apr;33(4):5548-5560. doi: 10.1096/fj.201802005R. Epub 2019 Jan 14.

PMID:
30640535
34.

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Tarnawski L, Reardon C, Caravaca AS, Rosas-Ballina M, Tusche MW, Drake AR, Hudson LK, Hanes WM, Li JH, Parrish WR, Ojamaa K, Al-Abed Y, Faltys M, Pavlov VA, Andersson U, Chavan SS, Levine YA, Mak TW, Tracey KJ, Olofsson PS.

Front Immunol. 2018 Nov 27;9:2648. doi: 10.3389/fimmu.2018.02648. eCollection 2018.

35.

Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism.

Leca J, Berger T, Mak TW.

Cell Metab. 2018 Dec 4;28(6):811-813. doi: 10.1016/j.cmet.2018.11.011.

36.

Localisation of Colorectal Polyps by Convolutional Neural Network Features Learnt from White Light and Narrow Band Endoscopic Images of Multiple Databases.

Zheng Y, Zhang R, Yu R, Jiang Y, Mak TWC, Wong SH, Lau JYW, Poon CCY.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4142-4145. doi: 10.1109/EMBC.2018.8513337.

PMID:
30441267
37.

The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism.

Elliott MJ, Jerzak KJ, Cockburn JG, Safikhani Z, Gwynne WD, Hassell JA, Bane A, Silvester J, Thu KL, Haibe-Kains B, Mak TW, Cescon DW.

Sci Rep. 2018 Nov 8;8(1):16562. doi: 10.1038/s41598-018-34348-0.

38.

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.

Li L, Li L, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W, Yang X, Jiang P.

Nat Commun. 2018 Nov 8;9(1):4683. doi: 10.1038/s41467-018-07127-8.

39.

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.

Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31.

40.

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition.

Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10810-E10811. doi: 10.1073/pnas.1813967115. Epub 2018 Oct 30. No abstract available.

41.

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY.

Cell Stem Cell. 2018 Dec 6;23(6):882-897.e11. doi: 10.1016/j.stem.2018.09.016. Epub 2018 Oct 18.

42.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.

Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15. Review.

43.

Gelsemium poisoning mediated by the non-toxic plant Cassytha filiformis parasitizing Gelsemium elegans.

Cheung WL, Law CY, Lee HCH, Tang CO, Lam YH, Ng SW, Chan SS, Chow TC, Pang KS, Mak TWL.

Toxicon. 2018 Nov;154:42-49. doi: 10.1016/j.toxicon.2018.09.009. Epub 2018 Sep 28.

PMID:
30273705
44.

Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration.

Rebalka IA, Monaco CMF, Varah NE, Berger T, D'souza DM, Zhou S, Mak TW, Hawke TJ.

Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C714-C721. doi: 10.1152/ajpcell.00195.2017. Epub 2018 Sep 26.

45.

Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.

Tang MHY, Chong YK, Chan CY, Ching CK, Lai CK, Li YK, Mak TWL.

Forensic Sci Int. 2018 Sep;290:238-243. doi: 10.1016/j.forsciint.2018.07.014. Epub 2018 Jul 24.

PMID:
30081327
46.

Targeting the cell cycle in breast cancer: towards the next phase.

Thu KL, Soria-Bretones I, Mak TW, Cescon DW.

Cell Cycle. 2018;17(15):1871-1885. doi: 10.1080/15384101.2018.1502567. Epub 2018 Sep 11. Review.

47.

RASAL2 promotes tumor progression through LATS2/YAP1 axis of hippo signaling pathway in colorectal cancer.

Pan Y, Tong JHM, Lung RWM, Kang W, Kwan JSH, Chak WP, Tin KY, Chung LY, Wu F, Ng SSM, Mak TWC, Yu J, Lo KW, Chan AWH, To KF.

Mol Cancer. 2018 Jul 23;17(1):102. doi: 10.1186/s12943-018-0853-6.

48.

Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.

Pan Y, Cheung ST, Tong JHM, Tin KY, Kang W, Lung RWM, Wu F, Li H, Ng SSM, Mak TWC, To KF, Chan AWH.

J Transl Med. 2018 Jun 4;16(1):150. doi: 10.1186/s12967-018-1530-7.

49.

Fighting Fire with Fire in Cancer.

Berger T, Saunders ME, Mak TW.

In: Nakao K, Minato N, Uemoto S, editors. Innovative Medicine: Basic Research and Development [Internet]. Tokyo: Springer; 2015.

50.

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.

Haxaire C, Hakobyan N, Pannellini T, Carballo C, McIlwain D, Mak TW, Rodeo S, Acharya S, Li D, Szymonifka J, Song X, Monette S, Srivastava A, Salmon JE, Blobel CP.

Blood. 2018 Sep 6;132(10):1064-1074. doi: 10.1182/blood-2017-12-820571. Epub 2018 May 18.

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