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Items: 1 to 50 of 159

1.

Use of small-molecule inhibitory compound of PERK-dependent signaling pathway as a promising target-based therapy for colorectal cancer.

Rozpędek W, Pytel D, Wawrzynkiewicz A, Siwecka N, Dziki A, Dziki Ł, Diehl JA, Majsterek I.

Curr Cancer Drug Targets. 2020 Jan 5. doi: 10.2174/1568009620666200106114826. [Epub ahead of print]

PMID:
31906838
2.

Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus.

Tokarska K, Majsterek I, Cuchra M, Woźniacka A.

Postepy Dermatol Alergol. 2019 Oct;36(5):513-518. doi: 10.5114/ada.2019.85251. Epub 2019 Nov 12. Review.

3.

Potential therapeutic application of PERK inhibitors

Basak J, Rozpędek W, Pytel D, Majsterek I.

Postepy Biochem. 2019 Jun 6;65(2):118-127. doi: 10.18388/pb.2019_262. Review. Polish.

PMID:
31642650
4.

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis.

Siwecka N, Rozpędek W, Pytel D, Wawrzynkiewicz A, Dziki A, Dziki Ł, Diehl JA, Majsterek I.

Int J Mol Sci. 2019 Sep 5;20(18). pii: E4354. doi: 10.3390/ijms20184354. Review.

5.

Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes.

Świderska E, Podolska M, Strycharz J, Szwed M, Abramczyk H, Brożek-Płuska B, Wróblewski A, Szemraj J, Majsterek I, Drzewoski J, Śliwińska A.

Nutrients. 2019 Aug 8;11(8). pii: E1835. doi: 10.3390/nu11081835.

6.

Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population.

Balinska K, Wilk D, Filipek B, Mik M, Zelga P, Skubel P, Dziki Ł, Dziki A, Mucha B, Kabziński J, Majsterek I.

Pol Przegl Chir. 2019 Mar 13;91(3):15-20. doi: 10.5604/01.3001.0013.1030.

7.

Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases.

Poplawski T, Pytel D, Dziadek J, Majsterek I.

Oxid Med Cell Longev. 2019 Apr 7;2019:6949347. doi: 10.1155/2019/6949347. eCollection 2019. Review. No abstract available.

8.

Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.

Macieja A, Kopa P, Galita G, Pastwa E, Majsterek I, Poplawski T.

Mol Biol Rep. 2019 Aug;46(4):3625-3636. doi: 10.1007/s11033-019-04605-0. Epub 2019 Apr 24.

PMID:
31020489
9.

The Role of the ER-Induced UPR Pathway and the Efficacy of Its Inhibitors and Inducers in the Inhibition of Tumor Progression.

Walczak A, Gradzik K, Kabzinski J, Przybylowska-Sygut K, Majsterek I.

Oxid Med Cell Longev. 2019 Feb 3;2019:5729710. doi: 10.1155/2019/5729710. eCollection 2019. Review.

10.

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.

Rozpędek W, Pytel D, Popławski T, Walczak A, Gradzik K, Wawrzynkiewicz A, Wojtczak R, Mucha B, Diehl JA, Majsterek I.

Curr Alzheimer Res. 2019;16(3):209-218. doi: 10.2174/1567205016666190228121157. Erratum in: Curr Alzheimer Res. 2019;16(6):575.

PMID:
30819079
11.
12.

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Czarnecka K, Girek M, Kręcisz P, Skibiński R, Łątka K, Jończyk J, Bajda M, Kabziński J, Majsterek I, Szymczyk P, Szymański P.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E498. doi: 10.3390/ijms20030498.

13.

New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease.

Chufarova N, Czarnecka K, Skibiński R, Cuchra M, Majsterek I, Szymański P.

Arch Pharm (Weinheim). 2018 Jul;351(7):e1800050. doi: 10.1002/ardp.201800050. Epub 2018 Jun 5.

PMID:
29870588
14.

Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk.

Mucha B, Pytel D, Markiewicz L, Cuchra M, Szymczak I, Przybylowska-Sygut K, Dziki A, Majsterek I, Dziki L.

Clin Colorectal Cancer. 2018 Jun;17(2):e435-e441. doi: 10.1016/j.clcc.2016.10.001. Epub 2017 Jan 10.

PMID:
29793654
15.

Impact of the Ser326Cys polymorphism of the OGG1 gene on the level of oxidative DNA damage in patients with colorectal cancer.

Kabzinski J, Walczak A, Dziki A, Mik M, Majsterek I.

Pol Przegl Chir. 2018 Apr 30;90(2):13-15. doi: 10.5604/01.3001.0011.7486.

16.

Polymorphism of Gly39Glu (c.116G>A) hMSH6 is associated with sporadic colorectal cancer development in the Polish population: Preliminary results.

Zelga P, Przybyłowska-Sygut K, Zelga M, Dziki A, Majsterek I.

Adv Clin Exp Med. 2017 Dec;26(9):1425-1429. doi: 10.17219/acem/64877.

17.

The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma.

Siwak M, Maślankiewicz M, Nowak-Zduńczyk A, Rozpędek W, Wojtczak R, Szymanek K, Szaflik M, Szaflik J, Szaflik JP, Majsterek I.

Ophthalmic Genet. 2018 Jun;39(3):325-331. doi: 10.1080/13816810.2018.1432061. Epub 2018 Jan 31.

PMID:
29384425
18.

Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.

Czarnecka K, Chufarova N, Halczuk K, Maciejewska K, Girek M, Skibiński R, Jończyk J, Bajda M, Kabziński J, Majsterek I, Szymański P.

Eur J Med Chem. 2018 Feb 10;145:760-769. doi: 10.1016/j.ejmech.2018.01.014. Epub 2018 Jan 9.

PMID:
29353726
19.

Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.

Rozpędek W, Pytel D, Nowak-Zduńczyk A, Lewko D, Wojtczak R, Diehl JA, Majsterek I.

Curr Med Chem. 2019;26(8):1425-1445. doi: 10.2174/0929867325666180117102233. Review.

PMID:
29345572
20.

Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population.

Mrowicka M, Mrowicki J, Mik M, Wojtczak R, Dziki L, Dziki A, Majsterek I.

Oncotarget. 2017 Nov 27;8(65):109332-109339. doi: 10.18632/oncotarget.22675. eCollection 2017 Dec 12.

21.

Tumour protein 53 is linked with type 2 diabetes mellitus.

Sliwinska A, Kasznicki J, Kosmalski M, Mikolajczyk M, Rogalska A, Przybylowska K, Majsterek I, Drzewoski J.

Indian J Med Res. 2017 Aug;146(2):237-243. doi: 10.4103/ijmr.IJMR_1401_15.

22.

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease.

Czarnecka K, Girek M, Maciejewska K, Skibiński R, Jończyk J, Bajda M, Kabziński J, Sołowiej P, Majsterek I, Szymański P.

J Enzyme Inhib Med Chem. 2017 Dec;33(1):158-170. doi: 10.1080/14756366.2017.1406485. Erratum in: J Enzyme Inhib Med Chem. 2018 Dec;33(1):558-559.

23.

Polymorphism of MSH2 Gly322Asp and MLH1 -93G>A in non-familial colon cancer - a case-controlled study.

Mik M, Dziki L, Malinowska K, Trzcinski R, Majsterek I, Dziki A.

Arch Med Sci. 2017 Oct;13(6):1295-1302. doi: 10.5114/aoms.2017.67024. Epub 2017 Apr 3.

24.

An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence.

Walczak A, Przybyłowska-Sygut K, Sygut A, Cieślak A, Mik M, Dziki Ł, Dziki A, Majsterek I.

Pol Przegl Chir. 2017 Oct 31;89(5):1-5. doi: 10.5604/01.3001.0010.5246.

25.

Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species.

Bielecka-Kowalska A, Czarny P, Wigner P, Synowiec E, Kowalski B, Szwed M, Krupa R, Toma M, Drzewiecka M, Majsterek I, Szemraj J, Sliwinski T, Kowalski M.

Toxicol In Vitro. 2018 Mar;47:8-17. doi: 10.1016/j.tiv.2017.10.028. Epub 2017 Oct 28.

PMID:
29107684
26.

Analysis of the polymorphic variants of RAN and GEMIN3 genes and risk of Primary Open-Angle Glaucoma in the Polish population.

Molasy M, Walczak A, Przybyłowska-Sygut K, Zaleska-Żmijewska A, Szaflik J, Szaflik JP, Majsterek I.

Ophthalmic Genet. 2018 Apr;39(2):180-188. doi: 10.1080/13816810.2017.1381978. Epub 2017 Nov 2.

PMID:
29095070
27.

Carbon nanotubes functionalized with folic acid attached via biomimetic peptide linker.

Fraczyk J, Walczak M, Szymanski L, Kolacinski Z, Wrzosek H, Majsterek I, Przybylowska-Sygut K, Kaminski ZJ.

Nanomedicine (Lond). 2017 Sep;12(18):2161-2182. doi: 10.2217/nnm-2017-0120. Epub 2017 Aug 17.

PMID:
28814127
28.

Decreased expression level of BER genes in Alzheimer's disease patients is not derivative of their DNA methylation status.

Sliwinska A, Sitarek P, Toma M, Czarny P, Synowiec E, Krupa R, Wigner P, Bialek K, Kwiatkowski D, Korycinska A, Majsterek I, Szemraj J, Galecki P, Sliwinski T.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):311-316. doi: 10.1016/j.pnpbp.2017.07.010. Epub 2017 Jul 11.

PMID:
28710029
29.

Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.

Rozpędek W, Pytel D, Dziki Ł, Nowak A, Dziki A, Diehl JA, Majsterek I.

Pol Przegl Chir. 2017 Jun 30;89(3):7-10.

30.

Association of the expression level of the neurodegeneration-related proteins with the risk of development and progression of primary open-angle glaucoma.

Nowak A, Rozpędek W, Cuchra M, Wojtczak R, Siwak M, Szymanek K, Szaflik M, Szaflik J, Szaflik J, Majsterek I.

Acta Ophthalmol. 2018 Feb;96(1):e97-e98. doi: 10.1111/aos.13479. Epub 2017 May 27. No abstract available.

31.

Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment.

Czarnecka K, Szymański P, Girek M, Mikiciuk-Olasik E, Skibiński R, Kabziński J, Majsterek I, Malawska B, Jończyk J, Bajda M.

Bioorg Chem. 2017 Jun;72:315-322. doi: 10.1016/j.bioorg.2017.05.003. Epub 2017 May 5.

PMID:
28501648
32.

Effect of copper(II) the activity of glutathione peroxidase in patients with head and neck cancer.

Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D.

Otolaryngol Pol. 2016 Nov 20;70(6):20-25. doi: 10.5604/01.3001.0009.3735.

33.

The 116G > A MSH6 and IVS1-1121C > T PMS2 Genes Polymorphisms Modulate the Risk of the Sporadic Colorectal Cancer Development in Polish Population.

Zelga P, Przybyłowska-Sygut K, Zelga M, Dziki A, Majsterek I.

Pathol Oncol Res. 2018 Apr;24(2):231-235. doi: 10.1007/s12253-017-0231-5. Epub 2017 Apr 27.

34.

Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status.

Bruzgielewicz A, Osuch-Wojcikiewicz E, Niemczyk K, Sieniawska-Buccella O, Siwak M, Walczak A, Nowak A, Majsterek I.

DNA Cell Biol. 2017 Jul;36(7):581-588. doi: 10.1089/dna.2016.3464. Epub 2017 Apr 21.

PMID:
28430523
35.

Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene.

Dziki L, Dziki A, Mik M, Majsterek I, Kabzinski J.

Gastroenterol Res Pract. 2017;2017:3840243. doi: 10.1155/2017/3840243. Epub 2017 Mar 12.

36.

Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of DNA damage signaling.

Szymański P, Olszewska P, Mikiciuk-Olasik E, Różalski A, Maszewska A, Markiewicz Ł, Cuchra M, Majsterek I.

Tumour Biol. 2017 Mar;39(3):1010428317695011. doi: 10.1177/1010428317695011.

PMID:
28351316
37.

Molecular Basis of Human Diseases and Targeted Therapy Based on Small-Molecule Inhibitors of ER Stress-Induced Signaling Pathways.

Rozpedek W, Nowak A, Pytel D, Diehl JA, Majsterek I.

Curr Mol Med. 2017;17(2):118-132. doi: 10.2174/1566524017666170306122643. Review.

PMID:
28266275
38.

Potential of redox therapies in neurodegenerative disorders.

Miller E, Markiewicz L, Kabzinski J, Odrobina D, Majsterek I.

Front Biosci (Elite Ed). 2017 Mar 1;9:214-234. Review.

PMID:
28199186
39.

Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.

Bruzgielewicz A, Osuch-Wójcikiewicz E, Walczak A, Nowak A, Uczkowski H, Majsterek I.

Pol J Pathol. 2016;67(3):283-290. doi: 10.5114/pjp.2016.63781.

40.

TC2 C776G polymorphism studies in patients with oral cancer in the Polish population.

Malinowska K, Morawiec-Sztandera A, Majsterek I, Kaczmarczyk D.

Pol J Pathol. 2016;67(3):277-282. doi: 10.5114/pjp.2016.63780.

41.

Evaluation of Effect CAT -262C/T, SOD + 35A/C, GPx1 Pro197Leu Polymorphisms in Patients with IBD in the Polish Population.

Mrowicki J, Mrowicka M, Majsterek I, Mik M, Dziki A, Dziki Ł.

Pol Przegl Chir. 2016 Dec 1;88(6):321-327. doi: 10.1515/pjs-2016-0071.

PMID:
28141554
42.

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

Pytel D, Gao Y, Mackiewicz K, Katlinskaya YV, Staschke KA, Paredes MC, Yoshida A, Qie S, Zhang G, Chajewski OS, Wu L, Majsterek I, Herlyn M, Fuchs SY, Diehl JA.

PLoS Genet. 2016 Dec 15;12(12):e1006518. doi: 10.1371/journal.pgen.1006518. eCollection 2016 Dec.

43.

Analysis of antioxidative factors related to AMD risk development in the polish patients.

Mrowicka M, Mrowicki J, Szaflik JP, Szaflik M, Ulinska M, Szaflik J, Majsterek I.

Acta Ophthalmol. 2017 Aug;95(5):530-536. doi: 10.1111/aos.13289. Epub 2016 Dec 9.

44.

The role of base excision repair in pathogenesis of breast cancer in the Polish population.

Cuchra M, Mucha B, Markiewicz L, Przybylowska-Sygut K, Pytel D, Jeziorski A, Kordek R, Majsterek I.

Mol Carcinog. 2016 Dec;55(12):1899-1914. doi: 10.1002/mc.22436. Epub 2015 Nov 19.

PMID:
27870262
45.

[Small molecule inhibitors of PERK-dependent signaling pathway as a novel, therapeutic molecular strategy in Alzheimer's disease treatment].

Rozpędek W, Pytel D, Diehl JA, Majsterek I.

Pol Merkur Lekarski. 2016 Jul 29;41(241):5-10. Review. Polish.

PMID:
27734813
46.

MicroRNAs in glaucoma and neurodegenerative diseases.

Molasy M, Walczak A, Szaflik J, Szaflik JP, Majsterek I.

J Hum Genet. 2017 Jan;62(1):105-112. doi: 10.1038/jhg.2016.91. Epub 2016 Jul 14. Review.

PMID:
27412874
47.

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.

Rozpedek W, Pytel D, Mucha B, Leszczynska H, Diehl JA, Majsterek I.

Curr Mol Med. 2016;16(6):533-44. Review.

48.

[The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2].

Rozpędek W, Markiewicz Ł, Diehl JA, Pytel D, Majsterek I.

Pol Merkur Lekarski. 2015 Dec;39(234):393-7. Review. Polish.

PMID:
26802695
49.

The analysis of single nucleotide polymorphisms of the DGCR8 and XPO5 genes, and their association with the incidence of primary open angle glaucoma.

Molasy M, Walczak A, Przybyłowska-Sygut K, Szymanek K, Szaflik J, Szaflik JP, Majsterek I.

Klin Oczna. 2016;118(2):122-32. Polish.

PMID:
29912490
50.

Evaluation pro/antioxidant balance in patients with wet form of age-related macular degeneration.

Mrowicka M, Mrowicki J, Szaflik JP, Szaflik MS, Ulińska M, Szaflik J, Majsterek I.

Klin Oczna. 2016;118(4):284-8. Polish.

PMID:
29911360

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