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Items: 50

1.

NRF2 Activation in Cancer: From DNA to Protein.

Cloer EW, Goldfarb D, Schrank TP, Weissman BE, Major MB.

Cancer Res. 2019 Mar 1;79(5):889-898. doi: 10.1158/0008-5472.CAN-18-2723. Epub 2019 Feb 13. Review.

PMID:
30760522
2.

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB.

Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023.

3.

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.

Fu J, Xiong Z, Huang C, Li J, Yang W, Han Y, Paiboonrungruan C, Major MB, Chen KN, Kang X, Chen X.

J Biol Chem. 2019 Jan 4;294(1):327-340. doi: 10.1074/jbc.RA118.005963. Epub 2018 Nov 8.

PMID:
30409900
4.

The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.

Gao Y, Kardos J, Yang Y, Tamir TY, Mutter-Rottmayer E, Weissman B, Major MB, Kim WY, Vaziri C.

Sci Rep. 2018 Oct 17;8(1):15304. doi: 10.1038/s41598-018-33601-w.

5.

Approximating Isotope Distributions of Biomolecule Fragments.

Goldfarb D, Lafferty MJ, Herring LE, Wang W, Major MB.

ACS Omega. 2018 Sep 30;3(9):11383-11391. doi: 10.1021/acsomega.8b01649. Epub 2018 Sep 19.

6.

p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.

Cloer EW, Siesser PF, Cousins EM, Goldfarb D, Mowrey DD, Harrison JS, Weir SJ, Dokholyan NV, Major MB.

Mol Cell Biol. 2018 Oct 29;38(22). pii: e00644-17. doi: 10.1128/MCB.00644-17. Print 2018 Nov 15.

7.

Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target.

Ma S, Paiboonrungruan C, Yan T, Williams KP, Major MB, Chen XL.

Ann N Y Acad Sci. 2018 Dec;1434(1):164-172. doi: 10.1111/nyas.13681. Epub 2018 May 11. Review.

PMID:
29752726
8.

Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.

Lang JD, Hendricks WPD, Orlando KA, Yin H, Kiefer J, Ramos P, Sharma R, Pirrotte P, Raupach EA, Sereduk C, Tang N, Liang WS, Washington M, Facista SJ, Zismann VL, Cousins EM, Major MB, Wang Y, Karnezis AN, Sekulic A, Hass R, Vanderhyden BC, Nair P, Weissman BE, Huntsman DG, Trent JM.

Clin Cancer Res. 2018 Apr 15;24(8):1932-1943. doi: 10.1158/1078-0432.CCR-17-1928. Epub 2018 Feb 9.

9.

Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.

Cousins EM, Goldfarb D, Yan F, Roques J, Darr D, Johnson GL, Major MB.

Mol Cancer Res. 2018 Feb;16(2):333-344. doi: 10.1158/1541-7786.MCR-17-0468. Epub 2017 Nov 13.

10.

Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.

Chen PH, Smith TJ, Wu J, Siesser PF, Bisnett BJ, Khan F, Hogue M, Soderblom E, Tang F, Marks JR, Major MB, Swarts BM, Boyce M, Chi JT.

EMBO J. 2017 Aug 1;36(15):2233-2250. doi: 10.15252/embj.201696113. Epub 2017 Jun 29.

11.

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ.

J Biol Chem. 2017 Jul 28;292(30):12503-12515. doi: 10.1074/jbc.M117.788448. Epub 2017 May 30.

12.

Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.

Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ.

PLoS One. 2017 Apr 5;12(4):e0174863. doi: 10.1371/journal.pone.0174863. eCollection 2017.

13.

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB.

J Biol Chem. 2016 Nov 4;291(45):23719-23733. Epub 2016 Sep 12.

14.

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB.

Elife. 2016 Sep 6;5. pii: e17101. doi: 10.7554/eLife.17101.

15.

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

Gao Y, Mutter-Rottmayer E, Greenwalt AM, Goldfarb D, Yan F, Yang Y, Martinez-Chacin RC, Pearce KH, Tateishi S, Major MB, Vaziri C.

Nat Commun. 2016 Jul 5;7:12105. doi: 10.1038/ncomms12105.

16.

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.

Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, Virshup DM, Chou MM, Major MB.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2945-54. doi: 10.1073/pnas.1605691113. Epub 2016 May 9.

17.

Weight loss reduces basal-like breast cancer through kinome reprogramming.

Qin Y, Sundaram S, Essaid L, Chen X, Miller SM, Yan F, Darr DB, Galanko JA, Montgomery SA, Major MB, Johnson GL, Troester MA, Makowski L.

Cancer Cell Int. 2016 Apr 1;16:26. doi: 10.1186/s12935-016-0300-y. eCollection 2016.

18.

MSAcquisitionSimulator: data-dependent acquisition simulator for LC-MS shotgun proteomics.

Goldfarb D, Wang W, Major MB.

Bioinformatics. 2016 Apr 15;32(8):1269-71. doi: 10.1093/bioinformatics/btv745. Epub 2015 Dec 17.

19.

Engineering a genetically encoded competitive inhibitor of the KEAP1-NRF2 interaction via structure-based design and phage display.

Guntas G, Lewis SM, Mulvaney KM, Cloer EW, Tripathy A, Lane TR, Major MB, Kuhlman B.

Protein Eng Des Sel. 2016 Jan;29(1):1-9. doi: 10.1093/protein/gzv055. Epub 2015 Oct 20.

20.

The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase.

Onyenwoke RU, Sexton JZ, Yan F, Díaz MC, Forsberg LJ, Major MB, Brenman JE.

Biochem J. 2015 Sep 15;470(3):331-42. doi: 10.1042/BJ20150219. Epub 2015 Jul 20.

21.

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.

Walker MP, Stopford CM, Cederlund M, Fang F, Jahn C, Rabinowitz AD, Goldfarb D, Graham DM, Yan F, Deal AM, Fedoriw Y, Richards KL, Davis IJ, Weidinger G, Damania B, Major MB.

Sci Signal. 2015 Feb 3;8(362):ra12. doi: 10.1126/scisignal.2005654.

22.

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB.

Mol Cell Biol. 2015 Jan;35(1):167-81. doi: 10.1128/MCB.00857-14. Epub 2014 Oct 20.

23.

Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.

Goldfarb D, Hast BE, Wang W, Major MB.

J Proteome Res. 2014 Dec 5;13(12):5944-55. doi: 10.1021/pr5008416. Epub 2014 Oct 20.

24.

Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo.

Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge JR, Schmidt EE, Yan F, Major MB, Chen X, Sang S.

Chem Res Toxicol. 2014 Sep 15;27(9):1575-85. doi: 10.1021/tx500211x. Epub 2014 Sep 2.

25.

BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.

Orvis T, Hepperla A, Walter V, Song S, Simon J, Parker J, Wilkerson MD, Desai N, Major MB, Hayes DN, Davis IJ, Weissman B.

Cancer Res. 2014 Nov 15;74(22):6486-6498. doi: 10.1158/0008-5472.CAN-14-0061. Epub 2014 Aug 12.

26.

SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development.

Wei D, Goldfarb D, Song S, Cannon C, Yan F, Sakellariou-Thompson D, Emanuele M, Major MB, Weissman BE, Kuwahara Y.

Mol Cancer Res. 2014 Nov;12(11):1574-85. doi: 10.1158/1541-7786.MCR-14-0005. Epub 2014 Jul 9.

27.

Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.

Shah PK, Walker MP, Sims CE, Major MB, Allbritton NL.

Integr Biol (Camb). 2014 Jul 24;6(7):673-84. doi: 10.1039/c4ib00050a. Epub 2014 May 28.

28.

FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

Conrad W, Major MB, Cleary MA, Ferrer M, Roberts B, Marine S, Chung N, Arthur WT, Moon RT, Berndt JD, Chien AJ.

Version 2. F1000Res. 2013 May 31 [revised 2013 Jan 1];2:134. doi: 10.12688/f1000research.2-134.v2. eCollection 2013.

29.

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB.

Cancer Res. 2014 Feb 1;74(3):808-17. doi: 10.1158/0008-5472.CAN-13-1655. Epub 2013 Dec 9.

30.

Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.

Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK.

J Biol Chem. 2013 Sep 6;288(36):26301-10. doi: 10.1074/jbc.M113.466086. Epub 2013 Jul 26.

31.

WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.

Arensman MD, Kovochich AN, Kulikauskas RM, Lay AR, Yang PT, Li X, Donahue T, Major MB, Moon RT, Chien AJ, Dawson DW.

Oncogene. 2014 Feb 13;33(7):899-908. doi: 10.1038/onc.2013.23. Epub 2013 Feb 18.

32.

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.

Cancer Res. 2013 Apr 1;73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4.

33.

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.

James RG, Davidson KC, Bosch KA, Biechele TL, Robin NC, Taylor RJ, Major MB, Camp ND, Fowler K, Martins TJ, Moon RT.

PLoS One. 2012;7(12):e50457. doi: 10.1371/journal.pone.0050457. Epub 2012 Dec 5.

34.

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

Sorrells S, Carbonneau S, Harrington E, Chen AT, Hast B, Milash B, Pyati U, Major MB, Zhou Y, Zon LI, Stewart RA, Look AT, Jette C.

PLoS Genet. 2012;8(8):e1002922. doi: 10.1371/journal.pgen.1002922. Epub 2012 Aug 30.

35.

FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.

Siesser PF, Motolese M, Walker MP, Goldfarb D, Gewain K, Yan F, Kulikauskas RM, Chien AJ, Wordeman L, Major MB.

Sci Signal. 2012 Sep 4;5(240):ra64. doi: 10.1126/scisignal.2002871.

36.

Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.

Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT.

J Biol Chem. 2012 Feb 24;287(9):6539-50. doi: 10.1074/jbc.M111.316471. Epub 2012 Jan 3.

37.

A 1,536-well ultra-high-throughput siRNA screen to identify regulators of the Wnt/beta-catenin pathway.

Chung N, Marine S, Smith EA, Liehr R, Smith ST, Locco L, Hudak E, Kreamer A, Rush A, Roberts B, Major MB, Moon RT, Arthur W, Cleary M, Strulovici B, Ferrer M.

Assay Drug Dev Technol. 2010 Jun;8(3):286-94. doi: 10.1089/adt.2009.0262.

PMID:
20578927
38.

Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.

James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT.

Sci Signal. 2009 May 26;2(72):ra25. doi: 10.1126/scisignal.2000230.

39.

"Omic" risk assessment.

Major MB, Moon RT.

Sci Signal. 2009 May 26;2(72):eg7. doi: 10.1126/scisignal.272eg7.

40.

Integrative analysis of genome-wide RNA interference screens.

Berndt JD, Biechele TL, Moon RT, Major MB.

Sci Signal. 2009 May 12;2(70):pt4. doi: 10.1126/scisignal.270pt4.

PMID:
19436058
41.

Beta-catenin gets jaded and von Hippel-Lindau is to blame.

Berndt JD, Moon RT, Major MB.

Trends Biochem Sci. 2009 Mar;34(3):101-4. doi: 10.1016/j.tibs.2008.12.002. Epub 2009 Feb 11.

PMID:
19217300
42.

Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.

Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1193-8. doi: 10.1073/pnas.0811902106. Epub 2009 Jan 14.

43.

New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening.

Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, Chung N, Ferrer M, Yi X, Stoick-Cooper CL, von Haller PD, Kategaya L, Chien A, Angers S, MacCoss M, Cleary MA, Arthur WT, Moon RT.

Sci Signal. 2008 Nov 11;1(45):ra12. doi: 10.1126/scisignal.2000037.

44.

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.

De Ferrari GV, Papassotiropoulos A, Biechele T, Wavrant De-Vrieze F, Avila ME, Major MB, Myers A, Sáez K, Henríquez JP, Zhao A, Wollmer MA, Nitsch RM, Hock C, Morris CM, Hardy J, Moon RT.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9434-9. Epub 2007 May 21.

45.

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S, Moon RT.

Science. 2007 May 18;316(5827):1043-6.

46.

Small-molecule synergist of the Wnt/beta-catenin signaling pathway.

Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8. Epub 2007 Apr 25. Erratum in: Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12581. Jian, Xiaoying [added]; Randazzo, Paul A [added].

47.

Distinct Wnt signaling pathways have opposing roles in appendage regeneration.

Stoick-Cooper CL, Weidinger G, Riehle KJ, Hubbert C, Major MB, Fausto N, Moon RT.

Development. 2007 Feb;134(3):479-89. Epub 2006 Dec 21.

48.

The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.

Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC.

J Biol Chem. 2004 Feb 20;279(8):6824-33. Epub 2003 Nov 21.

49.
50.

Developing cultural sensitivity.

Major MB.

Calif Nurse. 1987 Mar;83(2):5. No abstract available.

PMID:
3644683

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