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Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.

Fu J, Xiong Z, Huang C, Li J, Yang W, Han Y, Paiboonrungruan C, Major MB, Chen K, Kang X, Chen XL.

J Biol Chem. 2018 Nov 8. pii: jbc.RA118.005963. doi: 10.1074/jbc.RA118.005963. [Epub ahead of print]


Amputee perception of prosthetic ankle stiffness during locomotion.

Shepherd MK, Azocar AF, Major MJ, Rouse EJ.

J Neuroeng Rehabil. 2018 Nov 8;15(1):99. doi: 10.1186/s12984-018-0432-5.


The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.

Gao Y, Kardos J, Yang Y, Tamir TY, Mutter-Rottmayer E, Weissman B, Major MB, Kim WY, Vaziri C.

Sci Rep. 2018 Oct 17;8(1):15304. doi: 10.1038/s41598-018-33601-w.


Approximating Isotope Distributions of Biomolecule Fragments.

Goldfarb D, Lafferty MJ, Herring LE, Wang W, Major MB.

ACS Omega. 2018 Sep 30;3(9):11383-11391. doi: 10.1021/acsomega.8b01649. Epub 2018 Sep 19.


Frequency and Circumstances of Falls Reported by Ambulatory Unilateral Lower Limb Prosthesis Users: A Secondary Analysis.

Kim J, Major MJ, Hafner B, Sawers A.

PM R. 2018 Sep 7. pii: S1934-1482(18)30859-1. doi: 10.1016/j.pmrj.2018.08.385. [Epub ahead of print]


p62-dependent phase separation of patient-derived KEAP1 mutations and NRF2.

Cloer EW, Siesser PF, Cousins EM, Goldfarb D, Mowrey DD, Harrison JS, Weir SJ, Dokholyan NV, Major MB.

Mol Cell Biol. 2018 Aug 20. pii: MCB.00644-17. doi: 10.1128/MCB.00644-17. [Epub ahead of print]


Modeling of patient virus titers suggests that availability of a vaccine could reduce hepatitis C virus transmission among injecting drug users.

Major M, Gutfraind A, Shekhtman L, Cui Q, Kachko A, Cotler SJ, Hajarizadeh B, Sacks-Davis R, Page K, Boodram B, Dahari H.

Sci Transl Med. 2018 Jul 11;10(449). pii: eaao4496. doi: 10.1126/scitranslmed.aao4496.


Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target.

Ma S, Paiboonrungruan C, Yan T, Williams KP, Major MB, Chen XL.

Ann N Y Acad Sci. 2018 May 11. doi: 10.1111/nyas.13681. [Epub ahead of print] Review.


Virtual Surgical Planning for Correction of Delayed Presentation Scaphocephaly Using a Modified Melbourne Technique.

Macmillan A, Lopez J, Mundinger GS, Major M, Medina MA 3rd, Dorafshar AH.

J Craniofac Surg. 2018 Jun;29(4):914-919. doi: 10.1097/SCS.0000000000004290.


Kangaroo mother care for the prevention of neonatal hypothermia: a randomised controlled trial in term neonates.

Ramani M, Choe EA, Major M, Newton R, Mwenechanya M, Travers CP, Chomba E, Ambalavanan N, Carlo WA.

Arch Dis Child. 2018 May;103(5):492-497. doi: 10.1136/archdischild-2017-313744. Epub 2018 Feb 22.


Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.

Lang JD, Hendricks WPD, Orlando KA, Yin H, Kiefer J, Ramos P, Sharma R, Pirrotte P, Raupach EA, Sereduk C, Tang N, Liang WS, Washington M, Facista SJ, Zismann VL, Cousins EM, Major MB, Wang Y, Karnezis AN, Sekulic A, Hass R, Vanderhyden BC, Nair P, Weissman BE, Huntsman DG, Trent JM.

Clin Cancer Res. 2018 Apr 15;24(8):1932-1943. doi: 10.1158/1078-0432.CCR-17-1928. Epub 2018 Feb 9.


Proactive Locomotor Adjustments Are Specific to Perturbation Uncertainty in Below-Knee Prosthesis Users.

Major MJ, Serba CK, Chen X, Reimold N, Ndubuisi-Obi F, Gordon KE.

Sci Rep. 2018 Jan 30;8(1):1863. doi: 10.1038/s41598-018-20207-5.


Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry.

Kachko A, Costafreda MI, Zubkova I, Jacques J, Takeda K, Wells F, Kaplan G, Major ME.

J Virol. 2018 Feb 26;92(6). pii: e01742-17. doi: 10.1128/JVI.01742-17. Print 2018 Mar 15.


Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.

Cousins EM, Goldfarb D, Yan F, Roques J, Darr D, Johnson GL, Major MB.

Mol Cancer Res. 2018 Feb;16(2):333-344. doi: 10.1158/1541-7786.MCR-17-0468. Epub 2017 Nov 13.


Early clinical experiences with nintedanib in three UK tertiary interstitial lung disease centres.

Toellner H, Hughes G, Beswick W, Crooks MG, Donaldson C, Forrest I, Hart SP, Leonard C, Major M, Simpson AJ, Chaudhuri N.

Clin Transl Med. 2017 Nov 3;6(1):41. doi: 10.1186/s40169-017-0172-3.


The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression.

Januszyk M, Kwon SH, Wong VW, Padmanabhan J, Maan ZN, Whittam AJ, Major MR, Gurtner GC.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1915. doi: 10.3390/ijms18091915.


Qualitative differences in cellular immunogenicity elicited by hepatitis C virus T-Cell vaccines employing prime-boost regimens.

Tan WG, Zubkova I, Kachko A, Wells F, Adler H, Sutter G, Major ME.

PLoS One. 2017 Jul 21;12(7):e0181578. doi: 10.1371/journal.pone.0181578. eCollection 2017.


Skill assessment in upper limb myoelectric prosthesis users: Validation of a clinically feasible method for characterising upper limb temporal and amplitude variability during the performance of functional tasks.

Thies SB, Kenney LP, Sobuh M, Galpin A, Kyberd P, Stine R, Major MJ.

Med Eng Phys. 2017 Sep;47:137-143. doi: 10.1016/j.medengphy.2017.03.010. Epub 2017 Jul 3.


Modeling HCV cure after an ultra-short duration of therapy with direct acting agents.

Goyal A, Lurie Y, Meissner EG, Major M, Sansone N, Uprichard SL, Cotler SJ, Dahari H.

Antiviral Res. 2017 Aug;144:281-285. doi: 10.1016/j.antiviral.2017.06.019. Epub 2017 Jun 30.


Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.

Chen PH, Smith TJ, Wu J, Siesser PF, Bisnett BJ, Khan F, Hogue M, Soderblom E, Tang F, Marks JR, Major MB, Swarts BM, Boyce M, Chi JT.

EMBO J. 2017 Aug 1;36(15):2233-2250. doi: 10.15252/embj.201696113. Epub 2017 Jun 29.


Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy.

Pachêco-Pereira C, Alsufyani N, Major M, Palomino-Gómez S, Pereira JR, Flores-Mir C.

Am J Orthod Dentofacial Orthop. 2017 Jul;152(1):92-103. doi: 10.1016/j.ajodo.2016.11.024.


The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ.

J Biol Chem. 2017 Jul 28;292(30):12503-12515. doi: 10.1074/jbc.M117.788448. Epub 2017 May 30.


Predict the Medicare Functional Classification Level (K-level) using the Amputee Mobility Predictor in people with unilateral transfemoral and transtibial amputation: A pilot study.

Dillon MP, Major MJ, Kaluf B, Balasanov Y, Fatone S.

Prosthet Orthot Int. 2018 Apr;42(2):191-197. doi: 10.1177/0309364617706748. Epub 2017 May 23.


The effects of common footwear on stance-phase mechanical properties of the prosthetic foot-shoe system.

Major MJ, Scham J, Orendurff M.

Prosthet Orthot Int. 2018 Apr;42(2):198-207. doi: 10.1177/0309364617706749. Epub 2017 May 9.


Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.

Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ.

PLoS One. 2017 Apr 5;12(4):e0174863. doi: 10.1371/journal.pone.0174863. eCollection 2017.


Effect of foot and ankle immobilization on able-bodied gait as a model to increase understanding about bilateral transtibial amputee gait.

Nepomuceno A, Major MJ, Stine R, Gard S.

Prosthet Orthot Int. 2017 Dec;41(6):556-563. doi: 10.1177/0309364617698521. Epub 2017 Mar 20.


Metreleptin Treatment in Three Patients with Generalized Lipodystrophy.

Musso C, Major ML, Andres E, Simha V.

Clin Med Insights Case Rep. 2017 Jan 5;9:123-127. doi: 10.4137/CCRep.S40196. eCollection 2016.


Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease.

Niewczas MA, Mathew AV, Croall S, Byun J, Major M, Sabisetti VS, Smiles A, Bonventre JV, Pennathur S, Krolewski AS.

Diabetes Care. 2017 Mar;40(3):383-390. doi: 10.2337/dc16-0173. Epub 2017 Jan 13.


Incidence of post-anesthetic colic in non-fasted adult equine patients.

Bailey PA, Hague BA, Davis M, Major MD, Zubrod CJ, Brakenhoff JE.

Can Vet J. 2016 Dec;57(12):1263-1266.


Accuracy and reliability of orthodontists using cone-beam computerized tomography for assessment of adenoid hypertrophy.

Pachêco-Pereira C, Alsufyani NA, Major M, Heo G, Flores-Mir C.

Am J Orthod Dentofacial Orthop. 2016 Nov;150(5):782-788. doi: 10.1016/j.ajodo.2016.03.030.


Deployment of the 1st Area Medical Laboratory in a Split-Based Configuration During the Largest Ebola Outbreak in History.

Cardile AP, Littell CT, Backlund MG, Heipertz RA, Brammer JA, Palmer SM, Vento TJ, Ortiz FA, Rosa WR, Major MJ, Garman PM.

Mil Med. 2016 Nov;181(11):e1675-e1684.


The Effect of Timing on Breast Reconstruction Outcomes in Diabetic Women.

Major M, Devulapalli C, Bello RJ, Baltodano PA, Reinhardt ME, Manahan MA, Cooney CM, Rosson GD.

Plast Reconstr Surg Glob Open. 2016 Oct 25;4(10):e1090. eCollection 2016 Oct.


Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge.

Major ME, Kwakman R, Kho ME, Connolly B, McWilliams D, Denehy L, Hanekom S, Patman S, Gosselink R, Jones C, Nollet F, Needham DM, Engelbert RH, van der Schaaf M.

Crit Care. 2016 Oct 29;20(1):354.


Empirical validation of the Operative Entrustability Assessment using resident performance in autologous breast reconstruction and hand surgery.

Bello RJ, Major MR, Cooney DS, Rosson GD, Lifchez SD, Cooney CM.

Am J Surg. 2017 Feb;213(2):227-232. doi: 10.1016/j.amjsurg.2016.09.054. Epub 2016 Oct 8.


Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB.

J Biol Chem. 2016 Nov 4;291(45):23719-23733. Epub 2016 Sep 12.


Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB.

Elife. 2016 Sep 6;5. pii: e17101. doi: 10.7554/eLife.17101.


Comments regarding: The benefits of using a vacuum-assisted socket system to improve balance and gait in elderly transtibial amputees by Samitier et al.

Fatone S, Major M, Caldwell R.

Prosthet Orthot Int. 2016 Dec;40(6):767. Epub 2016 Aug 2. No abstract available.


Evaluation of a Prototype Hybrid Vacuum Pump to Provide Vacuum-Assisted Suspension for Above-Knee Prostheses.

Major MJ, Caldwell R, Fatone S.

J Med Device. 2015 Dec;9(4):0445041-445044. Epub 2015 Aug 6.


Nonoperative Management of Acute Upper Limb Ischemia.

Wong VW, Major MR, Higgins JP.

Hand (N Y). 2016 Jun;11(2):131-43. doi: 10.1177/1558944716628499. Epub 2016 Mar 8. Review.


A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

Gao Y, Mutter-Rottmayer E, Greenwalt AM, Goldfarb D, Yan F, Yang Y, Martinez-Chacin RC, Pearce KH, Tateishi S, Major MB, Vaziri C.

Nat Commun. 2016 Jul 5;7:12105. doi: 10.1038/ncomms12105.


The effect of buccal-lingual slot dimension size on third-order torque response.

Romanyk DL, Au K, Isfeld D, Heo G, Major MP, Major PW.

Eur J Orthod. 2017 Apr 1;39(2):209-214. doi: 10.1093/ejo/cjw043.


Validity of the iPhone M7 motion co-processor as a pedometer for able-bodied ambulation.

Major MJ, Alford M.

J Sports Sci. 2016 Dec;34(23):2160-2164. Epub 2016 May 30.


Accuracy and reliability of oral maxillofacial radiologists when evaluating cone-beam computed tomography imaging for adenoid hypertrophy screening: a comparison with nasopharyngoscopy.

Pachêco-Pereira C, Alsufyani NA, Major MP, Flores-Mir C.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jun;121(6):e168-74. doi: 10.1016/j.oooo.2016.03.010. Epub 2016 Mar 18.


USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.

Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, Virshup DM, Chou MM, Major MB.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2945-54. doi: 10.1073/pnas.1605691113. Epub 2016 May 9.


Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis.

Nagy B Jr, Nagy B, Fila L, Clarke LA, Gönczy F, Bede O, Nagy D, Újhelyi R, Szabó Á, Anghelyi A, Major M, Bene Z, Fejes Z, Antal-Szalmás P, Bhattoa HP, Balla G, Kappelmayer J, Amaral MD, Macek M Jr, Balogh I.

Chest. 2016 Sep;150(3):661-72. doi: 10.1016/j.chest.2016.04.006. Epub 2016 Apr 19.


Weight loss reduces basal-like breast cancer through kinome reprogramming.

Qin Y, Sundaram S, Essaid L, Chen X, Miller SM, Yan F, Darr DB, Galanko JA, Montgomery SA, Major MB, Johnson GL, Troester MA, Makowski L.

Cancer Cell Int. 2016 Apr 1;16:26. doi: 10.1186/s12935-016-0300-y. eCollection 2016.


Survey of U.S. Practitioners on the Validity of the Medicare Functional Classification Level System and Utility of Clinical Outcome Measures for Aiding K-Level Assignment.

Borrenpohl D, Kaluf B, Major MJ.

Arch Phys Med Rehabil. 2016 Jul;97(7):1053-63. doi: 10.1016/j.apmr.2016.02.024. Epub 2016 Mar 22.


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