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Does Decreasing Below-Knee Prosthesis Pylon Longitudinal Stiffness Increase Prosthetic Limb Collision and Push-Off Work During Gait?

Major MJ, Zavaleta JL, Gard SA.

J Appl Biomech. 2019 May 29:1-29. doi: 10.1123/jab.2019-0043. [Epub ahead of print]


Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI.

Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B, Ophoff RA.

Genet Epidemiol. 2019 May 13. doi: 10.1002/gepi.22209. [Epub ahead of print]


Modeling indicates efficient vaccine-based interventions for the elimination of hepatitis C virus among persons who inject drugs in metropolitan Chicago.

Echevarria D, Gutfraind A, Boodram B, Layden J, Ozik J, Page K, Cotler SJ, Major M, Dahari H.

Vaccine. 2019 May 1;37(19):2608-2616. doi: 10.1016/j.vaccine.2019.02.081. Epub 2019 Apr 5.


Physiotherapy treatment approaches for survivors of critical illness: a proposal from a Delphi study.

Kwakman RCH, Major ME, Dettling-Ihnenfeldt DS, Nollet F, Engelbert RHH, van der Schaaf M.

Physiother Theory Pract. 2019 Mar 1:1-11. doi: 10.1080/09593985.2019.1579283. [Epub ahead of print]


NRF2 Activation in Cancer: From DNA to Protein.

Cloer EW, Goldfarb D, Schrank TP, Weissman BE, Major MB.

Cancer Res. 2019 Mar 1;79(5):889-898. doi: 10.1158/0008-5472.CAN-18-2723. Epub 2019 Feb 13. Review.


A retrospective cohort study of racing performance in Quarter Horses undergoing prosthetic laryngoplasty for treatment of recurrent laryngeal neuropathy.

Krueger CR, Lewis RD, McIlwraith CW, Major MD, Brakenhoff JE, Hand DR, Rowland AL, Hess AM, Johnson SW, Hackett ES.

J Am Vet Med Assoc. 2019 Feb 15;254(4):496-500. doi: 10.2460/javma.254.4.496.


WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB.

Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023.


Detection of Antibodies to HCV E1E2 by Lectin-Capture ELISA.

Major M, Law M.

Methods Mol Biol. 2019;1911:421-432. doi: 10.1007/978-1-4939-8976-8_28.


Fall Prevalence and Contributors to the Likelihood of Falling in Persons With Upper Limb Loss.

Major MJ.

Phys Ther. 2019 Apr 1;99(4):377-387. doi: 10.1093/ptj/pzy156.


Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.

Fu J, Xiong Z, Huang C, Li J, Yang W, Han Y, Paiboonrungruan C, Major MB, Chen KN, Kang X, Chen X.

J Biol Chem. 2019 Jan 4;294(1):327-340. doi: 10.1074/jbc.RA118.005963. Epub 2018 Nov 8.


Amputee perception of prosthetic ankle stiffness during locomotion.

Shepherd MK, Azocar AF, Major MJ, Rouse EJ.

J Neuroeng Rehabil. 2018 Nov 8;15(1):99. doi: 10.1186/s12984-018-0432-5.


The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.

Gao Y, Kardos J, Yang Y, Tamir TY, Mutter-Rottmayer E, Weissman B, Major MB, Kim WY, Vaziri C.

Sci Rep. 2018 Oct 17;8(1):15304. doi: 10.1038/s41598-018-33601-w.


Approximating Isotope Distributions of Biomolecule Fragments.

Goldfarb D, Lafferty MJ, Herring LE, Wang W, Major MB.

ACS Omega. 2018 Sep 30;3(9):11383-11391. doi: 10.1021/acsomega.8b01649. Epub 2018 Sep 19.


Frequency and Circumstances of Falls Reported by Ambulatory Unilateral Lower Limb Prosthesis Users: A Secondary Analysis.

Kim J, Major MJ, Hafner B, Sawers A.

PM R. 2019 Apr;11(4):344-353. doi: 10.1016/j.pmrj.2018.08.385. Epub 2019 Jan 15.


p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.

Cloer EW, Siesser PF, Cousins EM, Goldfarb D, Mowrey DD, Harrison JS, Weir SJ, Dokholyan NV, Major MB.

Mol Cell Biol. 2018 Oct 29;38(22). pii: e00644-17. doi: 10.1128/MCB.00644-17. Print 2018 Nov 15.


Modeling of patient virus titers suggests that availability of a vaccine could reduce hepatitis C virus transmission among injecting drug users.

Major M, Gutfraind A, Shekhtman L, Cui Q, Kachko A, Cotler SJ, Hajarizadeh B, Sacks-Davis R, Page K, Boodram B, Dahari H.

Sci Transl Med. 2018 Jul 11;10(449). pii: eaao4496. doi: 10.1126/scitranslmed.aao4496.


Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target.

Ma S, Paiboonrungruan C, Yan T, Williams KP, Major MB, Chen XL.

Ann N Y Acad Sci. 2018 Dec;1434(1):164-172. doi: 10.1111/nyas.13681. Epub 2018 May 11. Review.


Virtual Surgical Planning for Correction of Delayed Presentation Scaphocephaly Using a Modified Melbourne Technique.

Macmillan A, Lopez J, Mundinger GS, Major M, Medina MA 3rd, Dorafshar AH.

J Craniofac Surg. 2018 Jun;29(4):914-919. doi: 10.1097/SCS.0000000000004290.


Kangaroo mother care for the prevention of neonatal hypothermia: a randomised controlled trial in term neonates.

Ramani M, Choe EA, Major M, Newton R, Mwenechanya M, Travers CP, Chomba E, Ambalavanan N, Carlo WA.

Arch Dis Child. 2018 May;103(5):492-497. doi: 10.1136/archdischild-2017-313744. Epub 2018 Feb 22.


Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.

Lang JD, Hendricks WPD, Orlando KA, Yin H, Kiefer J, Ramos P, Sharma R, Pirrotte P, Raupach EA, Sereduk C, Tang N, Liang WS, Washington M, Facista SJ, Zismann VL, Cousins EM, Major MB, Wang Y, Karnezis AN, Sekulic A, Hass R, Vanderhyden BC, Nair P, Weissman BE, Huntsman DG, Trent JM.

Clin Cancer Res. 2018 Apr 15;24(8):1932-1943. doi: 10.1158/1078-0432.CCR-17-1928. Epub 2018 Feb 9.


Proactive Locomotor Adjustments Are Specific to Perturbation Uncertainty in Below-Knee Prosthesis Users.

Major MJ, Serba CK, Chen X, Reimold N, Ndubuisi-Obi F, Gordon KE.

Sci Rep. 2018 Jan 30;8(1):1863. doi: 10.1038/s41598-018-20207-5.


Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry.

Kachko A, Costafreda MI, Zubkova I, Jacques J, Takeda K, Wells F, Kaplan G, Major ME.

J Virol. 2018 Feb 26;92(6). pii: e01742-17. doi: 10.1128/JVI.01742-17. Print 2018 Mar 15.


Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.

Cousins EM, Goldfarb D, Yan F, Roques J, Darr D, Johnson GL, Major MB.

Mol Cancer Res. 2018 Feb;16(2):333-344. doi: 10.1158/1541-7786.MCR-17-0468. Epub 2017 Nov 13.


Early clinical experiences with nintedanib in three UK tertiary interstitial lung disease centres.

Toellner H, Hughes G, Beswick W, Crooks MG, Donaldson C, Forrest I, Hart SP, Leonard C, Major M, Simpson AJ, Chaudhuri N.

Clin Transl Med. 2017 Nov 3;6(1):41. doi: 10.1186/s40169-017-0172-3.


The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression.

Januszyk M, Kwon SH, Wong VW, Padmanabhan J, Maan ZN, Whittam AJ, Major MR, Gurtner GC.

Int J Mol Sci. 2017 Sep 7;18(9). pii: E1915. doi: 10.3390/ijms18091915.


Qualitative differences in cellular immunogenicity elicited by hepatitis C virus T-Cell vaccines employing prime-boost regimens.

Tan WG, Zubkova I, Kachko A, Wells F, Adler H, Sutter G, Major ME.

PLoS One. 2017 Jul 21;12(7):e0181578. doi: 10.1371/journal.pone.0181578. eCollection 2017.


Skill assessment in upper limb myoelectric prosthesis users: Validation of a clinically feasible method for characterising upper limb temporal and amplitude variability during the performance of functional tasks.

Thies SB, Kenney LP, Sobuh M, Galpin A, Kyberd P, Stine R, Major MJ.

Med Eng Phys. 2017 Sep;47:137-143. doi: 10.1016/j.medengphy.2017.03.010. Epub 2017 Jul 3.


Modeling HCV cure after an ultra-short duration of therapy with direct acting agents.

Goyal A, Lurie Y, Meissner EG, Major M, Sansone N, Uprichard SL, Cotler SJ, Dahari H.

Antiviral Res. 2017 Aug;144:281-285. doi: 10.1016/j.antiviral.2017.06.019. Epub 2017 Jun 30.


Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.

Chen PH, Smith TJ, Wu J, Siesser PF, Bisnett BJ, Khan F, Hogue M, Soderblom E, Tang F, Marks JR, Major MB, Swarts BM, Boyce M, Chi JT.

EMBO J. 2017 Aug 1;36(15):2233-2250. doi: 10.15252/embj.201696113. Epub 2017 Jun 29.


Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy.

Pachêco-Pereira C, Alsufyani N, Major M, Palomino-Gómez S, Pereira JR, Flores-Mir C.

Am J Orthod Dentofacial Orthop. 2017 Jul;152(1):92-103. doi: 10.1016/j.ajodo.2016.11.024.


The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.

Yi JJ, Paranjape SR, Walker MP, Choudhury R, Wolter JM, Fragola G, Emanuele MJ, Major MB, Zylka MJ.

J Biol Chem. 2017 Jul 28;292(30):12503-12515. doi: 10.1074/jbc.M117.788448. Epub 2017 May 30.


Predict the Medicare Functional Classification Level (K-level) using the Amputee Mobility Predictor in people with unilateral transfemoral and transtibial amputation: A pilot study.

Dillon MP, Major MJ, Kaluf B, Balasanov Y, Fatone S.

Prosthet Orthot Int. 2018 Apr;42(2):191-197. doi: 10.1177/0309364617706748. Epub 2017 May 23.


The effects of common footwear on stance-phase mechanical properties of the prosthetic foot-shoe system.

Major MJ, Scham J, Orendurff M.

Prosthet Orthot Int. 2018 Apr;42(2):198-207. doi: 10.1177/0309364617706749. Epub 2017 May 9.


Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.

Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ.

PLoS One. 2017 Apr 5;12(4):e0174863. doi: 10.1371/journal.pone.0174863. eCollection 2017.


Effect of foot and ankle immobilization on able-bodied gait as a model to increase understanding about bilateral transtibial amputee gait.

Nepomuceno A, Major MJ, Stine R, Gard S.

Prosthet Orthot Int. 2017 Dec;41(6):556-563. doi: 10.1177/0309364617698521. Epub 2017 Mar 20.


Metreleptin Treatment in Three Patients with Generalized Lipodystrophy.

Musso C, Major ML, Andres E, Simha V.

Clin Med Insights Case Rep. 2017 Jan 5;9:123-127. doi: 10.4137/CCRep.S40196. eCollection 2016.


Circulating Modified Metabolites and a Risk of ESRD in Patients With Type 1 Diabetes and Chronic Kidney Disease.

Niewczas MA, Mathew AV, Croall S, Byun J, Major M, Sabisetti VS, Smiles A, Bonventre JV, Pennathur S, Krolewski AS.

Diabetes Care. 2017 Mar;40(3):383-390. doi: 10.2337/dc16-0173. Epub 2017 Jan 13.


Incidence of post-anesthetic colic in non-fasted adult equine patients.

Bailey PA, Hague BA, Davis M, Major MD, Zubrod CJ, Brakenhoff JE.

Can Vet J. 2016 Dec;57(12):1263-1266.


Accuracy and reliability of orthodontists using cone-beam computerized tomography for assessment of adenoid hypertrophy.

Pachêco-Pereira C, Alsufyani NA, Major M, Heo G, Flores-Mir C.

Am J Orthod Dentofacial Orthop. 2016 Nov;150(5):782-788. doi: 10.1016/j.ajodo.2016.03.030.


Deployment of the 1st Area Medical Laboratory in a Split-Based Configuration During the Largest Ebola Outbreak in History.

Cardile AP, Littell CT, Backlund MG, Heipertz RA, Brammer JA, Palmer SM, Vento TJ, Ortiz FA, Rosa WR, Major MJ, Garman PM.

Mil Med. 2016 Nov;181(11):e1675-e1684.


The Effect of Timing on Breast Reconstruction Outcomes in Diabetic Women.

Major M, Devulapalli C, Bello RJ, Baltodano PA, Reinhardt ME, Manahan MA, Cooney CM, Rosson GD.

Plast Reconstr Surg Glob Open. 2016 Oct 25;4(10):e1090. eCollection 2016 Oct.


Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge.

Major ME, Kwakman R, Kho ME, Connolly B, McWilliams D, Denehy L, Hanekom S, Patman S, Gosselink R, Jones C, Nollet F, Needham DM, Engelbert RH, van der Schaaf M.

Crit Care. 2016 Oct 29;20(1):354.


Empirical validation of the Operative Entrustability Assessment using resident performance in autologous breast reconstruction and hand surgery.

Bello RJ, Major MR, Cooney DS, Rosson GD, Lifchez SD, Cooney CM.

Am J Surg. 2017 Feb;213(2):227-232. doi: 10.1016/j.amjsurg.2016.09.054. Epub 2016 Oct 8.


Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.

Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB.

J Biol Chem. 2016 Nov 4;291(45):23719-23733. Epub 2016 Sep 12.


Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB.

Elife. 2016 Sep 6;5. pii: e17101. doi: 10.7554/eLife.17101.


Comments regarding: The benefits of using a vacuum-assisted socket system to improve balance and gait in elderly transtibial amputees by Samitier et al.

Fatone S, Major M, Caldwell R.

Prosthet Orthot Int. 2016 Dec;40(6):767. Epub 2016 Aug 2. No abstract available.


Evaluation of a Prototype Hybrid Vacuum Pump to Provide Vacuum-Assisted Suspension for Above-Knee Prostheses.

Major MJ, Caldwell R, Fatone S.

J Med Device. 2015 Dec;9(4):0445041-445044. Epub 2015 Aug 6.

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