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Items: 1 to 50 of 252

1.

An aspirin a day.

Majerus PW.

Adv Biol Regul. 2014 Jan;54:231-41. doi: 10.1016/j.jbior.2013.09.011. Epub 2013 Dec 4. Review.

PMID:
24361050
2.

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.

Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9539-44. doi: 10.1073/pnas.1207021109. Epub 2012 May 30.

3.

Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation.

Zhang C, Majerus PW, Wilson MP.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2290-5. doi: 10.1073/pnas.1119740109. Epub 2012 Jan 30.

4.

The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death.

Zou J, Majerus PW, Wilson DB, Schrade A, Chang SC, Wilson MP.

Adv Biol Regul. 2012 Jan;52(1):282-9. Review. No abstract available.

5.

Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans.

Ferron M, Boudiffa M, Arsenault M, Rached M, Pata M, Giroux S, Elfassihi L, Kisseleva M, Majerus PW, Rousseau F, Vacher J.

Cell Metab. 2011 Oct 5;14(4):466-77. doi: 10.1016/j.cmet.2011.08.013.

6.

Wandering through the laboratory.

Majerus PW.

J Biol Chem. 2011 Feb 18;286(7):4941-5. doi: 10.1074/jbc.X110.212894. Epub 2010 Dec 17. No abstract available.

7.

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.

Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22231-6. doi: 10.1073/pnas.1015245107. Epub 2010 Dec 2.

8.

The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model.

Marjanovic J, Wilson MP, Zhang C, Zou J, Nicholas P, Majerus PW.

Adv Enzyme Regul. 2011;51(1):101-5. doi: 10.1016/j.advenzreg.2010.11.006. Epub 2010 Nov 24. Review. No abstract available.

9.

Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.

Majerus PW, Wilson DB, Zhang C, Nicholas PJ, Wilson MP.

Adv Enzyme Regul. 2010;50(1):365-72. doi: 10.1016/j.advenzreg.2009.10.017. Epub 2009 Nov 13. No abstract available.

10.

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.

Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, Al-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG.

Nat Genet. 2009 Sep;41(9):1032-6. doi: 10.1038/ng.423. Epub 2009 Aug 9.

11.

Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase.

Wilson MP, Hugge C, Bielinska M, Nicholas P, Majerus PW, Wilson DB.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9831-5. doi: 10.1073/pnas.0904172106. Epub 2009 May 29.

12.

INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia.

Traynor-Kaplan AE, Moody M, Nur M, Gabriel S, Majerus PW, Drumm ML, Langton-Webster B.

Am J Respir Cell Mol Biol. 2010 Jan;42(1):105-12. doi: 10.1165/rcmb.2008-0380OC. Epub 2009 Apr 3.

13.

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.

Ivetac I, Gurung R, Hakim S, Horan KA, Sheffield DA, Binge LC, Majerus PW, Tiganis T, Mitchell CA.

EMBO Rep. 2009 May;10(5):487-93. doi: 10.1038/embor.2009.28. Epub 2009 Mar 27.

14.

MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.

Zou J, Chang SC, Marjanovic J, Majerus PW.

J Biol Chem. 2009 Jan 23;284(4):2064-71. doi: 10.1074/jbc.M804292200. Epub 2008 Nov 27.

15.

Phosphoinositide phosphatases and disease.

Majerus PW, York JD.

J Lipid Res. 2009 Apr;50 Suppl:S249-54. doi: 10.1194/jlr.R800072-JLR200. Epub 2008 Nov 11.

16.

The role of inositol signaling in the control of apoptosis.

Majerus PW, Zou J, Marjanovic J, Kisseleva MV, Wilson MP.

Adv Enzyme Regul. 2008;48:10-7. doi: 10.1016/j.advenzreg.2008.04.001. Epub 2008 Apr 29. No abstract available.

17.

A discrete signaling function for an inositol pyrophosphate.

Majerus PW.

Sci STKE. 2007 Dec 11;2007(416):pe72.

PMID:
18073384
18.

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.

Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16834-9. Epub 2007 Oct 16.

19.

The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.

Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18854-9. Epub 2005 Dec 19.

20.

Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate.

Chang SC, Majerus PW.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):209-16. Epub 2005 Nov 10.

PMID:
16293229
21.
22.

Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression.

Verbsky J, Lavine K, Majerus PW.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8448-53. Epub 2005 Jun 6.

23.
24.

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.

Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA.

Mol Biol Cell. 2005 May;16(5):2218-33. Epub 2005 Feb 16.

25.

The pathway for the production of inositol hexakisphosphate in human cells.

Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW.

J Biol Chem. 2005 Jan 21;280(3):1911-20. Epub 2004 Nov 5.

26.

Blasts from the past.

Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD.

J Clin Invest. 2004 Oct;114(8):1017-33.

27.

The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin.

Ungewickell A, Ward ME, Ungewickell E, Majerus PW.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13501-6. Epub 2004 Sep 7.

28.

The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155.

Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR.

Mol Cell Proteomics. 2004 Feb;3(2):145-55. Epub 2003 Nov 25.

29.

Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis.

Sun Y, Mochizuki Y, Majerus PW.

J Biol Chem. 2003 Oct 31;278(44):43645-53. Epub 2003 Aug 18.

30.

Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.

Mochizuki Y, Majerus PW.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9768-73. Epub 2003 Jul 30.

31.

Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.

Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8660-5. Epub 2003 Jul 7.

32.

Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1.

Sun Y, Wilson MP, Majerus PW.

J Biol Chem. 2002 Nov 29;277(48):45759-64. Epub 2002 Sep 24.

33.

The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.

Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW.

J Biol Chem. 2002 Nov 15;277(46):43836-43. Epub 2002 Sep 9.

34.

The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase.

Verbsky JW, Wilson MP, Kisseleva MV, Majerus PW, Wente SR.

J Biol Chem. 2002 Aug 30;277(35):31857-62. Epub 2002 Jun 25.

35.
36.

Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.

Wilson MP, Sun Y, Cao L, Majerus PW.

J Biol Chem. 2001 Nov 2;276(44):40998-1004. Epub 2001 Aug 31.

37.

Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity.

Nandurkar HH, Caldwell KK, Whisstock JC, Layton MJ, Gaudet EA, Norris FA, Majerus PW, Mitchell CA.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9499-504.

38.

Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export.

Feng Y, Wente SR, Majerus PW.

Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):875-9. Epub 2001 Jan 16.

39.

Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1.

Vyas P, Norris FA, Joseph R, Majerus PW, Orkin SH.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13696-701.

40.

An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity.

Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J.

Mol Biochem Parasitol. 2000 Apr 30;108(1):119-23. No abstract available.

PMID:
10802324
41.
42.

The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity.

Kunz J, Wilson MP, Kisseleva M, Hurley JH, Majerus PW, Anderson RA.

Mol Cell. 2000 Jan;5(1):1-11.

43.

Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome.

Ungewickell AJ, Majerus PW.

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13342-4.

44.

The role of phosphatases in inositol signaling reactions.

Majerus PW, Kisseleva MV, Norris FA.

J Biol Chem. 1999 Apr 16;274(16):10669-72. Review. No abstract available.

45.

The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol.

Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3640-5.

46.

SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase.

Norris FA, Wilson MP, Wallis TS, Galyov EE, Majerus PW.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14057-9.

47.

The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages.

Roach TI, Slater SE, White LS, Zhang X, Majerus PW, Brown EJ, Thomas ML.

Curr Biol. 1998 Sep 10;8(18):1035-8.

48.

Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation.

Damen JE, Liu L, Ware MD, Ermolaeva M, Majerus PW, Krystal G.

Blood. 1998 Aug 15;92(4):1199-205.

49.

Phosphatidylinositol signalling reactions.

Zhang X, Majerus PW.

Semin Cell Dev Biol. 1998 Apr;9(2):153-60. Review.

PMID:
9599410
50.

Prostaglandins: critical roles in pregnancy and colon cancer.

Majerus PW.

Curr Biol. 1998 Jan 29;8(3):R87-9. Review.

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