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Items: 1 to 50 of 299

1.

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW, Kopf M, Henderson NC, Zaiss DM.

Immunity. 2019 Feb 6. pii: S1074-7613(19)30031-7. doi: 10.1016/j.immuni.2019.01.008. [Epub ahead of print]

2.

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules.

Maizels RM, Smits HH, McSorley HJ.

Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016. Review.

3.

Chemical analyses and anthelmintic effects of Artemisia campestris essential oil.

Abidi A, Sebai E, Dhibi M, Alimi D, Rekik M, B'chir F, Maizels RM, Akkari H.

Vet Parasitol. 2018 Nov 15;263:59-65. doi: 10.1016/j.vetpar.2018.10.003. Epub 2018 Oct 9.

PMID:
30389026
4.

Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.

Rolot M, Dougall AM, Chetty A, Javaux J, Chen T, Xiao X, Machiels B, Selkirk ME, Maizels RM, Hokke C, Denis O, Brombacher F, Vanderplasschen A, Gillet L, Horsnell WGC, Dewals BG.

Nat Commun. 2018 Oct 30;9(1):4516. doi: 10.1038/s41467-018-06978-5.

5.

Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants.

Wilbers RHP, Schneiter R, Holterman MHM, Drurey C, Smant G, Asojo OA, Maizels RM, Lozano-Torres JL.

PLoS Pathog. 2018 Oct 18;14(10):e1007300. doi: 10.1371/journal.ppat.1007300. eCollection 2018 Oct. Review.

6.

Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion.

Smith KA, Löser S, Varyani F, Harcus Y, McSorley HJ, McKenzie AN, Maizels RM.

Elife. 2018 Sep 21;7. pii: e38269. doi: 10.7554/eLife.38269.

7.

DEMONSTRATION OF THE ANTHELMINTIC POTENCY OF MARIMASTAT IN THE HELIGMOSOMOIDES POLYGYRUS RODENT MODEL.

Robertson E, Harcus Y, Johnston CJC, Page AP, Walkinshaw MD, Maizels RM, Houston D.

J Parasitol. 2018 Aug 29. doi: 10.1645/18-33. [Epub ahead of print]

PMID:
30085900
8.

Special issue: molecular and cellular biology of helminth parasites XI.

Selkirk ME, Davis RE, Gounaris K, Maizels RM.

Int J Parasitol. 2018 Apr;48(5):319-320. doi: 10.1016/j.ijpara.2018.03.001. No abstract available.

9.

TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.

Smyth DJ, Harcus Y, White MPJ, Gregory WF, Nahler J, Stephens I, Toke-Bjolgerud E, Hewitson JP, Ivens A, McSorley HJ, Maizels RM.

Int J Parasitol. 2018 Apr;48(5):379-385. doi: 10.1016/j.ijpara.2017.12.004. Epub 2018 Mar 3.

10.

Heligmosomoides polygyrus Venom Allergen-like Protein-4 (HpVAL-4) is a sterol binding protein.

Asojo OA, Darwiche R, Gebremedhin S, Smant G, Lozano-Torres JL, Drurey C, Pollet J, Maizels RM, Schneiter R, Wilbers RHP.

Int J Parasitol. 2018 Apr;48(5):359-369. doi: 10.1016/j.ijpara.2018.01.002. Epub 2018 Mar 2.

11.

Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis.

Darwiche R, Lugo F, Drurey C, Varossieau K, Smant G, Wilbers RHP, Maizels RM, Schneiter R, Asojo OA.

Int J Parasitol. 2018 Apr;48(5):371-378. doi: 10.1016/j.ijpara.2017.12.003. Epub 2018 Mar 6.

12.

Immunology: The Neuronal Pathway to Mucosal Immunity.

Löser S, Maizels RM.

Curr Biol. 2018 Jan 8;28(1):R33-R36. doi: 10.1016/j.cub.2017.11.025.

13.

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM.

Nat Commun. 2017 Nov 23;8(1):1741. doi: 10.1038/s41467-017-01886-6.

14.

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

Osbourn M, Soares DC, Vacca F, Cohen ES, Scott IC, Gregory WF, Smyth DJ, Toivakka M, Kemter AM, le Bihan T, Wear M, Hoving D, Filbey KJ, Hewitson JP, Henderson H, Gonzàlez-Cìscar A, Errington C, Vermeren S, Astier AL, Wallace WA, Schwarze J, Ivens AC, Maizels RM, McSorley HJ.

Immunity. 2017 Oct 17;47(4):739-751.e5. doi: 10.1016/j.immuni.2017.09.015.

15.

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM.

Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013.

16.

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.

Pastille E, Frede A, McSorley HJ, Gräb J, Adamczyk A, Kollenda S, Hansen W, Epple M, Buer J, Maizels RM, Klopfleisch R, Westendorf AM.

PLoS Pathog. 2017 Sep 22;13(9):e1006649. doi: 10.1371/journal.ppat.1006649. eCollection 2017 Sep.

17.

Human toxocariasis.

Ma G, Holland CV, Wang T, Hofmann A, Fan CK, Maizels RM, Hotez PJ, Gasser RB.

Lancet Infect Dis. 2018 Jan;18(1):e14-e24. doi: 10.1016/S1473-3099(17)30331-6. Epub 2017 Aug 3. Review.

PMID:
28781085
18.

Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity.

Coakley G, McCaskill JL, Borger JG, Simbari F, Robertson E, Millar M, Harcus Y, McSorley HJ, Maizels RM, Buck AH.

Cell Rep. 2017 May 23;19(8):1545-1557. doi: 10.1016/j.celrep.2017.05.001.

19.

Macrophage origin limits functional plasticity in helminth-bacterial co-infection.

Rückerl D, Campbell SM, Duncan S, Sutherland TE, Jenkins SJ, Hewitson JP, Barr TA, Jackson-Jones LH, Maizels RM, Allen JE.

PLoS Pathog. 2017 Mar 23;13(3):e1006233. doi: 10.1371/journal.ppat.1006233. eCollection 2017 Mar.

20.

Helminths in the gastrointestinal tract as modulators of immunity and pathology.

Varyani F, Fleming JO, Maizels RM.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G537-G549. doi: 10.1152/ajpgi.00024.2017. Epub 2017 Mar 16. Review.

21.

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota.

McFarlane AJ, McSorley HJ, Davidson DJ, Fitch PM, Errington C, Mackenzie KJ, Gollwitzer ES, Johnston CJC, MacDonald AS, Edwards MR, Harris NL, Marsland BJ, Maizels RM, Schwarze J.

J Allergy Clin Immunol. 2017 Oct;140(4):1068-1078.e6. doi: 10.1016/j.jaci.2017.01.016. Epub 2017 Feb 11.

PMID:
28196762
22.

Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections.

Maizels RM, Hewitson JP.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0043-2016. Review.

23.

IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha.

Jackson-Jones LH, Rückerl D, Svedberg F, Duncan S, Maizels RM, Sutherland TE, Jenkins SJ, McSorley HJ, Bénézech C, MacDonald AS, Allen JE.

Eur J Immunol. 2016 Oct;46(10):2311-2321. doi: 10.1002/eji.201646442.

24.

Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.

Jackson-Jones LH, Duncan SM, Magalhaes MS, Campbell SM, Maizels RM, McSorley HJ, Allen JE, Bénézech C.

Nat Commun. 2016 Sep 1;7:12651. doi: 10.1038/ncomms12651.

25.

Regulation of the host immune system by helminth parasites.

Maizels RM, McSorley HJ.

J Allergy Clin Immunol. 2016 Sep;138(3):666-675. doi: 10.1016/j.jaci.2016.07.007. Epub 2016 Jul 29. Review.

26.

Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology.

Simbari F, McCaskill J, Coakley G, Millar M, Maizels RM, Fabriás G, Casas J, Buck AH.

J Extracell Vesicles. 2016 Jul 5;5:30741. doi: 10.3402/jev.v5.30741. eCollection 2016.

27.

Host parasite communications-Messages from helminths for the immune system: Parasite communication and cell-cell interactions.

Coakley G, Buck AH, Maizels RM.

Mol Biochem Parasitol. 2016 Jul;208(1):33-40. doi: 10.1016/j.molbiopara.2016.06.003. Epub 2016 Jun 11. Review.

28.

Parasitic helminth infections and the control of human allergic and autoimmune disorders.

Maizels RM.

Clin Microbiol Infect. 2016 Jun;22(6):481-6. doi: 10.1016/j.cmi.2016.04.024. Epub 2016 May 10. Review.

29.

Macrobiota - helminths as active participants and partners of the microbiota in host intestinal homeostasis.

Gause WC, Maizels RM.

Curr Opin Microbiol. 2016 Aug;32:14-18. doi: 10.1016/j.mib.2016.04.004. Epub 2016 Apr 23. Review.

30.

Corrigendum: CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Mackley EC, Houston S, Marriott CL, Halford EE, Lucas B, Cerovic V, Filbey KJ, Maizels RM, Hepworth MR, Sonnenberg GF, Milling S, Withers DR.

Nat Commun. 2016 Mar 29;7:11186. doi: 10.1038/ncomms11186. No abstract available.

31.

Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.

32.

Microbes and asthma: Opportunities for intervention.

Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C.

J Allergy Clin Immunol. 2016 Mar;137(3):690-7. doi: 10.1016/j.jaci.2016.01.004. Review.

PMID:
26947981
33.

Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut.

Obieglo K, Feng X, Bollampalli VP, Dellacasa-Lindberg I, Classon C, Österblad M, Helmby H, Hewitson JP, Maizels RM, Gigliotti Rothfuchs A, Nylén S.

J Immunol. 2016 Mar 1;196(5):2262-71. doi: 10.4049/jimmunol.1500970. Epub 2016 Jan 27.

34.

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites.

Gerbe F, Sidot E, Smyth DJ, Ohmoto M, Matsumoto I, Dardalhon V, Cesses P, Garnier L, Pouzolles M, Brulin B, Bruschi M, Harcus Y, Zimmermann VS, Taylor N, Maizels RM, Jay P.

Nature. 2016 Jan 14;529(7585):226-30. doi: 10.1038/nature16527.

PMID:
26762460
35.

Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus.

Hewitson JP, Nguyen DL, van Diepen A, Smit CH, Koeleman CA, McSorley HJ, Murray J, Maizels RM, Hokke CH.

Int J Parasitol. 2016 Mar;46(3):157-170. doi: 10.1016/j.ijpara.2015.10.004. Epub 2015 Dec 12.

36.

A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection.

Lundie RJ, Webb LM, Marley AK, Phythian-Adams AT, Cook PC, Jackson-Jones LH, Brown S, Maizels RM, Boon L, O'Keeffe M, MacDonald AS.

Immunol Cell Biol. 2016 Apr;94(4):400-10. doi: 10.1038/icb.2015.114. Epub 2015 Dec 11.

37.

TGF-β in tolerance, development and regulation of immunity.

Johnston CJ, Smyth DJ, Dresser DW, Maizels RM.

Cell Immunol. 2016 Jan;299:14-22. doi: 10.1016/j.cellimm.2015.10.006. Epub 2015 Nov 23.

38.

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.

Tyagi N, Farnell EJ, Fitzsimmons CM, Ryan S, Tukahebwa E, Maizels RM, Dunne DW, Thornton JM, Furnham N.

PLoS Comput Biol. 2015 Oct 29;11(10):e1004546. doi: 10.1371/journal.pcbi.1004546. eCollection 2015 Oct.

39.

Erratum: Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

Buck AH, Coakley G, Simbari F, McSorley HJ, Quintana JF, Le Bihan T, Kumar S, Abreu-Goodger C, Lear M, Harcus Y, Ceroni A, Babayan SA, Blaxter M, Ivens A, Maizels RM.

Nat Commun. 2015 Oct 22;6:8772. doi: 10.1038/ncomms9772. No abstract available.

40.

Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity.

Reynolds LA, Finlay BB, Maizels RM.

J Immunol. 2015 Nov 1;195(9):4059-66. doi: 10.4049/jimmunol.1501432. Review.

41.

Exosomes and Other Extracellular Vesicles: The New Communicators in Parasite Infections.

Coakley G, Maizels RM, Buck AH.

Trends Parasitol. 2015 Oct;31(10):477-489. doi: 10.1016/j.pt.2015.06.009. Review.

42.

Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.

Smith KA, Filbey KJ, Reynolds LA, Hewitson JP, Harcus Y, Boon L, Sparwasser T, Hämmerling G, Maizels RM.

Mucosal Immunol. 2016 Mar;9(2):428-43. doi: 10.1038/mi.2015.73. Epub 2015 Aug 19.

43.

Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.

Redpath SA, van der Werf N, MacDonald AS, Maizels RM, Taylor MD.

Infect Immun. 2015 Oct;83(10):3881-9. doi: 10.1128/IAI.00408-15. Epub 2015 Jul 20.

44.

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.

Cook PC, Owen H, Deaton AM, Borger JG, Brown SL, Clouaire T, Jones GR, Jones LH, Lundie RJ, Marley AK, Morrison VL, Phythian-Adams AT, Wachter E, Webb LM, Sutherland TE, Thomas GD, Grainger JR, Selfridge J, McKenzie AN, Allen JE, Fagerholm SC, Maizels RM, Ivens AC, Bird A, MacDonald AS.

Nat Commun. 2015 Apr 24;6:6920. doi: 10.1038/ncomms7920.

45.

Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM.

PLoS Pathog. 2015 Mar 27;11(3):e1004676. doi: 10.1371/journal.ppat.1004676. eCollection 2015 Mar.

46.

Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation.

McSorley HJ, Blair NF, Robertson E, Maizels RM.

Exp Parasitol. 2015 Nov;158:8-17. doi: 10.1016/j.exppara.2015.02.009. Epub 2015 Feb 26.

PMID:
25728231
47.

Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection.

Farnell EJ, Tyagi N, Ryan S, Chalmers IW, Pinot de Moira A, Jones FM, Wawrzyniak J, Fitzsimmons CM, Tukahebwa EM, Furnham N, Maizels RM, Dunne DW.

Front Immunol. 2015 Feb 3;6:26. doi: 10.3389/fimmu.2015.00026. eCollection 2015.

48.

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Mackley EC, Houston S, Marriott CL, Halford EE, Lucas B, Cerovic V, Filbey KJ, Maizels RM, Hepworth MR, Sonnenberg GF, Milling S, Withers DR.

Nat Commun. 2015 Jan 9;6:5862. doi: 10.1038/ncomms6862. Erratum in: Nat Commun. 2016;7:11186.

49.

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

Buck AH, Coakley G, Simbari F, McSorley HJ, Quintana JF, Le Bihan T, Kumar S, Abreu-Goodger C, Lear M, Harcus Y, Ceroni A, Babayan SA, Blaxter M, Ivens A, Maizels RM.

Nat Commun. 2014 Nov 25;5:5488. doi: 10.1038/ncomms6488. Erratum in: Nat Commun. 2015;6:8772.

50.

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.

Sutherland TE, Logan N, Rückerl D, Humbles AA, Allan SM, Papayannopoulos V, Stockinger B, Maizels RM, Allen JE.

Nat Immunol. 2014 Dec;15(12):1116-25. doi: 10.1038/ni.3023. Epub 2014 Oct 19.

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