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Items: 1 to 50 of 111

1.

A Translational Model for Diet-related Atherosclerosis: Effect of Statins on Hypercholesterolemia and Atherosclerosis in a Minipig.

Amuzie C, Swart JR, Rogers CS, Vihtelic T, Denham S, Mais DE.

Toxicol Pathol. 2016 Apr;44(3):442-9. doi: 10.1177/0192623315622304. Epub 2016 Feb 16.

PMID:
26883155
2.

VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever.

Leblanc P, Moise L, Luza C, Chantaralawan K, Lezeau L, Yuan J, Field M, Richer D, Boyle C, Martin WD, Fishman JB, Berg EA, Baker D, Zeigler B, Mais DE, Taylor W, Coleman R, Warren HS, Gelfand JA, De Groot AS, Brauns T, Poznansky MC.

Hum Vaccin Immunother. 2014;10(10):3022-38. doi: 10.4161/hv.34413. Review.

3.

Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation.

Roach SL, Higuchi RI, Hudson AR, Vassar A, Grant VH, Lamer R, Hooper C, Rungta D, Syka PM, Mais DE, Marschke KB, Zhi L.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1658-62. doi: 10.1016/j.bmcl.2011.01.106. Epub 2011 Jan 27.

PMID:
21349714
4.

Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.

Hudson AR, Higuchi RI, Roach SL, Valdez LJ, Adams ME, Vassar A, Rungta D, Syka PM, Mais DE, Marschke KB, Zhi L.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1654-7. doi: 10.1016/j.bmcl.2011.01.104. Epub 2011 Jan 27.

PMID:
21324689
5.

Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.

Hudson AR, Higuchi RI, Roach SL, Adams ME, Vassar A, Syka PM, Mais DE, Miner JN, Marschke KB, Zhi L.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1697-700. doi: 10.1016/j.bmcl.2011.01.093. Epub 2011 Jan 26.

PMID:
21316964
6.

Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.

Roach SL, Higuchi RI, Hudson AR, Adams ME, Syka PM, Mais DE, Miner JN, Marschke KB, Zhi L.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):168-71. doi: 10.1016/j.bmcl.2010.11.047. Epub 2010 Nov 11.

PMID:
21115247
7.

High-throughput screening for bioactive components from traditional Chinese medicine.

Zhu Y, Zhang Z, Zhang M, Mais DE, Wang MW.

Comb Chem High Throughput Screen. 2010 Dec;13(10):837-48. Review.

PMID:
20883195
8.

Characterization of a novel non-steroidal glucocorticoid receptor antagonist.

Li QY, Zhang M, Hallis TM, Derosier TA, Yue JM, Ye Y, Mais DE, Wang MW.

Biochem Biophys Res Commun. 2010 Jan 15;391(3):1531-6. doi: 10.1016/j.bbrc.2009.12.117. Epub 2009 Dec 24.

PMID:
20035723
9.

Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats.

Vajda EG, Hogue A, Griffiths KN, Chang WY, Burnett K, Chen Y, Marschke K, Mais DE, Pedram B, Shen Y, van Oeveren A, Zhi L, López FJ, Meglasson MD.

J Bone Miner Res. 2009 Feb;24(2):231-40. doi: 10.1359/jbmr.081007.

10.

A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.

Pedram B, van Oeveren A, Mais DE, Marschke KB, Verbost PM, Groen MB, Zhi L.

J Med Chem. 2008 Jul 10;51(13):3696-9. doi: 10.1021/jm8004256. Epub 2008 Jun 14.

PMID:
18553958
11.

Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.

Roach SL, Higuchi RI, Adams ME, Liu Y, Karanewsky DS, Marschke KB, Mais DE, Miner JN, Zhi L.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3504-8. doi: 10.1016/j.bmcl.2008.05.029. Epub 2008 May 11.

PMID:
18513967
12.

Discovery and biological characterization of a novel series of androgen receptor modulators.

Zhou C, Wu G, Feng Y, Li Q, Su H, Mais DE, Zhu Y, Li N, Deng Y, Yang D, Wang MW.

Br J Pharmacol. 2008 May;154(2):440-50. doi: 10.1038/bjp.2008.107. Epub 2008 Apr 14. Erratum in: Br J Pharmacol. 2008 Jul;154(5):1161.

13.

Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.

Miner JN, Ardecky B, Benbatoul K, Griffiths K, Larson CJ, Mais DE, Marschke K, Rosen J, Vajda E, Zhi L, Negro-Vilar A.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. Epub 2007 Nov 21.

14.

Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.

Hudson AR, Roach SL, Higuchi RI, Phillips DP, Bissonnette RP, Lamph WW, Yen J, Li Y, Adams ME, Valdez LJ, Vassar A, Cuervo C, Kallel EA, Gharbaoui CJ, Mais DE, Miner JN, Marschke KB, Rungta D, Negro-Vilar A, Zhi L.

J Med Chem. 2007 Sep 20;50(19):4699-709. Epub 2007 Aug 17.

PMID:
17705362
15.

Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.

Higuchi RI, Arienti KL, López FJ, Mani NS, Mais DE, Caferro TR, Long YO, Jones TK, Edwards JP, Zhi L, Schrader WT, Negro-Vilar A, Marschke KB.

J Med Chem. 2007 May 17;50(10):2486-96. Epub 2007 Apr 17.

PMID:
17439112
16.

Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes.

Leibowitz MD, Ardecky RJ, Boehm MF, Broderick CL, Carfagna MA, Crombie DL, D'Arrigo J, Etgen GJ, Faul MM, Grese TA, Havel H, Hein NI, Heyman RA, Jolley D, Klausing K, Liu S, Mais DE, Mapes CM, Marschke KB, Michellys PY, Montrose-Rafizadeh C, Ogilvie KM, Pascual B, Rungta D, Tyhonas JS, Urcan MS, Wardlow M, Yumibe N, Reifel-Miller A.

Endocrinology. 2006 Feb;147(2):1044-53. Epub 2005 Nov 3.

PMID:
16269450
17.

Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis.

Wang M, Winneroski LL, Ardecky RJ, Babine RE, Brooks DA, Etgen GJ, Hutchison DR, Kauffman RF, Kunkel A, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters MK, Rito CJ, Rungta DK, Tripp AE, Wilson SB, Xu Y, Zink RW, McCarthy JR.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6113-6.

PMID:
15546740
18.

Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.

Xu Y, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR.

J Med Chem. 2004 May 6;47(10):2422-5.

PMID:
15115385
19.

5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Motamedi M, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT.

J Med Chem. 2003 Sep 11;46(19):4104-12.

PMID:
12954062
20.

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.

Zhi L, Ringgenberg JD, Edwards JP, Tegley CM, West SJ, Pio B, Motamedi M, Jones TK, Marschke KB, Mais DE, Schrader WT.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2075-8.

PMID:
12781198
21.

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2071-4.

PMID:
12781197
22.

Synthesis and Characterization of a Highly Potent and Selective Isotopically Labeled Retinoic Acid Receptor Ligand, ALRT1550.

Bennani YL, Marron KS, Mais DE, Flatten K, Nadzan AM, Boehm MF.

J Org Chem. 1998 Feb 6;63(3):543-550.

PMID:
11672043
23.

A selective peroxisome proliferator-activated receptor-gamma (PPARgamma) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes.

Mukherjee R, Hoener PA, Jow L, Bilakovics J, Klausing K, Mais DE, Faulkner A, Croston GE, Paterniti JR Jr.

Mol Endocrinol. 2000 Sep;14(9):1425-33.

PMID:
10976920
24.

Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.

Zhi L, Tegley CM, Pio B, West SJ, Marschke KB, Mais DE, Jones TK.

Bioorg Med Chem Lett. 2000 Mar 6;10(5):415-8.

PMID:
10743938
25.

Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3.

Boehm MF, Fitzgerald P, Zou A, Elgort MG, Bischoff ED, Mere L, Mais DE, Bissonnette RP, Heyman RA, Nadzan AM, Reichman M, Allegretto EA.

Chem Biol. 1999 May;6(5):265-75.

26.
27.

Estrogen receptor beta activates the human retinoic acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen.

Zou A, Marschke KB, Arnold KE, Berger EM, Fitzgerald P, Mais DE, Allegretto EA.

Mol Endocrinol. 1999 Mar;13(3):418-30.

PMID:
10076999
28.

The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins.

Wagner BL, Pollio G, Giangrande P, Webster JC, Breslin M, Mais DE, Cook CE, Vedeckis WV, Cidlowski JA, McDonnell DP.

Endocrinology. 1999 Mar;140(3):1449-58.

PMID:
10067874
30.

5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.

Zhi L, Tegley CM, Edwards JP, West SJ, Marschke KB, Gottardis MM, Mais DE, Jones TK.

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3365-70.

PMID:
9873735
31.

Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.

Hamann LG, Winn DT, Pooley CL, Tegley CM, West SJ, Farmer LJ, Zhi L, Edwards JP, Marschke KB, Mais DE, Goldman ME, Jones TK.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2731-6.

PMID:
9873612
32.
33.

Expression, characterization, and purification of C-terminally hexahistidine-tagged thromboxane A2 receptors.

Pawate S, Schey KL, Meier GP, Ullian ME, Mais DE, Halushka PV.

J Biol Chem. 1998 Aug 28;273(35):22753-60.

34.

5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents.

Edwards JP, West SJ, Marschke KB, Mais DE, Gottardis MM, Jones TK.

J Med Chem. 1998 Jan 29;41(3):303-10.

PMID:
9464361
35.

5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.

Zhi L, Tegley CM, Kallel EA, Marschke KB, Mais DE, Gottardis MM, Jones TK.

J Med Chem. 1998 Jan 29;41(3):291-302.

PMID:
9464360
36.

Phytol metabolites are circulating dietary factors that activate the nuclear receptor RXR.

Kitareewan S, Burka LT, Tomer KB, Parker CE, Deterding LJ, Stevens RD, Forman BM, Mais DE, Heyman RA, McMorris T, Weinberger C.

Mol Biol Cell. 1996 Aug;7(8):1153-66.

37.

Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.

Zhang L, Nadzan AM, Heyman RA, Love DL, Mais DE, Croston G, Lamph WW, Boehm MF.

J Med Chem. 1996 Jul 5;39(14):2659-63.

PMID:
8709094
38.

Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.

Hamann LG, Farmer LJ, Johnson MG, Bender SL, Mais DE, Wang MW, Crombie D, Goldman ME, Jones TK.

J Med Chem. 1996 Apr 26;39(9):1778-89.

PMID:
8627601
39.

Discovery of novel intracellular receptor modulating drugs.

Jones TK, Pathirana C, Goldman ME, Hamann LG, Farmer LJ, Ianiro T, Johnson MG, Bender SL, Mais DE, Stein RB.

J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):61-6. Review.

PMID:
8603048
40.

Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.

Boehm MF, Zhang L, Zhi L, McClurg MR, Berger E, Wagoner M, Mais DE, Suto CM, Davies JA, Heyman RA, et al.

J Med Chem. 1995 Aug 4;38(16):3146-55.

PMID:
7636877
41.
42.

Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists.

Hamann LG, Farmer LJ, Johnson MG, Goldman ME, Mais DE, Davtian A, Bender SL, Jones TK.

Ann N Y Acad Sci. 1995 Jun 12;761:383-7. No abstract available.

PMID:
7625742
43.

Anti-progesterone antibody administration and the impairment of postpartum maternal care in mice.

Wang MW, Crombie DL, Mais DE, Hayes JS, Heap RB.

J Endocrinol. 1995 May;145(2):363-9.

PMID:
7616170
44.

Nonsteroidal human progesterone receptor modulators from the marine alga Cymopolia barbata.

Pathirana C, Stein RB, Berger TS, Fenical W, Ianiro T, Mais DE, Torres A, Goldman ME.

Mol Pharmacol. 1995 Mar;47(3):630-5.

PMID:
7700260
45.

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

Wen DX, Xu YF, Mais DE, Goldman ME, McDonnell DP.

Mol Cell Biol. 1994 Dec;14(12):8356-64.

46.

Effect of alkaline phosphatase on thromboxane mimetic induced platelet activation.

Margolin N, True TA, Saussy DL Jr, Mais DE.

Prostaglandins. 1994 Oct;48(4):235-46.

PMID:
7878191
47.

Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.

Boehm MF, Zhang L, Badea BA, White SK, Mais DE, Berger E, Suto CM, Goldman ME, Heyman RA.

J Med Chem. 1994 Sep 2;37(18):2930-41.

PMID:
8071941
48.

Ryanodine and an iodinated analog: doxorubicin effects on binding and Ca2+ accumulation in cardiac sarcoplasmic reticulum.

Bowling N, Mais DE, Gerzon K, Watanabe AM.

Eur J Pharmacol. 1994 Aug 16;268(3):365-73.

PMID:
7805760
50.

Characterization of thromboxane A2/prostaglandin H2 binding sites in guinea pig cardiac membrane preparations.

Bowling N, Dubé GP, Kurtz WL, Brune KA, Saussy DL Jr, Dorn GW 2nd, Mais DE.

J Mol Cell Cardiol. 1994 Jul;26(7):915-23.

PMID:
7966360

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