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Items: 1 to 50 of 300

1.

Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal Cannabis sativa Variety: Δ9-Tetrahydrocannabutol, the Butyl Homologue of Δ9-Tetrahydrocannabinol.

Linciano P, Citti C, Luongo L, Belardo C, Maione S, Vandelli MA, Forni F, Gigli G, Laganà A, Montone CM, Cannazza G.

J Nat Prod. 2020 Jan 24;83(1):88-98. doi: 10.1021/acs.jnatprod.9b00876. Epub 2019 Dec 31.

PMID:
31891265
2.

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol.

Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G.

Sci Rep. 2019 Dec 30;9(1):20335. doi: 10.1038/s41598-019-56785-1.

3.

Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer.

Benedetti R, Dell'Aversana C, De Marchi T, Rotili D, Liu NQ, Novakovic B, Boccella S, Di Maro S, Cosconati S, Baldi A, Niméus E, Schultz J, Höglund U, Maione S, Papulino C, Chianese U, Iovino F, Federico A, Mai A, Stunnenberg HG, Nebbioso A, Altucci L.

Cancers (Basel). 2019 Dec 16;11(12). pii: E2027. doi: 10.3390/cancers11122027.

4.

The cold case of metabotropic glutamate receptor 6: Unjust detention in the retina?

Palazzo E, Boccella S, Marabese I, Pierretti G, Guida F, Maione S.

Curr Neuropharmacol. 2019 Oct 1. doi: 10.2174/1570159X17666191001141849. [Epub ahead of print]

PMID:
31573889
5.

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice.

Medeiros P, de Freitas RL, Boccella S, Iannotta M, Belardo C, Mazzitelli M, Romano R, De Gregorio D, Coimbra NC, Palazzo E, Maione S.

J Neurosci Res. 2020 Feb;98(2):338-352. doi: 10.1002/jnr.24501. Epub 2019 Aug 8.

PMID:
31396990
6.

N-methyl-D-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain.

Medeiros P, Negrini-Ferrari SE, Palazzo E, Maione S, Ferreira SH, de Freitas RL, Coimbra NC.

Neurochem Res. 2019 Sep;44(9):2068-2080. doi: 10.1007/s11064-019-02843-z. Epub 2019 Jul 17.

PMID:
31317507
7.

The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum.

Boccella S, Marabese I, Guida F, Luongo L, Maione S, Palazzo E.

Curr Neuropharmacol. 2020;18(1):34-50. doi: 10.2174/1570159X17666190618121859.

PMID:
31210112
8.

Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain Injury.

Belardo C, Iannotta M, Boccella S, Rubino RC, Ricciardi F, Infantino R, Pieretti G, Stella L, Paino S, Marabese I, Maisto R, Luongo L, Maione S, Guida F.

Front Pharmacol. 2019 Apr 16;10:352. doi: 10.3389/fphar.2019.00352. eCollection 2019.

9.

Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain.

Boccella S, Marabese I, Iannotta M, Belardo C, Neugebauer V, Mazzitelli M, Pieretti G, Maione S, Palazzo E.

Int J Mol Sci. 2019 Apr 9;20(7). pii: E1757. doi: 10.3390/ijms20071757.

10.

Editorial: Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders.

Palazzo E, Neugebauer V, Maione S.

Front Mol Neurosci. 2019 Mar 22;12:67. doi: 10.3389/fnmol.2019.00067. eCollection 2019. No abstract available.

11.

Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain.

Guida F, Boccella S, Belardo C, Iannotta M, Piscitelli F, De Filippis F, Paino S, Ricciardi F, Siniscalco D, Marabese I, Luongo L, Ercolini D, Di Marzo V, Maione S.

Brain Behav Immun. 2019 Apr 3. pii: S0889-1591(18)31247-9. doi: 10.1016/j.bbi.2019.04.006. [Epub ahead of print]

12.

Sweeteners modulate bioactivity of endothelial progenitor cells but not induce detrimental effects both on inflammation and behavioural changes.

Schiano C, Grimaldi V, Boccella S, Iannotta M, Zullo A, Luongo L, Mancini FP, Maione S, Napoli C.

Int J Food Sci Nutr. 2019 Sep;70(6):725-737. doi: 10.1080/09637486.2018.1563052. Epub 2019 Feb 18.

PMID:
30775939
13.

Group II Metabotropic Glutamate Receptors: Role in Pain Mechanisms and Pain Modulation.

Mazzitelli M, Palazzo E, Maione S, Neugebauer V.

Front Mol Neurosci. 2018 Oct 9;11:383. doi: 10.3389/fnmol.2018.00383. eCollection 2018. Review.

14.

Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.

Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S, Luongo L.

Neurobiol Dis. 2019 Jan;121:106-119. doi: 10.1016/j.nbd.2018.09.023. Epub 2018 Sep 25.

PMID:
30266286
15.

FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug.

Ligresti A, Silvestri C, Vitale RM, Martos JL, Piscitelli F, Wang JW, Allarà M, Carling RW, Luongo L, Guida F, Illiano A, Amoresano A, Maione S, Amodeo P, Woodward DF, Di Marzo V, Marino G.

ACS Chem Neurosci. 2019 Jan 16;10(1):424-437. doi: 10.1021/acschemneuro.8b00315. Epub 2018 Oct 4.

PMID:
30226747
16.

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.

De Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J, Lopez-Canul M, Aboud M, Maione S, Comai S, Gobbi G.

Pain. 2019 Jan;160(1):136-150. doi: 10.1097/j.pain.0000000000001386.

17.

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

Boccella S, Guida F, De Logu F, De Gregorio D, Mazzitelli M, Belardo C, Iannotta M, Serra N, Nassini R, de Novellis V, Geppetti P, Maione S, Luongo L.

FASEB J. 2019 Jan;33(1):1062-1073. doi: 10.1096/fj.201801033R. Epub 2018 Aug 7.

PMID:
30085883
18.

Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.

Bruno F, Errico S, Pace S, Nawrozkij MB, Mkrtchyan AS, Guida F, Maisto R, Olgaç A, D'Amico M, Maione S, De Rosa M, Banoglu E, Werz O, Fiorentino A, Filosa R.

Eur J Med Chem. 2018 Jul 15;155:946-960. doi: 10.1016/j.ejmech.2018.05.041. Epub 2018 May 28.

PMID:
30015253
19.

N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.

Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R.

Neuropharmacology. 2019 Apr;148:320-331. doi: 10.1016/j.neuropharm.2018.03.020. Epub 2018 Mar 19.

PMID:
29567093
20.

Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats.

Marabese I, Boccella S, Iannotta M, Luongo L, de Novellis V, Guida F, Serra N, Farina A, Maione S, Palazzo E.

Neuropharmacology. 2018 Jun;135:86-99. doi: 10.1016/j.neuropharm.2018.03.003. Epub 2018 Mar 2.

PMID:
29505788
21.

Right Care in Hospital Medicine: Co-creation of Ten Opportunities in Overuse and Underuse for Improving Value in Hospital Medicine.

Cho HJ, Wray CM, Maione S, Macharet F, Bansal A, Lacy ME, Tsega S.

J Gen Intern Med. 2018 Jun;33(6):804-806. doi: 10.1007/s11606-018-4371-4. No abstract available.

22.

Neuroimmune-Driven Neuropathic Pain Establishment: A Focus on Gender Differences.

Coraggio V, Guida F, Boccella S, Scafuro M, Paino S, Romano D, Maione S, Luongo L.

Int J Mol Sci. 2018 Jan 17;19(1). pii: E281. doi: 10.3390/ijms19010281. Review.

23.

Celecoxib Prevents Cognitive Impairment and Neuroinflammation in Soluble Amyloid β-treated Rats.

Mhillaj E, Morgese MG, Tucci P, Furiano A, Luongo L, Bove M, Maione S, Cuomo V, Schiavone S, Trabace L.

Neuroscience. 2018 Feb 21;372:58-73. doi: 10.1016/j.neuroscience.2017.12.046. Epub 2018 Jan 3.

PMID:
29306052
24.

Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists.

Petrelli R, Scortichini M, Belardo C, Boccella S, Luongo L, Capone F, Kachler S, Vita P, Del Bello F, Maione S, Lavecchia A, Klotz KN, Cappellacci L.

J Med Chem. 2018 Jan 11;61(1):305-318. doi: 10.1021/acs.jmedchem.7b01399. Epub 2018 Jan 3.

PMID:
29257884
25.

Spared Nerve Injury as a Long-Lasting Model of Neuropathic Pain.

Boccella S, Guida F, Palazzo E, Marabese I, de Novellis V, Maione S, Luongo L.

Methods Mol Biol. 2018;1727:373-378. doi: 10.1007/978-1-4939-7571-6_28.

PMID:
29222796
26.

Polymorphism Analysis of Ch1 and Ch2 Genes in the Siberian Cat.

Sartore S, Landoni E, Maione S, Tarducci A, Borrelli A, Soglia D, Rasero R, Sacchi P.

Vet Sci. 2017 Dec 1;4(4). pii: E63. doi: 10.3390/vetsci4040063.

27.

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice.

Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S, Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S.

Brain Behav Immun. 2018 Jan;67:230-245. doi: 10.1016/j.bbi.2017.09.001. Epub 2017 Sep 7.

PMID:
28890155
28.

d-Aspartic acid ameliorates painful and neuropsychiatric changes and reduces β-amyloid Aβ1-42 peptide in a long lasting model of neuropathic pain.

D'Aniello A, Luongo L, Romano R, Iannotta M, Marabese I, Boccella S, Belardo C, de Novellis V, Arra C, Barbieri A, D'Aniello B, Scandurra A, Magliozzi L, Fisher G, Guida F, Maione S.

Neurosci Lett. 2017 Jun 9;651:151-158. doi: 10.1016/j.neulet.2017.04.041. Epub 2017 May 6.

PMID:
28487079
29.

Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.

Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L.

J Med Chem. 2017 May 25;60(10):4327-4341. doi: 10.1021/acs.jmedchem.7b00291. Epub 2017 May 5.

30.

Distinguishing industrial meat from that of indigenous chickens with molecular markers.

Soglia D, Sacchi P, Sartore S, Maione S, Schiavone A, De Marco M, Bottero MT, Dalmasso A, Pattono D, Rasero R.

Poult Sci. 2017 Aug 1;96(8):2552-2561. doi: 10.3382/ps/pex077.

31.

Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.

Sacchi S, Novellis V, Paolone G, Nuzzo T, Iannotta M, Belardo C, Squillace M, Bolognesi P, Rosini E, Motta Z, Frassineti M, Bertolino A, Pollegioni L, Morari M, Maione S, Errico F, Usiello A.

Sci Rep. 2017 Apr 10;7:46288. doi: 10.1038/srep46288.

32.

Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor.

Guida F, Luongo L, Boccella S, Giordano ME, Romano R, Bellini G, Manzo I, Furiano A, Rizzo A, Imperatore R, Iannotti FA, D'Aniello E, Piscitelli F, Sca Rossi F, Cristino L, Di Marzo V, de Novellis V, Maione S.

Sci Rep. 2017 Mar 23;7(1):375. doi: 10.1038/s41598-017-00342-1.

33.

Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain Injury.

Guida F, Boccella S, Iannotta M, De Gregorio D, Giordano C, Belardo C, Romano R, Palazzo E, Scafuro MA, Serra N, de Novellis V, Rossi F, Maione S, Luongo L.

Front Pharmacol. 2017 Mar 6;8:95. doi: 10.3389/fphar.2017.00095. eCollection 2017.

34.

Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE).

Luongo L, Starowicz K, Maione S, Di Marzo V.

Pharmacol Res. 2017 May;119:272-277. doi: 10.1016/j.phrs.2017.02.019. Epub 2017 Feb 22. Review.

PMID:
28237514
35.

PKCβII-mediated cross-talk of TRPV1/CB2 modulates the glucocorticoid-induced osteoclast overactivity.

Bellini G, Torella M, Manzo I, Tortora C, Luongo L, Punzo F, Colacurci N, Nobili B, Maione S, Rossi F.

Pharmacol Res. 2017 Jan;115:267-274. doi: 10.1016/j.phrs.2016.11.039. Epub 2016 Dec 2.

PMID:
27919827
36.

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors.

De Gregorio D, Posa L, Ochoa-Sanchez R, McLaughlin R, Maione S, Comai S, Gobbi G.

Pharmacol Res. 2016 Nov;113(Pt A):81-91. doi: 10.1016/j.phrs.2016.08.022. Epub 2016 Aug 17.

PMID:
27544651
37.

Nociception modulation by supraspinal group III metabotropic glutamate receptors.

Palazzo E, Marabese I, Luongo L, Guida F, de Novellis V, Maione S.

J Neurochem. 2017 May;141(4):507-519. doi: 10.1111/jnc.13725. Epub 2017 Feb 22. Review.

38.

Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications.

Palazzo E, Marabese I, de Novellis V, Rossi F, Maione S.

Curr Neuropharmacol. 2016;14(5):504-13. Review.

39.

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation.

Rossi F, Bellini G, Luongo L, Manzo I, Tolone S, Tortora C, Bernardo ME, Grandone A, Conforti A, Docimo L, Nobili B, Perrone L, Locatelli F, Maione S, Del Giudice EM.

J Clin Endocrinol Metab. 2016 Sep;101(9):3469-78. doi: 10.1210/jc.2015-4381. Epub 2016 Jun 13.

PMID:
27294325
40.

Genetic variability of two Italian indigenous chicken breeds inferred from microsatellite marker analysis.

Sartore S, Sacchi P, Soglia D, Maione S, Schiavone A, De Marco M, Ceccobelli S, Lasagna E, Rasero R.

Br Poult Sci. 2016 Aug;57(4):435-43. doi: 10.1080/00071668.2016.1187714. Epub 2016 Jun 15.

PMID:
27159279
41.

D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice.

Palazzo E, Luongo L, Guida F, Marabese I, Romano R, Iannotta M, Rossi F, D'Aniello A, Stella L, Marmo F, Usiello A, de Bartolomeis A, Maione S, de Novellis V.

Amino Acids. 2016 Jul;48(7):1553-67. doi: 10.1007/s00726-016-2205-4. Epub 2016 Apr 26.

PMID:
27115160
42.
43.

Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.

Punzo D, Errico F, Cristino L, Sacchi S, Keller S, Belardo C, Luongo L, Nuzzo T, Imperatore R, Florio E, De Novellis V, Affinito O, Migliarini S, Maddaloni G, Sisalli MJ, Pasqualetti M, Pollegioni L, Maione S, Chiariotti L, Usiello A.

J Neurosci. 2016 Mar 9;36(10):3064-78. doi: 10.1523/JNEUROSCI.3881-15.2016.

44.

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress.

Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C, Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A.

ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. doi: 10.1021/acschemneuro.5b00333. Epub 2016 Mar 22.

PMID:
26942555
45.

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.

Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S.

J Med Chem. 2016 Mar 24;59(6):2612-32. doi: 10.1021/acs.jmedchem.5b01812. Epub 2016 Mar 7.

46.

Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.

Peduto A, Krauth V, Collarile S, Dehm F, Ambruosi M, Belardo C, Guida F, Massa A, Esposito V, Maione S, de Rosa M, Werz O, Filosa R.

Eur J Med Chem. 2016 Jan 27;108:466-475. doi: 10.1016/j.ejmech.2015.11.048. Epub 2015 Dec 7.

PMID:
26708113
47.

The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche.

Bellini G, Grandone A, Torella M, Miraglia del Giudice E, Nobili B, Perrone L, Maione S, Rossi F.

PLoS One. 2015 Oct 8;10(10):e0140142. doi: 10.1371/journal.pone.0140142. eCollection 2015.

48.

Electroactive polymer-peptide conjugates for adhesive biointerfaces.

Maione S, Gil AM, Fabregat G, Del Valle LJ, Triguero J, Laurent A, Jacquemin D, Estrany F, Jiménez AI, Zanuy D, Cativiela C, Alemán C.

Biomater Sci. 2015 Oct 15;3(10):1395-405. doi: 10.1039/c5bm00160a. Epub 2015 Jul 8.

PMID:
26372182
49.

Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction.

Rinaldi B, Guida F, Furiano A, Donniacuo M, Luongo L, Gritti G, Urbanek K, Messina G, Maione S, Rossi F, de Novellis V.

Neural Plast. 2015;2015:265967. doi: 10.1155/2015/265967. Epub 2015 Jul 22.

50.

Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.

Guida F, Luongo L, Marmo F, Romano R, Iannotta M, Napolitano F, Belardo C, Marabese I, D'Aniello A, De Gregorio D, Rossi F, Piscitelli F, Lattanzi R, de Bartolomeis A, Usiello A, Di Marzo V, de Novellis V, Maione S.

Mol Brain. 2015 Aug 12;8:47. doi: 10.1186/s13041-015-0139-5.

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