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Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.

Mains RE, Blaby-Haas C, Rheaume BA, Eipper BA.

Endocrinology. 2018 Jul 1;159(7):2621-2639. doi: 10.1210/en.2018-00235.


Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme.

Kumar D, Thomason RT, Yankova M, Gitlin JD, Mains RE, Eipper BA, King SM.

Sci Rep. 2018 Mar 14;8(1):4547. doi: 10.1038/s41598-018-22732-9.


Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.

Katrancha SM, Wu Y, Zhu M, Eipper BA, Koleske AJ, Mains RE.

Hum Mol Genet. 2017 Dec 1;26(23):4728-4740. doi: 10.1093/hmg/ddx355.


Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors.

LaRese TP, Yan Y, Eipper BA, Mains RE.

BMC Neurosci. 2017 May 23;18(1):45. doi: 10.1186/s12868-017-0363-2.


A bioactive peptide amidating enzyme is required for ciliogenesis.

Kumar D, Strenkert D, Patel-King RS, Leonard MT, Merchant SS, Mains RE, King SM, Eipper BA.

Elife. 2017 May 17;6. pii: e25728. doi: 10.7554/eLife.25728.


Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.

Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE.

ACS Chem Neurosci. 2017 Jul 19;8(7):1554-1569. doi: 10.1021/acschemneuro.7b00076. Epub 2017 Apr 25.


The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.

Bäck N, Kanerva K, Kurutihalli V, Yanik A, Ikonen E, Mains RE, Eipper BA.

Eur J Cell Biol. 2017 Aug;96(5):407-417. doi: 10.1016/j.ejcb.2017.03.007. Epub 2017 Mar 28.


Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7.

Miller MB, Yan Y, Wu Y, Hao B, Mains RE, Eipper BA.

J Neurochem. 2017 Mar;140(6):889-902. doi: 10.1111/jnc.13749. Epub 2016 Sep 6.


Copper, zinc and calcium: imaging and quantification in anterior pituitary secretory granules.

Bonnemaison ML, Duffy ME, Mains RE, Vogt S, Eipper BA, Ralle M.

Metallomics. 2016 Sep 1;8(9):1012-22. doi: 10.1039/c6mt00079g. Epub 2016 Jul 18.


Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching.

Yan Y, Eipper BA, Mains RE.

Neuropharmacology. 2016 Aug;107:227-238. doi: 10.1016/j.neuropharm.2016.03.050. Epub 2016 Mar 30.


O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking.

Vishwanatha KS, Bäck N, Lam TT, Mains RE, Eipper BA.

J Biol Chem. 2016 Apr 29;291(18):9835-50. doi: 10.1074/jbc.M115.711838. Epub 2016 Mar 9.


Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity.

Kumar D, Blaby-Haas CE, Merchant SS, Mains RE, King SM, Eipper BA.

J Cell Sci. 2016 Mar 1;129(5):943-56. doi: 10.1242/jcs.177410. Epub 2016 Jan 19.


60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C.

Kumar D, Mains RE, Eipper BA.

J Mol Endocrinol. 2016 May;56(4):T63-76. doi: 10.1530/JME-15-0266. Epub 2015 Dec 14. Review.


Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells.

Carlson K, Pomerantz SC, Vafa O, Naso M, Strohl W, Mains RE, Eipper BA.

BMC Biotechnol. 2015 Oct 16;15:95. doi: 10.1186/s12896-015-0210-4.


Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme.

Bonnemaison ML, Bäck N, Duffy ME, Ralle M, Mains RE, Eipper BA.

J Biol Chem. 2015 Aug 28;290(35):21264-79. doi: 10.1074/jbc.M115.641027. Epub 2015 Jul 13.


Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells.

Carlson KR, Pomerantz SC, Li J, Vafa O, Naso M, Strohl W, Mains RE, Eipper BA.

BMC Biotechnol. 2015 Jun 27;15:61. doi: 10.1186/s12896-015-0173-5.


A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.

Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.

Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.


An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions.

Miller MB, Vishwanatha KS, Mains RE, Eipper BA.

J Biol Chem. 2015 May 22;290(21):13541-55. doi: 10.1074/jbc.M115.636746. Epub 2015 Apr 10.


Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching.

Yan Y, Eipper BA, Mains RE.

Cereb Cortex. 2015 Oct;25(10):3487-501. doi: 10.1093/cercor/bhu182. Epub 2014 Aug 21.


Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum.

Gaier ED, Kleppinger A, Ralle M, Covault J, Mains RE, Kenny AM, Eipper BA.

BMC Endocr Disord. 2014 Jul 15;14:58. doi: 10.1186/1472-6823-14-58.


Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.

Mandela P, Yan Y, LaRese T, Eipper BA, Mains RE.

Horm Behav. 2014 Jul;66(2):430-8. doi: 10.1016/j.yhbeh.2014.07.001. Epub 2014 Jul 9.


A histidine-rich linker region in peptidylglycine α-amidating monooxygenase has the properties of a pH sensor.

Vishwanatha K, Bäck N, Mains RE, Eipper BA.

J Biol Chem. 2014 May 2;289(18):12404-20. doi: 10.1074/jbc.M113.545947. Epub 2014 Mar 13.


Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl.

Ma XM, Miller MB, Vishwanatha KS, Gross MJ, Wang Y, Abbott T, Lam TT, Mains RE, Eipper BA.

Mol Biol Cell. 2014 May;25(9):1458-71. doi: 10.1091/mbc.E13-04-0215. Epub 2014 Mar 5.


Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function.

Gaier ED, Eipper BA, Mains RE.

Ann N Y Acad Sci. 2014 May;1314:15-23. doi: 10.1111/nyas.12378. Epub 2014 Mar 4.


In vivo and in vitro analyses of amygdalar function reveal a role for copper.

Gaier ED, Rodriguiz RM, Zhou J, Ralle M, Wetsel WC, Eipper BA, Mains RE.

J Neurophysiol. 2014 May;111(10):1927-39. doi: 10.1152/jn.00631.2013. Epub 2014 Feb 19.


The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.

Huang S, Eleniste PP, Wayakanon K, Mandela P, Eipper BA, Mains RE, Allen MR, Bruzzaniti A.

Bone. 2014 Mar;60:235-45. doi: 10.1016/j.bone.2013.12.023. Epub 2013 Dec 28.


Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity.

Gaier ED, Miller MB, Ralle M, Aryal D, Wetsel WC, Mains RE, Eipper BA.

J Neurochem. 2013 Dec;127(5):605-19. doi: 10.1111/jnc.12438. Epub 2013 Oct 13.


Role of adaptor proteins in secretory granule biogenesis and maturation.

Bonnemaison ML, Eipper BA, Mains RE.

Front Endocrinol (Lausanne). 2013 Aug 14;4:101. doi: 10.3389/fendo.2013.00101. eCollection 2013.


Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration.

Kiraly DD, Nemirovsky NE, LaRese TP, Tomek SE, Yahn SL, Olive MF, Eipper BA, Mains RE.

Mol Pharmacol. 2013 Oct;84(4):582-90. doi: 10.1124/mol.113.087106. Epub 2013 Jul 26.


Neuronal Rho GEFs in synaptic physiology and behavior.

Miller MB, Yan Y, Eipper BA, Mains RE.

Neuroscientist. 2013 Jun;19(3):255-73. doi: 10.1177/1073858413475486. Epub 2013 Feb 11. Review.


Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.

Wu JH, Fanaroff AC, Sharma KC, Smith LS, Brian L, Eipper BA, Mains RE, Freedman NJ, Zhang L.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):702-8. doi: 10.1161/ATVBAHA.112.300234. Epub 2013 Jan 3.


Kalrn plays key roles within and outside of the nervous system.

Mandela P, Yankova M, Conti LH, Ma XM, Grady J, Eipper BA, Mains RE.

BMC Neurosci. 2012 Nov 1;13:136. doi: 10.1186/1471-2202-13-136.


Copper signaling in the mammalian nervous system: synaptic effects.

Gaier ED, Eipper BA, Mains RE.

J Neurosci Res. 2013 Jan;91(1):2-19. doi: 10.1002/jnr.23143. Epub 2012 Nov 1. Review.


Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.

Eipper-Mains JE, Kiraly DD, Duff MO, Horowitz MJ, McManus CJ, Eipper BA, Graveley BR, Mains RE.

Genes Brain Behav. 2013 Feb;12(1):21-33. doi: 10.1111/j.1601-183X.2012.00873.x. Epub 2012 Nov 27.


Analysis of kalirin-7 knockout mice reveals different effects in female mice.

Mazzone CM, Larese TP, Kiraly DD, Eipper BA, Mains RE.

Mol Pharmacol. 2012 Dec;82(6):1241-9. doi: 10.1124/mol.112.080838. Epub 2012 Sep 18.


A role for kalirin in the response of rat medium spiny neurons to cocaine.

Ma XM, Huang JP, Xin X, Yan Y, Mains RE, Eipper BA.

Mol Pharmacol. 2012 Oct;82(4):738-45. Epub 2012 Jul 24.


Structural organization of the nine spectrin repeats of Kalirin.

Vishwanatha KS, Wang YP, Keutmann HT, Mains RE, Eipper BA.

Biochemistry. 2012 Jul 17;51(28):5663-73. Epub 2012 Jul 6.


Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression.

Eipper-Mains JE, Eipper BA, Mains RE.

Front Genet. 2012 Jun 13;3:109. doi: 10.3389/fgene.2012.00109. eCollection 2012.


Signaling from the secretory granule to the nucleus.

Rajagopal C, Mains RE, Eipper BA.

Crit Rev Biochem Mol Biol. 2012 Jul-Aug;47(4):391-406. doi: 10.3109/10409238.2012.694845. Epub 2012 Jun 8. Review.


High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics.

Gaier ED, Kleppinger A, Ralle M, Mains RE, Kenny AM, Eipper BA.

Exp Gerontol. 2012 Jul;47(7):491-6. doi: 10.1016/j.exger.2012.03.014. Epub 2012 Mar 29.


Probing the production of amidated peptides following genetic and dietary copper manipulations.

Yin P, Bousquet-Moore D, Annangudi SP, Southey BR, Mains RE, Eipper BA, Sweedler JV.

PLoS One. 2011;6(12):e28679. doi: 10.1371/journal.pone.0028679. Epub 2011 Dec 16.


Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity.

Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES.

BMC Neurosci. 2011 Dec 19;12:126. doi: 10.1186/1471-2202-12-126.


Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

Deinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA, Chao MV, Hempstead BL.

Sci Signal. 2011 Dec 6;4(202):ra82. doi: 10.1126/scisignal.2002060.


Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.

Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA.

J Neurosci. 2011 Aug 31;31(35):12554-65. doi: 10.1523/JNEUROSCI.3143-11.2011.


microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs.

Eipper-Mains JE, Kiraly DD, Palakodeti D, Mains RE, Eipper BA, Graveley BR.

RNA. 2011 Aug;17(8):1529-43. doi: 10.1261/rna.2775511. Epub 2011 Jun 27.


Identification of kalirin-7 as a potential post-synaptic density signaling hub.

Kiraly DD, Stone KL, Colangelo CM, Abbott T, Wang Y, Mains RE, Eipper BA.

J Proteome Res. 2011 Jun 3;10(6):2828-41. doi: 10.1021/pr200088w. Epub 2011 Apr 25.


Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.

Mains RE, Kiraly DD, Eipper-Mains JE, Ma XM, Eipper BA.

BMC Neurosci. 2011 Feb 17;12:20. doi: 10.1186/1471-2202-12-20.


Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase.

Chufán EE, Prigge ST, Siebert X, Eipper BA, Mains RE, Amzel LM.

J Am Chem Soc. 2010 Nov 10;132(44):15565-72. doi: 10.1021/ja103117r.


Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses.

Gaier ED, Rodriguiz RM, Ma XM, Sivaramakrishnan S, Bousquet-Moore D, Wetsel WC, Eipper BA, Mains RE.

J Neurosci. 2010 Oct 13;30(41):13656-69. doi: 10.1523/JNEUROSCI.2200-10.2010.


Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme.

Rajagopal C, Stone KL, Mains RE, Eipper BA.

J Biol Chem. 2010 Nov 5;285(45):34632-42. doi: 10.1074/jbc.M110.145334. Epub 2010 Sep 3.

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