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Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C.

Cell Death Dis. 2019 Feb 6;10(2):108. doi: 10.1038/s41419-018-1275-5.


Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field.

Weber EL, Woolley TE, Yeh CY, Ou KL, Maini PK, Chuong CM.

Exp Dermatol. 2019 Jan 25. doi: 10.1111/exd.13891. [Epub ahead of print]


A mathematical model of the use of supplemental oxygen to combat surgical site infection.

Jayathilake C, Maini PK, Hopf HW, Sean McElwain DL, Byrne HM, Flegg MB, Flegg JA.

J Theor Biol. 2019 Jan 16;466:11-23. doi: 10.1016/j.jtbi.2019.01.021. [Epub ahead of print]


Unraveling the Control of Cell Cycle Periods during Intestinal Stem Cell Differentiation.

Ballweg R, Lee S, Han X, Maini PK, Byrne H, Hong CI, Zhang T.

Biophys J. 2018 Dec 4;115(11):2250-2258. doi: 10.1016/j.bpj.2018.10.025. Epub 2018 Nov 3.


Post-buckling behaviour of a growing elastic rod.

Almet AA, Byrne HM, Maini PK, Moulton DE.

J Math Biol. 2018 Sep 11. doi: 10.1007/s00285-018-1292-0. [Epub ahead of print]


Identification of a Novel Clinical Phenotype of Severe Malaria using a Network-Based Clustering Approach.

Cominetti O, Smith D, Hoffman F, Jallow M, Thézénas ML, Huang H, Kwiatkowski D, Maini PK, Casals-Pascual C.

Sci Rep. 2018 Aug 27;8(1):12849. doi: 10.1038/s41598-018-31320-w.


Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK, Byrne HM.

J R Soc Interface. 2018 Aug;15(145). pii: 20180037. doi: 10.1098/rsif.2018.0037.


Inferring parameters of prey switching in a 1 predator-2 prey plankton system with a linear preference tradeoff.

Piltz SH, Harhanen L, Porter MA, Maini PK.

J Theor Biol. 2018 Nov 7;456:108-122. doi: 10.1016/j.jtbi.2018.07.005.


Theoretical Insights into the Retinal Dynamics of Vascular Endothelial Growth Factor in Patients Treated with Ranibizumab, Based on an Ocular Pharmacokinetic/Pharmacodynamic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Caruso A, Maini PK, Mazer NA.

Mol Pharm. 2018 Jul 2;15(7):2770-2784. doi: 10.1021/acs.molpharmaceut.8b00280. Epub 2018 May 29.


Mathematical Modeling of Cortical Neurogenesis Reveals that the Founder Population does not Necessarily Scale with Neurogenic Output.

Picco N, García-Moreno F, Maini PK, Woolley TE, Molnár Z.

Cereb Cortex. 2018 Jul 1;28(7):2540-2550. doi: 10.1093/cercor/bhy068.


Mathematical Oncology.

Anderson ARA, Maini PK.

Bull Math Biol. 2018 May;80(5):945-953. doi: 10.1007/s11538-018-0423-5. No abstract available.


The importance of geometry in the corneal micropocket angiogenesis assay.

Grogan JA, Connor AJ, Pitt-Francis JM, Maini PK, Byrne HM.

PLoS Comput Biol. 2018 Mar 9;14(3):e1006049. doi: 10.1371/journal.pcbi.1006049. eCollection 2018 Mar.


The impact of exclusion processes on angiogenesis models.

Pillay S, Byrne HM, Maini PK.

J Math Biol. 2018 Dec;77(6-7):1721-1759. doi: 10.1007/s00285-018-1214-1. Epub 2018 Mar 6.


The Evolution of Tumour Composition During Fractionated Radiotherapy: Implications for Outcome.

Lewin TD, Maini PK, Moros EG, Enderling H, Byrne HM.

Bull Math Biol. 2018 May;80(5):1207-1235. doi: 10.1007/s11538-018-0391-9. Epub 2018 Feb 27.


Editorial: Special Section on Multiscale Cancer Modeling.

Wang Z, Maini PK.

IEEE Trans Biomed Eng. 2017 Mar;64(3):501-503. doi: 10.1109/TBME.2017.2655439. Epub 2017 Feb 22. No abstract available.


DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion.

McLennan R, Bailey CM, Schumacher LJ, Teddy JM, Morrison JA, Kasemeier-Kulesa JC, Wolfe LA, Gogol MM, Baker RE, Maini PK, Kulesa PM.

J Cell Biol. 2017 Oct 2;216(10):3339-3354. doi: 10.1083/jcb.201612169. Epub 2017 Aug 15.


Semblance of Heterogeneity in Collective Cell Migration.

Schumacher LJ, Maini PK, Baker RE.

Cell Syst. 2017 Aug 23;5(2):119-127.e1. doi: 10.1016/j.cels.2017.06.006. Epub 2017 Jul 26.


Integrating Models to Quantify Environment-Mediated Drug Resistance.

Picco N, Sahai E, Maini PK, Anderson ARA.

Cancer Res. 2017 Oct 1;77(19):5409-5418. doi: 10.1158/0008-5472.CAN-17-0835. Epub 2017 Jul 28. Erratum in: Cancer Res. 2018 Feb 15;78(4):1124.


A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM, Maini PK.

PLoS Comput Biol. 2017 Jul 28;13(7):e1005688. doi: 10.1371/journal.pcbi.1005688. eCollection 2017 Jul.


Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Gadkar K, Mazer NA.

Mol Pharm. 2017 Aug 7;14(8):2690-2696. doi: 10.1021/acs.molpharmaceut.7b00164. Epub 2017 Jul 3.


Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.

Grogan JA, Connor AJ, Markelc B, Muschel RJ, Maini PK, Byrne HM, Pitt-Francis JM.

Biophys J. 2017 May 9;112(9):1767-1772. doi: 10.1016/j.bpj.2017.03.036.


A stochastic model for tumour control probability that accounts for repair from sublethal damage.

Ponce Bobadilla AV, Maini PK, Byrne H.

Math Med Biol. 2018 Jun 13;35(2):181-202. doi: 10.1093/imammb/dqw024.


Logistic Proliferation of Cells in Scratch Assays is Delayed.

Jin W, Shah ET, Penington CJ, McCue SW, Maini PK, Simpson MJ.

Bull Math Biol. 2017 May;79(5):1028-1050. doi: 10.1007/s11538-017-0267-4. Epub 2017 Mar 23.


Modeling angiogenesis: A discrete to continuum description.

Pillay S, Byrne HM, Maini PK.

Phys Rev E. 2017 Jan;95(1-1):012410. doi: 10.1103/PhysRevE.95.012410. Epub 2017 Jan 25.


Comparing individual-based approaches to modelling the self-organization of multicellular tissues.

Osborne JM, Fletcher AG, Pitt-Francis JM, Maini PK, Gavaghan DJ.

PLoS Comput Biol. 2017 Feb 13;13(2):e1005387. doi: 10.1371/journal.pcbi.1005387. eCollection 2017 Feb.


Obituary: Hans Meinhardt (1938-2016).

Maini PK, Othmer HG, Deutsch A.

Bull Math Biol. 2017 Feb;79(2):383-388. doi: 10.1007/s11538-016-0243-4. Epub 2017 Jan 4. No abstract available.


3D hybrid modelling of vascular network formation.

Perfahl H, Hughes BD, Alarcón T, Maini PK, Lloyd MC, Reuss M, Byrne HM.

J Theor Biol. 2017 Feb 7;414:254-268. doi: 10.1016/j.jtbi.2016.11.013. Epub 2016 Nov 24.


Modeling Longitudinal Preclinical Tumor Size Data to Identify Transient Dynamics in Tumor Response to Antiangiogenic Drugs.

Hutchinson LG, Mueller HJ, Gaffney EA, Maini PK, Wagg J, Phipps A, Boetsch C, Byrne HM, Ribba B.

CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):636-645. doi: 10.1002/psp4.12142. Epub 2016 Nov 14.


Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Parker A, Maclaren OJ, Fletcher AG, Muraro D, Kreuzaler PA, Byrne HM, Maini PK, Watson AJ, Pin C.

FASEB J. 2017 Feb;31(2):636-649. doi: 10.1096/fj.201601002. Epub 2016 Oct 20.


The spatial patterning potential of nonlinear diffusion: Comment on "Phase separation driven by density-dependent movement: A novel mechanism for ecological patterns" by Quan-Xing Liu et al.

Maini PK, Garikipati K.

Phys Life Rev. 2016 Dec;19:128-130. doi: 10.1016/j.plrev.2016.10.011. Epub 2016 Oct 26. No abstract available.


Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.

Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6630-E6638. Epub 2016 Oct 4. Erratum in: Proc Natl Acad Sci U S A. 2017 Jan 3;:.


Predicting the Influence of Microvascular Structure On Tumor Response to Radiotherapy.

Grogan JA, Markelc B, Connor AJ, Muschel RJ, Pitt-Francis JM, Maini PK, Byrne HM.

IEEE Trans Biomed Eng. 2017 Mar;64(3):504-511. doi: 10.1109/TBME.2016.2606563. Epub 2016 Sep 8.


The critical domain size of stochastic population models.

Reimer JR, Bonsall MB, Maini PK.

J Math Biol. 2017 Feb;74(3):755-782. doi: 10.1007/s00285-016-1021-5. Epub 2016 Jul 9.


Multidisciplinary approaches to understanding collective cell migration in developmental biology.

Schumacher LJ, Kulesa PM, McLennan R, Baker RE, Maini PK.

Open Biol. 2016 Jun;6(6). pii: 160056. doi: 10.1098/rsob.160056. Review.


Rethinking Models of Pattern Formation in Somitogenesis.

Maini PK, Baker RE, Schnell S.

Cell Syst. 2015 Oct 28;1(4):248-9. doi: 10.1016/j.cels.2015.10.004. Epub 2015 Oct 28.


Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.

Mukhopadhyay H, de Wet B, Clemens L, Maini PK, Allard J, van der Merwe PA, Dushek O.

Biophys J. 2016 Apr 26;110(8):1896-1906. doi: 10.1016/j.bpj.2016.03.024.


Vascular phenotype identification and anti-angiogenic treatment recommendation: A pseudo-multiscale mathematical model of angiogenesis.

Hutchinson LG, Gaffney EA, Maini PK, Wagg J, Phipps A, Byrne HM.

J Theor Biol. 2016 Jun 7;398:162-80. doi: 10.1016/j.jtbi.2016.03.002. Epub 2016 Mar 14.


Optimisation of simulations of stochastic processes by removal of opposing reactions.

Spill F, Maini PK, Byrne HM.

J Chem Phys. 2016 Feb 28;144(8):084105. doi: 10.1063/1.4942413.


Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model.

Scott JG, Fletcher AG, Anderson AR, Maini PK.

PLoS Comput Biol. 2016 Jan 22;12(1):e1004712. doi: 10.1371/journal.pcbi.1004712. eCollection 2016 Jan.


Models, measurement and inference in epithelial tissue dynamics.

Maclaren OJ, Byrne HM, Fletcher AG, Maini PK.

Math Biosci Eng. 2015 Dec;12(6):1321-40. doi: 10.3934/mbe.2015.12.1321. Review.


A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration.

Hutton-Smith LA, Gaffney EA, Byrne HM, Maini PK, Schwab D, Mazer NA.

Mol Pharm. 2016 Sep 6;13(9):2941-50. doi: 10.1021/acs.molpharmaceut.5b00849. Epub 2016 Jan 14.


Approximating the Critical Domain Size of Integrodifference Equations.

Reimer JR, Bonsall MB, Maini PK.

Bull Math Biol. 2016 Jan;78(1):72-109. doi: 10.1007/s11538-015-0129-x. Epub 2015 Dec 31.


On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process.

Flegg JA, Menon SN, Maini PK, McElwain DL.

Front Physiol. 2015 Sep 30;6:262. doi: 10.3389/fphys.2015.00262. eCollection 2015. Review.


Hybrid approaches for multiple-species stochastic reaction-diffusion models.

Spill F, Guerrero P, Alarcon T, Maini PK, Byrne H.

J Comput Phys. 2015 Oct 15;299:429-445.


Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.

Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG.

PLoS Comput Biol. 2015 Sep 11;11(9):e1004493. doi: 10.1371/journal.pcbi.1004493. eCollection 2015 Sep.


An integrated approach to quantitative modelling in angiogenesis research.

Connor AJ, Nowak RP, Lorenzon E, Thomas M, Herting F, Hoert S, Quaiser T, Shochat E, Pitt-Francis J, Cooper J, Maini PK, Byrne HM.

J R Soc Interface. 2015 Sep 6;12(110):0546. doi: 10.1098/rsif.2015.0546.


VEGF signals induce trailblazer cell identity that drives neural crest migration.

McLennan R, Schumacher LJ, Morrison JA, Teddy JM, Ridenour DA, Box AC, Semerad CL, Li H, McDowell W, Kay D, Maini PK, Baker RE, Kulesa PM.

Dev Biol. 2015 Nov 1;407(1):12-25. doi: 10.1016/j.ydbio.2015.08.011. Epub 2015 Aug 13.


A morphoelastic model for dermal wound closure.

Bowden LG, Byrne HM, Maini PK, Moulton DE.

Biomech Model Mechanobiol. 2016 Jun;15(3):663-81. doi: 10.1007/s10237-015-0716-7. Epub 2015 Aug 12.


What has mathematics done for biology?

Mackey MC, Maini PK.

Bull Math Biol. 2015 May;77(5):735-8. doi: 10.1007/s11538-015-0065-9. No abstract available.


Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front.

McLennan R, Schumacher LJ, Morrison JA, Teddy JM, Ridenour DA, Box AC, Semerad CL, Li H, McDowell W, Kay D, Maini PK, Baker RE, Kulesa PM.

Development. 2015 Jun 1;142(11):2014-25. doi: 10.1242/dev.117507. Epub 2015 May 14.

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