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Shared immunotherapeutic approaches in HIV and hepatitis B virus: combine and conquer.

Maini MK, Peppa D.

Curr Opin HIV AIDS. 2020 Mar 9. doi: 10.1097/COH.0000000000000621. [Epub ahead of print]


Cirrhosis Hampers Early and Rapid Normalization of Natural Killer Cell Phenotype and Function in Hepatitis C Patients Undergoing Interferon-Free Therapy.

Perpiñán E, Pérez-Del-Pulgar S, Londoño MC, Mariño Z, Bartres C, González P, García-López M, Pose E, Lens S, Maini MK, Forns X, Koutsoudakis G.

Front Immunol. 2020 Feb 25;11:129. doi: 10.3389/fimmu.2020.00129. eCollection 2020.


Liver-resident CD8+ T cells: learning lessons from the local experts.

Swadling L, Pallett LJ, Maini MK.

J Hepatol. 2020 Feb 28. pii: S0168-8278(20)30068-4. doi: 10.1016/j.jhep.2020.02.001. [Epub ahead of print] No abstract available.


Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence.

Swadling L, Pallett LJ, Diniz MO, Baker JM, Amin OE, Stegmann KA, Burton AR, Schmidt NM, Jeffery-Smith A, Zakeri N, Suveizdyte K, Froghi F, Fusai G, Rosenberg WM, Davidson BR, Schurich A, Simon AK, Maini MK.

Cell Rep. 2020 Jan 21;30(3):687-698.e6. doi: 10.1016/j.celrep.2019.12.050.


Restoring, releasing or replacing adaptive immunity in chronic hepatitis B.

Maini MK, Burton AR.

Nat Rev Gastroenterol Hepatol. 2019 Nov;16(11):662-675. doi: 10.1038/s41575-019-0196-9. Epub 2019 Sep 23. Review.


CD8+ T cells cure without killing.

Maini MK.

Nat Rev Immunol. 2019 Apr;19(4):201. doi: 10.1038/s41577-019-0150-7. No abstract available.


Fine needle aspirates comprehensively sample intrahepatic immunity.

Gill US, Pallett LJ, Thomas N, Burton AR, Patel AA, Yona S, Kennedy PTF, Maini MK.

Gut. 2019 Aug;68(8):1493-1503. doi: 10.1136/gutjnl-2018-317071. Epub 2018 Nov 28.


Hepatitis B assessment without hepatitis B virus DNA quantification: a prospective cohort study in Uganda.

Laing N, Tufton H, Ochola E, P'Kingston OG, Maini MK, Easom N.

Trans R Soc Trop Med Hyg. 2019 Jan 1;113(1):11-17. doi: 10.1093/trstmh/try117.


Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver.

Otano I, Escors D, Schurich A, Singh H, Robertson F, Davidson BR, Fusai G, Vargas FA, Tan ZMD, Aw JYJ, Hansi N, Kennedy PTF, Xue SA, Stauss HJ, Bertoletti A, Pavesi A, Maini MK.

Mol Ther. 2018 Nov 7;26(11):2553-2566. doi: 10.1016/j.ymthe.2018.08.013. Epub 2018 Aug 16.


Circulating and intrahepatic antiviral B cells are defective in hepatitis B.

Burton AR, Pallett LJ, McCoy LE, Suveizdyte K, Amin OE, Swadling L, Alberts E, Davidson BR, Kennedy PT, Gill US, Mauri C, Blair PA, Pelletier N, Maini MK.

J Clin Invest. 2018 Oct 1;128(10):4588-4603. doi: 10.1172/JCI121960. Epub 2018 Aug 9.


Defective T-cell immunity in hepatitis B virus infection: why therapeutic vaccination needs a helping hand.

Maini MK, Pallett LJ.

Lancet Gastroenterol Hepatol. 2018 Mar;3(3):192-202. doi: 10.1016/S2468-1253(18)30007-4. Review.


IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction.

Easom NJW, Stegmann KA, Swadling L, Pallett LJ, Burton AR, Odera D, Schmidt N, Huang WC, Fusai G, Davidson B, Maini MK.

Front Immunol. 2018 May 9;9:1009. doi: 10.3389/fimmu.2018.01009. eCollection 2018.


Adaptive Reconfiguration of Natural Killer Cells in HIV-1 Infection.

Peppa D, Pedroza-Pacheco I, Pellegrino P, Williams I, Maini MK, Borrow P.

Front Immunol. 2018 Mar 16;9:474. doi: 10.3389/fimmu.2018.00474. eCollection 2018.


Liver sampling: a vital window into HBV pathogenesis on the path to functional cure.

Gill US, Pallett LJ, Kennedy PTF, Maini MK.

Gut. 2018 Apr;67(4):767-775. doi: 10.1136/gutjnl-2017-314873. Epub 2018 Jan 13. Review.


Natural Killer Cells in Liver Disease.

Male V, Stegmann KA, Easom NJ, Maini MK.

Semin Liver Dis. 2017 Aug;37(3):198-209. doi: 10.1055/s-0037-1603946. Epub 2017 Aug 28. Review. No abstract available.


TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.

Singh HD, Otano I, Rombouts K, Singh KP, Peppa D, Gill US, Böttcher K, Kennedy PTF, Oben J, Pinzani M, Walczak H, Fusai G, Rosenberg WMC, Maini MK.

Sci Rep. 2017 Jul 17;7(1):5514. doi: 10.1038/s41598-017-05845-5.


Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity.

Duriez M, Mandouri Y, Lekbaby B, Wang H, Schnuriger A, Redelsperger F, Guerrera CI, Lefevre M, Fauveau V, Ahodantin J, Quetier I, Chhuon C, Gourari S, Boissonnas A, Gill U, Kennedy P, Debzi N, Sitterlin D, Maini MK, Kremsdorf D, Soussan P.

J Hepatol. 2017 Oct;67(4):687-699. doi: 10.1016/j.jhep.2017.05.025. Epub 2017 Jun 7.


IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.

Pallett LJ, Davies J, Colbeck EJ, Robertson F, Hansi N, Easom NJW, Burton AR, Stegmann KA, Schurich A, Swadling L, Gill US, Male V, Luong T, Gander A, Davidson BR, Kennedy PTF, Maini MK.

J Exp Med. 2017 Jun 5;214(6):1567-1580. doi: 10.1084/jem.20162115. Epub 2017 May 19.


HBV in 2016: Global and immunotherapeutic insights into hepatitis B.

Maini MK, Bertoletti A.

Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):71-72. doi: 10.1038/nrgastro.2016.196. Epub 2017 Jan 5. Review. No abstract available.


T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System.

Huang WC, Easom NJ, Tang XZ, Gill US, Singh H, Robertson F, Chang C, Trowsdale J, Davidson BR, Rosenberg WM, Fusai G, Toubert A, Kennedy PT, Peppa D, Maini MK.

J Immunol. 2017 Feb 1;198(3):1172-1182. doi: 10.4049/jimmunol.1601313. Epub 2016 Dec 28.


Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.

Cuff AO, Robertson FP, Stegmann KA, Pallett LJ, Maini MK, Davidson BR, Male V.

J Immunol. 2016 Dec 1;197(11):4283-4291. Epub 2016 Oct 21.


Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo.

Gill US, Peppa D, Micco L, Singh HD, Carey I, Foster GR, Maini MK, Kennedy PT.

PLoS Pathog. 2016 Aug 3;12(8):e1005788. doi: 10.1371/journal.ppat.1005788. eCollection 2016 Aug.


Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host.

Schurich A, Pallett LJ, Jajbhay D, Wijngaarden J, Otano I, Gill US, Hansi N, Kennedy PT, Nastouli E, Gilson R, Frezza C, Henson SM, Maini MK.

Cell Rep. 2016 Aug 2;16(5):1243-1252. doi: 10.1016/j.celrep.2016.06.078. Epub 2016 Jul 21.


Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice.

Di Scala M, Otano I, Gil-Fariña I, Vanrell L, Hommel M, Olagüe C, Vales A, Galarraga M, Guembe L, Ortiz de Solorzano C, Ghosh I, Maini MK, Prieto J, González-Aseguinolaza G.

J Virol. 2016 Sep 12;90(19):8563-74. doi: 10.1128/JVI.01030-16. Print 2016 Oct 1.


CXCR6 marks a novel subset of T-bet(lo)Eomes(hi) natural killer cells residing in human liver.

Stegmann KA, Robertson F, Hansi N, Gill U, Pallant C, Christophides T, Pallett LJ, Peppa D, Dunn C, Fusai G, Male V, Davidson BR, Kennedy P, Maini MK.

Sci Rep. 2016 May 23;6:26157. doi: 10.1038/srep26157.


The role of innate immunity in the immunopathology and treatment of HBV infection.

Maini MK, Gehring AJ.

J Hepatol. 2016 Apr;64(1 Suppl):S60-S70. doi: 10.1016/j.jhep.2016.01.028. Review.


T cell receptor-therapy in HBV-related hepatocellularcarcinoma.

Bertoletti A, Brunetto M, Maini MK, Bonino F, Qasim W, Stauss H.

Oncoimmunology. 2015 Mar 19;4(6):e1008354. eCollection 2015 Jun.


Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.

Pallett LJ, Gill US, Quaglia A, Sinclair LV, Jover-Cobos M, Schurich A, Singh KP, Thomas N, Das A, Chen A, Fusai G, Bertoletti A, Cantrell DA, Kennedy PT, Davies NA, Haniffa M, Maini MK.

Nat Med. 2015 Jun;21(6):591-600. doi: 10.1038/nm.3856. Epub 2015 May 11.


Disease-promoting effects of type I interferons in viral, bacterial, and coinfections.

Davidson S, Maini MK, Wack A.

J Interferon Cytokine Res. 2015 Apr;35(4):252-64. doi: 10.1089/jir.2014.0227. Epub 2015 Feb 25. Review.


Reply to: "To target or not to target viral antigens in HBV related HCC?".

Qasim W, Brunetto M, Gehring AJ, Maini MK, Bonino F, Stauss H, Bertoletti A.

J Hepatol. 2015 Jun;62(6):1450-2. doi: 10.1016/j.jhep.2015.02.026. Epub 2015 Feb 21. No abstract available.


Defective natural killer cell anti-viral capacity in paediatric HBV infection.

Heiberg IL, Pallett LJ, Winther TN, Høgh B, Maini MK, Peppa D.

Clin Exp Immunol. 2015 Mar;179(3):466-76. doi: 10.1111/cei.12470.


Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient.

Qasim W, Brunetto M, Gehring AJ, Xue SA, Schurich A, Khakpoor A, Zhan H, Ciccorossi P, Gilmour K, Cavallone D, Moriconi F, Farzhenah F, Mazzoni A, Chan L, Morris E, Thrasher A, Maini MK, Bonino F, Stauss H, Bertoletti A.

J Hepatol. 2015 Feb;62(2):486-91. doi: 10.1016/j.jhep.2014.10.001. Epub 2014 Oct 13.


Direct-acting antivirals trump interferon-alpha in their capacity to rescue exhausted T cells upon HCV clearance.

Maini MK, Schurich A.

J Hepatol. 2014 Sep;61(3):459-61. doi: 10.1016/j.jhep.2014.06.017. Epub 2014 Jun 19. No abstract available.


The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells.

Schurich A, Pallett LJ, Lubowiecki M, Singh HD, Gill US, Kennedy PT, Nastouli E, Tanwar S, Rosenberg W, Maini MK.

PLoS Pathog. 2013 Mar;9(3):e1003208. doi: 10.1371/journal.ppat.1003208. Epub 2013 Mar 14.


NK cells: a double-edged sword in chronic hepatitis B virus infection.

Maini MK, Peppa D.

Front Immunol. 2013 Mar 1;4:57. doi: 10.3389/fimmu.2013.00057. eCollection 2013.


Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.

Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, Micco L, Nebbia G, Singh HD, Adams DH, Kennedy PT, Maini MK.

J Exp Med. 2013 Jan 14;210(1):99-114. doi: 10.1084/jem.20121172. Epub 2012 Dec 17.


Pathogenesis of hepatitis B virus infection and potential for new therapies.

Peppa D, Maini MK.

Br J Hosp Med (Lond). 2012 Oct;73(10):581-4. Review.


Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.

Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, Cheng Y, Rosenberg W, Dusheiko G, Gilson R, ChinAleong J, Kennedy P, Maini MK.

PLoS One. 2012;7(10):e47648. doi: 10.1371/journal.pone.0047648. Epub 2012 Oct 24.


Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B.

Micco L, Peppa D, Loggi E, Schurich A, Jefferson L, Cursaro C, Panno AM, Bernardi M, Brander C, Bihl F, Andreone P, Maini MK.

J Hepatol. 2013 Feb;58(2):225-33. doi: 10.1016/j.jhep.2012.09.029. Epub 2012 Oct 6.


IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection.

Das A, Ellis G, Pallant C, Lopes AR, Khanna P, Peppa D, Chen A, Blair P, Dusheiko G, Gill U, Kennedy PT, Brunetto M, Lampertico P, Mauri C, Maini MK.

J Immunol. 2012 Oct 15;189(8):3925-35. doi: 10.4049/jimmunol.1103139. Epub 2012 Sep 12.


Platelets harness the immune response to drive liver cancer.

Maini MK, Schurich A.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12840-1. doi: 10.1073/pnas.1210296109. Epub 2012 Jul 23. No abstract available.


Rare inborn errors associated with chronic hepatitis B virus infection.

Zhao Q, Peng L, Huang W, Li Q, Pei Y, Yuan P, Zheng L, Zhang Y, Deng J, Zhong C, Hu B, Ding H, Fang W, Li R, Liao Q, Lin C, Deng W, Yan H, Hou J, Wu Q, Xu T, Liu J, Hu L, Peng T, Chen S, Lai KN, Yuen MF, Wang Y, Maini MK, Li C, Li M, Wang J, Zhang X, Sham PC, Wang J, Gao ZL, Wang Y.

Hepatology. 2012 Nov;56(5):1661-70. doi: 10.1002/hep.25850. Epub 2012 Oct 14.


Living in the liver: hepatic infections.

Protzer U, Maini MK, Knolle PA.

Nat Rev Immunol. 2012 Feb 24;12(3):201-13. doi: 10.1038/nri3169. Review.


Hepatitis B infection: current concepts and future challenges.

Nebbia G, Peppa D, Maini MK.

QJM. 2012 Feb;105(2):109-13. doi: 10.1093/qjmed/hcr270. Review.


IL-2-engineered nano-APC effectively activates viral antigen-mediated T cell responses from chronic hepatitis B virus-infected patients.

Liu M, Miao T, Zhu H, Symonds AL, Li L, Schurich A, Maini MK, Zhang J, Kennedy PT, Li S, Wang P.

J Immunol. 2012 Feb 1;188(3):1534-43. doi: 10.4049/jimmunol.1102709. Epub 2011 Dec 30.


Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.

Gehring AJ, Koh S, Chia A, Paramasivam K, Chew VS, Ho ZZ, Lee KH, Maini MK, Madhavan K, Lim SG, Bertoletti A.

PLoS One. 2011;6(8):e23330. doi: 10.1371/journal.pone.0023330. Epub 2011 Aug 18.


Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection.

Schurich A, Khanna P, Lopes AR, Han KJ, Peppa D, Micco L, Nebbia G, Kennedy PT, Geretti AM, Dusheiko G, Maini MK.

Hepatology. 2011 May;53(5):1494-503. doi: 10.1002/hep.24249.


Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection.

Peppa D, Micco L, Javaid A, Kennedy PT, Schurich A, Dunn C, Pallant C, Ellis G, Khanna P, Dusheiko G, Gilson RJ, Maini MK.

PLoS Pathog. 2010 Dec 16;6(12):e1001227. doi: 10.1371/journal.ppat.1001227.


Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines.

Gehring AJ, Xue SA, Ho ZZ, Teoh D, Ruedl C, Chia A, Koh S, Lim SG, Maini MK, Stauss H, Bertoletti A.

J Hepatol. 2011 Jul;55(1):103-10. doi: 10.1016/j.jhep.2010.10.025. Epub 2010 Nov 23.


The host-pathogen interaction during HBV infection: immunological controversies.

Bertoletti A, Maini MK, Ferrari C.

Antivir Ther. 2010;15 Suppl 3:15-24. doi: 10.3851/IMP1620. Review.


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