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A Multicentric, Open-Label, Randomized, Comparative Clinical Trial of Two Different Doses of Expanded hBM-MSCs Plus Biomaterial versus Iliac Crest Autograft, for Bone Healing in Nonunions after Long Bone Fractures: Study Protocol.

Gómez-Barrena E, Padilla-Eguiluz NG, Avendaño-Solá C, Payares-Herrera C, Velasco-Iglesias A, Torres F, Rosset P, Gebhard F, Baldini N, Rubio-Suarez JC, García-Rey E, Cordero-Ampuero J, Vaquero-Martin J, Chana F, Marco F, García-Coiradas J, Caba-Dessoux P, de la Cuadra P, Hernigou P, Flouzat-Lachaniette CH, Gouin F, Mainard D, Laffosse JM, Kalbitz M, Marzi I, Südkamp N, Stöckle U, Ciapetti G, Donati DM, Zagra L, Pazzaglia U, Zarattini G, Capanna R, Catani F.

Stem Cells Int. 2018 Feb 22;2018:6025918. doi: 10.1155/2018/6025918. eCollection 2018.


Non-canonical Wnt induces chondrocyte de-differentiation through Frizzled 6 and DVL-2/B-raf/CaMKIIα/syndecan 4 axis.

Xie Z, Khair M, Shaukat I, Netter P, Mainard D, Barré L, Ouzzine M.

Cell Death Differ. 2018 Jan 19. doi: 10.1038/s41418-017-0050-y. [Epub ahead of print]


Reply to the letter by D. Ollat and O. Barbier.

Barla M, Mainard D.

Orthop Traumatol Surg Res. 2018 Feb;104(1):157. doi: 10.1016/j.otsr.2017.12.002. Epub 2017 Dec 16. No abstract available.


Comparison of an Innovative Rehabilitation, Combining Reduced Conventional Rehabilitation with Balneotherapy, and a Conventional Rehabilitation after Anterior Cruciate Ligament Reconstruction in Athletes.

Peultier-Celli L, Mainard D, Wein F, Paris N, Boisseau P, Ferry A, Gueguen R, Chary-Valckenaere I, Paysant J, Perrin P.

Front Surg. 2017 Nov 7;4:61. doi: 10.3389/fsurg.2017.00061. eCollection 2017.


Osteosynthesis of periprosthetic type A and B femoral fractures using an unlocked plate with integrated cerclage cable and trochanteric hook: A multicenter retrospective study of 45 patients with mean follow-up of 20 months.

Gavanier B, Houfani F, Dumoulin Q, Bernard E, Mangin M, Mainard D.

Injury. 2017 Dec;48(12):2827-2832. doi: 10.1016/j.injury.2017.10.023. Epub 2017 Oct 10.


Erratum to "What are the risk factors for dislocation in primary total hip arthroplasty? A multicenter case-control study of 128 unstable and 438 stable hips" [Orthop. Traumatol. Surg. Res. 103 (2017) 663-8].

Fessy MH, Putman S, Viste A, Isida R, Ramdane N, Ferreira A, Leglise A, Rubens-Duval B, Bonin N, Bonnomet F, Combes A, Boisgard S, Mainard D, Leclercq S, Migaud H; Société Française de chirurgie de la Hanche et du Genou (SFHG).

Orthop Traumatol Surg Res. 2017 Nov;103(7):1137. doi: 10.1016/j.otsr.2017.08.001. Epub 2017 Oct 12. No abstract available.


Advantages of external hybrid fixators for treating Schatzker V-VI tibial plateau fractures: A retrospective study of 40 cases.

Gross JB, Gavanier B, Belleville R, Coudane H, Mainard D.

Orthop Traumatol Surg Res. 2017 Oct;103(6):965-970. doi: 10.1016/j.otsr.2017.05.023. Epub 2017 Jul 28.


Is amputation a viable treatment option in lower extremity trauma?

Barla M, Gavanier B, Mangin M, Parot J, Bauer C, Mainard D.

Orthop Traumatol Surg Res. 2017 Oct;103(6):971-975. doi: 10.1016/j.otsr.2017.05.022. Epub 2017 Jul 14.


What are the risk factors for dislocation in primary total hip arthroplasty? A multicenter case-control study of 128 unstable and 438 stable hips.

Fessy MH, Putman S, Viste A, Isida R, Ramdane N, Ferreira A, Leglise A, Rubens-Duval B, Bonin N, Bonnomet F, Combes A, Boisgard S, Mainard D, Leclercq S, Migaud H; SFHG.

Orthop Traumatol Surg Res. 2017 Sep;103(5):663-668. doi: 10.1016/j.otsr.2017.05.014. Epub 2017 Jun 16. Erratum in: Orthop Traumatol Surg Res. 2017 Nov;103(7):1137.


The concept of a waiting period for preoperative patient consent: Prospective study of 51 shoulder arthroscopy cases.

Coudane H, Mangin M, Karam Y, Seivert V, Mainard D, Danan JL, Py B, Lighezzolo-Alnot J.

Orthop Traumatol Surg Res. 2017 Sep;103(5):791-794. doi: 10.1016/j.otsr.2017.03.025. Epub 2017 May 31.


Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold.

Schiavi J, Reppel L, Charif N, de Isla N, Mainard D, Benkirane-Jessel N, Stoltz JF, Rahouadj R, Huselstein C.

J Tissue Eng Regen Med. 2018 Feb;12(2):360-369. doi: 10.1002/term.2461. Epub 2017 Aug 22.


Label-free relative quantification of secreted proteins as a non-invasive method for the quality control of chondrogenesis in bioengineered substitutes for cartilage repair.

Henrionnet C, Gillet P, Mainard D, Vincourt JB, Pinzano A.

J Tissue Eng Regen Med. 2018 Mar;12(3):e1757-e1766. doi: 10.1002/term.2454. Epub 2017 Jul 14.


New tools for non-invasive exploration of collagen network in cartilaginous tissue-engineered substitute.

Henrionnet C, Dumas D, Hupont S, Stoltz JF, Mainard D, Gillet P, Pinzano A.

Biomed Mater Eng. 2017;28(s1):S229-S235. doi: 10.3233/BME-171645.


Accuracy and reproducibility of preoperative three-dimensional planning for total hip arthroplasty using biplanar low-dose radiographs : A pilot study.

Mainard D, Barbier O, Knafo Y, Belleville R, Mainard-Simard L, Gross JB.

Orthop Traumatol Surg Res. 2017 Jun;103(4):531-536. doi: 10.1016/j.otsr.2017.03.001. Epub 2017 Mar 18.


The infrapatellar fat pad induces inflammatory and degradative effects in articular cells but not through leptin or adiponectin.

Gross JB, Guillaume C, Gegout-Pottie P, Reboul P, Jouzeau JY, Mainard D, Presle N.

Clin Exp Rheumatol. 2017 Jan-Feb;35(1):53-60. Epub 2016 Nov 13.


Fibroblast Growth Factor 23 drives MMP13 expression in human osteoarthritic chondrocytes in a Klotho-independent manner.

Bianchi A, Guibert M, Cailotto F, Gasser A, Presle N, Mainard D, Netter P, Kempf H, Jouzeau JY, Reboul P.

Osteoarthritis Cartilage. 2016 Nov;24(11):1961-1969. doi: 10.1016/j.joca.2016.06.003. Epub 2016 Jun 13.


Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution.

Zhang G, Brion A, Willemin AS, Piet MH, Moby V, Bianchi A, Mainard D, Galois L, Gillet P, Rousseau M.

J Biomed Mater Res A. 2017 Feb;105(2):662-671. doi: 10.1002/jbm.a.35939. Epub 2016 Nov 7. Review.


Is arthroplasty preferable to internal fixation for the treatment of extracapsular fracture of the upper femur in the elderly?

Duriez P, Devaux T, Chantelot C, Baudrier N, Hery JY, Mainard D, Favier T, Massin P.

Orthop Traumatol Surg Res. 2016 Oct;102(6):689-94. doi: 10.1016/j.otsr.2016.05.015. Epub 2016 Aug 16.


Developments in imaging methods used in hip arthroplasty: A diagnostic algorithm.

Blum A, Gondim-Teixeira P, Gabiache E, Roche O, Sirveaux F, Olivier P, Coudane H; Nancy Association for Prosthesis Exploration (NAPE), Raymond A, Louis M, Grandhaye M, Meyer JB, Mainard D, Molé D.

Diagn Interv Imaging. 2016 Jul-Aug;97(7-8):735-47. doi: 10.1016/j.diii.2016.07.001. Epub 2016 Jul 22.


Plantar pressure displacement after anesthetic motor block and tibial nerve neurotomy in spastic equinovarus foot.

Khalil N, Chauvière C, Le Chapelain L, Guesdon H, Speyer E, Bouaziz H, Mainard D, Beis JM, Paysant J.

J Rehabil Res Dev. 2016;53(2):219-28. doi: 10.1682/JRRD.2014.11.0298.


A new method for the separation and purification of the osteogenic compounds of nacre Ethanol Soluble Matrix.

Zhang G, Willemin AS, Brion A, Piet MH, Moby V, Bianchi A, Mainard D, Galois L, Gillet P, Rousseau M.

J Struct Biol. 2016 Nov;196(2):127-137. doi: 10.1016/j.jsb.2016.03.016. Epub 2016 Mar 16.


New trends in articular cartilage repair.

Cucchiarini M, Henrionnet C, Mainard D, Pinzano A, Madry H.

J Exp Orthop. 2015 Dec;2(1):8. doi: 10.1186/s40634-015-0026-0. Epub 2015 Apr 2.


Expression of the semicarbazide-sensitive amine oxidase in articular cartilage: its role in terminal differentiation of chondrocytes in rat and human.

Filip A, Pinzano A, Bianchi A, Fève B, Jalkanen S, Gillet P, Mainard D, Lacolley P, Magdalou J, Mercier N.

Osteoarthritis Cartilage. 2016 Jul;24(7):1223-34. doi: 10.1016/j.joca.2016.01.340. Epub 2016 Feb 4.


Nacre extract restores the mineralization capacity of subchondral osteoarthritis osteoblasts.

Brion A, Zhang G, Dossot M, Moby V, Dumas D, Hupont S, Piet MH, Bianchi A, Mainard D, Galois L, Gillet P, Rousseau M.

J Struct Biol. 2015 Dec;192(3):500-509. doi: 10.1016/j.jsb.2015.10.012. Epub 2015 Oct 20.


Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine.

Schiavi J, Keller L, Morand DN, De Isla N, Huck O, Lutz JC, Mainard D, Schwinté P, Benkirane-Jessel N.

Nanomedicine (Lond). 2015;10(5):753-63. doi: 10.2217/nnm.14.228. Erratum in: Nanomedicine (Lond). 2016;11(5):567.


Outcomes of talar dome osteochondral defect repair using osteocartilaginous autografts: 37 cases of Mosaicplasty®.

de l'Escalopier N, Barbier O, Mainard D, Mayer J, Ollat D, Versier G.

Orthop Traumatol Surg Res. 2015 Feb;101(1):97-102. doi: 10.1016/j.otsr.2014.11.006. Epub 2015 Jan 16.


Percutaneous autologous bone marrow injection for treatment of delayed and non-union of long bone: a retrospective study of 45 cases.

Gross JB, Diligent J, Bensoussan D, Galois L, Stoltz JF, Mainard D.

Biomed Mater Eng. 2015;25(1 Suppl):187-97. doi: 10.3233/BME-141235.


Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH]₂ vitamin D₃ potency to stimulate osteocalcin.

Hu Y, Liu Y, Lajeunesse D, Mainard D, Jouzeau JY, Reboul P.

Biomed Mater Eng. 2015;25(1 Suppl):103-10. doi: 10.3233/BME-141230.


A simple two dimensional culture method to study the hypertrophic differentiation of rat articular chondrocytes.

Filip A, Bianchi A, Mainard D, Lacolley P, Magdalou J, Mercier N.

Biomed Mater Eng. 2015;25(1 Suppl):87-102. doi: 10.3233/BME-141252.


Label-free relative quantification applied to LC-MALDI acquisition for rapid analysis of chondrocyte secretion modulation.

Riffault M, Moulin D, Grossin L, Mainard D, Magdalou J, Vincourt JB.

J Proteomics. 2015 Jan 30;114:263-73. doi: 10.1016/j.jprot.2014.10.026. Epub 2014 Nov 21.


Locking plate fixation versus antegrade nailing of 3- and 4-part proximal humerus fractures in patients without osteoporosis. Comparative retrospective study of 63 cases.

Boudard G, Pomares G, Milin L, Lemonnier I, Coudane H, Mainard D, Delagoutte JP.

Orthop Traumatol Surg Res. 2014 Dec;100(8):917-24. doi: 10.1016/j.otsr.2014.09.021. Epub 2014 Nov 13.


Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts.

Bouvard B, Abed E, Yéléhé-Okouma M, Bianchi A, Mainard D, Netter P, Jouzeau JY, Lajeunesse D, Reboul P.

Arthritis Res Ther. 2014 Oct 14;16(5):459. doi: 10.1186/s13075-014-0459-3.


Does Biolox Delta ceramic reduce the rate of component fractures in total hip replacement?

Massin P, Lopes R, Masson B, Mainard D; French Hip & Knee Society (SFHG).

Orthop Traumatol Surg Res. 2014 Oct;100(6 Suppl):S317-21. doi: 10.1016/j.otsr.2014.05.010. Epub 2014 Aug 12. Review.


The reliability of the anterior pelvic plane for computer navigated acetabular component placement during total hip arthroplasty: prospective study with the EOS imaging system.

Barbier O, Skalli W, Mainard L, Mainard D; Computer Assisted Orthopedic Surgery–France (CAOS-France).

Orthop Traumatol Surg Res. 2014 Oct;100(6 Suppl):S287-91. doi: 10.1016/j.otsr.2014.07.003. Epub 2014 Aug 14.


Antegrade nailing evolution for proximal humeral fractures, the Telegraph IV(®): a study of 67 patients.

Cuny C, Goetzmann T, Dedome D, Gross JB, Irrazi M, Berrichi A, Mayer J, Le Coadou PY, Precup S, Galois L, Mainard D.

Eur J Orthop Surg Traumatol. 2015 Feb;25(2):287-95. doi: 10.1007/s00590-014-1493-1. Epub 2014 Jun 20.


Donor's age dependent proliferation decrease of human bone marrow mesenchymal stem cells is linked to diminished clonogenicity.

Li Y, Charif N, Mainard D, Bensoussan D, Stoltz JF, de Isla N.

Biomed Mater Eng. 2014;24(1 Suppl):47-52. doi: 10.3233/BME-140973.


Synovial fluid levels of adipokines in osteoarthritis: Association with local factors of inflammation and cartilage maintenance.

Gross JB, Guillaume C, Gégout-Pottie P, Mainard D, Presle N.

Biomed Mater Eng. 2014;24(1 Suppl):17-25. doi: 10.3233/BME-140970.


Comparison of modified Hackethal bundle nailing versus anterograde nailing for fixation of surgical neck fractures of the humerus: retrospective study of 105 cases.

Milin L, Sirveaux F, Eloy F, Mainard D, Molé D, Coudane H.

Orthop Traumatol Surg Res. 2014 May;100(3):265-70. doi: 10.1016/j.otsr.2014.01.005. Epub 2014 Mar 25.


Association between adiponectin and cartilage degradation in human osteoarthritis.

Francin PJ, Abot A, Guillaume C, Moulin D, Bianchi A, Gegout-Pottie P, Jouzeau JY, Mainard D, Presle N.

Osteoarthritis Cartilage. 2014 Mar;22(3):519-26. doi: 10.1016/j.joca.2014.01.002. Epub 2014 Jan 24.


Collagen implants equipped with 'fish scale'-like nanoreservoirs of growth factors for bone regeneration.

Eap S, Ferrand A, Schiavi J, Keller L, Kokten T, Fioretti F, Mainard D, Ladam G, Benkirane-Jessel N.

Nanomedicine (Lond). 2014;9(8):1253-61. doi: 10.2217/nnm.13.122. Epub 2013 Nov 27.


Current concept for the use of PRP in arthroscopic surgery.

Nourissat G, Mainard D, Kelberine F; French Arthroscopic Society (SFA).

Orthop Traumatol Surg Res. 2013 Dec;99(8 Suppl):S407-10. doi: 10.1016/j.otsr.2013.10.010. Epub 2013 Nov 15. Review.


Influencing factors of functional result and bone union in tibiotalocalcaneal arthrodesis with intramedullary locking nail: a retrospective series of 30 cases.

Gross JB, Belleville R, Nespola A, Poircuitte JM, Coudane H, Mainard D, Galois L.

Eur J Orthop Surg Traumatol. 2014 May;24(4):627-33. doi: 10.1007/s00590-013-1347-2. Epub 2013 Oct 27.


Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway.

Bantsimba-Malanda C, Cottet J, Netter P, Dumas D, Mainard D, Magdalou J, Vincourt JB.

Matrix Biol. 2013 Oct-Nov;32(7-8):443-51. doi: 10.1016/j.matbio.2013.06.002. Epub 2013 Jul 10.


Osteogenic differentiation of human bone marrow mesenchymal stem cells in hydrogel containing nacre powder.

Flausse A, Henrionnet C, Dossot M, Dumas D, Hupont S, Pinzano A, Mainard D, Galois L, Magdalou J, Lopez E, Gillet P, Rousseau M.

J Biomed Mater Res A. 2013 Nov;101(11):3211-8. doi: 10.1002/jbm.a.34629. Epub 2013 Apr 3.


A multilayer braided scaffold for Anterior Cruciate Ligament: mechanical modeling at the fiber scale.

Laurent CP, Durville D, Mainard D, Ganghoffer JF, Rahouadj R.

J Mech Behav Biomed Mater. 2012 Aug;12:184-96. doi: 10.1016/j.jmbbm.2012.03.005. Epub 2012 Mar 24.


Ambivalent properties of hyaluronate and hylan during post-traumatic OA in the rat knee.

Galois L, Etienne S, Henrionnet C, Scala-Bertola J, Grossin L, Mainard D, Gillet P, Pinzano A.

Biomed Mater Eng. 2012;22(4):235-42. doi: 10.3233/BME-2012-0713.


Effect of dynamic loading on MSCs chondrogenic differentiation in 3-D alginate culture.

Henrionnet C, Wang Y, Roeder E, Gambier N, Galois L, Mainard D, Bensoussan D, Gillet P, Pinzano A.

Biomed Mater Eng. 2012;22(4):209-18. doi: 10.3233/BME-2012-0710.


Electrospun nanofibrous 3D scaffold for bone tissue engineering.

Eap S, Ferrand A, Palomares CM, Hébraud A, Stoltz JF, Mainard D, Schlatter G, Benkirane-Jessel N.

Biomed Mater Eng. 2012;22(1-3):137-41. doi: 10.3233/BME-2012-0699.


Factitious torsion dystonia in rehabilitation: a singular new case and literature review.

Beis JM, Bertoni N, Isner-Horobeti ME, Kandel M, Mainard D, Martinet N, Chapelain LL, Paysant J.

NeuroRehabilitation. 2012;30(3):235-7. doi: 10.3233/NRE-2012-0750. Review.


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