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Items: 1 to 50 of 127

1.

Inhibition of Inositol kinase B controls acute and chronic graft-versus-host disease.

Thangavelu G, Du J, Paz KG, Loschi M, Zaiken MC, Flynn R, Taylor PA, Kirchmeier AK, Panoskaltsis-Mortari A, Luznik L, MacDonald KP, Hill GR, Maillard I, Munn DH, Serody JS, Murphy WJ, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Dahlberg C, Miller AT, Blazar BR.

Blood. 2019 Oct 15. pii: blood.2019000032. doi: 10.1182/blood.2019000032. [Epub ahead of print]

PMID:
31697815
2.

Notch signalling in T cell homeostasis and differentiation.

Brandstadter JD, Maillard I.

Open Biol. 2019 Nov 29;9(11):190187. doi: 10.1098/rsob.190187. Epub 2019 Nov 6.

3.

Notch in the niche: new insights into the role of Notch signaling in the bone marrow.

Vanderbeck AN, Maillard I.

Haematologica. 2019 Nov;104(11):2117-2119. doi: 10.3324/haematol.2019.230854. No abstract available.

4.

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.

Saha A, Taylor PA, Lees CJ, Panoskaltsis-Mortari A, Osborn MJ, Feser CJ, Thangavelu G, Melchinger W, Refaeli Y, Hill GR, Munn DH, Murphy WJ, Serody JS, Maillard I, Kreymborg K, van den Brink M, Dong C, Huang S, Zang X, Allison JP, Zeiser R, Blazar BR.

JCI Insight. 2019 Oct 3;4(19). pii: 127716. doi: 10.1172/jci.insight.127716.

5.

Compartmentalized effects of aging on group 2 innate lymphoid cell development and function.

D'Souza SS, Shen X, Fung ITH, Ye L, Kuentzel M, Chittur SV, Furuya Y, Siebel CW, Maillard IP, Metzger DW, Yang Q.

Aging Cell. 2019 Dec;18(6):e13019. doi: 10.1111/acel.13019. Epub 2019 Aug 20.

6.

Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease.

Chung J, Radojcic V, Perkey E, Parnell TJ, Niknafs Y, Jin X, Friedman A, Labrecque N, Blazar BR, Brennan TV, Siebel CW, Maillard I.

J Immunol. 2019 Jul 15;203(2):557-568. doi: 10.4049/jimmunol.1900192. Epub 2019 Jun 10.

PMID:
31182480
7.

The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation.

Saha N, Ropa J, Chen L, Hu H, Mysliwski M, Friedman A, Maillard I, Muntean AG.

Stem Cell Reports. 2019 May 14;12(5):1069-1083. doi: 10.1016/j.stemcr.2019.03.010. Epub 2019 Apr 25.

8.

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR.

Am J Transplant. 2019 Jun;19(6):1820-1830. doi: 10.1111/ajt.15305. Epub 2019 Mar 19.

PMID:
30748099
9.

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease.

Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Bradner JE, Melnick AM, Blazar BR.

Blood. 2019 Jan 3;133(1):94-99. doi: 10.1182/blood-2018-03-839993. Epub 2018 Oct 2.

PMID:
30279226
10.

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.

Radojcic V, Paz K, Chung J, Du J, Perkey ET, Flynn R, Ivcevic S, Zaiken M, Friedman A, Yan M, Pletneva MA, Sarantopoulos S, Siebel CW, Blazar BR, Maillard I.

Blood. 2018 Nov 15;132(20):2188-2200. doi: 10.1182/blood-2018-03-841155. Epub 2018 Sep 4.

PMID:
30181175
11.

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.

Wang Q, Yan R, Pinnell N, McCarter AC, Oh Y, Liu Y, Sha C, Garber NF, Chen Y, Wu Q, Ku CJ, Tran I, Serna Alarcon A, Kuick R, Engel JD, Maillard I, Cierpicki T, Chiang MY.

Blood. 2018 Sep 20;132(12):1279-1292. doi: 10.1182/blood-2018-02-835850. Epub 2018 Aug 3.

12.

Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection.

Ting HA, de Almeida Nagata D, Rasky AJ, Malinczak CA, Maillard IP, Schaller MA, Lukacs NW.

Mucosal Immunol. 2018 Sep;11(5):1524-1536. doi: 10.1038/s41385-018-0052-1. Epub 2018 Jul 23.

13.

The FOSSIL Study: FLAG or standard 7+3 induction therapy in secondary acute myeloid leukemia.

Vulaj V, Perissinotti AJ, Uebel JR, Nachar VR, Scappaticci GB, Crouch A, Bixby DL, Burke PW, Maillard I, Talpaz M, Marini BL.

Leuk Res. 2018 Jul;70:91-96. doi: 10.1016/j.leukres.2018.05.011. Epub 2018 Jun 1.

PMID:
29908418
14.

An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling.

Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, Kim DI, Emont MP, Zestos AG, Cho JS, Liu J, Kennedy RT, Maillard I, Xu XZS, Wu J.

Nat Med. 2018 Jun;24(6):814-822. doi: 10.1038/s41591-018-0032-8. Epub 2018 May 21.

15.

MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis.

Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC.

Cancer Res. 2018 Jul 1;78(13):3510-3521. doi: 10.1158/0008-5472.CAN-17-3592. Epub 2018 May 3.

16.

Can genetics resolve what Notch does in HSCs?

Maillard I, Pear WS.

Blood. 2018 Apr 12;131(15):1633-1635. doi: 10.1182/blood-2018-02-829069. No abstract available.

17.

New Insights into Graft-Versus-Host Disease and Graft Rejection.

Perkey E, Maillard I.

Annu Rev Pathol. 2018 Jan 24;13:219-245. doi: 10.1146/annurev-pathol-020117-043720. Epub 2017 Nov 3. Review.

PMID:
29099650
18.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.

Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE.

Mol Cancer Res. 2018 Jan;16(1):58-68. doi: 10.1158/1541-7786.MCR-17-0408. Epub 2017 Sep 28.

19.

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.

Poe JC, Jia W, Su H, Anand S, Rose JJ, Tata PV, Suthers AN, Jones CD, Kuan PF, Vincent BG, Serody JS, Horwitz ME, Ho VT, Pavletic SZ, Hakim FT, Owzar K, Zhang D, Blazar BR, Siebel CW, Chao NJ, Maillard I, Sarantopoulos S.

Blood. 2017 Nov 9;130(19):2131-2145. doi: 10.1182/blood-2017-05-782466. Epub 2017 Aug 29.

20.

Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing.

Kimball AS, Joshi AD, Boniakowski AE, Schaller M, Chung J, Allen R, Bermick J, Carson WF 4th, Henke PK, Maillard I, Kunkel SL, Gallagher KA.

Front Immunol. 2017 Jun 1;8:635. doi: 10.3389/fimmu.2017.00635. eCollection 2017.

21.

T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection.

Neal LM, Qiu Y, Chung J, Xing E, Cho W, Malachowski AN, Sandy-Sloat AR, Osterholzer JJ, Maillard I, Olszewski MA.

J Immunol. 2017 Jul 15;199(2):643-655. doi: 10.4049/jimmunol.1601715. Epub 2017 Jun 14.

22.

Fetal hematopoietic stem cells are making waves.

Waas B, Maillard I.

Stem Cell Investig. 2017 Apr 7;4:25. doi: 10.21037/sci.2017.03.06. eCollection 2017. No abstract available.

23.

GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.

Ku CJ, Sekiguchi JM, Panwar B, Guan Y, Takahashi S, Yoh K, Maillard I, Hosoya T, Engel JD.

Mol Cell Biol. 2017 May 31;37(12). pii: e00052-17. doi: 10.1128/MCB.00052-17. Print 2017 Jun 15.

24.

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I.

J Clin Invest. 2017 Apr 3;127(4):1574-1588. doi: 10.1172/JCI89535. Epub 2017 Mar 20.

25.

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production.

Du J, Paz K, Flynn R, Vulic A, Robinson TM, Lineburg KE, Alexander KA, Meng J, Roy S, Panoskaltsis-Mortari A, Loschi M, Hill GR, Serody JS, Maillard I, Miklos D, Koreth J, Cutler CS, Antin JH, Ritz J, MacDonald KP, Schacker TW, Luznik L, Blazar BR.

Blood. 2017 May 4;129(18):2570-2580. doi: 10.1182/blood-2017-01-758854. Epub 2017 Mar 2.

26.

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells.

Valls E, Lobry C, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P, Yang SN, Oswald E, Graham CW, Jiang Y, Hatzi K, Agirre X, Perkey E, Li Z, Tam W, Bhatt K, Leonard JP, Zweidler-McKay PA, Maillard I, Elemento O, Ci W, Aifantis I, Melnick A.

Cancer Discov. 2017 May;7(5):506-521. doi: 10.1158/2159-8290.CD-16-1189. Epub 2017 Feb 23.

27.

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells.

Zhang K, Xu X, Pasha MA, Siebel CW, Costello A, Haczku A, MacNamara K, Liang T, Zhu J, Bhandoola A, Maillard I, Yang Q.

J Immunol. 2017 Mar 1;198(5):1798-1803. doi: 10.4049/jimmunol.1601421. Epub 2017 Jan 23.

28.

Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection.

Ting HA, Schaller MA, de Almeida Nagata DE, Rasky AJ, Maillard IP, Lukacs NW.

J Immunol. 2017 Feb 15;198(4):1492-1502. doi: 10.4049/jimmunol.1601654. Epub 2017 Jan 11.

29.

Notch Signaling and Immune Regulation in Alloimmunity.

Murakami N, Maillard I, Riella LV.

Curr Transplant Rep. 2016 Dec;3(4):294-302. doi: 10.1007/s40472-016-0126-5. Epub 2016 Oct 10.

30.

Targeting the Notch Pathway to Prevent Rejection.

Chung J, Riella LV, Maillard I.

Am J Transplant. 2016 Nov;16(11):3079-3085. doi: 10.1111/ajt.13816. Epub 2016 May 5. Review.

31.

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma.

Wang Y, Huang D, Chen KY, Cui M, Wang W, Huang X, Awadellah A, Li Q, Friedman A, Xin WW, Di Martino L, Cominelli F, Miron A, Chan R, Fox JG, Xu Y, Shen X, Kalady MF, Markowitz S, Maillard I, Lowe JB, Xin W, Zhou L.

Gastroenterology. 2017 Jan;152(1):193-205.e10. doi: 10.1053/j.gastro.2016.09.004. Epub 2016 Sep 14.

32.

Notch Signaling and Alloreactivity.

Radojcic V, Maillard I.

Transplantation. 2016 Dec;100(12):2593-2600. Review.

33.

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner.

McDonald-Hyman C, Flynn R, Panoskaltsis-Mortari A, Peterson N, MacDonald KP, Hill GR, Luznik L, Serody JS, Murphy WJ, Maillard I, Munn DH, Turka LA, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Blazar BR.

Blood. 2016 Aug 18;128(7):1013-7. doi: 10.1182/blood-2016-05-715896. Epub 2016 Jul 6.

34.

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice.

Khoriaty R, Everett L, Chase J, Zhu G, Hoenerhoff M, McKnight B, Vasievich MP, Zhang B, Tomberg K, Williams J, Maillard I, Ginsburg D.

Sci Rep. 2016 Jun 14;6:27802. doi: 10.1038/srep27802.

35.

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.

Chiang MY, Radojcic V, Maillard I.

Curr Opin Hematol. 2016 Jul;23(4):362-70. doi: 10.1097/MOH.0000000000000254. Review.

36.

The shelterin complex and hematopoiesis.

Jones M, Bisht K, Savage SA, Nandakumar J, Keegan CE, Maillard I.

J Clin Invest. 2016 May 2;126(5):1621-9. doi: 10.1172/JCI84547. Epub 2016 May 2. Review.

37.

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

Flynn R, Paz K, Du J, Reichenbach DK, Taylor PA, Panoskaltsis-Mortari A, Vulic A, Luznik L, MacDonald KK, Hill GR, Nyuydzefe MS, Weiss JM, Chen W, Trzeciak A, Serody JS, Aguilar EG, Murphy WJ, Maillard I, Munn D, Koreth J, Cutler CS, Antin JH, Ritz J, Waksal SD, Zanin-Zhorov A, Blazar BR.

Blood. 2016 Apr 28;127(17):2144-54. doi: 10.1182/blood-2015-10-678706. Epub 2016 Mar 16.

38.

Metabolism: Inflammation keeps old mice healthy.

Maillard I, Saltiel AR.

Nature. 2015 Dec 3;528(7580):44-6. doi: 10.1038/nature15648. Epub 2015 Nov 18. No abstract available.

PMID:
26580010
39.

The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.

Pinnell N, Yan R, Cho HJ, Keeley T, Murai MJ, Liu Y, Alarcon AS, Qin J, Wang Q, Kuick R, Elenitoba-Johnson KS, Maillard I, Samuelson LC, Cierpicki T, Chiang MY.

Immunity. 2015 Nov 17;43(5):870-83. doi: 10.1016/j.immuni.2015.10.007. Epub 2015 Oct 27.

40.

A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance.

Ku CJ, Lim KC, Kalantry S, Maillard I, Engel JD, Hosoya T.

Genes Dev. 2015 Sep 15;29(18):1930-41. doi: 10.1101/gad.265025.115.

41.

The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice.

Brinkmeier ML, Geister KA, Jones M, Waqas M, Maillard I, Camper SA.

Biol Reprod. 2015 Nov;93(5):121. doi: 10.1095/biolreprod.115.131516. Epub 2015 Sep 2.

42.

Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.

Rogawski DS, Ndoj J, Cho HJ, Maillard I, Grembecka J, Cierpicki T.

Biochemistry. 2015 Sep 8;54(35):5401-13. doi: 10.1021/acs.biochem.5b00697. Epub 2015 Aug 25.

43.

Trithorax group genes in hematopoiesis.

Chase J, Grembecka J, Maillard I.

Oncotarget. 2015 Jul 20;6(20):17855-6. No abstract available.

44.

Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.

Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD.

J Immunol. 2015 Jul 1;195(1):31-5. doi: 10.4049/jimmunol.1402639. Epub 2015 May 22.

45.

Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.

Jones M, Chase J, Brinkmeier M, Xu J, Weinberg DN, Schira J, Friedman A, Malek S, Grembecka J, Cierpicki T, Dou Y, Camper SA, Maillard I.

J Clin Invest. 2015 May;125(5):2007-20. doi: 10.1172/JCI78124. Epub 2015 Apr 13.

46.

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.

Flynn R, Allen JL, Luznik L, MacDonald KP, Paz K, Alexander KA, Vulic A, Du J, Panoskaltsis-Mortari A, Taylor PA, Poe JC, Serody JS, Murphy WJ, Hill GR, Maillard I, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Chao NJ, Clynes RA, Sarantopoulos S, Blazar BR.

Blood. 2015 Jun 25;125(26):4085-94. doi: 10.1182/blood-2014-08-595470. Epub 2015 Apr 7.

47.

Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration.

Carulli AJ, Keeley TM, Demitrack ES, Chung J, Maillard I, Samuelson LC.

Dev Biol. 2015 Jun 1;402(1):98-108. doi: 10.1016/j.ydbio.2015.03.012. Epub 2015 Mar 30.

48.

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.

Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, Purohit T, Malik B, Zhao T, Wang J, Wen B, Zong H, Jones M, Danet-Desnoyers G, Guzman ML, Talpaz M, Bixby DL, Sun D, Hess JL, Muntean AG, Maillard I, Cierpicki T, Grembecka J.

Cancer Cell. 2015 Apr 13;27(4):589-602. doi: 10.1016/j.ccell.2015.02.016. Epub 2015 Mar 26.

49.

Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

Wood S, Feng J, Chung J, Radojcic V, Sandy-Sloat AR, Friedman A, Shelton A, Yan M, Siebel CW, Bishop DK, Maillard I.

J Immunol. 2015 Mar 15;194(6):2899-908. doi: 10.4049/jimmunol.1402034. Epub 2015 Feb 16.

50.

Subcutaneous panniculitis-like T-cell lymphoma with bone marrow involvement.

Brown NA, Ross CW, Gudjonsson JE, Wale D, Pawarode A, Maillard I, Hristov AC.

Am J Clin Pathol. 2015 Feb;143(2):265-73. doi: 10.1309/AJCPVZYB19NEDXXZ.

PMID:
25596253

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