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Items: 1 to 50 of 72

1.

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH.

Mol Cell. 2019 Jun 19. pii: S1097-2765(19)30435-6. doi: 10.1016/j.molcel.2019.06.002. [Epub ahead of print]

2.

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.

Tollenaere MAX, Tiedje C, Rasmussen S, Nielsen JC, Vind AC, Blasius M, Batth TS, Mailand N, Olsen JV, Gaestel M, Bekker-Jensen S.

Cell Rep. 2019 Mar 26;26(13):3511-3521.e4. doi: 10.1016/j.celrep.2019.03.006.

3.

SUMOylation promotes protective responses to DNA-protein crosslinks.

Borgermann N, Ackermann L, Schwertman P, Hendriks IA, Thijssen K, Liu JC, Lans H, Nielsen ML, Mailand N.

EMBO J. 2019 Apr 15;38(8). pii: e101496. doi: 10.15252/embj.2019101496. Epub 2019 Mar 26.

4.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C.

Cell. 2018 May 3;173(4):972-988.e23. doi: 10.1016/j.cell.2018.03.050. Epub 2018 Apr 12.

5.

ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

Haahr P, Borgermann N, Guo X, Typas D, Achuthankutty D, Hoffmann S, Shearer R, Sixma TK, Mailand N.

Mol Cell. 2018 Apr 5;70(1):165-174.e6. doi: 10.1016/j.molcel.2018.02.024. Epub 2018 Mar 22.

6.

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.

Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P.

Nat Commun. 2018 Mar 9;9(1):1017. doi: 10.1038/s41467-018-03417-3.

7.

RADX interacts with single-stranded DNA to promote replication fork stability.

Schubert L, Ho T, Hoffmann S, Haahr P, Guérillon C, Mailand N.

EMBO Rep. 2017 Nov;18(11):1991-2003. doi: 10.15252/embr.201744877. Epub 2017 Oct 11.

8.

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.

Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S.

Nat Cell Biol. 2016 Dec;18(12):1357-1366. doi: 10.1038/ncb3436. Epub 2016 Nov 7.

9.

Activation of the ATR kinase by the RPA-binding protein ETAA1.

Haahr P, Hoffmann S, Tollenaere MA, Ho T, Toledo LI, Mann M, Bekker-Jensen S, Räschle M, Mailand N.

Nat Cell Biol. 2016 Nov;18(11):1196-1207. doi: 10.1038/ncb3422. Epub 2016 Oct 10.

PMID:
27723717
10.

Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair.

Smeenk G, Mailand N.

Front Genet. 2016 Jun 28;7:122. doi: 10.3389/fgene.2016.00122. eCollection 2016. Review.

11.

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.

Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A.

Nature. 2016 Jun 30;534(7609):714-718. doi: 10.1038/nature18312. Epub 2016 Jun 22.

12.

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers.

Schwertman P, Bekker-Jensen S, Mailand N.

Nat Rev Mol Cell Biol. 2016 May 23;17(6):379-94. doi: 10.1038/nrm.2016.58. Review.

PMID:
27211488
13.

Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO.

Diehl C, Akke M, Bekker-Jensen S, Mailand N, Streicher W, Wikström M.

J Biol Chem. 2016 Jun 10;291(24):12658-72. doi: 10.1074/jbc.M115.711325. Epub 2016 Apr 25.

14.

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.

Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N.

J Cell Biol. 2016 Jan 4;212(1):63-75. doi: 10.1083/jcb.201506071. Epub 2015 Dec 28.

15.

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.

Tollenaere MAX, Villumsen BH, Blasius M, Nielsen JC, Wagner SA, Bartek J, Beli P, Mailand N, Bekker-Jensen S.

Nat Commun. 2015 Nov 30;6:10075. doi: 10.1038/ncomms10075.

16.

RNF138 joins the HR team.

Bekker-Jensen S, Mailand N.

Nat Cell Biol. 2015 Nov;17(11):1375-7. doi: 10.1038/ncb3262.

PMID:
26515018
17.

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, Narita T, Sixma TK, Choudhary C, Bekker-Jensen S, Mailand N.

Nature. 2015 Nov 19;527(7578):389-93. doi: 10.1038/nature15401. Epub 2015 Oct 21.

PMID:
26503038
18.

SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA.

Nat Commun. 2015 Jul 7;6:7499. doi: 10.1038/ncomms8499.

19.

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.

Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M.

Science. 2015 May 1;348(6234):1253671. doi: 10.1126/science.1253671. Epub 2015 Apr 30.

20.

Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.

Oka Y, Bekker-Jensen S, Mailand N.

EMBO J. 2015 May 12;34(10):1385-98. doi: 10.15252/embj.201490376. Epub 2015 Apr 9.

21.

Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.

Gibbs-Seymour I, Markiewicz E, Bekker-Jensen S, Mailand N, Hutchison CJ.

Aging Cell. 2015 Apr;14(2):162-9. doi: 10.1111/acel.12258. Epub 2015 Jan 23.

22.

SLX4: not SIMply a nuclease scaffold?

Gibbs-Seymour I, Mailand N.

Mol Cell. 2015 Jan 8;57(1):3-5. doi: 10.1016/j.molcel.2014.12.032.

23.

Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.

Gibbs-Seymour I, Oka Y, Rajendra E, Weinert BT, Passmore LA, Patel KJ, Olsen JV, Choudhary C, Bekker-Jensen S, Mailand N.

Mol Cell. 2015 Jan 8;57(1):150-64. doi: 10.1016/j.molcel.2014.12.001. Epub 2014 Dec 31.

24.

Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.

Bursomanno S, Beli P, Khan AM, Minocherhomji S, Wagner SA, Bekker-Jensen S, Mailand N, Choudhary C, Hickson ID, Liu Y.

DNA Repair (Amst). 2015 Jan;25:84-96. doi: 10.1016/j.dnarep.2014.10.011. Epub 2014 Nov 25.

PMID:
25497329
25.

Centriolar satellites: key mediators of centrosome functions.

Tollenaere MA, Mailand N, Bekker-Jensen S.

Cell Mol Life Sci. 2015 Jan;72(1):11-23. doi: 10.1007/s00018-014-1711-3. Epub 2014 Aug 31. Review.

PMID:
25173771
26.

UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells.

Oka Y, Varmark H, Vitting-Seerup K, Beli P, Waage J, Hakobyan A, Mistrik M, Choudhary C, Rohde M, Bekker-Jensen S, Mailand N.

EMBO Rep. 2014 Sep;15(9):956-64. doi: 10.15252/embr.201438679. Epub 2014 Aug 4.

27.

Molecular basis and regulation of OTULIN-LUBAC interaction.

Elliott PR, Nielsen SV, Marco-Casanova P, Fiil BK, Keusekotten K, Mailand N, Freund SM, Gyrd-Hansen M, Komander D.

Mol Cell. 2014 May 8;54(3):335-48. doi: 10.1016/j.molcel.2014.03.018. Epub 2014 Apr 10.

28.

Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.

Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo CX, Tang TS, Zhu BT, Xu XZ, Mailand N, Yang YG, Qi Y, Rendtlew Danielsen JM.

Cell Res. 2014 May;24(5):532-41. doi: 10.1038/cr.2014.36. Epub 2014 Mar 25.

29.

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J.

Cell. 2013 Nov 21;155(5):1088-103. doi: 10.1016/j.cell.2013.10.043. Erratum in: Cell. 2014 Jan 16;156(1-2):374.

30.

ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress.

Yamada M, Watanabe K, Mistrik M, Vesela E, Protivankova I, Mailand N, Lee M, Masai H, Lukas J, Bartek J.

Genes Dev. 2013 Nov 15;27(22):2459-72. doi: 10.1101/gad.224568.113.

31.

A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis.

Villumsen BH, Danielsen JR, Povlsen L, Sylvestersen KB, Merdes A, Beli P, Yang YG, Choudhary C, Nielsen ML, Mailand N, Bekker-Jensen S.

EMBO J. 2013 Nov 27;32(23):3029-40. doi: 10.1038/emboj.2013.223. Epub 2013 Oct 11.

32.

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

Damgaard RB, Fiil BK, Speckmann C, Yabal M, zur Stadt U, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M.

EMBO Mol Med. 2013 Aug;5(8):1278-95. doi: 10.1002/emmm.201303090. Epub 2013 Jul 1.

33.

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.

Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M.

Mol Cell. 2013 Jun 27;50(6):818-830. doi: 10.1016/j.molcel.2013.06.004.

34.

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ, Streicher W, Wikström M, Choudhary C, Houtsmuller AB, Marteijn JA, Bekker-Jensen S, Mailand N.

J Cell Biol. 2013 Jun 10;201(6):797-807. doi: 10.1083/jcb.201212075.

35.

The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.

Mosbech A, Lukas C, Bekker-Jensen S, Mailand N.

J Biol Chem. 2013 Jun 7;288(23):16579-87. doi: 10.1074/jbc.M113.459917. Epub 2013 Apr 24.

36.

Regulation of PCNA-protein interactions for genome stability.

Mailand N, Gibbs-Seymour I, Bekker-Jensen S.

Nat Rev Mol Cell Biol. 2013 May;14(5):269-82. doi: 10.1038/nrm3562. Epub 2013 Apr 18. Review.

PMID:
23594953
37.

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling.

Smeenk G, Wiegant WW, Marteijn JA, Luijsterburg MS, Sroczynski N, Costelloe T, Romeijn RJ, Pastink A, Mailand N, Vermeulen W, van Attikum H.

J Cell Sci. 2013 Feb 15;126(Pt 4):889-903. doi: 10.1242/jcs.109413. Epub 2012 Dec 21.

38.

DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.

Mosbech A, Gibbs-Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, Nielsen SV, Smedegaard S, Sedgwick G, Lukas C, Hartmann-Petersen R, Lukas J, Choudhary C, Pocock R, Bekker-Jensen S, Mailand N.

Nat Struct Mol Biol. 2012 Nov;19(11):1084-92. doi: 10.1038/nsmb.2395. Epub 2012 Oct 7.

PMID:
23042605
39.

RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells.

Oestergaard VH, Pentzold C, Pedersen RT, Iosif S, Alpi A, Bekker-Jensen S, Mailand N, Lisby M.

DNA Repair (Amst). 2012 Nov 1;11(11):892-905. doi: 10.1016/j.dnarep.2012.08.005. Epub 2012 Sep 24.

PMID:
23010445
40.

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.

Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.

Nat Cell Biol. 2012 Oct;14(10):1089-98. doi: 10.1038/ncb2579. Epub 2012 Sep 23.

PMID:
23000965
41.

Ubiquitin and the DNA damage response: a new handle on histones.

Bekker-Jensen S, Mailand N.

Cell Cycle. 2012 Sep 1;11(17):3153. doi: 10.4161/cc.21718. Epub 2012 Aug 16. No abstract available.

42.

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.

Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C.

Cell. 2012 Aug 17;150(4):697-709. doi: 10.1016/j.cell.2012.06.039. Epub 2012 Aug 9. Erratum in: Cell. 2014 Dec 4;159(6):1476-7.

43.

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M.

Mol Cell. 2012 Jun 29;46(6):746-58. doi: 10.1016/j.molcel.2012.04.014. Epub 2012 May 17.

44.

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.

Luijsterburg MS, Acs K, Ackermann L, Wiegant WW, Bekker-Jensen S, Larsen DH, Khanna KK, van Attikum H, Mailand N, Dantuma NP.

EMBO J. 2012 May 30;31(11):2511-27. doi: 10.1038/emboj.2012.104. Epub 2012 Apr 24.

45.

ICLs: a chicken without an egg.

Bekker-Jensen S, Mailand N.

Nat Rev Mol Cell Biol. 2012 Apr 25;13(6):342. doi: 10.1038/nrm3348. No abstract available.

PMID:
22531379
46.

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.

Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikström M, Bekker-Jensen S, Mailand N.

J Cell Biol. 2012 Apr 16;197(2):179-87. doi: 10.1083/jcb.201106152.

47.

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks.

Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N.

J Cell Biol. 2012 Apr 16;197(2):189-99. doi: 10.1083/jcb.201109100. Epub 2012 Apr 9.

48.

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H, Ramadan K.

Nat Cell Biol. 2011 Oct 23;13(11):1376-82. doi: 10.1038/ncb2367.

PMID:
22020440
49.

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks.

Bekker-Jensen S, Mailand N.

FEBS Lett. 2011 Sep 16;585(18):2914-9. doi: 10.1016/j.febslet.2011.05.056. Epub 2011 Jun 12. Review.

50.

Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.

Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.

Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. doi: 10.1074/mcp.M110.003590. Epub 2010 Dec 7.

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