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Predictors of delirium after cardiac surgery in patients with sleep disordered breathing.

Tafelmeier M, Knapp M, Lebek S, Floerchinger B, Camboni D, Creutzenberg M, Wittmann S, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M.

Eur Respir J. 2019 Aug 8;54(2). pii: 1900354. doi: 10.1183/13993003.00354-2019. Print 2019 Aug.


The role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition.

Schlossbauer MH, Hubauer U, Stadler S, Hupf J, Sag S, Birner C, Zimmermann M, Orso E, Fischer M, Luchner A, Maier LS, Jungbauer CG.

Biomark Med. 2019 Apr;13(5):379-392. doi: 10.2217/bmm-2018-0275. Epub 2019 Mar 28.


Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock.

Sossalla S, Meindl C, Fischer M, Lubnow M, Müller T, Maier LS.

Circ Cardiovasc Interv. 2019 Feb;12(2):e007425. doi: 10.1161/CIRCINTERVENTIONS.118.007425. No abstract available.


Empagliflozin enhances human and murine cardiomyocyte glucose uptake by increased expression of GLUT1.

Mustroph J, Lücht CM, Wagemann O, Sowa T, Hammer KP, Sag CM, Tarnowski D, Holzamer A, Pabel S, Beuthner BE, Sossalla S, Maier LS, Wagner S.

Diabetologia. 2019 Apr;62(4):726-729. doi: 10.1007/s00125-019-4819-z. No abstract available.


Achieving Guideline-Directed Heart Rate ControlEarly Posthospitalization.

Jungbauer CG, Maier LS, Emoto K, Zirille FM, Mirro MJ.

Am J Cardiol. 2019 Apr 1;123(7):1096-1100. doi: 10.1016/j.amjcard.2018.12.032. Epub 2019 Jan 4.


Mechanisms of cardiac ethanol toxicity and novel treatment options.

Mustroph J, Lebek S, Maier LS, Neef S.

Pharmacol Ther. 2019 May;197:1-10. doi: 10.1016/j.pharmthera.2018.12.006. Epub 2018 Dec 14. Review.


Impact of Body Mass Index on Outcomes in the Edoxaban Versus Warfarin Therapy Groups in Patients Underwent Cardioversion of Atrial Fibrillation (from ENSURE-AF).

Lip GYH, Merino JL, Banach M, de Groot JR, Maier LS, Themistoclakis S, Boriani G, Jin J, Melino M, Winters SM, Goette A.

Am J Cardiol. 2019 Feb 15;123(4):592-597. doi: 10.1016/j.amjcard.2018.11.019. Epub 2018 Nov 24.


Prognostic significance of emergency department bypass in stable and unstable patients with ST-segment elevation myocardial infarction.

Scholz KH, Friede T, Meyer T, Jacobshagen C, Lengenfelder B, Jung J, Fleischmann C, Moehlis H, Olbrich HG, Ott R, Elsässer A, Schröder S, Thilo C, Raut W, Franke A, Maier LS, Maier SK.

Eur Heart J Acute Cardiovasc Care. 2018 Nov 27:2048872618813907. doi: 10.1177/2048872618813907. [Epub ahead of print]


The functional consequences of sodium channel NaV 1.8 in human left ventricular hypertrophy.

Ahmad S, Tirilomis P, Pabel S, Dybkova N, Hartmann N, Molina CE, Tirilomis T, Kutschka I, Frey N, Maier LS, Hasenfuss G, Streckfuss-Bömeke K, Sossalla S.

ESC Heart Fail. 2019 Feb;6(1):154-163. doi: 10.1002/ehf2.12378. Epub 2018 Oct 30.


Insights into permanent pacemaker implantation following TAVR in a real-world cohort.

Tichelbäcker T, Bergau L, Puls M, Friede T, Mütze T, Maier LS, Frey N, Hasenfuß G, Zabel M, Jacobshagen C, Sossalla S.

PLoS One. 2018 Oct 17;13(10):e0204503. doi: 10.1371/journal.pone.0204503. eCollection 2018.


Empagliflozin directly improves diastolic function in human heart failure.

Pabel S, Wagner S, Bollenberg H, Bengel P, Kovács Á, Schach C, Tirilomis P, Mustroph J, Renner A, Gummert J, Fischer T, Van Linthout S, Tschöpe C, Streckfuss-Bömeke K, Hasenfuss G, Maier LS, Hamdani N, Sossalla S.

Eur J Heart Fail. 2018 Dec;20(12):1690-1700. doi: 10.1002/ejhf.1328. Epub 2018 Oct 17.


Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.

Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Wang Y, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuß G, El-Armouche A, Sossalla S.

Eur J Heart Fail. 2018 Dec;20(12):1673-1685. doi: 10.1002/ejhf.1297. Epub 2018 Sep 7.


One-Year Outcomes after PCI Strategies in Cardiogenic Shock.

Thiele H, Akin I, Sandri M, de Waha-Thiele S, Meyer-Saraei R, Fuernau G, Eitel I, Nordbeck P, Geisler T, Landmesser U, Skurk C, Fach A, Jobs A, Lapp H, Piek JJ, Noc M, Goslar T, Felix SB, Maier LS, Stepinska J, Oldroyd K, Serpytis P, Montalescot G, Barthelemy O, Huber K, Windecker S, Hunziker L, Savonitto S, Torremante P, Vrints C, Schneider S, Zeymer U, Desch S; CULPRIT-SHOCK Investigators.

N Engl J Med. 2018 Nov 1;379(18):1699-1710. doi: 10.1056/NEJMoa1808788. Epub 2018 Aug 25.


Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.

Mustroph J, Wagemann O, Lücht CM, Trum M, Hammer KP, Sag CM, Lebek S, Tarnowski D, Reinders J, Perbellini F, Terracciano C, Schmid C, Schopka S, Hilker M, Zausig Y, Pabel S, Sossalla ST, Schweda F, Maier LS, Wagner S.

ESC Heart Fail. 2018 Aug;5(4):642-648. doi: 10.1002/ehf2.12336.


The detrimental potential of arrhythmia-induced cardiomyopathy.

Eiringhaus J, Hamer OW, Hollemann D, Brochhausen C, Vollmann D, Maier LS, Sossalla S.

ESC Heart Fail. 2018 Oct;5(5):960-964. doi: 10.1002/ehf2.12343. Epub 2018 Aug 6.


The German CPU registry: Comparison of smokers and nonsmokers.

Bock D, Senges J, Pohlmann C, Hochadel M, Münzel T, Giannitsis E, Schmitt C, Heusch G, Voigtländer T, Mudra H, Schumacher B, Darius H, Maier LS, Hailer B, Haude M, Gohlke H, Hink U.

Herz. 2018 Jul 27. doi: 10.1007/s00059-018-4733-z. [Epub ahead of print]


Clinical care for patients with recurrent myocardial ischemia in Germany-the VOICES trial.

Berliner D, Maier LS, Wollenberg U, Limberg R, Schmitto JD, Westermann D, Bauersachs J.

J Thorac Dis. 2018 Jun;10(Suppl 15):S1777-S1784. doi: 10.21037/jtd.2017.10.123.


Postoperative complications after elective coronary artery bypass grafting surgery in patients with sleep-disordered breathing.

Tafelmeier M, Weizenegger T, Ripfel S, Fauser M, Floerchinger B, Camboni D, Zausig Y, Wittmann S, Drzymalski MA, Zeman F, Schmid C, Maier LS, Wagner S, Arzt M.

Clin Res Cardiol. 2018 Dec;107(12):1148-1159. doi: 10.1007/s00392-018-1289-0. Epub 2018 Jun 12.


Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.

Dybkova N, Ahmad S, Pabel S, Tirilomis P, Hartmann N, Fischer TH, Bengel P, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Ellenberger D, Wagner S, Frey N, Maier LS, Streckfuss-Bömeke K, Hasenfuss G, Sossalla S.

Cardiovasc Res. 2018 Nov 1;114(13):1728-1737. doi: 10.1093/cvr/cvy152.


SCN10A-Dependent Late INa Current: Never Too Late for Cardiac Conduction?

Maier LS, Sossalla S, Schulze-Bahr E.

Circ Genom Precis Med. 2018 May;11(5):e002167. doi: 10.1161/CIRCGEN.118.002167. No abstract available.


The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.

Lebek S, Plößl A, Baier M, Mustroph J, Tarnowski D, Lücht CM, Schopka S, Flörchinger B, Schmid C, Zausig Y, Pagratis N, Marchand B, Koltun DO, Hung WK, Ahmadyar S, Belardinelli L, Maier LS, Wagner S.

J Mol Cell Cardiol. 2018 May;118:159-168. doi: 10.1016/j.yjmcc.2018.03.020. Epub 2018 Mar 31.


Cardiac unloading by LVAD support differentially influences components of the cGMP-PKG signaling pathway in ischemic and dilated cardiomyopathy.

Persoon S, Paulus M, Hirt S, Jungbauer C, Dietl A, Luchner A, Schmid C, Maier LS, Birner C.

Heart Vessels. 2018 Aug;33(8):948-957. doi: 10.1007/s00380-018-1149-x. Epub 2018 Mar 15.


Guideline-adherence regarding critical time intervals in the German Chest Pain Unit registry.

Vafaie M, Hochadel M, Münzel T, Hailer B, Schumacher B, Heusch G, Voigtländer T, Mudra H, Haude M, Barth S, Schmitt C, Darius H, Maier LS, Katus HA, Senges J, Giannitsis E.

Eur Heart J Acute Cardiovasc Care. 2018 Mar 1:2048872618762639. doi: 10.1177/2048872618762639. [Epub ahead of print]


Sleep-disordered breathing is associated with disturbed cardiac repolarization in patients with a coronary artery bypass graft surgery.

Schmidleitner C, Arzt M, Tafelmeier M, Ripfel S, Fauser M, Weizenegger T, Flörchinger B, Camboni D, Wittmann S, Zeman F, Schmid C, Maier LS, Wagner S, Fisser C.

Sleep Med. 2018 Feb;42:13-20. doi: 10.1016/j.sleep.2017.12.007. Epub 2018 Jan 8.


Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial.

Scholz KH, Maier SKG, Maier LS, Lengenfelder B, Jacobshagen C, Jung J, Fleischmann C, Werner GS, Olbrich HG, Ott R, Mudra H, Seidl K, Schulze PC, Weiss C, Haimerl J, Friede T, Meyer T.

Eur Heart J. 2018 Apr 1;39(13):1065-1074. doi: 10.1093/eurheartj/ehy004.


A RAndomized Trial to compare the acute reconnection after pulmonary vein ISolation with Laser-BalloON versus radiofrequency Ablation: RATISBONA trial.

Ücer E, Janeczko Y, Seegers J, Fredersdorf S, Friemel S, Poschenrieder F, Maier LS, Jungbauer CG.

J Cardiovasc Electrophysiol. 2018 May;29(5):733-739. doi: 10.1111/jce.13465. Epub 2018 Mar 8.


Long-term outcomes and predictors of recurrence after pulmonary vein isolation with multielectrode ablation catheter in patients with atrial fibrillation.

Fredersdorf S, Fenzl C, Jungbauer C, Weber S, von Bary C, Dietl A, Seegers J, Maier LS, Ücer E.

J Cardiovasc Med (Hagerstown). 2018 Apr;19(4):148-154. doi: 10.2459/JCM.0000000000000631.


Invasive treatment of NSTEMI patients in German Chest Pain Units - Evidence for a treatment paradox.

Schmidt FP, Schmitt C, Hochadel M, Giannitsis E, Darius H, Maier LS, Schmitt C, Heusch G, Voigtländer T, Mudra H, Gori T, Senges J, Münzel T; German Chest Pain Unit Registry.

Int J Cardiol. 2018 Mar 15;255:15-19. doi: 10.1016/j.ijcard.2017.11.018.


SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure.

Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S.

J Mol Cell Cardiol. 2018 Mar;116:81-90. doi: 10.1016/j.yjmcc.2018.02.002. Epub 2018 Feb 3.


Adaptive servo-ventilation and sleep quality in treatment emergent central sleep apnea and central sleep apnea in patients with heart disease and preserved ejection fraction.

Heider K, Arzt M, Lerzer C, Kolb L, Pfeifer M, Maier LS, Gfüllner F, Malfertheiner MV.

Clin Res Cardiol. 2018 May;107(5):421-429. doi: 10.1007/s00392-018-1203-9. Epub 2018 Jan 25.


Nocturnal hypoxemic burden is associated with epicardial fat volume in patients with acute myocardial infarction.

Linz D, Colling S, Nußstein W, Debl K, Hohl M, Fellner C, Böhm M, Maier LS, Hamer OW, Buchner S, Arzt M.

Sleep Breath. 2018 Sep;22(3):703-711. doi: 10.1007/s11325-017-1616-0. Epub 2018 Jan 11.


Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study.

Olivotto I, Camici PG, Merlini PA, Rapezzi C, Patten M, Climent V, Sinagra G, Tomberli B, Marin F, Ehlermann P, Maier LS, Fornaro A, Jacobshagen C, Ganau A, Moretti L, Hernandez Madrid A, Coppini R, Reggiardo G, Poggesi C, Fattirolli F, Belardinelli L, Gensini G, Mugelli A.

Circ Heart Fail. 2018 Jan;11(1):e004124. doi: 10.1161/CIRCHEARTFAILURE.117.004124.


3D vena contracta area after MitraClip© procedure: precise quantification of residual mitral regurgitation and identification of prognostic information.

Dietl A, Prieschenk C, Eckert F, Birner C, Luchner A, Maier LS, Buchner S.

Cardiovasc Ultrasound. 2018 Jan 9;16(1):1. doi: 10.1186/s12947-017-0120-9.


Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.

Neef S, Steffens A, Pellicena P, Mustroph J, Lebek S, Ort KR, Schulman H, Maier LS.

J Mol Cell Cardiol. 2018 Feb;115:73-81. doi: 10.1016/j.yjmcc.2017.12.015. Epub 2017 Dec 30.


Erratum to: Resolution of ST deviation after myocardial infarction in patients with and without sleep-disordered breathing.

Sterz U, Buchner S, Hetzenecker A, Satzl A, Debl K, Luchner A, Husser O, Hamer OW, Fellner C, Zeman F, Maier LS, Arzt M.

Somnologie (Berl). 2018;22(2):130. doi: 10.1007/s11818-018-0165-5. Epub 2018 May 23.


A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.

Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11.


Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.

Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, Maier LS, Conti M, Wess J, El-Armouche A, Hasenfuß G, Nikolaev VO.

Sci Rep. 2017 Nov 9;7(1):15222. doi: 10.1038/s41598-017-15632-x.


PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock.

Thiele H, Akin I, Sandri M, Fuernau G, de Waha S, Meyer-Saraei R, Nordbeck P, Geisler T, Landmesser U, Skurk C, Fach A, Lapp H, Piek JJ, Noc M, Goslar T, Felix SB, Maier LS, Stepinska J, Oldroyd K, Serpytis P, Montalescot G, Barthelemy O, Huber K, Windecker S, Savonitto S, Torremante P, Vrints C, Schneider S, Desch S, Zeymer U; CULPRIT-SHOCK Investigators.

N Engl J Med. 2017 Dec 21;377(25):2419-2432. doi: 10.1056/NEJMoa1710261. Epub 2017 Oct 30.


Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart.

Molina CE, Jacquet E, Ponien P, Muñoz-Guijosa C, Baczkó I, Maier LS, Donzeau-Gouge P, Dobrev D, Fischmeister R, Garnier A.

Cardiovasc Res. 2018 Feb 1;114(2):247-258. doi: 10.1093/cvr/cvx182.


Acute Renal Graft-Versus-Host Disease in a Murine Model of Allogeneic Bone Marrow Transplantation.

Schmid PM, Bouazzaoui A, Schmid K, Birner C, Schach C, Maier LS, Holler E, Endemann DH.

Cell Transplant. 2017 Aug;26(8):1428-1440. doi: 10.1177/0963689717720295.


C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.

Burel S, Coyan FC, Lorenzini M, Meyer MR, Lichti CF, Brown JH, Loussouarn G, Charpentier F, Nerbonne JM, Townsend RR, Maier LS, Marionneau C.

J Biol Chem. 2017 Oct 20;292(42):17431-17448. doi: 10.1074/jbc.M117.787788. Epub 2017 Sep 7.


Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A.

Basic Res Cardiol. 2017 Sep;112(5):51. doi: 10.1007/s00395-017-0638-x. No abstract available.


[Acute Coronary Syndrome - What should the general practitioner do?]

Stadler S, Endemann D, Maier LS.

Dtsch Med Wochenschr. 2017 Jul;142(13):994-999. doi: 10.1055/s-0042-124042. Epub 2017 Jul 3. Review. German.


Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability.

Neef S, Mann C, Zwenger A, Dybkova N, Maier LS.

Basic Res Cardiol. 2017 Jul;112(4):45. doi: 10.1007/s00395-017-0637-y. Epub 2017 Jun 13.


Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation.

Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A.

Basic Res Cardiol. 2017 Jul;112(4):43. doi: 10.1007/s00395-017-0635-0. Epub 2017 Jun 9. Erratum in: Basic Res Cardiol. 2017 Sep;112(5):51.


Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.


Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A.

Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840.


Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):857-862. doi: 10.1007/s00210-017-1376-1. Epub 2017 Apr 27.


Association of sleep-disordered breathing and disturbed cardiac repolarization in patients with ST-segment elevation myocardial infarction.

Fisser C, Marcinek A, Hetzenecker A, Debl K, Luchner A, Sterz U, Priefert J, Zeman F, Kohler M, Maier LS, Buchner S, Arzt M.

Sleep Med. 2017 May;33:61-67. doi: 10.1016/j.sleep.2017.01.007. Epub 2017 Jan 23.


Whom are we treating with adaptive servo-ventilation? A clinical post hoc analysis.

Malfertheiner MV, Lerzer C, Kolb L, Heider K, Zeman F, Gfüllner F, Maier LS, Pfeifer M, Arzt M.

Clin Res Cardiol. 2017 Sep;106(9):702-710. doi: 10.1007/s00392-017-1112-3. Epub 2017 Apr 17.


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