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Items: 20


α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.

Levine PM, Galesic A, Balana AT, Mahul-Mellier AL, Navarro MX, De Leon CA, Lashuel HA, Pratt MR.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1511-1519. doi: 10.1073/pnas.1808845116. Epub 2019 Jan 16.


Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.

Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA.

Nat Commun. 2017 Nov 22;8(1):1678. doi: 10.1038/s41467-017-01575-4.


Amyloid single-cell cytotoxicity assays by nanomotion detection.

Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G.

Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017.


Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D.

ACS Chem Biol. 2016 Sep 16;11(9):2428-37. doi: 10.1021/acschembio.6b00539. Epub 2016 Jul 11.


Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer.

Alzoubi S, Brody L, Rahman S, Mahul-Mellier AL, Mercado N, Ito K, El-Bahrawy M, Silver A, Boobis A, Bell JD, Hajji N.

Oncotarget. 2016 Jul 12;7(28):44505-44521. doi: 10.18632/oncotarget.9887.


Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies.

Benmessaoud IR, Mahul-Mellier AL, Horváth E, Maco B, Spina M, Lashuel HA, Forró L.

Toxicol Res (Camb). 2015 Nov 25;5(2):407-419. doi: 10.1039/c5tx00303b. eCollection 2016 Mar 1.


Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.

Mahul-Mellier AL, Vercruysse F, Maco B, Ait-Bouziad N, De Roo M, Muller D, Lashuel HA.

Cell Death Differ. 2015 Dec;22(12):2107-22. doi: 10.1038/cdd.2015.79. Epub 2015 Jul 3.


Stefan Grimm, 1963-2014, a tragic loss for the scientific community.

Mahul-Mellier AL, Huc L, Lemarié A, Irshad S, Hwang M, Datler C, Pazarentzos E.

Cell Death Differ. 2015 Feb;22(2):247. doi: 10.1038/cdd.2014.196. No abstract available.


IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention.

Pazarentzos E, Mahul-Mellier AL, Datler C, Chaisaklert W, Hwang MS, Kroon J, Qize D, Osborne F, Al-Rubaish A, Al-Ali A, Mazarakis ND, Aboagye EO, Grimm S.

EMBO J. 2014 Dec 1;33(23):2814-28. doi: 10.15252/embj.201488183. Epub 2014 Oct 31.


The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA.

J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16.


CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex.

Datler C, Pazarentzos E, Mahul-Mellier AL, Chaisaklert W, Hwang MS, Osborne F, Grimm S.

J Cell Sci. 2014 Apr 15;127(Pt 8):1816-28. doi: 10.1242/jcs.140467. Epub 2014 Feb 12.


c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA.

Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.


De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1.

Mahul-Mellier AL, Datler C, Pazarentzos E, Lin B, Chaisaklert W, Abuali G, Grimm S.

Biochim Biophys Acta. 2012 Aug;1823(8):1353-65. doi: 10.1016/j.bbamcr.2012.05.022. Epub 2012 May 30.


De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.

Mahul-Mellier AL, Pazarentzos E, Datler C, Iwasawa R, AbuAli G, Lin B, Grimm S.

Cell Death Differ. 2012 May;19(5):891-9. doi: 10.1038/cdd.2011.185. Epub 2011 Dec 16.


Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.

Iwasawa R, Mahul-Mellier AL, Datler C, Pazarentzos E, Grimm S.

EMBO J. 2011 Feb 2;30(3):556-68. doi: 10.1038/emboj.2010.346. Epub 2010 Dec 24.


Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction.

Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S.

Cell Death Differ. 2011 Feb;18(2):338-49. doi: 10.1038/cdd.2010.93. Epub 2010 Aug 13.


Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.

Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S.

Cell Death Differ. 2009 Jun;16(6):890-8. doi: 10.1038/cdd.2009.21. Epub 2009 Mar 13.


Alix and ALG-2 make a link between endosomes and neuronal death.

Mahul-Mellier AL, Strappazzon F, Chatellard-Causse C, Blot B, Béal D, Torch S, Hemming F, Petiot A, Verna JM, Fraboulet S, Sadoul R.

Biochem Soc Trans. 2009 Feb;37(Pt 1):200-3. doi: 10.1042/BST0370200. Review.


Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.

Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, Blot B, Freeman K, Kuhn L, Garin J, Verna JM, Fraboulet S, Sadoul R.

J Biol Chem. 2008 Dec 12;283(50):34954-65. doi: 10.1074/jbc.M803140200. Epub 2008 Oct 20.


Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo.

Mahul-Mellier AL, Hemming FJ, Blot B, Fraboulet S, Sadoul R.

J Neurosci. 2006 Jan 11;26(2):542-9.

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