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Discovery, Validation, and Application of Novel Methylated DNA Markers for Detection of Esophageal Cancer in Plasma.

Qin Y, Wu CW, Taylor WR, Sawas T, Burger KN, Mahoney DW, Sun Z, Yab TC, Lidgard GP, Allawi HT, Buttar NS, Smyrk TC, Iyer PG, Katzka DA, Ahlquist DA, Kisiel JB.

Clin Cancer Res. 2019 Dec 15;25(24):7396-7404. doi: 10.1158/1078-0432.CCR-19-0740. Epub 2019 Sep 16.


Low Incidence of Aerodigestive Cancers in Patients With Negative Results From Colonoscopies, Regardless of Findings From Multitarget Stool DNA Tests.

Berger BM, Kisiel JB, Imperiale TF, Geenen DJ, Heigh RI, Mahoney DW, Hilsden RJ.

Clin Gastroenterol Hepatol. 2019 Aug 5. pii: S1542-3565(19)30846-8. doi: 10.1016/j.cgh.2019.07.057. [Epub ahead of print]


Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls.

Majumder S, Raimondo M, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Devens ME, Mahoney DW, Smyrk TC, Pannala R, Chari ST, Vege SS, Topazian MD, Petersen BT, Levy MJ, Rajan E, Gleeson FC, Dayyeh BA, Nguyen CC, Faigel DO, Woodward TA, Wallace MB, Petersen G, Allawi HT, Lidgard GP, Kisiel JB, Ahlquist DA.

Clin Gastroenterol Hepatol. 2019 Jul 16. pii: S1542-3565(19)30750-5. doi: 10.1016/j.cgh.2019.07.017. [Epub ahead of print]


Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.

Majumder S, Taylor WR, Yab TC, Berger CK, Dukek BA, Cao X, Foote PH, Wu CW, Mahoney DW, Aslanian HR, Fernández-Del Castillo C, Doyle LA, Farrell JJ, Fisher WE, Lee LS, Lee YN, Park W, Rodrigues C, Gould Rothberg BE, Salem RR, Simeone DM, Urs S, Van Buren G, Smyrk TC, Allawi HT, Lidgard GP, Raimondo M, Chari ST, Kendrick ML, Kisiel JB, Topazian MD, Ahlquist DA.

Am J Gastroenterol. 2019 Sep;114(9):1539-1549. doi: 10.14309/ajg.0000000000000284.



Kisiel JB, Mahoney DW, Taylor WR, Klepp P.

Clin Gastroenterol Hepatol. 2019 Jul 4. pii: S1542-3565(19)30729-3. doi: 10.1016/j.cgh.2019.06.038. [Epub ahead of print] No abstract available.


Serum Proteomics on the Basis of Discovery of Predictive Biomarkers of Response to Androgen Deprivation Therapy in Advanced Prostate Cancer.

Kohli M, Oberg AL, Mahoney DW, Riska SM, Sherwood R, Zhang Y, Zenka RM, Sahasrabudhe D, Qin R, Zhang S.

Clin Genitourin Cancer. 2019 Aug;17(4):248-253.e7. doi: 10.1016/j.clgc.2019.03.006. Epub 2019 Mar 15.


Hepatocellular Carcinoma Detection by Plasma Methylated DNA: Discovery, Phase I Pilot, and Phase II Clinical Validation.

Kisiel JB, Dukek BA, V S R Kanipakam R, Ghoz HM, Yab TC, Berger CK, Taylor WR, Foote PH, Giama NH, Onyirioha K, Abdallah MA, Burger KN, Slettedahl SW, Mahoney DW, Smyrk TC, Lewis JT, Giakoumopoulos M, Allawi HT, Lidgard GP, Roberts LR, Ahlquist DA.

Hepatology. 2019 Mar;69(3):1180-1192. doi: 10.1002/hep.30244. Epub 2019 Feb 5.


Burden of Tricuspid Regurgitation in Patients Diagnosed in the Community Setting.

Topilsky Y, Maltais S, Medina Inojosa J, Oguz D, Michelena H, Maalouf J, Mahoney DW, Enriquez-Sarano M.

JACC Cardiovasc Imaging. 2019 Mar;12(3):433-442. doi: 10.1016/j.jcmg.2018.06.014. Epub 2018 Aug 15.


Highly Discriminant Methylated DNA Markers for the Non-endoscopic Detection of Barrett's Esophagus.

Iyer PG, Taylor WR, Johnson ML, Lansing RL, Maixner KA, Yab TC, Simonson JA, Devens ME, Slettedahl SW, Mahoney DW, Berger CK, Foote PH, Smyrk TC, Wang KK, Wolfsen HC, Ahlquist DA.

Am J Gastroenterol. 2018 Aug;113(8):1156-1166. doi: 10.1038/s41395-018-0107-7. Epub 2018 Jun 12.


Detection of Gastric Cancer with Novel Methylated DNA Markers: Discovery, Tissue Validation, and Pilot Testing in Plasma.

Anderson BW, Suh YS, Choi B, Lee HJ, Yab TC, Taylor WR, Dukek BA, Berger CK, Cao X, Foote PH, Devens ME, Boardman LA, Kisiel JB, Mahoney DW, Slettedahl SW, Allawi HT, Lidgard GP, Smyrk TC, Yang HK, Ahlquist DA.

Clin Cancer Res. 2018 Nov 15;24(22):5724-5734. doi: 10.1158/1078-0432.CCR-17-3364. Epub 2018 May 29.


A Comprehensive Approach to Sequence-oriented IsomiR annotation (CASMIR): demonstration with IsomiR profiling in colorectal neoplasia.

Wu CW, Evans JM, Huang S, Mahoney DW, Dukek BA, Taylor WR, Yab TC, Smyrk TC, Jen J, Kisiel JB, Ahlquist DA.

BMC Genomics. 2018 May 25;19(1):401. doi: 10.1186/s12864-018-4794-7.


Analysis of DNA Methylation at Specific Loci in Stool Samples Detects Colorectal Cancer and High-Grade Dysplasia in Patients With Inflammatory Bowel Disease.

Kisiel JB, Klepp P, Allawi HT, Taylor WR, Giakoumopoulos M, Sander T, Yab TC, Moum BA, Lidgard GP, Brackmann S, Mahoney DW, Roseth A, Ahlquist DA.

Clin Gastroenterol Hepatol. 2019 Apr;17(5):914-921.e5. doi: 10.1016/j.cgh.2018.05.004. Epub 2018 May 15.


Novel Approach to Fecal Occult Blood Testing by Assay of Erythrocyte-Specific microRNA Markers.

Wu CW, Cao X, Berger CK, Foote PH, Mahoney DW, Simonson JA, Anderson BW, Yab TC, Taylor WR, Boardman LA, Kisiel JB, Ahlquist DA.

Dig Dis Sci. 2017 Aug;62(8):1985-1994. doi: 10.1007/s10620-017-4627-6. Epub 2017 Jun 28.


Long-term Follow-up of Patients Having False-Positive Multitarget Stool DNA Tests after Negative Screening Colonoscopy: The LONG-HAUL Cohort Study.

Cotter TG, Burger KN, Devens ME, Simonson JA, Lowrie KL, Heigh RI, Mahoney DW, Johnson DH, Ahlquist DA, Kisiel JB.

Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):614-621. doi: 10.1158/1055-9965.EPI-16-0800. Epub 2016 Dec 20.


Multitarget stool DNA test: clinical performance and impact on yield and quality of colonoscopy for colorectal cancer screening.

Johnson DH, Kisiel JB, Burger KN, Mahoney DW, Devens ME, Ahlquist DA, Sweetser S.

Gastrointest Endosc. 2017 Mar;85(3):657-665.e1. doi: 10.1016/j.gie.2016.11.012. Epub 2016 Nov 21.


Germline genetic variation in JAK2 as a prognostic marker in castration-resistant prostate cancer.

Zhang BY, Riska SM, Mahoney DW, Costello BA, Kohli R, Quevedo JF, Cerhan JR, Kohli M.

BJU Int. 2017 Mar;119(3):489-495. doi: 10.1111/bju.13584. Epub 2016 Aug 6.


Mitral Valve Prolapse, Psychoemotional Status, and Quality of Life: Prospective Investigation in the Current Era.

Bayer-Topilsky T, Suri RM, Topilsky Y, Marmor YN, Trenerry MR, Antiel RM, Mahoney DW, Schaff HV, Enriquez-Sarano M.

Am J Med. 2016 Oct;129(10):1100-9. doi: 10.1016/j.amjmed.2016.05.004. Epub 2016 May 24.


DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance.

Johnson DH, Taylor WR, Aboelsoud MM, Foote PH, Yab TC, Cao X, Smyrk TC, Loftus EV Jr, Mahoney DW, Ahlquist DA, Kisiel JB.

Inflamm Bowel Dis. 2016 Jul;22(7):1559-67. doi: 10.1097/MIB.0000000000000795.


Incidence and Predictors of Infective Endocarditis in Mitral Valve Prolapse: A Population-Based Study.

Katan O, Michelena HI, Avierinos JF, Mahoney DW, DeSimone DC, Baddour LM, Suri RM, Enriquez-Sarano M.

Mayo Clin Proc. 2016 Mar;91(3):336-42. doi: 10.1016/j.mayocp.2015.12.006. Epub 2016 Feb 5.


Mutational Landscapes of Sequential Prostate Metastases and Matched Patient Derived Xenografts during Enzalutamide Therapy.

Kohli M, Wang L, Xie F, Sicotte H, Yin P, Dehm SM, Hart SN, Vedell PT, Barman P, Qin R, Mahoney DW, Carlson RE, Eckel-Passow JE, Atwell TD, Eiken PW, McMenomy BP, Wieben ED, Jha G, Jimenez RE, Weinshilboum R, Wang L.

PLoS One. 2015 Dec 22;10(12):e0145176. doi: 10.1371/journal.pone.0145176. eCollection 2015.


Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People.

Redwood DG, Asay ED, Blake ID, Sacco PE, Christensen CM, Sacco FD, Tiesinga JJ, Devens ME, Alberts SR, Mahoney DW, Yab TC, Foote PH, Smyrk TC, Provost EM, Ahlquist DA.

Mayo Clin Proc. 2016 Jan;91(1):61-70. doi: 10.1016/j.mayocp.2015.10.008. Epub 2015 Oct 28.


Endoscopic overestimation of colorectal polyp size.

Anderson BW, Smyrk TC, Anderson KS, Mahoney DW, Devens ME, Sweetser SR, Kisiel JB, Ahlquist DA.

Gastrointest Endosc. 2016 Jan;83(1):201-8. doi: 10.1016/j.gie.2015.06.058. Epub 2015 Aug 28.


Fecal Recovery of Ingested Cellular DNA: Implications for Noninvasive Detection of Upper Gastrointestinal Neoplasms.

Strauss BB, Yab TC, O'Connor HM, Taylor WR, Mahoney DW, Simonson JA, Christensen J, Chari ST, Ahlquist DA.

Dig Dis Sci. 2016 Jan;61(1):117-25. doi: 10.1007/s10620-015-3845-z. Epub 2015 Aug 22.


New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice.

Kisiel JB, Raimondo M, Taylor WR, Yab TC, Mahoney DW, Sun Z, Middha S, Baheti S, Zou H, Smyrk TC, Boardman LA, Petersen GM, Ahlquist DA.

Clin Cancer Res. 2015 Oct 1;21(19):4473-81. doi: 10.1158/1078-0432.CCR-14-2469. Epub 2015 May 28.


Is there an outcome penalty linked to guideline-based indications for valvular surgery? Early and long-term analysis of patients with organic mitral regurgitation.

Enriquez-Sarano M, Suri RM, Clavel MA, Mantovani F, Michelena HI, Pislaru S, Mahoney DW, Schaff HV.

J Thorac Cardiovasc Surg. 2015 Jul;150(1):50-8. doi: 10.1016/j.jtcvs.2015.04.009. Epub 2015 Apr 9.


Psychoemotional and quality of life response to mitral operations in patients with mitral regurgitation: a prospective study.

Bayer-Topilsky T, Suri RM, Topilsky Y, Marmor YN, Trenerry MR, Antiel RM, Mahoney DW, Schaff HV, Enriquez-Sarano M.

Ann Thorac Surg. 2015 Mar;99(3):847-54. doi: 10.1016/j.athoracsur.2014.10.030. Epub 2015 Jan 23.


Clinical outcome of isolated tricuspid regurgitation.

Topilsky Y, Nkomo VT, Vatury O, Michelena HI, Letourneau T, Suri RM, Pislaru S, Park S, Mahoney DW, Biner S, Enriquez-Sarano M.

JACC Cardiovasc Imaging. 2014 Dec;7(12):1185-94. doi: 10.1016/j.jcmg.2014.07.018. Epub 2014 Nov 5.


Particle-size and radiochemical purity evaluations of filtered 99mTc-sulfur colloid prepared with different heating times.

Michenfelder MM, Bartlett LJ, Mahoney DW, Herold TJ, Hung JC.

J Nucl Med Technol. 2014 Dec;42(4):283-8. doi: 10.2967/jnmt.114.145391. Epub 2014 Aug 7.


Stool methylated DNA markers decrease following colorectal cancer resection--implications for surveillance.

Kisiel JB, Yab TC, Taylor WR, Mahoney DW, Ahlquist DA.

Dig Dis Sci. 2014 Aug;59(8):1764-7. doi: 10.1007/s10620-014-3265-5. Epub 2014 Jul 4.


Detection rate and outcome of colonic serrated epithelial changes in patients with ulcerative colitis or Crohn's colitis.

Johnson DH, Khanna S, Smyrk TC, Loftus EV Jr, Anderson KS, Mahoney DW, Ahlquist DA, Kisiel JB.

Aliment Pharmacol Ther. 2014 Jun;39(12):1408-17. doi: 10.1111/apt.12774. Epub 2014 Apr 30.


B-type natriuretic peptide clinical activation in aortic stenosis: impact on long-term survival.

Clavel MA, Malouf J, Michelena HI, Suri RM, Jaffe AS, Mahoney DW, Enriquez-Sarano M.

J Am Coll Cardiol. 2014 May 20;63(19):2016-25. doi: 10.1016/j.jacc.2014.02.581. Epub 2014 Mar 26.


The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota.

Dandamudi S, Slusser J, Mahoney DW, Redfield MM, Rodeheffer RJ, Chen HH.

J Card Fail. 2014 May;20(5):304-9. doi: 10.1016/j.cardfail.2014.02.007. Epub 2014 Feb 24.


Quantitative Doppler-echocardiographic imaging and clinical outcomes with left ventricular systolic dysfunction: independent effect of pulmonary hypertension.

Miller WL, Mahoney DW, Enriquez-Sarano M.

Circ Cardiovasc Imaging. 2014 Mar;7(2):330-6. doi: 10.1161/CIRCIMAGING.113.001184. Epub 2014 Jan 31.


Detection of colorectal serrated polyps by stool DNA testing: comparison with fecal immunochemical testing for occult blood (FIT).

Heigh RI, Yab TC, Taylor WR, Hussain FT, Smyrk TC, Mahoney DW, Domanico MJ, Berger BM, Lidgard GP, Ahlquist DA.

PLoS One. 2014 Jan 20;9(1):e85659. doi: 10.1371/journal.pone.0085659. eCollection 2014.


Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine.

Hogan MC, Johnson KL, Zenka RM, Charlesworth MC, Madden BJ, Mahoney DW, Oberg AL, Huang BQ, Leontovich AA, Nesbitt LL, Bakeberg JL, McCormick DJ, Bergen HR, Ward CJ.

Kidney Int. 2014 May;85(5):1225-37. doi: 10.1038/ki.2013.422. Epub 2013 Nov 6.


Psycho-emotional manifestations of valvular heart diseases: prospective assessment in mitral regurgitation.

Bayer-Topilsky T, Trenerry MR, Suri R, Topilsky Y, Antiel RM, Marmor Y, Mahoney DW, Schaff HV, Enriquez-Sarano M.

Am J Med. 2013 Oct;126(10):916-24. doi: 10.1016/j.amjmed.2013.05.013. Epub 2013 Aug 8.


Impact of ageing on presentation and outcome of mitral regurgitation due to flail leaflet: a multicentre international study.

Avierinos JF, Tribouilloy C, Grigioni F, Suri R, Barbieri A, Michelena HI, Ionico T, Rusinaru D, Ansaldi S, Habib G, Szymanski C, Giorgi R, Mahoney DW, Enriquez-Sarano M; Mitral regurgitation International DAtabase (MIDA) Investigators.

Eur Heart J. 2013 Sep;34(33):2600-9. doi: 10.1093/eurheartj/eht250. Epub 2013 Jul 12.


Quality assessment metrics for whole genome gene expression profiling of paraffin embedded samples.

Mahoney DW, Therneau TM, Anderson SK, Jen J, Kocher JP, Reinholz MM, Perez EA, Eckel-Passow JE.

BMC Res Notes. 2013 Jan 30;6:33. doi: 10.1186/1756-0500-6-33.


Stool DNA testing for the detection of colorectal neoplasia in patients with inflammatory bowel disease.

Kisiel JB, Yab TC, Nazer Hussain FT, Taylor WR, Garrity-Park MM, Sandborn WJ, Loftus EV, Wolff BG, Smyrk TC, Itzkowitz SH, Rubin DT, Zou H, Mahoney DW, Ahlquist DA.

Aliment Pharmacol Ther. 2013 Mar;37(5):546-54. doi: 10.1111/apt.12218. Epub 2013 Jan 24.


Statistical methods for quantitative mass spectrometry proteomic experiments with labeling.

Oberg AL, Mahoney DW.

BMC Bioinformatics. 2012;13 Suppl 16:S7. doi: 10.1186/1471-2105-13-S16-S7. Epub 2012 Nov 5. Review.


Clinical context and mechanism of functional tricuspid regurgitation in patients with and without pulmonary hypertension.

Topilsky Y, Khanna A, Le Tourneau T, Park S, Michelena H, Suri R, Mahoney DW, Enriquez-Sarano M.

Circ Cardiovasc Imaging. 2012 May 1;5(3):314-23. doi: 10.1161/CIRCIMAGING.111.967919. Epub 2012 Mar 23.


Mitral valve prolapse with mid-late systolic mitral regurgitation: pitfalls of evaluation and clinical outcome compared with holosystolic regurgitation.

Topilsky Y, Michelena H, Bichara V, Maalouf J, Mahoney DW, Enriquez-Sarano M.

Circulation. 2012 Apr 3;125(13):1643-51. doi: 10.1161/CIRCULATIONAHA.111.055111. Epub 2012 Mar 2.


Germline predictors of androgen deprivation therapy response in advanced prostate cancer.

Kohli M, Riska SM, Mahoney DW, Chai HS, Hillman DW, Rider DN, Costello BA, Qin R, Lamba J, Sahasrabudhe DM, Cerhan JR.

Mayo Clin Proc. 2012 Mar;87(3):240-6. doi: 10.1016/j.mayocp.2011.09.009.


Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates.

Kisiel JB, Yab TC, Taylor WR, Chari ST, Petersen GM, Mahoney DW, Ahlquist DA.

Cancer. 2012 May 15;118(10):2623-31. doi: 10.1002/cncr.26558. Epub 2011 Sep 22.


Next-generation stool DNA test accurately detects colorectal cancer and large adenomas.

Ahlquist DA, Zou H, Domanico M, Mahoney DW, Yab TC, Taylor WR, Butz ML, Thibodeau SN, Rabeneck L, Paszat LF, Kinzler KW, Vogelstein B, Bjerregaard NC, Laurberg S, Sørensen HT, Berger BM, Lidgard GP.

Gastroenterology. 2012 Feb;142(2):248-56; quiz e25-6. doi: 10.1053/j.gastro.2011.10.031. Epub 2011 Nov 4.


The stool DNA test is more accurate than the plasma septin 9 test in detecting colorectal neoplasia.

Ahlquist DA, Taylor WR, Mahoney DW, Zou H, Domanico M, Thibodeau SN, Boardman LA, Berger BM, Lidgard GP.

Clin Gastroenterol Hepatol. 2012 Mar;10(3):272-7.e1. doi: 10.1016/j.cgh.2011.10.008. Epub 2011 Oct 20.


Contribution of ventricular diastolic dysfunction to pulmonary hypertension complicating chronic systolic heart failure.

Miller WL, Mahoney DW, Michelena HI, Pislaru SV, Topilsky Y, Enriquez-Sarano M.

JACC Cardiovasc Imaging. 2011 Sep;4(9):946-54. doi: 10.1016/j.jcmg.2011.06.017.


Bi-Linear Regression for O Quantification: Modeling across the Elution Profile.

Eckel-Passow JE, Mahoney DW, Oberg AL, Zenka RM, Johnson KL, Nair KS, Kudva YC, Bergen HR 3rd, Therneau TM.

J Proteomics Bioinform. 2010 Dec 15;3(12):314-320.


Progression of left ventricular diastolic dysfunction and risk of heart failure.

Kane GC, Karon BL, Mahoney DW, Redfield MM, Roger VL, Burnett JC Jr, Jacobsen SJ, Rodeheffer RJ.

JAMA. 2011 Aug 24;306(8):856-63. doi: 10.1001/jama.2011.1201.


Relative quantification: characterization of bias, variability and fold changes in mass spectrometry data from iTRAQ-labeled peptides.

Mahoney DW, Therneau TM, Heppelmann CJ, Higgins L, Benson LM, Zenka RM, Jagtap P, Nelsestuen GL, Bergen HR, Oberg AL.

J Proteome Res. 2011 Sep 2;10(9):4325-33. doi: 10.1021/pr2001308. Epub 2011 Aug 2.

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