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Visualizing Oncolytic Virus-Host Interactions in Live Mice Using Intravital Microscopy.

Naumenko V, Van S, Dastidar H, Kim DS, Kim SJ, Zeng Z, Deniset J, Lau A, Zhang C, Macia N, Heyne B, Jenne CN, Mahoney DJ.

Mol Ther Oncolytics. 2018 Jul 14;10:14-27. doi: 10.1016/j.omto.2018.06.001. eCollection 2018 Sep 28.


Tracking Cell Recruitment and Behavior within the Tumor Microenvironment Using Advanced Intravital Imaging Approaches.

Turk M, Naumenko V, Mahoney DJ, Jenne CN.

Cells. 2018 Jul 3;7(7). pii: E69. doi: 10.3390/cells7070069.


Author Correction: Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.

Kim DS, Dastidar H, Zhang C, Zemp FJ, Lau K, Ernst M, Rakic A, Sikdar S, Rajwani J, Naumenko V, Balce DR, Ewanchuk BW, Tailor P, Yates RM, Jenne C, Gafuik C, Mahoney DJ.

Nat Commun. 2018 May 24;9(1):2109. doi: 10.1038/s41467-018-04597-8.


Rhabdoviruses as vaccine platforms for infectious disease and cancer.

Zemp F, Rajwani J, Mahoney DJ.

Biotechnol Genet Eng Rev. 2018 Apr;34(1):122-138. doi: 10.1080/02648725.2018.1474320. Epub 2018 May 21. Review.


Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy.

Allan KJ, Mahoney DJ, Baird SD, Lefebvre CA, Stojdl DF.

J Vis Exp. 2018 Apr 3;(134). doi: 10.3791/56913.


The complex interplay between neutrophils and cancer.

Rakic A, Beaudry P, Mahoney DJ.

Cell Tissue Res. 2018 Mar;371(3):517-529. doi: 10.1007/s00441-017-2777-7. Epub 2018 Feb 9. Review.


Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.

Kim DS, Dastidar H, Zhang C, Zemp FJ, Lau K, Ernst M, Rakic A, Sikdar S, Rajwani J, Naumenko V, Balce DR, Ewanchuk BW, Tailor P, Yates RM, Jenne C, Gafuik C, Mahoney DJ.

Nat Commun. 2017 Aug 24;8(1):344. doi: 10.1038/s41467-017-00324-x. Erratum in: Nat Commun. 2018 May 24;9(1):2109.


Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis.

Sabokbar A, Afrough S, Mahoney DJ, Uchihara Y, Swales C, Athanasou NA.

World J Exp Med. 2017 May 20;7(2):49-57. doi: 10.5493/wjem.v7.i2.49. eCollection 2017 May 20.


Intravital Microscopy for Imaging the Tumor Microenvironment in Live Mice.

Naumenko V, Jenne C, Mahoney DJ.

Methods Mol Biol. 2016;1458:217-30. doi: 10.1007/978-1-4939-3801-8_16.


Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases.

Sabokbar A, Mahoney DJ, Hemingway F, Athanasou NA.

Clin Rev Allergy Immunol. 2016 Aug;51(1):16-26. doi: 10.1007/s12016-015-8523-6. Review.


Management considerations to minimize environmental impacts of arsenic following monosodium methylarsenate (MSMA) applications to turfgrass.

Mahoney DJ, Gannon TW, Jeffries MD, Matteson AR, Polizzotto ML.

J Environ Manage. 2015 Mar 1;150:444-450. doi: 10.1016/j.jenvman.2014.12.027. Epub 2014 Dec 31.


Virus therapy for cancer.

Mahoney DJ, Stojdl DF, Laird G.

Sci Am. 2014 Nov;311(5):54-9. No abstract available.


Integrated field lysimetry and porewater sampling for evaluation of chemical mobility in soils and established vegetation.

Matteson AR, Mahoney DJ, Gannon TW, Polizzotto ML.

J Vis Exp. 2014 Jul 4;(89). doi: 10.3791/51862.


Smac mimetics and innate immune stimuli synergize to promote tumor death.

Beug ST, Tang VA, LaCasse EC, Cheung HH, Beauregard CE, Brun J, Nuyens JP, Earl N, St-Jean M, Holbrook J, Dastidar H, Mahoney DJ, Ilkow C, Le Boeuf F, Bell JC, Korneluk RG.

Nat Biotechnol. 2014 Feb;32(2):182-90. doi: 10.1038/nbt.2806. Epub 2014 Jan 26.


A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function.

Higman VA, Briggs DC, Mahoney DJ, Blundell CD, Sattelle BM, Dyer DP, Green DE, DeAngelis PL, Almond A, Milner CM, Day AJ.

J Biol Chem. 2014 Feb 28;289(9):5619-34. doi: 10.1074/jbc.M113.542357. Epub 2014 Jan 8.


Molecular pathways: multimodal cancer-killing mechanisms employed by oncolytic vesiculoviruses.

Mahoney DJ, Stojdl DF.

Clin Cancer Res. 2013 Feb 15;19(4):758-63. doi: 10.1158/1078-0432.CCR-11-3149. Epub 2012 Dec 26. Review.


Functional genomic screening to enhance oncolytic virotherapy.

Mahoney DJ, Stojdl DF.

Br J Cancer. 2013 Feb 5;108(2):245-9. doi: 10.1038/bjc.2012.467. Epub 2012 Nov 20. Review.


Oncolytic Vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosum.

Brun J, Mahoney DJ, Le Boeuf F, Lefebvre C, Sanaei CA, Falls T, Mccart JA, Stojdl DF.

Int J Cancer. 2013 Feb 1;132(3):726-31. doi: 10.1002/ijc.27695. Epub 2012 Sep 28.


Fighting fire with fire: rewiring tumor cells for oncolytic virotherapy.

Mahoney DJ, Stojdl DF.

Future Oncol. 2012 Mar;8(3):219-21. doi: 10.2217/fon.12.2. No abstract available.


Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.

Mahoney DJ, Lefebvre C, Allan K, Brun J, Sanaei CA, Baird S, Pearce N, Grönberg S, Wilson B, Prakesh M, Aman A, Isaac M, Mamai A, Uehling D, Al-Awar R, Falls T, Alain T, Stojdl DF.

Cancer Cell. 2011 Oct 18;20(4):443-56. doi: 10.1016/j.ccr.2011.09.005.


TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin.

Mahoney DJ, Swales C, Athanasou NA, Bombardieri M, Pitzalis C, Kliskey K, Sharif M, Day AJ, Milner CM, Sabokbar A.

Arthritis Rheum. 2011 Apr;63(4):1034-43. doi: 10.1002/art.30201.


Potentiating oncolytic viruses by targeted drug intervention.

Mahoney DJ, Stojdl DF.

Curr Opin Mol Ther. 2010 Aug;12(4):394-402. Review.


A call to arms: using RNAi screening to improve oncolytic viral therapy.

Mahoney DJ, Stojdl DF.

Cytokine Growth Factor Rev. 2010 Apr-Jun;21(2-3):161-7. doi: 10.1016/j.cytogfr.2010.02.013. Epub 2010 Mar 6. Review.


Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound.

Cheung HH, Mahoney DJ, Lacasse EC, Korneluk RG.

Cancer Res. 2009 Oct 1;69(19):7729-38. doi: 10.1158/0008-5472.CAN-09-1794. Epub 2009 Sep 22.


Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, Shiba T, Yang X, Yeh WC, Mak TW, Korneluk RG, Cheng G.

Nat Immunol. 2008 Dec;9(12):1371-8. doi: 10.1038/ni.1676. Epub 2008 Nov 9.


IAP-targeted therapies for cancer.

LaCasse EC, Mahoney DJ, Cheung HH, Plenchette S, Baird S, Korneluk RG.

Oncogene. 2008 Oct 20;27(48):6252-75. doi: 10.1038/onc.2008.302. Review.


Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation.

Mahoney DJ, Cheung HH, Mrad RL, Plenchette S, Simard C, Enwere E, Arora V, Mak TW, Lacasse EC, Waring J, Korneluk RG.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11778-83. doi: 10.1073/pnas.0711122105. Epub 2008 Aug 12.


TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.

Mahoney DJ, Mikecz K, Ali T, Mabilleau G, Benayahu D, Plaas A, Milner CM, Day AJ, Sabokbar A.

J Biol Chem. 2008 Sep 19;283(38):25952-62. doi: 10.1074/jbc.M802138200. Epub 2008 Jun 26.


The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.

Cheung HH, Plenchette S, Kern CJ, Mahoney DJ, Korneluk RG.

Mol Biol Cell. 2008 Jul;19(7):2729-40. doi: 10.1091/mbc.E08-01-0107. Epub 2008 Apr 23.


Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.

Mahoney DJ, Safdar A, Parise G, Melov S, Fu M, MacNeil L, Kaczor J, Payne ET, Tarnopolsky MA.

Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1901-10. doi: 10.1152/ajpregu.00847.2007. Epub 2008 Mar 5.


TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly.

Kuznetsova SA, Mahoney DJ, Martin-Manso G, Ali T, Nentwich HA, Sipes JM, Zeng B, Vogel T, Day AJ, Roberts DD.

Matrix Biol. 2008 Apr;27(3):201-10. Epub 2007 Oct 25.


Plasticity of the TSG-6 HA-binding loop and mobility in the TSG-6-HA complex revealed by NMR and X-ray crystallography.

Higman VA, Blundell CD, Mahoney DJ, Redfield C, Noble ME, Day AJ.

J Mol Biol. 2007 Aug 17;371(3):669-84. Epub 2007 Jun 2.


Determining the molecular basis for the pH-dependent interaction between the link module of human TSG-6 and hyaluronan.

Blundell CD, Mahoney DJ, Cordell MR, Almond A, Kahmann JD, Perczel A, Taylor JD, Campbell ID, Day AJ.

J Biol Chem. 2007 Apr 27;282(17):12976-88. Epub 2007 Feb 15.


Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction.

Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG.

Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11.


Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.

Rodriguez MC, MacDonald JR, Mahoney DJ, Parise G, Beal MF, Tarnopolsky MA.

Muscle Nerve. 2007 Feb;35(2):235-42.


Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.

Mahoney DJ, Kaczor JJ, Bourgeois J, Yasuda N, Tarnopolsky MA.

Muscle Nerve. 2006 Jun;33(6):809-16.


Understanding skeletal muscle adaptation to exercise training in humans: contributions from microarray studies.

Mahoney DJ, Tarnopolsky MA.

Phys Med Rehabil Clin N Am. 2005 Nov;16(4):859-73, vii. Review. No abstract available.


The N-terminal module of thrombospondin-1 interacts with the link domain of TSG-6 and enhances its covalent association with the heavy chains of inter-alpha-trypsin inhibitor.

Kuznetsova SA, Day AJ, Mahoney DJ, Rugg MS, Mosher DF, Roberts DD.

J Biol Chem. 2005 Sep 2;280(35):30899-908. Epub 2005 Jul 8.


Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise.

Mahoney DJ, Parise G, Melov S, Safdar A, Tarnopolsky MA.

FASEB J. 2005 Sep;19(11):1498-500. Epub 2005 Jun 28.


Characterization of the interaction between tumor necrosis factor-stimulated gene-6 and heparin: implications for the inhibition of plasmin in extracellular matrix microenvironments.

Mahoney DJ, Mulloy B, Forster MJ, Blundell CD, Fries E, Milner CM, Day AJ.

J Biol Chem. 2005 Jul 22;280(29):27044-55. Epub 2005 May 24.


Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily.

Blundell CD, Almond A, Mahoney DJ, DeAngelis PL, Campbell ID, Day AJ.

J Biol Chem. 2005 May 6;280(18):18189-201. Epub 2005 Feb 17.


Treadmill training-induced adaptations in muscle phenotype in persons with incomplete spinal cord injury.

Stewart BG, Tarnopolsky MA, Hicks AL, McCartney N, Mahoney DJ, Staron RS, Phillips SM.

Muscle Nerve. 2004 Jul;30(1):61-8.


A method for the non-covalent immobilization of heparin to surfaces.

Mahoney DJ, Whittle JD, Milner CM, Clark SJ, Mulloy B, Buttle DJ, Jones GC, Day AJ, Short RD.

Anal Biochem. 2004 Jul 1;330(1):123-9.


Real-time RT-PCR analysis of housekeeping genes in human skeletal muscle following acute exercise.

Mahoney DJ, Carey K, Fu MH, Snow R, Cameron-Smith D, Parise G, Tarnopolsky MA.

Physiol Genomics. 2004 Jul 8;18(2):226-31.


Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy.

Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, Biggar D.

Neurology. 2004 May 25;62(10):1771-7.


Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis.

Mahoney DJ, Rodriguez C, Devries M, Yasuda N, Tarnopolsky MA.

Muscle Nerve. 2004 May;29(5):656-62.


Body-weight-support treadmill training improves blood glucose regulation in persons with incomplete spinal cord injury.

Phillips SM, Stewart BG, Mahoney DJ, Hicks AL, McCartney N, Tang JE, Wilkinson SB, Armstrong D, Tarnopolsky MA.

J Appl Physiol (1985). 2004 Aug;97(2):716-24. Epub 2004 Apr 23.


TSG-6 modulates the interaction between hyaluronan and cell surface CD44.

Lesley J, Gál I, Mahoney DJ, Cordell MR, Rugg MS, Hyman R, Day AJ, Mikecz K.

J Biol Chem. 2004 Jun 11;279(24):25745-54. Epub 2004 Apr 1.


PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.

Salustri A, Garlanda C, Hirsch E, De Acetis M, Maccagno A, Bottazzi B, Doni A, Bastone A, Mantovani G, Beck Peccoz P, Salvatori G, Mahoney DJ, Day AJ, Siracusa G, Romani L, Mantovani A.

Development. 2004 Apr;131(7):1577-86. Epub 2004 Mar 3. Erratum in: Development. 2004 May;131(4):2235.

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