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Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX.

Koruza K, Lafumat B, Nyblom M, Mahon BP, Knecht W, McKenna R, Fisher SZ.

Acta Crystallogr D Struct Biol. 2019 Oct 1;75(Pt 10):895-903. doi: 10.1107/S2059798319010027. Epub 2019 Aug 22.


The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy.

Weiss DJ, English K, Krasnodembskaya A, Isaza-Correa JM, Hawthorne IJ, Mahon BP.

Front Immunol. 2019 Jun 4;10:1228. doi: 10.3389/fimmu.2019.01228. eCollection 2019. Review.


Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.

Koruza K, Mahon BP, Blakeley MP, Ostermann A, Schrader TE, McKenna R, Knecht W, Fisher SZ.

J Struct Biol. 2019 Feb 1;205(2):147-154. doi: 10.1016/j.jsb.2018.12.009. Epub 2019 Jan 11.


Exchanging breastmilk: Introduction.

Cassidy TM, Dowling S, Mahon BP, Dykes FC.

Matern Child Nutr. 2018 Dec;14 Suppl 6:e12748. doi: 10.1111/mcn.12748. No abstract available.


Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography.

Mahon BP, McKenna R.

Methods Mol Biol. 2018;1826:9-39. doi: 10.1007/978-1-4939-8645-3_2.


Carbonic anhydrase II microcrystals suitable for XFEL studies.

Lomelino CL, Kim JK, Lee C, Lim SW, Andring JT, Mahon BP, Chung M, Kim CU, McKenna R.

Acta Crystallogr F Struct Biol Commun. 2018 Jun 1;74(Pt 6):327-330. doi: 10.1107/S2053230X18006118. Epub 2018 May 17.


Carbonic Anhydrases: Role in pH Control and Cancer.

Mboge MY, Mahon BP, McKenna R, Frost SC.

Metabolites. 2018 Feb 28;8(1). pii: E19. doi: 10.3390/metabo8010019. Review.


Active-site solvent replenishment observed during human carbonic anhydrase II catalysis.

Kim JK, Lomelino CL, Avvaru BS, Mahon BP, McKenna R, Park S, Kim CU.

IUCrJ. 2018 Jan 1;5(Pt 1):93-102. doi: 10.1107/S2052252517017626. eCollection 2018 Jan 1.


Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.

Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas AR.

Biochemistry. 2018 Feb 20;57(7):1096-1107. doi: 10.1021/acs.biochem.7b01171. Epub 2018 Feb 6.


Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.

Cadoni R, Pala N, Lomelino C, Mahon BP, McKenna R, Dallocchio R, Dessì A, Carcelli M, Rogolino D, Sanna V, Rassu M, Iaccarino C, Vullo D, Supuran CT, Sechi M.

ACS Med Chem Lett. 2017 Jul 31;8(9):941-946. doi: 10.1021/acsmedchemlett.7b00229. eCollection 2017 Sep 14.


Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.

Mboge MY, Mahon BP, Lamas N, Socorro L, Carta F, Supuran CT, Frost SC, McKenna R.

Eur J Med Chem. 2017 May 26;132:184-191. doi: 10.1016/j.ejmech.2017.03.026. Epub 2017 Mar 19.


The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?

Carty F, Mahon BP, English K.

Clin Exp Immunol. 2017 Apr;188(1):1-11. doi: 10.1111/cei.12929. Epub 2017 Feb 20. Review.


Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity.

Bhatt A, Mahon BP, Cruzeiro VW, Cornelio B, Laronze-Cochard M, Ceruso M, Sapi J, Rance GA, Khlobystov AN, Fontana A, Roitberg A, Supuran CT, McKenna R.

Chembiochem. 2017 Jan 17;18(2):213-222. doi: 10.1002/cbic.201600513. Epub 2016 Dec 22.


Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.

Liu Z, Huang X, Hu L, Pham L, Poole KM, Tang Y, Mahon BP, Tang W, Li K, Goldfarb NE, Dunn BM, McKenna R, Fanucci GE.

J Biol Chem. 2016 Oct 21;291(43):22741-22756. Epub 2016 Aug 30.


The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.

Mahon BP, Bhatt A, Socorro L, Driscoll JM, Okoh C, Lomelino CL, Mboge MY, Kurian JJ, Tu C, Agbandje-McKenna M, Frost SC, McKenna R.

Biochemistry. 2016 Aug 23;55(33):4642-53. doi: 10.1021/acs.biochem.6b00243. Epub 2016 Aug 5.


Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis.

Cahill EF, Kennelly H, Carty F, Mahon BP, English K.

Stem Cells Transl Med. 2016 Oct;5(10):1307-1318. Epub 2016 Jul 7.


Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection.

McClean S, Healy ME, Collins C, Carberry S, O'Shaughnessy L, Dennehy R, Adams Á, Kennelly H, Corbett JM, Carty F, Cahill LA, Callaghan M, English K, Mahon BP, Doyle S, Shinoy M.

Infect Immun. 2016 Apr 22;84(5):1424-1437. doi: 10.1128/IAI.01248-15. Print 2016 May.


Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.

Lomelino CL, Mahon BP, McKenna R, Carta F, Supuran CT.

Bioorg Med Chem. 2016 Mar 1;24(5):976-81. doi: 10.1016/j.bmc.2016.01.019. Epub 2016 Jan 11.


Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.

Vullo D, Bhatt A, Mahon BP, McKenna R, Supuran CT.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):401-405. doi: 10.1016/j.bmcl.2015.11.104. Epub 2015 Dec 1.


A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

Pinard MA, Aggarwal M, Mahon BP, Tu C, McKenna R.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1352-8. doi: 10.1107/S2053230X1501239X. Epub 2015 Sep 23.


Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.

Mahon BP, Lomelino CL, Salguero AL, Driscoll JM, Pinard MA, McKenna R.

Protein Sci. 2015 Nov;24(11):1800-7. doi: 10.1002/pro.2771. Epub 2015 Sep 15.


Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.

Díaz-Torres NA, Mahon BP, Boone CD, Pinard MA, Tu C, Ng R, Agbandje-McKenna M, Silverman D, Scott K, McKenna R.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1745-56. doi: 10.1107/S1399004715012183. Epub 2015 Jul 31.


Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?

Mahon BP, Okoh CO, McKenna R.

Future Oncol. 2015;11(15):2117-9. doi: 10.2217/fon.15.137. No abstract available.


Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.

Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R.

J Med Chem. 2015 Aug 27;58(16):6630-8. doi: 10.1021/acs.jmedchem.5b00845. Epub 2015 Aug 13.


Mesenchymal stromal cells protect against caspase 3-mediated apoptosis of CD19(+) peripheral B cells through contact-dependent upregulation of VEGF.

Healy ME, Bergin R, Mahon BP, English K.

Stem Cells Dev. 2015 Oct 15;24(20):2391-402. doi: 10.1089/scd.2015.0089. Epub 2015 Jul 21.


Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.

Mahon BP, Díaz-Torres NA, Pinard MA, Tu C, Silverman DN, Scott KM, McKenna R.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4937-4940. doi: 10.1016/j.bmcl.2015.05.001. Epub 2015 May 6.


Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells.

Cahill EF, Tobin LM, Carty F, Mahon BP, English K.

Stem Cell Res Ther. 2015 Mar 11;6:19. doi: 10.1186/s13287-015-0021-5.


Targeting carbonic anhydrase IX activity and expression.

Mahon BP, Pinard MA, McKenna R.

Molecules. 2015 Jan 30;20(2):2323-48. doi: 10.3390/molecules20022323. Review.


Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.

Mahon BP, Hendon AM, Driscoll JM, Rankin GM, Poulsen SA, Supuran CT, McKenna R.

Bioorg Med Chem. 2015 Feb 15;23(4):849-54. doi: 10.1016/j.bmc.2014.12.030. Epub 2014 Dec 23.


Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.

Goldfarb NE, Ohanessian M, Biswas S, McGee TD Jr, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM.

Biochemistry. 2015 Jan 20;54(2):422-33. doi: 10.1021/bi501088e. Epub 2015 Jan 7.


Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.

Moeker J, Mahon BP, Bornaghi LF, Vullo D, Supuran CT, McKenna R, Poulsen SA.

J Med Chem. 2014 Oct 23;57(20):8635-45. doi: 10.1021/jm5012935. Epub 2014 Oct 8.


IFN-γ stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro.

Noone C, Kihm A, English K, O'Dea S, Mahon BP.

Stem Cells Dev. 2013 Nov 15;22(22):3003-14. doi: 10.1089/scd.2013.0028. Epub 2013 Jul 30.


Mesenchymal stromal cells; role in tissue repair, drug discovery and immune modulation.

English K, Mahon BP, Wood KJ.

Curr Drug Deliv. 2014;11(5):561-71. Review.


Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.

Siednienko J, Jackson R, Mellett M, Delagic N, Yang S, Wang B, Tang LS, Callanan JJ, Mahon BP, Moynagh PN.

Nat Immunol. 2012 Nov;13(11):1055-62. doi: 10.1038/ni.2429. Epub 2012 Oct 7.


Fabrication of CaO-NaO-SiO(2)/TiO (2) scaffolds for surgical applications.

Wren AW, Coughlan A, Smale KE, Misture ST, Mahon BP, Clarkin OM, Towler MR.

J Mater Sci Mater Med. 2012 Dec;23(12):2881-91. doi: 10.1007/s10856-012-4746-8. Epub 2012 Aug 14.


Understanding Solvent Effects in the Solvolyses of 4-Fluorophenyl Chlorothionoformate.

D'Souza M, Hailey S, Mahon B, Kevill D.

Chem Sci J. 2011 Jun 27;2011. pii: CSJ-35.


Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor.

Duffy MM, Pindjakova J, Hanley SA, McCarthy C, Weidhofer GA, Sweeney EM, English K, Shaw G, Murphy JM, Barry FP, Mahon BP, Belton O, Ceredig R, Griffin MD.

Eur J Immunol. 2011 Oct;41(10):2840-51. doi: 10.1002/eji.201141499. Epub 2011 Aug 30.


IL-17A induces CCL28, supporting the chemotaxis of IgE-secreting B cells.

Scanlon KM, Hawksworth RJ, Lane SJ, Mahon BP.

Int Arch Allergy Immunol. 2011;156(1):51-61. doi: 10.1159/000322178. Epub 2011 Mar 29.


Allogeneic mesenchymal stem cells: agents of immune modulation.

English K, Mahon BP.

J Cell Biochem. 2011 Aug;112(8):1963-8. doi: 10.1002/jcb.23119. Review.


A live, attenuated Bordetella pertussis vaccine provides long-term protection against virulent challenge in a murine model.

Skerry CM, Mahon BP.

Clin Vaccine Immunol. 2011 Feb;18(2):187-93. doi: 10.1128/CVI.00371-10. Epub 2010 Dec 8.


Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells.

Kavanagh H, Mahon BP.

Allergy. 2011 Apr;66(4):523-31. doi: 10.1111/j.1398-9995.2010.02509.x. Epub 2010 Nov 17.


Immunological aspects of allogeneic mesenchymal stem cell therapies.

Griffin MD, Ritter T, Mahon BP.

Hum Gene Ther. 2010 Dec;21(12):1641-55. doi: 10.1089/hum.2010.156. Review.


Analysis of the nucleophilic solvation effects in isopropyl chlorothioformate solvolysis.

D'Souza MJ, Mahon BP, Kevill DN.

Int J Mol Sci. 2010 Jun 29;11(7):2597-611. doi: 10.3390/ijms11072597.


Zinc and silver glass polyalkenoate cements: an evaluation of their antibacterial nature.

Coughlan A, Scanlon K, Mahon BP, Towler MR.

Biomed Mater Eng. 2010;20(2):99-106. doi: 10.3233/BME-2010-0620.


Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model.

Kavanagh H, Noone C, Cahill E, English K, Locht C, Mahon BP.

Clin Exp Allergy. 2010 Jun;40(6):933-41. doi: 10.1111/j.1365-2222.2010.03459.x. Epub 2010 Feb 22.


Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1.

Madsen D, Cantwell ER, O'Brien T, Johnson PA, Mahon BP.

J Gen Virol. 2009 Nov;90(Pt 11):2622-33. doi: 10.1099/vir.0.014175-0. Epub 2009 Jul 29.


A live attenuated Bordetella pertussis candidate vaccine does not cause disseminating infection in gamma interferon receptor knockout mice.

Skerry CM, Cassidy JP, English K, Feunou-Feunou P, Locht C, Mahon BP.

Clin Vaccine Immunol. 2009 Sep;16(9):1344-51. doi: 10.1128/CVI.00082-09. Epub 2009 Jul 22.


Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.

English K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP.

Clin Exp Immunol. 2009 Apr;156(1):149-60. doi: 10.1111/j.1365-2249.2009.03874.x. Epub 2009 Feb 3.

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