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Items: 1 to 50 of 298

1.

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.

Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW.

J Alzheimers Dis. 2019;68(3):991-1011. doi: 10.3233/JAD-181184.

2.

Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases.

Mahley RW.

Clin Chem. 2017 Jan;63(1):14-20. doi: 10.1373/clinchem.2016.255695. No abstract available.

3.

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.

Mahley RW.

J Mol Med (Berl). 2016 Jul;94(7):739-46. doi: 10.1007/s00109-016-1427-y. Epub 2016 Jun 9. Review.

4.

Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism.

Mahley RW.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1305-15. doi: 10.1161/ATVBAHA.116.307023. Epub 2016 May 12. Review.

5.

Ancient human genomes suggest three ancestral populations for present-day Europeans.

Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K, Sudmant PH, Schraiber JG, Castellano S, Lipson M, Berger B, Economou C, Bollongino R, Fu Q, Bos KI, Nordenfelt S, Li H, de Filippo C, Prüfer K, Sawyer S, Posth C, Haak W, Hallgren F, Fornander E, Rohland N, Delsate D, Francken M, Guinet JM, Wahl J, Ayodo G, Babiker HA, Bailliet G, Balanovska E, Balanovsky O, Barrantes R, Bedoya G, Ben-Ami H, Bene J, Berrada F, Bravi CM, Brisighelli F, Busby GB, Cali F, Churnosov M, Cole DE, Corach D, Damba L, van Driem G, Dryomov S, Dugoujon JM, Fedorova SA, Gallego Romero I, Gubina M, Hammer M, Henn BM, Hervig T, Hodoglugil U, Jha AR, Karachanak-Yankova S, Khusainova R, Khusnutdinova E, Kittles R, Kivisild T, Klitz W, Kučinskas V, Kushniarevich A, Laredj L, Litvinov S, Loukidis T, Mahley RW, Melegh B, Metspalu E, Molina J, Mountain J, Näkkäläjärvi K, Nesheva D, Nyambo T, Osipova L, Parik J, Platonov F, Posukh O, Romano V, Rothhammer F, Rudan I, Ruizbakiev R, Sahakyan H, Sajantila A, Salas A, Starikovskaya EB, Tarekegn A, Toncheva D, Turdikulova S, Uktveryte I, Utevska O, Vasquez R, Villena M, Voevoda M, Winkler CA, Yepiskoposyan L, Zalloua P, Zemunik T, Cooper A, Capelli C, Thomas MG, Ruiz-Linares A, Tishkoff SA, Singh L, Thangaraj K, Villems R, Comas D, Sukernik R, Metspalu M, Meyer M, Eichler EE, Burger J, Slatkin M, Pääbo S, Kelso J, Reich D, Krause J.

Nature. 2014 Sep 18;513(7518):409-13. doi: 10.1038/nature13673.

6.

Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.

Huang Y, Mahley RW.

Neurobiol Dis. 2014 Dec;72 Pt A:3-12. doi: 10.1016/j.nbd.2014.08.025. Epub 2014 Aug 27. Review.

7.

Shinya Yamanaka, M.D., Ph.D. - 2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists.

Mahley RW.

Anadolu Kardiyol Derg. 2013 May;13(3):204-6. doi: 10.5152/akd.2013.132. Epub 2013 Apr 22. No abstract available.

8.

Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Mahley RW, Huang Y.

Neuron. 2012 Dec 6;76(5):871-85. doi: 10.1016/j.neuron.2012.11.020. Review.

9.
10.

Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.

Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, Feinberg LF, Frisoni G, Green C, Guimaraes RM, Gwyther LP, Hefti FF, Hutton M, Kawas C, Kent DM, Kuller L, Langa KM, Mahley RW, Maslow K, Masters CL, Meier DE, Neumann PJ, Paul SM, Petersen RC, Sager MA, Sano M, Schenk D, Soares H, Sperling RA, Stahl SM, van Deerlin V, Stern Y, Weir D, Wolk DA, Trojanowski JQ.

Alzheimers Dement. 2012 Sep;8(5):445-52. doi: 10.1016/j.jalz.2012.08.001.

11.

Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations.

Hodoğlugil U, Mahley RW.

Ann Hum Genet. 2012 Mar;76(2):128-41. doi: 10.1111/j.1469-1809.2011.00701.x.

12.

Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

J Biol Chem. 2012 Feb 17;287(8):5253-66. doi: 10.1074/jbc.M111.276162. Epub 2011 Dec 12.

13.

Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks.

Hodoğlugil U, Williamson DW, Yu Y, Farrer LA, Mahley RW.

Ann Hum Genet. 2011 May;75(3):398-417. doi: 10.1111/j.1469-1809.2011.00644.x.

14.

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.

Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y.

J Biol Chem. 2011 May 13;286(19):17217-26. doi: 10.1074/jbc.M110.217380. Epub 2011 Mar 18.

15.

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.

Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

J Biol Chem. 2011 Feb 18;286(7):5215-21. doi: 10.1074/jbc.M110.151084. Epub 2010 Nov 30.

16.

Genetic variants influencing circulating lipid levels and risk of coronary artery disease.

Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, Luan J, Ashford S, Wheeler E, Young EH, Hadley D, Thompson JR, Braund PS, Johnson T, Struchalin M, Surakka I, Luben R, Khaw KT, Rodwell SA, Loos RJ, Boekholdt SM, Inouye M, Deloukas P, Elliott P, Schlessinger D, Sanna S, Scuteri A, Jackson A, Mohlke KL, Tuomilehto J, Roberts R, Stewart A, Kesäniemi YA, Mahley RW, Grundy SM; Wellcome Trust Case Control Consortium, McArdle W, Cardon L, Waeber G, Vollenweider P, Chambers JC, Boehnke M, Abecasis GR, Salomaa V, Järvelin MR, Ruokonen A, Barroso I, Epstein SE, Hakonarson HH, Rader DJ, Reilly MP, Witteman JC, Hall AS, Samani NJ, Strachan DP, Barter P, van Duijn CM, Kooner JS, Peltonen L, Wareham NJ, McPherson R, Mooser V, Sandhu MS.

Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2264-76. doi: 10.1161/ATVBAHA.109.201020. Epub 2010 Sep 23.

17.

GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.

Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y.

Cell Stem Cell. 2009 Dec 4;5(6):634-45. doi: 10.1016/j.stem.2009.10.015.

18.

Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.

Hodoglugil U, Williamson DW, Mahley RW.

J Lipid Res. 2010 Feb;51(2):422-30. doi: 10.1194/jlr.P001578. Epub 2009 Sep 4.

19.

Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches.

Mahley RW, Huang Y.

Ann Neurol. 2009 Jun;65(6):623-5. doi: 10.1002/ana.21736. No abstract available.

PMID:
19557874
20.

Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.

Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Cohen JC, Grundy SM, Mooser VE, Mitchell BD.

Obesity (Silver Spring). 2009 Apr;17(4):737-44. doi: 10.1038/oby.2008.625. Epub 2009 Jan 22.

21.

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

Mahley RW, Weisgraber KH, Huang Y.

J Lipid Res. 2009 Apr;50 Suppl:S183-8. doi: 10.1194/jlr.R800069-JLR200. Epub 2008 Dec 22.

22.

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.

Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID.

Obesity (Silver Spring). 2008 Nov;16(11):2468-71. doi: 10.1038/oby.2008.397. Epub 2008 Aug 21.

23.

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.

Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK.

Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8718-23. doi: 10.1073/pnas.0803526105. Epub 2008 Jun 18.

24.

Genes contributing to prion pathogenesis.

Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB.

J Gen Virol. 2008 Jul;89(Pt 7):1777-88. doi: 10.1099/vir.0.2008/001255-0.

25.

LDL-cholesterol concentrations: a genome-wide association study.

Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X, Johnson T, Ashford S, Inouye M, Luben R, Sims M, Hadley D, McArdle W, Barter P, Kesäniemi YA, Mahley RW, McPherson R, Grundy SM; Wellcome Trust Case Control Consortium, Bingham SA, Khaw KT, Loos RJ, Waeber G, Barroso I, Strachan DP, Deloukas P, Vollenweider P, Wareham NJ, Mooser V.

Lancet. 2008 Feb 9;371(9611):483-91. doi: 10.1016/S0140-6736(08)60208-1.

26.

Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.

Mahley RW, Huang Y, Weisgraber KH.

Curr Alzheimer Res. 2007 Dec;4(5):537-40. Review.

PMID:
18220516
27.

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1343-6. doi: 10.1073/pnas.0709906104. Epub 2008 Jan 22.

28.
29.
30.

Human prions and plasma lipoproteins.

Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11312-7. Epub 2006 Jul 18.

31.

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).

Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW.

Pharmacogenomics J. 2007 Feb;7(1):10-28. Epub 2006 Jun 13. Review.

PMID:
16770341
32.
33.

Putting cholesterol in its place: apoE and reverse cholesterol transport.

Mahley RW, Huang Y, Weisgraber KH.

J Clin Invest. 2006 May;116(5):1226-9.

34.

Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis.

Huang Y, Mahley RW.

Alzheimers Dement. 2006 Apr;2(2):71-3. doi: 10.1016/j.jalz.2005.12.006. No abstract available.

PMID:
19595858
35.

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Mahley RW, Weisgraber KH, Huang Y.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5644-51. Epub 2006 Mar 27. Review.

36.

High density lipoprotein cholesterol in coronary artery patients: is it as low as expected?

Mahley RW, Bersot TP.

Anadolu Kardiyol Derg. 2006 Mar;6(1):94-6; author reply 96. No abstract available.

37.
38.

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18694-9. Epub 2005 Dec 12.

39.

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5. Epub 2005 Dec 12.

40.

Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.

Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW.

J Biol Chem. 2006 Feb 3;281(5):2683-92. Epub 2005 Nov 17.

41.

Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.

Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW.

J Lipid Res. 2006 Jan;47(1):144-53. Epub 2005 Oct 28.

42.

Modulation of high-density lipoproteins in a population in istanbul, Turkey, with low levels of high-density lipoproteins.

Mahley RW, Can S, Ozbayrakçi S, Bersot TP, Tanir S, Palaoğlu KE, Pépin GM.

Am J Cardiol. 2005 Aug 15;96(4):547-55.

PMID:
16098310
43.

Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.

Yu Y, Wyszynski DF, Waterworth DM, Wilton SD, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Ma Q, Sharma SS, Montgomery DS, Middleton LT, Sundseth SS, Mooser V, Grundy SM, Farrer LA.

J Lipid Res. 2005 Oct;46(10):2202-13. Epub 2005 Aug 1.

45.
46.

Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project).

Wyszynski DF, Waterworth DM, Barter PJ, Cohen J, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Sharma SS, Nolan V, Middleton LT, Sundseth SS, Farrer LA, Mooser V, Grundy SM.

Am J Cardiol. 2005 Jan 15;95(2):194-8.

PMID:
15642551
47.

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.

Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y.

J Biol Chem. 2004 Oct 22;279(43):44795-801. Epub 2004 Aug 20.

48.

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.

Huang Y, Weisgraber KH, Mucke L, Mahley RW.

J Mol Neurosci. 2004;23(3):189-204. Review.

PMID:
15181247
49.

Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.

Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y.

J Biol Chem. 2004 Jun 11;279(24):25511-6. Epub 2004 Mar 30.

50.

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

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