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Items: 1 to 50 of 144

1.

An in Vitro Selection Strategy Identifying Naked DNA That Localizes to Cell Nuclei.

Smestad J, Wilbanks B, Maher LJ 3rd.

J Am Chem Soc. 2019 Nov 20;141(46):18375-18379. doi: 10.1021/jacs.9b06736. Epub 2019 Nov 12.

PMID:
31702902
2.

Dependence of DNA looping on Escherichia coli culture density.

Peters JP, Rao VN, Becker NA, Maher LJ 3rd.

Int J Biochem Mol Biol. 2019 Aug 15;10(3):32-41. eCollection 2019.

3.

A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome.

Al Khazal F, Holte MN, Bolon B, White TA, LeBrasseur N, Maher LJ 3rd.

FASEB J. 2019 Dec;33(12):13189-13201. doi: 10.1096/fj.201802655RR. Epub 2019 Aug 30.

PMID:
31469588
4.

Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.

Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA.

Nature. 2019 Sep;573(7773):E2. doi: 10.1038/s41586-019-1490-y.

PMID:
31447485
5.

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations.

Smestad JA, Maher LJ 3rd.

BMC Cancer. 2019 Jun 24;19(1):619. doi: 10.1186/s12885-019-5813-z.

6.

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.

Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA.

Nature. 2019 Jul;571(7765):403-407. doi: 10.1038/s41586-019-1311-3. Epub 2019 Jun 19. Erratum in: Nature. 2019 Sep;573(7773):E2.

PMID:
31217581
7.

Glial cells as therapeutic targets in progressive multiple sclerosis.

Wilbanks B, Maher LJ 3rd, Rodriguez M.

Expert Rev Neurother. 2019 Jun;19(6):481-494. doi: 10.1080/14737175.2019.1614443. Epub 2019 May 13.

PMID:
31081705
8.

Optimization of a 40-mer Antimyelin DNA Aptamer Identifies a 20-mer with Enhanced Properties for Potential Multiple Sclerosis Therapy.

Wilbanks B, Smestad J, Heider RM, Warrington AE, Rodriguez M, Maher LJ 3rd.

Nucleic Acid Ther. 2019 Jun;29(3):126-135. doi: 10.1089/nat.2018.0776. Epub 2019 Mar 11.

9.

Evidence for a bind-then-bend mechanism for architectural DNA binding protein yNhp6A.

Sarangi MK, Zvoda V, Holte MN, Becker NA, Peters JP, Maher LJ, Ansari A.

Nucleic Acids Res. 2019 Apr 8;47(6):2871-2883. doi: 10.1093/nar/gkz022.

10.

Single and double box HMGB proteins differentially destabilize nucleosomes.

McCauley MJ, Huo R, Becker N, Holte MN, Muthurajan UM, Rouzina I, Luger K, Maher LJ 3rd, Israeloff NE, Williams MC.

Nucleic Acids Res. 2019 Jan 25;47(2):666-678. doi: 10.1093/nar/gky1119.

11.

Surface Plasmon Resonance Sensing on Naturally Derived Membranes: A Remyelination-Promoting Human Antibody Binds Myelin with Extraordinary Affinity.

Vala M, Jordan LR, Warrington AE, Maher LJ 3rd, Rodriguez M, Wittenberg NJ, Oh SH.

Anal Chem. 2018 Nov 6;90(21):12567-12573. doi: 10.1021/acs.analchem.8b02664. Epub 2018 Oct 15.

PMID:
30231202
12.

Approaches for Determining DNA Persistence Length Using Atomic Force Microscopy.

Peters JP, Maher LJ 3rd.

Methods Mol Biol. 2018;1837:211-256. doi: 10.1007/978-1-4939-8675-0_13.

PMID:
30109614
13.

High-Resolution Characterization of DNA/Protein Complexes in Living Bacteria.

Becker NA, Peters JP, Maher LJ 3rd.

Methods Mol Biol. 2018;1837:95-115. doi: 10.1007/978-1-4939-8675-0_6.

PMID:
30109607
14.

Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism.

Smestad J, Erber L, Chen Y, Maher LJ 3rd.

iScience. 2018 Apr 27;2:63-75. doi: 10.1016/j.isci.2018.03.012.

15.

An Assay that Predicts In Vivo Efficacy for DNA Aptamers that Stimulate Remyelination in a Mouse Model of Multiple Sclerosis.

Heider RM, Smestad JA, Lemus HN, Wilbanks B, Warrington AE, Peters JP, Rodriguez M, Maher LJ 3rd.

Mol Ther Methods Clin Dev. 2018 Mar 21;9:270-277. doi: 10.1016/j.omtm.2018.03.005. eCollection 2018 Jun 15.

16.

Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma.

Smestad J, Hamidi O, Wang L, Holte MN, Khazal FA, Erber L, Chen Y, Maher LJ 3rd.

Oncotarget. 2017 Dec 22;9(5):6109-6127. doi: 10.18632/oncotarget.23639. eCollection 2018 Jan 19.

17.

A comparison of human natural monoclonal antibodies and aptamer conjugates for promotion of CNS remyelination: where are we now and what comes next?

Perwein MK, Smestad JA, Warrington AE, Heider RM, Kaczor MW, Maher LJ 3rd, Wootla B, Kunbaz A, Rodriguez M.

Expert Opin Biol Ther. 2018 May;18(5):545-560. doi: 10.1080/14712598.2018.1441284. Epub 2018 Feb 25. Review.

PMID:
29460650
18.

Bacterial gene control by DNA looping using engineered dimeric transcription activator like effector (TALE) proteins.

Becker NA, Schwab TL, Clark KJ, Maher LJ 3rd.

Nucleic Acids Res. 2018 Mar 16;46(5):2690-2696. doi: 10.1093/nar/gky047.

19.

Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.

Peters JP, Kowal EA, Pallan PS, Egli M, Maher LJ 3rd.

J Biomol Struct Dyn. 2018 Aug;36(11):2753-2772. doi: 10.1080/07391102.2017.1369164. Epub 2017 Sep 4.

20.

Accurate nanoscale flexibility measurement of DNA and DNA-protein complexes by atomic force microscopy in liquid.

Murugesapillai D, Bouaziz S, Maher LJ, Israeloff NE, Cameron CE, Williams MC.

Nanoscale. 2017 Aug 10;9(31):11327-11337. doi: 10.1039/c7nr04231k.

21.

Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter.

Uchida A, Murugesapillai D, Kastner M, Wang Y, Lodeiro MF, Prabhakar S, Oliver GV, Arnold JJ, Maher LJ, Williams MC, Cameron CE.

Elife. 2017 Jul 26;6. pii: e27283. doi: 10.7554/eLife.27283.

22.

Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying.

Hayashi Y, Toyomasu Y, Saravanaperumal SA, Bardsley MR, Smestad JA, Lorincz A, Eisenman ST, Cipriani G, Nelson Holte MH, Al Khazal FJ, Syed SA, Gajdos GB, Choi KM, Stoltz GJ, Miller KE, Kendrick ML, Rubin BP, Gibbons SJ, Bharucha AE, Linden DR, Maher LJ 3rd, Farrugia G, Ordog T.

Gastroenterology. 2017 Aug;153(2):521-535.e20. doi: 10.1053/j.gastro.2017.04.020. Epub 2017 Apr 21.

23.

Single-molecule studies of high-mobility group B architectural DNA bending proteins.

Murugesapillai D, McCauley MJ, Maher LJ 3rd, Williams MC.

Biophys Rev. 2016 Nov 15;9(1):17-40. doi: 10.1007/s12551-016-0236-4. eCollection 2017 Feb. Review.

24.

Supercoiling Effects on Short-Range DNA Looping in E. coli.

Mogil LS, Becker NA, Maher LJ 3rd.

PLoS One. 2016 Oct 26;11(10):e0165306. doi: 10.1371/journal.pone.0165306. eCollection 2016.

25.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

26.

Anti-Transcription Factor RNA Aptamers as Potential Therapeutics.

Mondragón E, Maher LJ 3rd.

Nucleic Acid Ther. 2016 Feb;26(1):29-43. doi: 10.1089/nat.2015.0566. Epub 2015 Oct 28. Review.

27.

Should patients in a persistent vegetative state be allowed to die? Guidelines for a new standard of care in Australian hospitals.

Kendal E, Maher LJ.

Monash Bioeth Rev. 2015 Jun-Sep;33(2-3):148-66. doi: 10.1007/s40592-015-0039-6.

PMID:
26507136
28.

Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription.

Smestad JA, Maher LJ 3rd.

BMC Med Genet. 2015 Oct 8;16:91. doi: 10.1186/s12881-015-0236-4.

29.

Modeling dioxygenase enzyme kinetics in familial paraganglioma.

Peters JP, Her YF, Maher LJ 3rd.

Biol Open. 2015 Sep 14;4(10):1281-9. doi: 10.1242/bio.013623.

30.

Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics.

Her YF, Maher LJ 3rd.

Int J Endocrinol. 2015;2015:296167. doi: 10.1155/2015/296167. Epub 2015 Jul 29. Review.

31.

Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells.

Badal S, Her YF, Maher LJ 3rd.

J Biol Chem. 2015 Sep 4;290(36):22287-97. doi: 10.1074/jbc.M115.671222. Epub 2015 Jul 23.

32.

RNA aptamer inhibitors of a restriction endonuclease.

Mondragón E, Maher LJ 3rd.

Nucleic Acids Res. 2015 Sep 3;43(15):7544-55. doi: 10.1093/nar/gkv702. Epub 2015 Jul 15.

33.

High-resolution mapping of architectural DNA binding protein facilitation of a DNA repression loop in Escherichia coli.

Becker NA, Maher LJ 3rd.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7177-82. doi: 10.1073/pnas.1500412112. Epub 2015 May 26.

34.

Oxygen concentration controls epigenetic effects in models of familial paraganglioma.

Her YF, Nelson-Holte M, Maher LJ 3rd.

PLoS One. 2015 May 18;10(5):e0127471. doi: 10.1371/journal.pone.0127471. eCollection 2015.

35.

Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice.

Xekouki P, Szarek E, Bullova P, Giubellino A, Quezado M, Mastroyannis SA, Mastorakos P, Wassif CA, Raygada M, Rentia N, Dye L, Cougnoux A, Koziol D, Sierra Mde L, Lyssikatos C, Belyavskaya E, Malchoff C, Moline J, Eng C, Maher LJ 3rd, Pacak K, Lodish M, Stratakis CA.

J Clin Endocrinol Metab. 2015 May;100(5):E710-9. doi: 10.1210/jc.2014-4297. Epub 2015 Feb 19.

36.

Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice.

Perschbacher K, Smestad JA, Peters JP, Standiford MM, Denic A, Wootla B, Warrington AE, Rodriguez M, Maher LJ 3rd.

Nucleic Acid Ther. 2015 Feb;25(1):11-9. doi: 10.1089/nat.2014.0515. Epub 2014 Dec 23.

37.

DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin.

Murugesapillai D, McCauley MJ, Huo R, Nelson Holte MH, Stepanyants A, Maher LJ 3rd, Israeloff NE, Williams MC.

Nucleic Acids Res. 2014 Aug;42(14):8996-9004. doi: 10.1093/nar/gku635. Epub 2014 Jul 24.

38.

Mechanical properties of base-modified DNA are not strictly determined by base stacking or electrostatic interactions.

Peters JP, Mogil LS, McCauley MJ, Williams MC, Maher LJ 3rd.

Biophys J. 2014 Jul 15;107(2):448-459. doi: 10.1016/j.bpj.2014.04.066.

39.

The free solution mobility of DNA and other analytes varies as the logarithm of the fractional negative charge.

Stellwagen NC, Peters JP, Dong Q, Maher LJ 3rd, Stellwagen E.

Electrophoresis. 2014 Jul;35(12-13):1855-63. doi: 10.1002/elps.201400040. Epub 2014 Jun 5.

40.

Bacterial promoter repression by DNA looping without protein-protein binding competition.

Becker NA, Greiner AM, Peters JP, Maher LJ 3rd.

Nucleic Acids Res. 2014 May;42(9):5495-504. doi: 10.1093/nar/gku180. Epub 2014 Mar 5.

41.

DNA A-tracts are not curved in solutions containing high concentrations of monovalent cations.

Stellwagen E, Peters JP, Maher LJ 3rd, Stellwagen NC.

Biochemistry. 2013 Jun 18;52(24):4138-48. doi: 10.1021/bi400118m. Epub 2013 Jun 6.

42.

High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.

Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ 3rd.

PLoS One. 2013;8(2):e56827. doi: 10.1371/journal.pone.0056827. Epub 2013 Feb 22.

43.

Single-molecule FRET analysis of DNA binding and bending by yeast HMGB protein Nhp6A.

Coats JE, Lin Y, Rueter E, Maher LJ 3rd, Rasnik I.

Nucleic Acids Res. 2013 Jan;41(2):1372-81. doi: 10.1093/nar/gks1208. Epub 2012 Dec 5.

44.

Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis.

Smestad J, Maher LJ 3rd.

Nucleic Acids Res. 2013 Jan;41(2):1329-42. doi: 10.1093/nar/gks1093. Epub 2012 Nov 21.

45.

Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility.

McCauley MJ, Rueter EM, Rouzina I, Maher LJ 3rd, Williams MC.

Nucleic Acids Res. 2013 Jan 7;41(1):167-81. doi: 10.1093/nar/gks1031. Epub 2012 Nov 9.

46.

Mechanism of promoter repression by Lac repressor-DNA loops.

Becker NA, Peters JP, Maher LJ 3rd, Lionberger TA.

Nucleic Acids Res. 2013 Jan 7;41(1):156-66. doi: 10.1093/nar/gks1011. Epub 2012 Nov 9. Erratum in: Nucleic Acids Res. 2013 Apr 1;41(6):3962. Lionberger, Troy A [added].

47.

Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression.

Meinhardt S, Manley MW Jr, Becker NA, Hessman JA, Maher LJ 3rd, Swint-Kruse L.

Nucleic Acids Res. 2012 Nov;40(21):11139-54. doi: 10.1093/nar/gks806. Epub 2012 Sep 10.

48.

An ace in the hole...

Mondragon E, Maher LJ 3rd.

Structure. 2012 Aug 8;20(8):1285-6. doi: 10.1016/j.str.2012.07.006. No abstract available.

49.

Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis.

Nastasijevic B, Wright BR, Smestad J, Warrington AE, Rodriguez M, Maher LJ 3rd.

PLoS One. 2012;7(6):e39595. doi: 10.1371/journal.pone.0039595. Epub 2012 Jun 27.

50.

Improved prediction of RNA tertiary structure with insights into native state dynamics.

Bida JP, Maher LJ 3rd.

RNA. 2012 Mar;18(3):385-93. doi: 10.1261/rna.027201.111. Epub 2012 Jan 25.

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