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Items: 17


Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children.

Hollensted M, Fogh M, Schnurr TM, Kloppenborg JT, Have CT, Ruest Haarmark Nielsen T, Rask J, Asp Vonsild Lund M, Frithioff-Bøjsøe C, Østergaard Johansen M, Vincent Rosenbaum Appel E, Mahendran Y, Grarup N, Kadarmideen HN, Pedersen O, Holm JC, Hansen T.

Obesity (Silver Spring). 2018 Dec;26(12):1915-1922. doi: 10.1002/oby.22308. Erratum in: Obesity (Silver Spring). 2019 May;27(5):866.


Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis.

Skaaby T, Kilpeläinen TO, Taylor AE, Mahendran Y, Wong A, Ahluwalia TS, Paternoster L, Trompet S, Stott DJ, Flexeder C, Zhou A, Brusselle G, Sajjad A, Lahousse L, Tiemeier H, Have CT, Thuesen BH, Kårhus LL, Møllehave LT, Leth-Møller KB, Shabanzadeh DM, Gonzalez-Quintela A, Power C, Hyppönen E, Kuh D, Hardy R, Meitinger T, Jukema JW, Völker U, Nauck M, Völzke H, Friedrich N, Bonten TN, Noordam R, Mook-Kanamori DO, Tolstrup JS, Taube C, Peters A, Grallert H, Strauch K, Schulz H, Grarup N, Hansen T, Pedersen O, Burgess S, Munafò MR, Linneberg A.

Addiction. 2019 Feb;114(2):216-225. doi: 10.1111/add.14438. Epub 2018 Oct 30.


An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese.

Graae AS, Hollensted M, Kloppenborg JT, Mahendran Y, Schnurr TM, Appel EVR, Rask J, Nielsen TRH, Johansen MØ, Linneberg A, Jørgensen ME, Grarup N, Kadarmideen HN, Holst B, Pedersen O, Holm JC, Hansen T.

Diabetologia. 2018 Aug;61(8):1769-1779. doi: 10.1007/s00125-018-4640-0. Epub 2018 May 31.


Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation.

Engelbrechtsen L, Gybel-Brask D, Mahendran Y, Crusell M, Hansen TH, Schnurr TM, Hogdall E, Skibsted L, Hansen T, Vestergaard H.

Sci Rep. 2018 May 30;8(1):8376. doi: 10.1038/s41598-018-26752-3.


Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses.

Engelbrechtsen L, Mahendran Y, Jonsson A, Gjesing AP, Weeke PE, Jørgensen ME, Færch K, Witte DR, Holst JJ, Jørgensen T, Grarup N, Pedersen O, Vestergaard H, Torekov S, Kanters JK, Hansen T.

BMC Genet. 2018 Mar 16;19(1):15. doi: 10.1186/s12863-018-0602-2.


Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.

Grarup N, Moltke I, Andersen MK, Dalby M, Vitting-Seerup K, Kern T, Mahendran Y, Jørsboe E, Larsen CVL, Dahl-Petersen IK, Gilly A, Suveges D, Dedoussis G, Zeggini E, Pedersen O, Andersson R, Bjerregaard P, Jørgensen ME, Albrechtsen A, Hansen T.

Nat Genet. 2018 Feb;50(2):172-174. doi: 10.1038/s41588-017-0022-7. Epub 2018 Jan 8.


Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids.

Wewer Albrechtsen NJ, Færch K, Jensen TM, Witte DR, Pedersen J, Mahendran Y, Jonsson AE, Galsgaard KD, Winther-Sørensen M, Torekov SS, Lauritzen T, Pedersen O, Knop FK, Hansen T, Jørgensen ME, Vistisen D, Holst JJ.

Diabetologia. 2018 Mar;61(3):671-680. doi: 10.1007/s00125-017-4535-5. Epub 2018 Jan 5.


Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB.

Engelbrechtsen L, Lundgren J, Wewer Albrechtsen NJ, Mahendran Y, Iepsen EW, Finocchietto P, Jonsson AE, Madsbad S, Holst JJ, Vestergaard H, Hansen T, Torekov SS.

Obes Sci Pract. 2017 Nov 21;3(4):425-433. doi: 10.1002/osp4.133. eCollection 2017 Dec.


Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children.

Schnurr TM, Viitasalo A, Eloranta AM, Damsgaard CT, Mahendran Y, Have CT, Väistö J, Hjorth MF, Christensen LB, Brage S, Atalay M, Lyytikäinen LP, Lindi V, Lakka T, Michaelsen KF, Kilpeläinen TO, Hansen T.

Int J Obes (Lond). 2018 Jan;42(1):111-114. doi: 10.1038/ijo.2017.235. Epub 2017 Sep 26.


Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins.

Engelbrechtsen L, Hansen TH, Mahendran Y, Pyl P, Andersson E, Jonsson A, Gjesing A, Linneberg A, Jørgensen T, Hansen T, Vestergaard H.

Sci Rep. 2017 Feb 21;7:43128. doi: 10.1038/srep43128.


Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels.

Mahendran Y, Jonsson A, Have CT, Allin KH, Witte DR, Jørgensen ME, Grarup N, Pedersen O, Kilpeläinen TO, Hansen T.

Diabetologia. 2017 May;60(5):873-878. doi: 10.1007/s00125-017-4222-6. Epub 2017 Feb 10.


Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology.

Schnurr TM, Gjesing AP, Sandholt CH, Jonsson A, Mahendran Y, Have CT, Ekstrøm CT, Bjerregaard AL, Brage S, Witte DR, Jørgensen ME, Aadahl M, Thuesen BH, Linneberg A, Eiberg H, Pedersen O, Grarup N, Kilpeläinen TO, Hansen T.

PLoS One. 2016 Nov 15;11(11):e0166738. doi: 10.1371/journal.pone.0166738. eCollection 2016.


Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.

Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stančáková A, Schwab U, Kuusisto J, Laakso M.

Am J Clin Nutr. 2014 Jan;99(1):79-85. doi: 10.3945/ajcn.113.069740. Epub 2013 Oct 23.


Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men.

Mahendran Y, Cederberg H, Vangipurapu J, Kangas AJ, Soininen P, Kuusisto J, Uusitupa M, Ala-Korpela M, Laakso M.

Diabetes Care. 2013 Nov;36(11):3732-8. doi: 10.2337/dc13-0800. Epub 2013 Sep 11.


Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M.

Diabetes. 2013 Oct;62(10):3618-26. doi: 10.2337/db12-1363. Epub 2013 Apr 4.


Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children.

Tabassum R, Mahendran Y, Dwivedi OP, Chauhan G, Ghosh S, Marwaha RK, Tandon N, Bharadwaj D.

Diabetes. 2012 Mar;61(3):626-31. doi: 10.2337/db11-1501. Epub 2012 Jan 6.


Common variants of FTO and the risk of obesity and type 2 diabetes in Indians.

Chauhan G, Tabassum R, Mahajan A, Dwivedi OP, Mahendran Y, Kaur I, Nigam S, Dubey H, Varma B, Madhu SV, Mathur SK, Ghosh S, Tandon N, Bharadwaj D.

J Hum Genet. 2011 Oct;56(10):720-6. doi: 10.1038/jhg.2011.87. Epub 2011 Aug 4.


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