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Items: 11


Use of in-silico assays to characterize the ADMET profile and identify potential therapeutic targets of fusarochromanone, a novel anti-cancer agent.

El-Saadi MW, Williams-Hart T, Salvatore BA, Mahdavian E.

In Silico Pharmacol. 2015 Dec;3(1):6. doi: 10.1186/s40203-015-0010-5. Epub 2015 Jun 4.


Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5.

Gu Y, Barzegar M, Chen X, Wu Y, Shang C, Mahdavian E, Salvatore BA, Jiang S, Huang S.

Oncotarget. 2015 Dec 8;6(39):42322-33. doi: 10.18632/oncotarget.5996.


Fusarochromanone induces G1 cell cycle arrest and apoptosis in COS7 and HEK293 cells.

Gu Y, Chen X, Shang C, Singh K, Barzegar M, Mahdavian E, Salvatore BA, Jiang S, Huang S.

PLoS One. 2014 Nov 10;9(11):e112641. doi: 10.1371/journal.pone.0112641. eCollection 2014.


Biological activities of fusarochromanone: a potent anti-cancer agent.

Mahdavian E, Palyok P, Adelmund S, Williams-Hart T, Furmanski BD, Kim YJ, Gu Y, Barzegar M, Wu Y, Bhinge KN, Kolluru GK, Quick Q, Liu YY, Kevil CG, Salvatore BA, Huang S, Clifford JL.

BMC Res Notes. 2014 Sep 3;7:601. doi: 10.1186/1756-0500-7-601.


Caspase-dependent signaling underlies glioblastoma cell death in response to the fungal metabolite, fusarochromanone.

Mahdavian E, Marshall M, Martin PM, Cagle P, Salvatore BA, Quick QA.

Int J Mol Med. 2014 Sep;34(3):880-5. doi: 10.3892/ijmm.2014.1842. Epub 2014 Jul 9.


Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.

Dong LF, Jameson VJ, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, Goodwin J, Salvatore BA, Novotna J, Turanek J, Ledvina M, Hozak P, Zhivotovsky B, Coster MJ, Ralph SJ, Smith RA, Neuzil J.

Free Radic Biol Med. 2011 Jun 1;50(11):1546-55. doi: 10.1016/j.freeradbiomed.2011.02.032. Epub 2011 Mar 12. Erratum in: Free Radic Biol Med. 2013 Dec;65:895-6.


Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II.

Dong LF, Jameson VJ, Tilly D, Cerny J, Mahdavian E, Marín-Hernández A, Hernández-Esquivel L, Rodríguez-Enríquez S, Stursa J, Witting PK, Stantic B, Rohlena J, Truksa J, Kluckova K, Dyason JC, Ledvina M, Salvatore BA, Moreno-Sánchez R, Coster MJ, Ralph SJ, Smith RA, Neuzil J.

J Biol Chem. 2011 Feb 4;286(5):3717-28. doi: 10.1074/jbc.M110.186643. Epub 2010 Nov 8.


Liposomal formulation of alpha-tocopheryl maleamide: in vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice.

Turánek J, Wang XF, Knötigová P, Koudelka S, Dong LF, Vrublová E, Mahdavian E, Procházka L, Sangsura S, Vacek A, Salvatore BA, Neuzil J.

Toxicol Appl Pharmacol. 2009 Jun 15;237(3):249-57. doi: 10.1016/j.taap.2009.01.027.


Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity.

Tomic-Vatic A, Eytina J, Chapman J, Mahdavian E, Neuzil J, Salvatore BA.

Int J Cancer. 2005 Nov 1;117(2):188-93.


Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Phan J, Mahdavian E, Nivens MC, Minor W, Berger S, Spencer HT, Dunlap RB, Lebioda L.

Biochemistry. 2000 Jun 13;39(23):6969-78.


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