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Items: 25


Hermansky-Pudlak syndrome type 2 manifests with fibrosing lung disease early in childhood.

Hengst M, Naehrlich L, Mahavadi P, Grosse-Onnebrink J, Terheggen-Lagro S, Skanke LH, Schuch LA, Brasch F, Guenther A, Reu S, Ley-Zaporozhan J, Griese M.

Orphanet J Rare Dis. 2018 Mar 27;13(1):42. doi: 10.1186/s13023-018-0780-z.


Gender-Specific Reference Charts of Fetal Head Circumference in a Singaporean Population.

Yeo GS, Qi M, Du R, Mahavadi PL, Yung CF, Thoon KC, Thia EW, Tan KL, Lai FM, Lee NK.

Ann Acad Med Singapore. 2017 Oct;46(10):367-373.


Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells.

Aslani F, Sebastian T, Keidel M, Fröhlich S, Elsässer HP, Schuppe HC, Klug J, Mahavadi P, Fijak M, Bergmann M, Meinhardt A, Bhushan S.

Mol Hum Reprod. 2017 Jun 1;23(6):370-380. doi: 10.1093/molehr/gax022.


Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis.

Mahavadi P, Knudsen L, Venkatesan S, Henneke I, Hegermann J, Wrede C, Ochs M, Ahuja S, Chillappagari S, Ruppert C, Seeger W, Korfei M, Guenther A.

J Pathol Clin Res. 2015 Jun 3;1(4):252-63. doi: 10.1002/cjp2.20. eCollection 2015 Oct.


MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.

Ahuja S, Knudsen L, Chillappagari S, Henneke I, Ruppert C, Korfei M, Gochuico BR, Bellusci S, Seeger W, Ochs M, Guenther A, Mahavadi P.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L519-31. doi: 10.1152/ajplung.00213.2015. Epub 2015 Dec 30.


Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death.

Richter M, Vidovic N, Honrath B, Mahavadi P, Dodel R, Dolga AM, Culmsee C.

Cell Death Differ. 2016 May;23(5):814-27. doi: 10.1038/cdd.2015.146. Epub 2015 Nov 20.


A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation.

Chillappagari S, Müller C, Mahavadi P, Guenther A, Nährlich L, Rosenblum J, Rubin BK, Henke MO.

J Cyst Fibros. 2016 May;15(3):325-31. doi: 10.1016/j.jcf.2015.10.008. Epub 2015 Oct 30.


Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.

Korfei M, Skwarna S, Henneke I, MacKenzie B, Klymenko O, Saito S, Ruppert C, von der Beck D, Mahavadi P, Klepetko W, Bellusci S, Crestani B, Pullamsetti SS, Fink L, Seeger W, Krämer OH, Guenther A.

Thorax. 2015 Nov;70(11):1022-32. doi: 10.1136/thoraxjnl-2014-206411. Epub 2015 Sep 10.


Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction.

Chillappagari S, Preuss J, Licht S, Müller C, Mahavadi P, Sarode G, Vogelmeier C, Guenther A, Nahrlich L, Rubin BK, Henke MO.

Respir Res. 2015 Jul 15;16:85. doi: 10.1186/s12931-015-0247-x.


Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.

Birkelbach B, Lutz D, Ruppert C, Henneke I, Lopez-Rodriguez E, Günther A, Ochs M, Mahavadi P, Knudsen L.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L63-75. doi: 10.1152/ajplung.00279.2014. Epub 2015 May 8.


Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.

Chillappagari S, Venkatesan S, Garapati V, Mahavadi P, Munder A, Seubert A, Sarode G, Guenther A, Schmeck BT, Tümmler B, Henke MO.

Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L791-9. doi: 10.1152/ajplung.00167.2014. Epub 2014 Sep 19.


Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.

Mahavadi P, Henneke I, Ruppert C, Knudsen L, Venkatesan S, Liebisch G, Chambers RC, Ochs M, Schmitz G, Vancheri C, Seeger W, Korfei M, Guenther A.

Toxicol Sci. 2014 Nov;142(1):285-97. doi: 10.1093/toxsci/kfu177. Epub 2014 Aug 27.


Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis.

Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, Günther A, Klepetko W, Bates JH, Smith B, Geiser T, Ochs M, Knudsen L.

Am J Respir Cell Mol Biol. 2015 Feb;52(2):232-43. doi: 10.1165/rcmb.2014-0078OC.


Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.

Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D.

Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L405-19. doi: 10.1152/ajplung.00143.2013. Epub 2013 Dec 27.


Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP) and organ donors.

Korfei M, von der Beck D, Henneke I, Markart P, Ruppert C, Mahavadi P, Ghanim B, Klepetko W, Fink L, Meiners S, Krämer OH, Seeger W, Vancheri C, Guenther A.

J Proteomics. 2013 Jun 24;85:109-28. doi: 10.1016/j.jprot.2013.04.033. Epub 2013 May 6.


Soluble polysialylated NCAM: a novel player of the innate immune system in the lung.

Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R, Galuska SP.

Cell Mol Life Sci. 2013 Oct;70(19):3695-708. doi: 10.1007/s00018-013-1342-0. Epub 2013 Apr 26.


Hermansky-Pudlak syndrome interstitial pneumonia: it's the epithelium, stupid!

Mahavadi P, Guenther A, Gochuico BR.

Am J Respir Crit Care Med. 2012 Nov 15;186(10):939-40. doi: 10.1164/rccm.201210-1771ED. No abstract available.


Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.

Günther A, Korfei M, Mahavadi P, von der Beck D, Ruppert C, Markart P.

Eur Respir Rev. 2012 Jun 1;21(124):152-60. doi: 10.1183/09059180.00001012. Review.


Hypoxia-inducible factor 2α plays a critical role in the formation of alveoli and surfactant.

Huang Y, Kempen MB, Munck AB, Swagemakers S, Driegen S, Mahavadi P, Meijer D, van Ijcken W, van der Spek P, Grosveld F, Günther A, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2012 Feb;46(2):224-32. doi: 10.1165/rcmb.2011-0024OC.


Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs.

Korfei M, Schmitt S, Ruppert C, Henneke I, Markart P, Loeh B, Mahavadi P, Wygrecka M, Klepetko W, Fink L, Bonniaud P, Preissner KT, Lochnit G, Schaefer L, Seeger W, Guenther A.

J Proteome Res. 2011 May 6;10(5):2185-205. doi: 10.1021/pr1009355. Epub 2011 Mar 29.


Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.

Mahavadi P, Korfei M, Henneke I, Liebisch G, Schmitz G, Gochuico BR, Markart P, Bellusci S, Seeger W, Ruppert C, Guenther A.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):207-19. doi: 10.1164/rccm.200909-1414OC. Epub 2010 Apr 8.


Inhibition of urokinase activity reduces primary tumor growth and metastasis formation in a murine lung carcinoma model.

Henneke I, Greschus S, Savai R, Korfei M, Markart P, Mahavadi P, Schermuly RT, Wygrecka M, Stürzebecher J, Seeger W, Günther A, Ruppert C.

Am J Respir Crit Care Med. 2010 Mar 15;181(6):611-9. doi: 10.1164/rccm.200903-0342OC. Epub 2010 Jan 7.


Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase.

Ruppert C, Mahavadi P, Wygrecka M, Weaver TE, Magdolen V, Idell S, Preissner KT, Seeger W, Günther A, Markart P.

Thromb Haemost. 2008 Dec;100(6):1185-92.


Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases.

Markart P, Luboeinski T, Korfei M, Schmidt R, Wygrecka M, Mahavadi P, Mayer K, Wilhelm J, Seeger W, Guenther A, Ruppert C.

Antioxid Redox Signal. 2009 Feb;11(2):227-40. doi: 10.1089/ARS.2008.2105.


Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis.

Korfei M, Ruppert C, Mahavadi P, Henneke I, Markart P, Koch M, Lang G, Fink L, Bohle RM, Seeger W, Weaver TE, Guenther A.

Am J Respir Crit Care Med. 2008 Oct 15;178(8):838-46. doi: 10.1164/rccm.200802-313OC. Epub 2008 Jul 17.

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