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A major interspecies difference in the ionic selectivity of megakaryocyte Ca2+-activated channels sensitive to the TMEM16F inhibitor CaCCinh-A01.

Taylor KA, Mahaut-Smith MP.

Platelets. 2019 Apr 22:1-5. doi: 10.1080/09537104.2019.1595560. [Epub ahead of print]


Fluorescence Approaches to Image and Quantify the Demarcation Membrane System in Living Megakaryocytes.

Osman S, Dalmay D, Mahaut-Smith M.

Methods Mol Biol. 2018;1812:195-215. doi: 10.1007/978-1-4939-8585-2_12.


P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.

Ilkan Z, Watson S, Watson SP, Mahaut-Smith MP.

Thromb Haemost. 2018 Feb;118(2):369-380. doi: 10.1160/TH17-07-0530. Epub 2018 Jan 29.


Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions.

Pugh N, Maddox BD, Bihan D, Taylor KA, Mahaut-Smith MP, Farndale RW.

Thromb Haemost. 2017 Jul 26;117(8):1588-1600. doi: 10.1160/TH16-12-0906. Epub 2017 May 24.


Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.

Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP.

J Biol Chem. 2017 Jun 2;292(22):9204-9217. doi: 10.1074/jbc.M116.766196. Epub 2017 Apr 17.


Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain.

Lörinczi E, Helliwell M, Finch A, Stansfeld PJ, Davies NW, Mahaut-Smith M, Muskett FW, Mitcheson JS.

J Biol Chem. 2016 Aug 19;291(34):17907-18. doi: 10.1074/jbc.M116.733576. Epub 2016 Jun 20.


Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines.

Wright JR, Amisten S, Goodall AH, Mahaut-Smith MP.

Thromb Haemost. 2016 Aug 1;116(2):272-84. doi: 10.1160/TH15-11-0891. Epub 2016 Jun 9.


Impaired P2X1 Receptor-Mediated Adhesion in Eosinophils from Asthmatic Patients.

Wright A, Mahaut-Smith M, Symon F, Sylvius N, Ran S, Bafadhel M, Muessel M, Bradding P, Wardlaw A, Vial C.

J Immunol. 2016 Jun 15;196(12):4877-84. doi: 10.4049/jimmunol.1501585. Epub 2016 May 9.


Calcium Signalling through Ligand-Gated Ion Channels such as P2X1 Receptors in the Platelet and other Non-Excitable Cells.

Mahaut-Smith MP, Taylor KA, Evans RJ.

Adv Exp Med Biol. 2016;898:305-29. doi: 10.1007/978-3-319-26974-0_13. Review.


Detachment of surface membrane invagination systems by cationic amphiphilic drugs.

Osman S, Taylor KA, Allcock N, Rainbow RD, Mahaut-Smith MP.

Sci Rep. 2016 Jan 4;6:18536. doi: 10.1038/srep18536.


The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling.

Rinne A, Mobarec JC, Mahaut-Smith M, Kolb P, Bünemann M.

Sci Signal. 2015 Nov 3;8(401):ra110. doi: 10.1126/scisignal.aac7419.


Regulation of Pannexin-1 channel activity.

Taylor KA, Wright JR, Mahaut-Smith MP.

Biochem Soc Trans. 2015 Jun;43(3):502-7. doi: 10.1042/BST20150042. Review.


Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation.

Jones S, Evans RJ, Mahaut-Smith MP.

Mol Pharmacol. 2014 Sep;86(3):243-51. doi: 10.1124/mol.114.092528. Epub 2014 Jun 12.


Amplification of human platelet activation by surface pannexin-1 channels.

Taylor KA, Wright JR, Vial C, Evans RJ, Mahaut-Smith MP.

J Thromb Haemost. 2014 Jun;12(6):987-98. doi: 10.1111/jth.12566.


Connexin40 regulates platelet function.

Vaiyapuri S, Moraes LA, Sage T, Ali MS, Lewis KR, Mahaut-Smith MP, Oviedo-Orta E, Simon AM, Gibbins JM.

Nat Commun. 2013;4:2564. doi: 10.1038/ncomms3564.


A role for platelet TRPC channels in the Ca2+ response that induces procoagulant activity.

Mahaut-Smith MP.

Sci Signal. 2013 Jun 25;6(281):pe23. doi: 10.1126/scisignal.2004399.


Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.

Lalo U, Jones S, Roberts JA, Mahaut-Smith MP, Evans RJ.

J Biol Chem. 2012 Sep 21;287(39):32747-54. Epub 2012 Jul 31.


The unique contribution of ion channels to platelet and megakaryocyte function.

Mahaut-Smith MP.

J Thromb Haemost. 2012 Sep;10(9):1722-32. doi: 10.1111/j.1538-7836.2012.04837.x. Review.


Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.

Vaiyapuri S, Jones CI, Sasikumar P, Moraes LA, Munger SJ, Wright JR, Ali MS, Sage T, Kaiser WJ, Tucker KL, Stain CJ, Bye AP, Jones S, Oviedo-Orta E, Simon AM, Mahaut-Smith MP, Gibbins JM.

Circulation. 2012 May 22;125(20):2479-91. doi: 10.1161/CIRCULATIONAHA.112.101246. Epub 2012 Apr 23.


FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.

Markovic D, Holdich J, Al-Sabah S, Mistry R, Krasel C, Mahaut-Smith MP, Challiss RA.

PLoS One. 2012;7(1):e29946. doi: 10.1371/journal.pone.0029946. Epub 2012 Jan 17.


Purification of native bone marrow megakaryocytes for studies of gene expression.

Tolhurst G, Carter RN, Miller N, Mahaut-Smith MP.

Methods Mol Biol. 2012;788:259-73. doi: 10.1007/978-1-61779-307-3_18.


The P2X1 receptor and platelet function.

Mahaut-Smith MP, Jones S, Evans RJ.

Purinergic Signal. 2011 Sep;7(3):341-56. doi: 10.1007/s11302-011-9224-0. Epub 2011 Mar 22.


Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.

Jones S, Evans RJ, Mahaut-Smith MP.

Br J Haematol. 2011 Apr;153(1):83-91. doi: 10.1111/j.1365-2141.2010.08499.x. Epub 2011 Feb 20.


P2X1 receptor mobility and trafficking; regulation by receptor insertion and activation.

Lalo U, Allsopp RC, Mahaut-Smith MP, Evans RJ.

J Neurochem. 2010 Jun;113(5):1177-87. doi: 10.1111/j.1471-4159.2010.06730.x. Epub 2010 Apr 2.


Direct voltage control of endogenous lysophosphatidic acid G-protein-coupled receptors in Xenopus oocytes.

Martinez-Pinna J, Gurung IS, Mahaut-Smith MP, Morales A.

J Physiol. 2010 May 15;588(Pt 10):1683-93. doi: 10.1113/jphysiol.2009.183418. Epub 2010 Mar 29.


Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.

McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut-Smith MP.

J Physiol. 2010 May 1;588(Pt 9):1399-406. doi: 10.1113/jphysiol.2010.188136. Epub 2010 Mar 22.


Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

Qiu MR, Jiang L, Matthaei KI, Schoenwaelder SM, Kuffner T, Mangin P, Joseph JE, Low J, Connor D, Valenzuela SM, Curmi PM, Brown LJ, Mahaut-Smith M, Jackson SP, Breit SN.

Genesis. 2010 Feb;48(2):127-36. doi: 10.1002/dvg.20590. Erratum in: Genesis. 2010 May;48(5):351.


P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window.

Fung CY, Marcus AJ, Broekman MJ, Mahaut-Smith MP.

Trends Cardiovasc Med. 2009 Jan;19(1):1-5. doi: 10.1016/j.tcm.2009.01.005. Review.


A role for membrane potential in regulating GPCRs?

Mahaut-Smith MP, Martinez-Pinna J, Gurung IS.

Trends Pharmacol Sci. 2008 Aug;29(8):421-9. doi: 10.1016/ Epub 2008 Jul 11. Review.


Expression profiling and electrophysiological studies suggest a major role for Orai1 in the store-operated Ca2+ influx pathway of platelets and megakaryocytes.

Tolhurst G, Carter RN, Amisten S, Holdich JP, Erlinge D, Mahaut-Smith MP.

Platelets. 2008 Jun;19(4):308-13. doi: 10.1080/09537100801935710.


Novel consequences of voltage-dependence to G-protein-coupled P2Y1 receptors.

Gurung IS, Martinez-Pinna J, Mahaut-Smith MP.

Br J Pharmacol. 2008 Jun;154(4):882-9. doi: 10.1038/bjp.2008.97. Epub 2008 Apr 14.


Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet.

Fung CY, Cendana C, Farndale RW, Mahaut-Smith MP.

J Thromb Haemost. 2007 May;5(5):910-7. Epub 2007 Mar 14.


Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart.

Killeen MJ, Thomas G, Gurung IS, Goddard CA, Fraser JA, Mahaut-Smith MP, Colledge WH, Grace AA, Huang CL.

Acta Physiol (Oxf). 2007 Jan;189(1):33-46.


Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.

Thomas G, Gurung IS, Killeen MJ, Hakim P, Goddard CA, Mahaut-Smith MP, Colledge WH, Grace AA, Huang CL.

J Physiol. 2007 Jan 1;578(Pt 1):85-97. Epub 2006 Nov 16.


Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.

Carter RN, Tolhurst G, Walmsley G, Vizuete-Forster M, Miller N, Mahaut-Smith MP.

J Physiol. 2006 Oct 1;576(Pt 1):151-62. Epub 2006 Jul 20.


Differential sensitivity of human platelet P2X1 and P2Y1 receptors to disruption of lipid rafts.

Vial C, Fung CY, Goodall AH, Mahaut-Smith MP, Evans RJ.

Biochem Biophys Res Commun. 2006 May 5;343(2):415-9. Epub 2006 Mar 9.


Temperature dependence of human ether-a-go-go-related gene K+ currents.

Vandenberg JI, Varghese A, Lu Y, Bursill JA, Mahaut-Smith MP, Huang CL.

Am J Physiol Cell Physiol. 2006 Jul;291(1):C165-75. Epub 2006 Feb 1.


The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range.

Horner S, Menke K, Hildebrandt C, Kassack MU, Nickel P, Ullmann H, Mahaut-Smith MP, Lambrecht G.

Naunyn Schmiedebergs Arch Pharmacol. 2005 Jul;372(1):1-13. Epub 2005 Sep 13.


A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets.

Fung CY, Brearley CA, Farndale RW, Mahaut-Smith MP.

Thromb Haemost. 2005 Jul;94(1):37-40.


Potentiation of P2Y receptors by physiological elevations of extracellular K+ via a mechanism independent of Ca2+ influx.

Pitt SJ, Martinez-Pinna J, Barnard EA, Mahaut-Smith MP.

Mol Pharmacol. 2005 May;67(5):1705-13. Epub 2005 Feb 14.


Direct voltage control of signaling via P2Y1 and other Galphaq-coupled receptors.

Martinez-Pinna J, Gurung IS, Vial C, Leon C, Gachet C, Evans RJ, Mahaut-Smith MP.

J Biol Chem. 2005 Jan 14;280(2):1490-8. Epub 2004 Nov 4.


The interpretation of current-clamp recordings in the cell-attached patch-clamp configuration.

Mason MJ, Simpson AK, Mahaut-Smith MP, Robinson HP.

Biophys J. 2005 Jan;88(1):739-50. Epub 2004 Oct 29.


Patch-clamp recordings of electrophysiological events in the platelet and megakaryocyte.

Mahaut-Smith MP.

Methods Mol Biol. 2004;273:277-300. No abstract available.


Measurement and manipulation of intracellular Ca2+ in single platelets and megakaryocytes.

Mason MJ, Mahaut-Smith MP.

Methods Mol Biol. 2004;273:251-76. No abstract available.


Emerging roles for P2X1 receptors in platelet activation.

Mahaut-Smith MP, Tolhurst G, Evans RJ.

Platelets. 2004 May;15(3):131-44. Review.


Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+ mobilization in the rat megakaryocyte.

Martinez-Pinna J, Tolhurst G, Gurung IS, Vandenberg JI, Mahaut-Smith MP.

J Physiol. 2004 Feb 15;555(Pt 1):61-70. Epub 2003 Nov 28.


Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.

Lu Y, Mahaut-Smith MP, Huang CL, Vandenberg JI.

J Physiol. 2003 Aug 15;551(Pt 1):253-62. Epub 2003 Jun 18.


Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis.

Vial C, Pitt SJ, Roberts J, Rolf MG, Mahaut-Smith MP, Evans RJ.

Blood. 2003 Nov 15;102(10):3646-51. Epub 2003 Aug 7.

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