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Items: 30


Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation.

Mahasenan KV, Batuecas MT, De Benedetti S, Kim C, Rana N, Lee M, Hesek D, Fisher JF, Sanz-Aparicio J, Hermoso JA, Mobashery S.

ACS Chem Biol. 2020 Jan 17;15(1):189-196. doi: 10.1021/acschembio.9b00754. Epub 2020 Jan 7.


Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division.

Alcorlo M, Dik DA, De Benedetti S, Mahasenan KV, Lee M, Domínguez-Gil T, Hesek D, Lastochkin E, López D, Boggess B, Mobashery S, Hermoso JA.

Nat Commun. 2019 Dec 5;10(1):5567. doi: 10.1038/s41467-019-13354-4.


The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May.


A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.

Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S.

Biochemistry. 2018 Oct 23;57(42):6090-6098. doi: 10.1021/acs.biochem.8b00800. Epub 2018 Oct 10.


Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

Nguyen TT, Ding D, Wolter WR, Pérez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, Chang M.

J Med Chem. 2018 Oct 11;61(19):8825-8837. doi: 10.1021/acs.jmedchem.8b01005. Epub 2018 Sep 27.


In Search of Selectivity in Inhibition of ADAM10.

Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2018 Jun 11;9(7):708-713. doi: 10.1021/acsmedchemlett.8b00163. eCollection 2018 Jul 12.


Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa.

Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4393-4398. doi: 10.1073/pnas.1801298115. Epub 2018 Apr 9.


Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S.

Sci Rep. 2018 Mar 7;8(1):4110. doi: 10.1038/s41598-018-22527-y.


Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.

Bernardo-García N, Mahasenan KV, Batuecas MT, Lee M, Hesek D, Petráčková D, Doubravová L, Branny P, Mobashery S, Hermoso JA.

ACS Chem Biol. 2018 Mar 16;13(3):694-702. doi: 10.1021/acschembio.7b00817. Epub 2018 Jan 30.


Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2017 May 1;8(6):654-659. doi: 10.1021/acsmedchemlett.7b00130. eCollection 2017 Jun 8.


Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.

Acebrón I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 May 24;139(20):6795-6798. doi: 10.1021/jacs.7b01626. Epub 2017 May 10.


Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2017 Feb 8;139(5):2102-2110. doi: 10.1021/jacs.6b12565. Epub 2017 Jan 27.


Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity.

Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF.

Structure. 2017 Feb 7;25(2):295-304. doi: 10.1016/j.str.2016.12.007. Epub 2017 Jan 12.


Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S.

ACS Chem Biol. 2016 Oct 21;11(10):2936. Epub 2016 Sep 6. No abstract available.


Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa.

Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA.

Structure. 2016 Oct 4;24(10):1729-1741. doi: 10.1016/j.str.2016.07.019. Epub 2016 Sep 8.


Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M.

ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. Epub 2016 Aug 25.


Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S.

ACS Chem Biol. 2016 Jun 17;11(6):1525-31. doi: 10.1021/acschembio.6b00194. Epub 2016 Apr 11. Erratum in: ACS Chem Biol. 2016 Oct 21;11(10 ):2936.


Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Leemans E, Mahasenan KV, Kumarasiri M, Spink E, Ding D, O'Daniel PI, Boudreau MA, Lastochkin E, Testero SA, Yamaguchi T, Lee M, Hesek D, Fisher JF, Chang M, Mobashery S.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):1011-1015. doi: 10.1016/j.bmcl.2015.12.041. Epub 2015 Dec 12.


Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, Pileri S, Agostinelli C, Ayers L, Bradner JE, Chen-Kiang S, Elemento O, Motiwala T, Majumder S, Byrd JC, Jacob S, Sif S, Li C, Baiocchi RA.

Blood. 2015 Apr 16;125(16):2530-43. doi: 10.1182/blood-2014-12-619783. Epub 2015 Mar 5.


Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli.

Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA.

ACS Chem Biol. 2014 Sep 19;9(9):2058-66. doi: 10.1021/cb500439c. Epub 2014 Jul 10.


Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).

Fu HL, Valiathan RR, Payne L, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Fridman R.

J Biol Chem. 2014 Mar 28;289(13):9275-87. doi: 10.1074/jbc.M113.541102. Epub 2014 Feb 7.


O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.

Gooyit M, Song W, Mahasenan KV, Lichtenwalter K, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

J Med Chem. 2013 Oct 24;56(20):8139-50. doi: 10.1021/jm401217d. Epub 2013 Oct 8.


Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases.

Fu HL, Sohail A, Valiathan RR, Wasinski BD, Kumarasiri M, Mahasenan KV, Bernardo MM, Tokmina-Roszyk D, Fields GB, Mobashery S, Fridman R.

J Biol Chem. 2013 Apr 26;288(17):12114-29. doi: 10.1074/jbc.M112.409599. Epub 2013 Mar 21.


Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.

Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R.

J Biol Chem. 2013 Mar 15;288(11):7430-7. doi: 10.1074/jbc.R112.444158. Epub 2013 Jan 18. Review.


8,8-dialkyldihydroberberines with potent antiprotozoal activity.

Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, Drew ME, Werbovetz KA.

J Nat Prod. 2013 Mar 22;76(3):311-5. doi: 10.1021/np300638f. Epub 2012 Nov 20.


Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction.

Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K.

ACS Chem Biol. 2012 Apr 20;7(4):761-9. doi: 10.1021/cb200450w. Epub 2012 Feb 13.


Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening.

Mahasenan KV, Pavlovicz RE, Henderson BJ, González-Cestari TF, Yi B, McKay DB, Li C.

ACS Med Chem Lett. 2011 Sep 18;2(11):855-60. doi: 10.1021/ml2001714. eCollection 2011 Nov 10.


Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives.

Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA.

J Med Chem. 2010 Feb 11;53(3):966-82. doi: 10.1021/jm900723w.


Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.

George TG, Endeshaw MM, Morgan RE, Mahasenan KV, Delfín DA, Mukherjee MS, Yakovich AJ, Fotie J, Li C, Werbovetz KA.

Bioorg Med Chem. 2007 Sep 15;15(18):6071-9. Epub 2007 Jun 27.

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