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Items: 24

1.

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Harris PA, Marinis JM, Lich JD, Berger SB, Chirala A, Cox JA, Eidam PM, Finger JN, Gough PJ, Jeong JU, Kang J, Kasparcova V, Leister LK, Mahajan MK, Miller G, Nagilla R, Ouellette MT, Reilly MA, Rendina AR, Rivera EJ, Sun HH, Thorpe JH, Totoritis RD, Wang W, Wu D, Zhang D, Bertin J, Marquis RW.

ACS Med Chem Lett. 2019 May 9;10(6):857-862. doi: 10.1021/acsmedchemlett.9b00108. eCollection 2019 Jun 13.

2.

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW.

J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2.

PMID:
31013427
3.

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

Wang W, Marinis JM, Beal AM, Savadkar S, Wu Y, Khan M, Taunk PS, Wu N, Su W, Wu J, Ahsan A, Kurz E, Chen T, Yaboh I, Li F, Gutierrez J, Diskin B, Hundeyin M, Reilly M, Lich JD, Harris PA, Mahajan MK, Thorpe JH, Nassau P, Mosley JE, Leinwand J, Kochen Rossi JA, Mishra A, Aykut B, Glacken M, Ochi A, Verma N, Kim JI, Vasudevaraja V, Adeegbe D, Almonte C, Bagdatlioglu E, Cohen DJ, Wong KK, Bertin J, Miller G.

Cancer Cell. 2018 Nov 12;34(5):757-774.e7. doi: 10.1016/j.ccell.2018.10.006.

PMID:
30423296
4.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Haile PA, Casillas LN, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Hughes TV, DeMartino MP, Wang GZ, Romano JJ, Dong X, Plotnikov NV, Lakdawala AS, Convery MA, Votta BJ, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, LePage C, Ouellette MT, Totoritis RD, Donovan BT, Brown BS, Chaudhary KW, Gough PJ, Bertin J, Marquis RW.

ACS Med Chem Lett. 2018 Sep 26;9(10):1039-1044. doi: 10.1021/acsmedchemlett.8b00344. eCollection 2018 Oct 11.

PMID:
30344914
5.

Are Biomarkers Predictive of Anthracycline-Induced Cardiac Dysfunction?

Malik A, Jeyaraj PA, Calton R, Uppal B, Negi P, Shankar A, Patil J, Mahajan MK.

Asian Pac J Cancer Prev. 2016;17(4):2301-5.

6.

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, Beal AM, Finger JN, Cook MN, King BW, Ouellette MT, Totoritis RD, Pierdomenico M, Negroni A, Stronati L, Cucchiara S, Ziółkowski B, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Casillas LN.

J Med Chem. 2016 May 26;59(10):4867-80. doi: 10.1021/acs.jmedchem.6b00211. Epub 2016 May 4.

PMID:
27109867
7.

Aromatase Inhibition and Capecitabine Combination as 1st or 2nd Line Treatment for Metastatic Breast Cancer - a Retrospective Analysis.

Shankar A, Roy S, Rath GK, Julka PK, Kamal VK, Malik A, Patil J, Jeyaraj PA, Mahajan MK.

Asian Pac J Cancer Prev. 2015;16(15):6359-64.

8.

Occupational radiation exposure from C arm fluoroscopy during common orthopaedic surgical procedures and its prevention.

Mahajan A, Samuel S, Saran AK, Mahajan MK, Mam MK.

J Clin Diagn Res. 2015 Mar;9(3):RC01-4. doi: 10.7860/JCDR/2015/10520.5672. Epub 2015 Mar 1.

9.

Contralateral breast cancer: a clinico-pathological study of second primaries in opposite breasts after treatment of breast malignancy.

Shankar A, Roy S, Malik A, Kamal VK, Bhandari R, Kishor K, Mahajan M, Sachdev J, Jeyaraj P, Rath G.

Asian Pac J Cancer Prev. 2015;16(3):1207-11.

10.
11.

Gaint axillary lipoma following excision.

Bashir M, Zaki IA, Mahajan MK.

Indian J Surg. 2013 Jun;75(Suppl 1):158-9. doi: 10.1007/s12262-012-0561-1. Epub 2012 Jun 16.

12.

Carcinoma base of tongue: single institution 15 year experiences.

Banipal RP, Mahajan MK, George G, Sachdev J, Jeyaraj P.

Indian J Cancer. 2012 Apr-Jun;49(2):220-4. doi: 10.4103/0019-509X.102867.

13.

Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: a prospective longitudinal study.

Tiwana MS, Mahajan MK, Uppal B, Koshy G, Sachdeva J, Lee HN, Talole SD.

Indian J Cancer. 2011 Jul-Sep;48(3):289-95. doi: 10.4103/0019-509X.84918.

14.

Thyroid diseases as a sequelae following treatment of head and neck cancer.

Banipal R, Mahajan MK, Uppal B, John M.

Indian J Cancer. 2011 Apr-Jun;48(2):194-8. doi: 10.4103/0019-509X.82886.

15.

In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.

Mahajan MK, Uttamsingh V, Daniels JS, Gan LS, LeDuc BW, Williams DA.

Drug Metab Dispos. 2011 Apr;39(4):693-702. doi: 10.1124/dmd.110.036004. Epub 2010 Dec 21.

PMID:
21177487
16.

Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9.

Mahajan MK, Uttamsingh V, Gan LS, Leduc B, Williams DA.

J Pharm Sci. 2011 Feb;100(2):784-93. doi: 10.1002/jps.22303.

PMID:
20669329
17.

Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry.

Mahajan MK, Evans CA.

Rapid Commun Mass Spectrom. 2008 Apr;22(7):1032-40. doi: 10.1002/rcm.3458.

PMID:
18320543
18.

Assessment of efficacy of pyridoxine in control of radiation induced sickness.

Mahajan MK, Singh V.

J Indian Med Assoc. 1998 Mar;96(3):82-3.

PMID:
9828551
19.

Epithelioid granulomas in Hodgkin's disease--prognostic significance.

Chopra R, Rana R, Zachariah A, Mahajan MK, Prabhakar BR.

Indian J Pathol Microbiol. 1995 Oct;38(4):427-33.

PMID:
9726157
20.

Hodgkin's disease: a clinicopathologic study.

Rana R, Chopra R, Masih K, Zachariah A, Prabhakar BR, Mahajan MK.

Indian J Pathol Microbiol. 1995 Jul;38(3):245-9.

PMID:
8819654
21.

Lymphangiographic evaluation of patients with clinical lepromatous leprosy on clofazimine.

Oommen ST, Natu MV, Mahajan MK, Kadyan RS.

Int J Lepr Other Mycobact Dis. 1994 Mar;62(1):32-6.

PMID:
8189086
22.

Isolation of Toxoplasma gondii from suspected human cases.

Chhabra MB, Mahajan RC, Mahajan MK.

Indian J Med Res. 1979 May;69:746-51. No abstract available.

PMID:
511256
23.

In vitro behaviour of lymphocytes from cancer patients and normal individuals cultured with PHA.

Datta U, Gupta BD, Mahajan MK, Aikat BK.

Indian J Cancer. 1977 Sep;14(3):211-5. No abstract available.

PMID:
924501
24.

Uncommon presentation of toxoplasmosis--a case report.

Mahajan RC, Chhabra MB, Mahajan MK, Gupta BD, Chtikara NL.

J Assoc Physicians India. 1976 Jul;24(7):463-4. No abstract available.

PMID:
1025127

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