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Items: 1 to 50 of 68

1.

A specific proteinase 3 activity footprint in α1-antitrypsin deficiency.

Newby PR, Crossley D, Crisford H, Stockley JA, Mumford RA, Carter RI, Bolton CE, Hopkinson NS, Mahadeva R, Steiner MC, Wilkinson TMA, Sapey E, Stockley RA.

ERJ Open Res. 2019 Aug 5;5(3). pii: 00095-2019. doi: 10.1183/23120541.00095-2019. eCollection 2019 Jul.

2.

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation.

Hamesch K, Mandorfer M, Pereira VM, Moeller LS, Pons M, Dolman GE, Reichert MC, Schneider CV, Woditsch V, Voss J, Lindhauer C, Fromme M, Spivak I, Guldiken N, Zhou B, Arslanow A, Schaefer B, Zoller H, Aigner E, Reiberger T, Wetzel M, Siegmund B, Simões C, Gaspar R, Maia L, Costa D, Bento-Miranda M, van Helden J, Yagmur E, Bzdok D, Stolk J, Gleiber W, Knipel V, Windisch W, Mahadeva R, Bals R, Koczulla R, Barrecheguren M, Miravitlles M, Janciauskiene S, Stickel F, Lammert F, Liberal R, Genesca J, Griffiths WJ, Trauner M, Krag A, Trautwein C, Strnad P; European Alpha1-Liver Study Group.

Gastroenterology. 2019 Sep;157(3):705-719.e18. doi: 10.1053/j.gastro.2019.05.013. Epub 2019 May 20.

PMID:
31121167
3.

The role of a multidisciplinary severe chronic obstructive pulmonary disease hyperinflation service in patient selection for lung volume reduction.

Chew J, Mahadeva R.

J Thorac Dis. 2018 Oct;10(Suppl 27):S3335-S3343. doi: 10.21037/jtd.2018.07.36. Review.

4.

Lung function improvements in emphysema following pneumonia.

Kayani K, Mahadeva R, Stinchcombe S, Rutter M, Babar J, Fuld J.

Respir Med Case Rep. 2018 Nov 1;26:1-5. doi: 10.1016/j.rmcr.2018.10.025. eCollection 2019.

5.

Trends of testing for and diagnosis of α1-antitrypsin deficiency in the UK: more testing is needed.

Soriano JB, Lucas SJ, Jones R, Miravitlles M, Carter V, Small I, Price D, Mahadeva R; Respiratory Effectiveness Group.

Eur Respir J. 2018 Jul 4;52(1). pii: 1800360. doi: 10.1183/13993003.00360-2018. Print 2018 Jul.

PMID:
29853490
6.

Living with COPD: the struggle for breath and for lung volume reduction therapies.

Mahadeva R, Zoumot Z.

ERJ Open Res. 2018 Apr 20;4(2). pii: 00005-2018. doi: 10.1183/23120541.00005-2018. eCollection 2018 Apr.

7.

British Thoracic Society Quality Standards for acute non-invasive ventilation in adults.

Davies M, Allen M, Bentley A, Bourke SC, Creagh-Brown B, D'Oliveiro R, Glossop A, Gray A, Jacobs P, Mahadeva R, Moses R, Setchfield I.

BMJ Open Respir Res. 2018 Apr 5;5(1):e000283. doi: 10.1136/bmjresp-2018-000283. eCollection 2018.

8.

Do patients and carers agree on symptom burden in advanced COPD?

Mi E, Mi E, Ewing G, White P, Mahadeva R, Gardener AC, Farquhar M.

Int J Chron Obstruct Pulmon Dis. 2018 Mar 22;13:969-977. doi: 10.2147/COPD.S147892. eCollection 2018.

9.

European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency.

Miravitlles M, Dirksen A, Ferrarotti I, Koblizek V, Lange P, Mahadeva R, McElvaney NG, Parr D, Piitulainen E, Roche N, Stolk J, Thabut G, Turner A, Vogelmeier C, Stockley RA.

Eur Respir J. 2017 Nov 30;50(5). pii: 1700610. doi: 10.1183/13993003.00610-2017. Print 2017 Nov. Review.

10.

Associations between the psychological health of patients and carers in advanced COPD.

Mi E, Mi E, Ewing G, Mahadeva R, Gardener AC, Holt Butcher H, Booth S, Farquhar M.

Int J Chron Obstruct Pulmon Dis. 2017 Sep 30;12:2813-2821. doi: 10.2147/COPD.S139188. eCollection 2017.

11.

Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance.

Janciauskiene S, Tumpara S, Wiese M, Wrenger S, Vijayan V, Gueler F, Chen R, Madyaningrana K, Mahadeva R, Welte T, Immenschuh S, Chorostowska-Wynimko J.

J Leukoc Biol. 2017 Oct;102(4):1127-1141. doi: 10.1189/jlb.3A0317-124R. Epub 2017 Jul 17.

PMID:
28716864
12.

Six key topics informal carers of patients with breathlessness in advanced disease want to learn about and why: MRC phase I study to inform an educational intervention.

Farquhar M, Penfold C, Benson J, Lovick R, Mahadeva R, Howson S, Burkin J, Booth S, Gilligan D, Todd C, Ewing G.

PLoS One. 2017 May 5;12(5):e0177081. doi: 10.1371/journal.pone.0177081. eCollection 2017.

13.

α1-Antitrypsin deficiency: count me in please!

Soriano JB, Mahadeva R.

Eur Respir J. 2017 Jan 4;49(1). pii: 1601941. doi: 10.1183/13993003.01941-2016. Print 2017 Jan. No abstract available.

14.

Clinicians' Views of Educational Interventions for Carers of Patients With Breathlessness Due to Advanced Disease: Findings From an Online Survey.

Ewing G, Penfold C, Benson JA, Mahadeva R, Howson S, Burkin J, Booth S, Lovick R, Gilligan D, Todd C, Farquhar M.

J Pain Symptom Manage. 2017 Feb;53(2):265-271. doi: 10.1016/j.jpainsymman.2016.08.015. Epub 2016 Oct 8.

PMID:
27725250
15.

α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide induced IL-1β in human blood neutrophils.

Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S.

Mol Med. 2016 Dec;22:680-693. doi: 10.2119/molmed.2016.00119. Epub 2016 Oct 4.

16.

New and emerging technologies for the diagnosis and monitoring of chronic obstructive pulmonary disease: A horizon scanning review.

Dixon LC, Ward DJ, Smith J, Holmes S, Mahadeva R.

Chron Respir Dis. 2016 Nov;13(4):321-336. doi: 10.1177/1479972316636994. Epub 2016 Jun 23.

17.

α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression.

Frenzel E, Wrenger S, Brügger B, Salipalli S, Immenschuh S, Aggarwal N, Lichtinghagen R, Mahadeva R, Marcondes AM, Dinarello CA, Welte T, Janciauskiene S.

J Immunol. 2015 Oct 15;195(8):3605-16. doi: 10.4049/jimmunol.1500740. Epub 2015 Sep 11.

18.

An unusual case of rapid radiological progression of bullous emphysema secondary to severe α1-antitrypsin deficiency.

Chew JR, Roy K, Babar J, Mahadeva R.

BMJ Case Rep. 2015 May 7;2015. pii: bcr2015209346. doi: 10.1136/bcr-2015-209346. No abstract available.

19.

The evolving role of MDCT in the assessment of patients with chronic obstructive pulmonary disease.

Karia S, Mahadeva R, Balan A, Babar J.

Clin Radiol. 2015 Jul;70(7):752-9. doi: 10.1016/j.crad.2015.02.015. Epub 2015 Apr 8. Review.

PMID:
25861874
20.

Automated measurement of pulmonary emphysema and small airway remodeling in cigarette smoke-exposed mice.

Laucho-Contreras ME, Taylor KL, Mahadeva R, Boukedes SS, Owen CA.

J Vis Exp. 2015 Jan 16;(95):52236. doi: 10.3791/52236.

21.

Pneumothorax after endobronchial valve treatment: no drain, no gain?

Kemp SV, Zoumot Z, Mahadeva R, Shah PL.

Respiration. 2014;87(6):452-5. doi: 10.1159/000360643. Epub 2014 Apr 5. No abstract available.

22.

Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion.

Frenzel E, Wrenger S, Immenschuh S, Koczulla R, Mahadeva R, Deeg HJ, Dinarello CA, Welte T, Marcondes AM, Janciauskiene S.

J Immunol. 2014 Jun 1;192(11):5354-62. doi: 10.4049/jimmunol.1400378. Epub 2014 Apr 23.

23.

Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease.

Alam S, Li Z, Atkinson C, Jonigk D, Janciauskiene S, Mahadeva R.

Am J Respir Crit Care Med. 2014 Apr 15;189(8):909-31. doi: 10.1164/rccm.201308-1458OC.

24.

Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase.

Jonigk D, Al-Omari M, Maegel L, Müller M, Izykowski N, Hong J, Hong K, Kim SH, Dorsch M, Mahadeva R, Laenger F, Kreipe H, Braun A, Shahaf G, Lewis EC, Welte T, Dinarello CA, Janciauskiene S.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15007-12. doi: 10.1073/pnas.1309648110. Epub 2013 Aug 23.

25.

Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A.

Alam S, Wang J, Janciauskiene S, Mahadeva R.

J Hepatol. 2012 Jul;57(1):116-24. doi: 10.1016/j.jhep.2012.02.025. Epub 2012 Mar 14.

PMID:
22425623
26.

The serpinopathies studying serpin polymerization in vivo.

Irving JA, Ekeowa UI, Belorgey D, Haq I, Gooptu B, Miranda E, Pérez J, Roussel BD, Ordóñez A, Dalton LE, Thomas SE, Marciniak SJ, Parfrey H, Chilvers ER, Teckman JH, Alam S, Mahadeva R, Rashid ST, Vallier L, Lomas DA.

Methods Enzymol. 2011;501:421-66. doi: 10.1016/B978-0-12-385950-1.00018-3.

PMID:
22078544
27.

Targeting serpins in high-throughput and structure-based drug design.

Chang YP, Mahadeva R, Patschull AO, Nobeli I, Ekeowa UI, McKay AR, Thalassinos K, Irving JA, Haq I, Nyon MP, Christodoulou J, Ordóñez A, Miranda E, Gooptu B.

Methods Enzymol. 2011;501:139-75. doi: 10.1016/B978-0-12-385950-1.00008-0.

PMID:
22078534
28.

Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration.

Al-Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein DJ, Welte T, Mahadeva R, Janciauskiene S.

Mol Med. 2011 Sep-Oct;17(9-10):865-74. doi: 10.2119/molmed.2011.00089. Epub 2011 Apr 11.

29.

Tonsillar cyst: an unusual cause of ventilatory failure.

Loke J, Rutter M, Mahadeva R.

JRSM Short Rep. 2010 Oct 26;1(5):45. doi: 10.1258/shorts.2010.010052. No abstract available.

30.

Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.

Alam S, Li Z, Janciauskiene S, Mahadeva R.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):261-9. doi: 10.1165/rcmb.2010-0328OC. Epub 2010 Oct 22.

PMID:
20971880
31.

Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1.

Subramaniyam D, Zhou H, Liang M, Welte T, Mahadeva R, Janciauskiene S.

Int J Biochem Cell Biol. 2010 Sep;42(9):1562-70. doi: 10.1016/j.biocel.2010.06.009. Epub 2010 Jun 16.

PMID:
20561599
32.

Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema.

Li Z, Alam S, Wang J, Sandstrom CS, Janciauskiene S, Mahadeva R.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L388-400. doi: 10.1152/ajplung.90373.2008. Epub 2009 Jun 12.

33.

Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization.

Chang YP, Mahadeva R, Chang WS, Lin SC, Chu YH.

J Cell Mol Med. 2009 Aug;13(8B):2304-16. doi: 10.1111/j.1582-4934.2008.00608.x.

34.

An association between Type 2 diabetes and alpha-antitrypsin deficiency.

Sandström CS, Ohlsson B, Melander O, Westin U, Mahadeva R, Janciauskiene S.

Diabet Med. 2008 Nov;25(11):1370-3. doi: 10.1111/j.1464-5491.2008.02584.x.

PMID:
19046232
35.

Acupuncture induced pneumothorax - a case report.

Juss JK, Speed CA, Warrington J, Mahadeva R.

Acupunct Med. 2008 Sep;26(3):193-6.

PMID:
18818566
36.

Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report.

McCormick LM, Goddard M, Mahadeva R.

J Med Case Rep. 2008 Aug 5;2:257. doi: 10.1186/1752-1947-2-257.

37.

Animal models of pulmonary emphysema.

Mahadeva R, Shapiro SD.

Curr Drug Targets Inflamm Allergy. 2005 Dec;4(6):665-73. Review.

PMID:
17305522
38.

Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.

Howard L, Gopalan D, Griffiths M, Mahadeva R.

Chest. 2006 Jun;129(6):1718-21.

PMID:
16778294
39.

Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z alpha1-antitrypsin.

Chang YP, Mahadeva R, Chang WS, Shukla A, Dafforn TR, Chu YH.

Am J Respir Cell Mol Biol. 2006 Nov;35(5):540-8. Epub 2006 Jun 15.

PMID:
16778151
40.

Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo.

Mahadeva R, Atkinson C, Li Z, Stewart S, Janciauskiene S, Kelley DG, Parmar J, Pitman R, Shapiro SD, Lomas DA.

Am J Pathol. 2005 Feb;166(2):377-86.

41.

Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema.

Parfrey H, Dafforn TR, Belorgey D, Lomas DA, Mahadeva R.

Am J Respir Cell Mol Biol. 2004 Aug;31(2):133-9. Epub 2004 Mar 11.

PMID:
15016619
42.

Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.

Parfrey H, Mahadeva R, Ravenhill NA, Zhou A, Dafforn TR, Foreman RC, Lomas DA.

J Biol Chem. 2003 Aug 29;278(35):33060-6. Epub 2003 Jun 13.

43.

Alpha(1)-antitrypsin deficiency, liver disease and emphysema.

Parfrey H, Mahadeva R, Lomas DA.

Int J Biochem Cell Biol. 2003 Jul;35(7):1009-14. Review.

PMID:
12672469
44.

Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy.

Lomas DA, Mahadeva R.

J Clin Invest. 2002 Dec;110(11):1585-90. Review. No abstract available.

45.
46.

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema.

Parmar JS, Mahadeva R, Reed BJ, Farahi N, Cadwallader KA, Keogan MT, Bilton D, Chilvers ER, Lomas DA.

Am J Respir Cell Mol Biol. 2002 Jun;26(6):723-30.

PMID:
12034572
47.
48.
49.

Characterization of a new variant of alpha(1)-antitrypsin E(Johannesburg) (H15N) in association with asthma.

Mahadeva R, Gaillard M, Pillay V, Halkas A, Lomas D.

Hum Mutat. 2001 Feb;17(2):156. No abstract available.

PMID:
11180610
50.

A novel polymorphism (471C-->T) in alpha-1-antitrypsin in a patient with asthma.

Pillay V, Halsall DJ, Gaillard C, Lomas DA, Mahadeva R.

Hum Mutat. 2001 Feb;17(2):155-6. No abstract available.

PMID:
11180608

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