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Items: 1 to 50 of 81

1.

FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer.

Weiss A, Adler F, Buhles A, Stamm C, Fairhurst RA, Kiffe M, Sterker D, Centeleghe M, Wartmann M, Kinyamu-Akunda J, Schadt HS, Couttet P, Wolf A, Wang Y, Barzaghi-Rinaudo P, Murakami M, Kauffmann A, Knoepfel T, Buschmann N, Leblanc C, Mah R, Furet P, Blank J, Hofmann F, Sellers WR, Graus Porta D.

Mol Cancer Ther. 2019 Dec;18(12):2194-2206. doi: 10.1158/1535-7163.MCT-18-1291. Epub 2019 Aug 13.

PMID:
31409633
2.

Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.

Kallen J, Izaac A, Chau S, Wirth E, Schoepfer J, Mah R, Schlapbach A, Stutz S, Vaupel A, Guagnano V, Masuya K, Stachyra TM, Salem B, Chene P, Gessier F, Holzer P, Furet P.

ChemMedChem. 2019 Jul 17;14(14):1305-1314. doi: 10.1002/cmdc.201900201. Epub 2019 May 27.

PMID:
31066983
3.

Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress.

Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL.

Cardiovasc Res. 2019 Jan 31. doi: 10.1093/cvr/cvz029. [Epub ahead of print]

PMID:
30715197
4.

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.

Vaupel A, Holzer P, Ferretti S, Guagnano V, Kallen J, Mah R, Masuya K, Ruetz S, Rynn C, Schlapbach A, Stachyra T, Stutz S, Todorov M, Jeay S, Furet P.

Bioorg Med Chem Lett. 2018 Nov 1;28(20):3404-3408. doi: 10.1016/j.bmcl.2018.08.027. Epub 2018 Aug 26.

PMID:
30217415
5.

A framework for the extended monitoring of levels of cognitive function in unresponsive patients.

Mah RL, Connolly JF.

PLoS One. 2018 Jul 19;13(7):e0200793. doi: 10.1371/journal.pone.0200793. eCollection 2018.

6.

2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4.

Knoepfel T, Furet P, Mah R, Buschmann N, Leblanc C, Ripoche S, Graus-Porta D, Wartmann M, Galuba I, Fairhurst RA.

ACS Med Chem Lett. 2018 Feb 1;9(3):215-220. doi: 10.1021/acsmedchemlett.7b00485. eCollection 2018 Mar 8.

7.

How Older Adults Experience an Emergency Department Visit: Development and Validation of Measures.

McCusker J, Cetin-Sahin D, Cossette S, Ducharme F, Vadeboncoeur A, Vu TTM, Veillette N, Ciampi A, Belzile E, Berthelot S, Lachance PA, Mah R.

Ann Emerg Med. 2018 Jun;71(6):755-766.e4. doi: 10.1016/j.annemergmed.2018.01.009. Epub 2018 Feb 17.

PMID:
29459058
8.

Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver.

Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL.

FASEB J. 2018 Jun;32(6):3254-3263. doi: 10.1096/fj.201701080R. Epub 2018 Jan 19.

PMID:
29401611
9.

Automatic and continuous assessment of ERPs for mismatch negativity detection.

Armanfard N, Komeili M, Reilly JP, Mah R, Connolly JF.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:969-972. doi: 10.1109/EMBC.2016.7590863.

PMID:
28268485
10.

Letter to the Editor: Verification of the RIDA®GENE Bordetella real-time PCR Kit for the Detection of Bordetella pertussis and other Bordetella species from Nasopharyngeal Swabs Collected in Regan-Lowe Transport Medium.

Zhou HY, Shokoples S, Adachi D, Detwiler B, Hay M, Leedell D, Lundeberg R, Mah R, Drews SJ.

Ann Clin Lab Sci. 2017 Jan;47(1):106-108. No abstract available.

PMID:
28249928
11.

Mediating Order and Modulating Porosity by Controlled Hydrolysis in a Phosphonate Monoester Metal-Organic Framework.

Gelfand BS, Huynh RP, Mah RK, Shimizu GK.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14614-14617. doi: 10.1002/anie.201607745. Epub 2016 Oct 21.

PMID:
27766722
12.

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.

Furet P, Masuya K, Kallen J, Stachyra-Valat T, Ruetz S, Guagnano V, Holzer P, Mah R, Stutz S, Vaupel A, Chène P, Jeay S, Schlapbach A.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4837-4841. doi: 10.1016/j.bmcl.2016.08.010. Epub 2016 Aug 9.

PMID:
27542305
13.

Normal Brain Response to Propofol in Advance of Recovery from Unresponsive Wakefulness Syndrome.

Blain-Moraes S, Boshra R, Ma HK, Mah R, Ruiter K, Avidan M, Connolly JF, Mashour GA.

Front Hum Neurosci. 2016 Jun 2;10:248. doi: 10.3389/fnhum.2016.00248. eCollection 2016.

14.

Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Gerspacher M, Imbach-Weese P, Mah R, Caravatti G, Furet P, Fritsch C, Schnell C, Blanz J, Blasco F, Desrayaud S, Guthy DA, Knapp M, Arz D, Wirth J, Roehn-Carnemolla E, Luu VH.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3575-81. doi: 10.1016/j.bmcl.2015.06.067. Epub 2015 Jun 26.

PMID:
26199119
15.

Discovery of a novel tricyclic 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity.

Gerspacher M, Fairhurst RA, Mah R, Roehn-Carnemolla E, Furet P, Fritsch C, Guthy DA.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3582-4. doi: 10.1016/j.bmcl.2015.06.077. Epub 2015 Jun 30.

PMID:
26164189
16.

Hypovitaminosis D correction and high-sensitivity C-reactive protein levels in hypertensive adults.

Carlson N, Mah R, Aburto M, Peters MJ, Dupper MV, Chen LH.

Perm J. 2013 Fall;17(4):19-21. doi: 10.7812/TPP/13-007.

17.

Drug discovery considerations in the development of covalent inhibitors.

Mah R, Thomas JR, Shafer CM.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):33-9. doi: 10.1016/j.bmcl.2013.10.003. Epub 2013 Oct 10. Review.

PMID:
24314671
18.

Enhancing order and porosity in a highly robust tin(IV) triphosphonate framework.

Mah RK, Lui MW, Shimizu GK.

Inorg Chem. 2013 Jul 1;52(13):7311-3. doi: 10.1021/ic400274e. Epub 2013 Jun 14.

PMID:
23768095
19.

Zn7O2(RCOO)10 clusters and nitro aromatic linkers in a porous metal-organic framework.

Iremonger SS, Vaidhyanathan R, Mah RK, Shimizu GK.

Inorg Chem. 2013 Apr 15;52(8):4124-6. doi: 10.1021/ic302127y. Epub 2013 Mar 22.

PMID:
23521490
20.

Facile proton conduction via ordered water molecules in a phosphonate metal-organic framework.

Taylor JM, Mah RK, Moudrakovski IL, Ratcliffe CI, Vaidhyanathan R, Shimizu GK.

J Am Chem Soc. 2010 Oct 13;132(40):14055-7. doi: 10.1021/ja107035w.

PMID:
20857972
21.

The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin.

Yamaguchi Y, Menear K, Cohen NC, Mah R, Cumin F, Schnell C, Wood JM, Maibaum J.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4863-7. doi: 10.1016/j.bmcl.2009.05.128. Epub 2009 Jun 26.

PMID:
19615901
22.

Emergency department overcrowding as a threat to patient dignity.

Mah R.

CJEM. 2009 Jul;11(4):365-74. English, French. No abstract available.

PMID:
19594976
23.

The future role of intelligent probes in detecting and managing prostate cancer.

Kommu SS, Andrews RJ, Mah RW.

BJU Int. 2006 Oct;98(4):717-9. No abstract available.

24.

Real-time multiple microsensor tissue recognition and its potential application in the management of prostate cancer.

Kommu SS, Andrews RJ, Mah RW.

BJU Int. 2006 Feb;97(2):222-3. No abstract available.

25.

The NASA Smart Probe Project for real-time multiple microsensor tissue recognition.

Andrews RJ, Mah RW.

Stereotact Funct Neurosurg. 2003;80(1-4):114-9.

PMID:
14745219
26.

Structure-based design of aliskiren, a novel orally effective renin inhibitor.

Wood JM, Maibaum J, Rahuel J, Grütter MG, Cohen NC, Rasetti V, Rüger H, Göschke R, Stutz S, Fuhrer W, Schilling W, Rigollier P, Yamaguchi Y, Cumin F, Baum HP, Schnell CR, Herold P, Mah R, Jensen C, O'Brien E, Stanton A, Bedigian MP.

Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705.

PMID:
12927775
27.

Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists.

Mah R, Gerspacher M, von Sprecher A, Stutz S, Tschinke V, Anderson GP, Bertrand C, Subramanian N, Ball HA.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2065-8.

PMID:
12127505
28.

Immunohistochemical detection of nestin in pediatric brain tumors.

Almqvist PM, Mah R, Lendahl U, Jacobsson B, Hendson G.

J Histochem Cytochem. 2002 Feb;50(2):147-58.

PMID:
11799134
29.

Dual neurokinin NK(1)/NK(2) antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamides and 3-[N'-3,5-bis(trifluoromethyl)benzoyl-N-arylmethyl-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamides.

Gerspacher M, La Vecchia L, Mah R, von Sprecher A, Anderson GP, Subramanian N, Hauser K, Bammerlin H, Kimmel S, Pawelzik V, Ryffel K, Ball HA.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3081-4.

PMID:
11714615
30.

N-[(R,R)-(E)-1-(4-chloro-benzyl)-3-(2-oxo-azepan-3-ylcarbamoyl)-allyl]-N-methyl-3,5-bis-trifluoromethyl-benzamide: an orally active neurokinin NK1/NK2 antagonist.

Gerspacher M, von Sprecher A, Mah R, Anderson GP, Bertrand C, Subramanian N, Hauser K, Ball HA.

Bioorg Med Chem Lett. 2000 Jul 3;10(13):1467-70.

PMID:
10888334
31.

Multimodality stereotactic brain tissue identification: the NASA smart probe project.

Andrews R, Mah R, Aghevli A, Freitas K, Galvagni A, Guerrero M, Papsin R, Reed C, Stassinopoulos D.

Stereotact Funct Neurosurg. 1999;73(1-4):1-8.

PMID:
10853089
32.

Salinivibrio costicola subsp. vallismortis subsp. nov., a halotolerant facultative anaerobe from Death Valley, and emended description of Salinivibrio costicola.

Huang CY, Garcia JL, Patel BK, Cayol JL, Baresi L, Mah RA.

Int J Syst Evol Microbiol. 2000 Mar;50 Pt 2:615-22.

PMID:
10758867
34.

Caldicellulosiruptor owensensis sp. nov., an anaerobic, extremely thermophilic, xylanolytic bacterium.

Huang CY, Patel BK, Mah RA, Baresi L.

Int J Syst Bacteriol. 1998 Jan;48 Pt 1:91-7.

PMID:
9542080
35.

Robotic multimodality stereotactic brain tissue identification: work in progress.

Andrews R, Mah R, Galvagni A, Guerrero M, Papasin R, Wallace M, Winters J.

Stereotact Funct Neurosurg. 1997;68(1-4 Pt 1):72-9.

PMID:
9711699
36.

Periapical changes after orthodontic movement of root-filled ferret canines.

Mah R, Holland GR, Pehowich E.

J Endod. 1996 Jun;22(6):298-303.

PMID:
8934989
37.

Reevaluating the classification of Halobacteroides and Haloanaerobacter species based on sequence comparisons of the 16S ribosomal RNA gene.

Patel BK, Andrews KT, Ollivier B, Mah RA, Garcia JL.

FEMS Microbiol Lett. 1995 Dec 1;134(1):115-9.

PMID:
8593948
38.

The bldA-encoded tRNA is poorly expressed in the bldI mutant of Streptomyces coelicolor A3(2).

Leskiw BK, Mah R.

Microbiology. 1995 Aug;141 ( Pt 8):1921-6.

PMID:
7551054
39.

Haloanaerobium alcaliphilum sp. nov., an anaerobic moderate halophile from the sediments of Great Salt Lake, Utah.

Tsai CR, Garcia JL, Patel BK, Cayol JL, Baresi L, Mah RA.

Int J Syst Bacteriol. 1995 Apr;45(2):301-7.

PMID:
7537063
40.

Anaerobic bacteria from hypersaline environments.

Ollivier B, Caumette P, Garcia JL, Mah RA.

Microbiol Rev. 1994 Mar;58(1):27-38. Review.

41.

Accumulation of bldA-specified tRNA is temporally regulated in Streptomyces coelicolor A3(2).

Leskiw BK, Mah R, Lawlor EJ, Chater KF.

J Bacteriol. 1993 Apr;175(7):1995-2005.

43.

Isolation and characterization of disaggregatase from Methanosarcina mazei LYC.

Xun LY, Mah RA, Boone DR.

Appl Environ Microbiol. 1990 Dec;56(12):3693-8.

44.

Acetate production by methanogenic bacteria.

Westermann P, Ahring BK, Mah RA.

Appl Environ Microbiol. 1989 Sep;55(9):2257-61.

45.

Temperature Compensation in Methanosarcina barkeri by Modulation of Hydrogen and Acetate Affinity.

Westermann P, Ahring BK, Mah RA.

Appl Environ Microbiol. 1989 May;55(5):1262-6.

46.

Threshold acetate concentrations for acetate catabolism by aceticlastic methanogenic bacteria.

Westermann P, Ahring BK, Mah RA.

Appl Environ Microbiol. 1989 Feb;55(2):514-5.

47.

Control of the Life Cycle of Methanosarcina mazei S-6 by Manipulation of Growth Conditions.

Xun L, Boone DR, Mah RA.

Appl Environ Microbiol. 1988 Aug;54(8):2064-8.

48.

Methanohalophilus zhilinae sp. nov., an alkaliphilic, halophilic, methylotrophic methanogen.

Mathrani IM, Boone DR, Mah RA, Fox GE, Lau PP.

Int J Syst Bacteriol. 1988 Apr;38(2):139-42.

PMID:
11540079
49.
50.

H(2)-CO(2) Recirculation and pH Control for Growth of Methanogens in Mass Culture.

Boone DR, Mathrani IM, Mah RA.

Appl Environ Microbiol. 1987 May;53(5):946-8.

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