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Items: 45

1.

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6812-6817. doi: 10.1073/pnas.1817246116. Epub 2019 Mar 20.

PMID:
30894493
2.

Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption.

Johnson K, Levine K, Sergi J, Chamoun J, Roach R, Vekich J, Favis M, Horn M, Cao X, Miller B, Snyder W, Aivazian D, Reagan W, Berryman E, Colangelo J, Markiewicz V, Bagi CM, Brown TP, Coyle A, Mohammadi M, Magram J.

J Bone Miner Res. 2017 Oct;32(10):2062-2073. doi: 10.1002/jbmr.3197. Epub 2017 Aug 25.

3.

Fully human antibodies against the Protease-Activated Receptor-2 (PAR-2) with anti-inflammatory activity.

Giblin P, Boxhammer R, Desai S, Kroe-Barrett R, Hansen G, Ksiazek J, Panzenbeck M, Ralph K, Schwartz R, Zimmitti C, Pracht C, Miller S, Magram J, Litzenburger T.

Hum Antibodies. 2011;20(3-4):83-94. doi: 10.3233/HAB-2011-0243.

PMID:
22129678
4.

Meetings of the minds: maximizing drug discovery.

Magram J.

Dis Model Mech. 2008 Nov-Dec;1(4-5):192-4. doi: 10.1242/dmm.000893. No abstract available.

5.

Overview of approaches to the identification of inhibitors of cytokine action.

Woska JR Jr, Magram J.

Curr Protoc Pharmacol. 2005 Jan 1;Chapter 1:Unit 1.31. doi: 10.1002/0471141755.ph0131s27.

PMID:
22294126
6.
7.
8.

Characterization of glucokinase regulatory protein-deficient mice.

Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF.

J Biol Chem. 2000 Mar 17;275(11):7826-31.

9.

Pancreas-infiltrating Th1 cells and diabetes develop in IL-12-deficient nonobese diabetic mice.

Trembleau S, Penna G, Gregori S, Chapman HD, Serreze DV, Magram J, Adorini L.

J Immunol. 1999 Sep 1;163(5):2960-8.

10.

Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice.

Rakhit A, Yeon MM, Ferrante J, Fettner S, Nadeau R, Motzer R, Bukowski R, Carvajal DM, Wilkinson VL, Presky DH, Magram J, Gately MK.

Clin Pharmacol Ther. 1999 Jun;65(6):615-29.

PMID:
10391667
11.

Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits.

Wang X, Wilkinson VL, Podlaski FJ, Wu C, Stern AS, Presky DH, Magram J.

Eur J Immunol. 1999 Jun;29(6):2007-13.

12.

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes.

Brombacher F, Dorfmüller A, Magram J, Dai WJ, Köhler G, Wunderlin A, Palmer-Lehmann K, Gately MK, Alber G.

Int Immunol. 1999 Mar;11(3):325-32.

PMID:
10221644
13.

Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans.

Decken K, Köhler G, Palmer-Lehmann K, Wunderlin A, Mattner F, Magram J, Gately MK, Alber G.

Infect Immun. 1998 Oct;66(10):4994-5000.

14.
15.

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses.

Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH.

Annu Rev Immunol. 1998;16:495-521. Review.

PMID:
9597139
16.

Alloantigen-reactive Th1 development in IL-12-deficient mice.

Piccotti JR, Li K, Chan SY, Ferrante J, Magram J, Eichwald EJ, Bishop DK.

J Immunol. 1998 Feb 1;160(3):1132-8.

17.

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.

Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ.

J Reprod Immunol. 1997 Nov 15;35(2):111-33.

PMID:
9421796
20.

Impaired Th2 subset development in the absence of CD4.

Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM.

Immunity. 1997 May;6(5):559-69.

21.
22.

The role of IL-12 and IL-4 in Leishmania major infection.

Mattner F, Alber G, Magram J, Kopf M.

Chem Immunol. 1997;68:86-109. Review. No abstract available.

PMID:
9329218
23.

Structural and functional aspects of the IL-12 receptor complex.

Stern AS, Gubler U, Presky DH, Magram J.

Chem Immunol. 1997;68:23-37. Review. No abstract available.

PMID:
9329214
24.

Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice.

McIntyre KW, Shuster DJ, Gillooly KM, Warrier RR, Connaughton SE, Hall LB, Arp LH, Gately MK, Magram J.

Eur J Immunol. 1996 Dec;26(12):2933-8.

PMID:
8977288
25.

The role of IL-12 in the pathogenesis of Th1 cell-mediated autoimmune diseases.

Adorini L, Gregori S, Magram J, Trembleau S.

Ann N Y Acad Sci. 1996 Oct 31;795:208-15. Review. No abstract available.

PMID:
8958932
26.

IL-12-deficient mice are defective but not devoid of type 1 cytokine responses.

Magram J, Sfarra J, Connaughton S, Faherty D, Warrier R, Carvajal D, Wu CY, Stewart C, Sarmiento U, Gately MK.

Ann N Y Acad Sci. 1996 Oct 31;795:60-70.

PMID:
8958917
27.
28.

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

Mattner F, Magram J, Ferrante J, Launois P, Di Padova K, Behin R, Gately MK, Louis JA, Alber G.

Eur J Immunol. 1996 Jul;26(7):1553-9.

PMID:
8766560
29.

HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

Ito K, Bian HJ, Molina M, Han J, Magram J, Saar E, Belunis C, Bolin DR, Arceo R, Campbell R, Falcioni F, Vidović D, Hammer J, Nagy ZA.

J Exp Med. 1996 Jun 1;183(6):2635-44.

30.

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses.

Magram J, Connaughton SE, Warrier RR, Carvajal DM, Wu CY, Ferrante J, Stewart C, Sarmiento U, Faherty DA, Gately MK.

Immunity. 1996 May;4(5):471-81.

31.

Interleukin-12 an integral cytokine in the immune response.

Stern AS, Magram J, Presky DH.

Life Sci. 1996;58(8):639-54. Review.

PMID:
8594314
32.

Regulation of interleukin 12 p40 expression through an NF-kappa B half-site.

Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM.

Mol Cell Biol. 1995 Oct;15(10):5258-67.

33.

The role of endogenous IL12 in the induction of Th1-cell-mediated autoimmune diseases.

Adorini L, Magram J, Trembeau S.

Res Immunol. 1995 Sep-Oct;146(7-8):645-51. Review. No abstract available.

PMID:
8839173
34.

Vascular endothelial cell lineage-specific promoter in transgenic mice.

Schlaeger TM, Qin Y, Fujiwara Y, Magram J, Sato TN.

Development. 1995 Apr;121(4):1089-98.

35.

Dominant male sterility in mice caused by insertion of a transgene.

Magram J, Bishop JM.

Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10327-31.

36.

Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

Magram J, Niederreither K, Costantini F.

Mol Cell Biol. 1989 Oct;9(10):4581-4.

37.

Analysis of human gamma and beta globin gene regulation using transgenic mice.

Perez-Stable C, Magram J, Niederreither K, Costantini F.

Prog Clin Biol Res. 1989;316A:203-15. No abstract available.

PMID:
2594807
38.
39.

Expression of normal, mutant and hybrid human globin genes in transgenic mice.

Trudel M, Magram J, Chada K, Wilson R, Costantini F.

Prog Clin Biol Res. 1987;251:305-21. No abstract available.

PMID:
2448804
40.

Correction of murine beta-thalassemia by gene transfer into the germ line.

Costantini F, Chada K, Magram J.

Science. 1986 Sep 12;233(4769):1192-4.

PMID:
3461564
41.

An embryonic pattern of expression of a human fetal globin gene in transgenic mice.

Chada K, Magram J, Costantini F.

Nature. 1986 Feb 20-26;319(6055):685-9.

PMID:
3951540
42.

Developmental regulation of a cloned adult beta-globin gene in transgenic mice.

Magram J, Chada K, Costantini F.

Nature. 1985 May 23-29;315(6017):338-40.

PMID:
3858676
43.

Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice.

Chada K, Magram J, Raphael K, Radice G, Lacy E, Costantini F.

Nature. 1985 Mar 28-Apr 3;314(6009):377-80.

PMID:
3982505
44.

Developmental regulation of human globin genes in transgenic mice.

Costantini F, Radice G, Magram J, Stamatoyannopoulos G, Papayannopoulou T, Chada K.

Cold Spring Harb Symp Quant Biol. 1985;50:361-70. No abstract available.

PMID:
3868484
45.

Tissue- and stage-specific expression of a cloned adult beta globin gene in transgenic mice.

Chada K, Magram J, Costantini F.

Prog Clin Biol Res. 1985;191:305-19. No abstract available.

PMID:
2996024

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