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Items: 31


Duration of pretomanid/moxifloxacin/pyrazinamide therapy compared with standard therapy based on time-to-extinction mathematics.

Srivastava S, Deshpande D, Magombedze G, van Zyl J, Cirrincione K, Martin K, Bendet P, Berg A, Hanna D, Romero K, Hermann D, Gumbo T.

J Antimicrob Chemother. 2020 Feb 1;75(2):392-399. doi: 10.1093/jac/dkz460.


Minocycline treatment for pulmonary Mycobacterium avium complex disease based on pharmacokinetics/pharmacodynamics and Bayesian framework mathematical models.

Ruth MM, Magombedze G, Gumbo T, Bendet P, Sangen JJN, Zweijpfenning S, Hoefsloot W, Pennings L, Koeken VACM, Wertheim HFL, Lee PS, van Ingen J, Deshpande D.

J Antimicrob Chemother. 2019 Jul 1;74(7):1952-1961. doi: 10.1093/jac/dkz143.


Once-a-week tigecycline for the treatment of drug-resistant TB.

Deshpande D, Magombedze G, Srivastava S, Bendet P, Lee PS, Cirrincione KN, Martin KR, Dheda K, Gumbo T.

J Antimicrob Chemother. 2019 Jun 1;74(6):1607-1617. doi: 10.1093/jac/dkz061.


Deciphering the virulence of Mycobacterium avium subsp. paratuberculosis isolates in animal macrophages using mathematical models.

Alonso-Hearn M, Magombedze G, AbendaƱo N, Landin M, Juste RA.

J Theor Biol. 2019 May 7;468:82-91. doi: 10.1016/j.jtbi.2019.01.040. Epub 2019 Feb 19.


Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Dheda K, Lenders L, Srivastava S, Magombedze G, Wainwright H, Raj P, Bush SJ, Pollara G, Steyn R, Davids M, Pooran A, Pennel T, Linegar A, McNerney R, Moodley L, Pasipanodya JG, Turner CT, Noursadeghi M, Warren RM, Wakeland E, Gumbo T.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):370-380. doi: 10.1164/rccm.201807-1361OC.


Efficacy Versus Hepatotoxicity of High-dose Rifampin, Pyrazinamide, and Moxifloxacin to Shorten Tuberculosis Therapy Duration: There Is Still Fight in the Old Warriors Yet!

Srivastava S, Deshpande D, Magombedze G, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S359-S364. doi: 10.1093/cid/ciy627.


Transformation Morphisms and Time-to-Extinction Analysis That Map Therapy Duration From Preclinical Models to Patients With Tuberculosis: Translating From Apples to Oranges.

Magombedze G, Pasipanodya JG, Srivastava S, Deshpande D, Visser ME, Chigutsa E, McIlleron H, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S349-S358. doi: 10.1093/cid/ciy623.


Artificial intelligence-derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis.

Pasipanodya JG, Smythe W, Merle CS, Olliaro PL, Deshpande D, Magombedze G, McIlleron H, Gumbo T.

Clin Infect Dis. 2018 Nov 28;67(suppl_3):S284-S292. doi: 10.1093/cid/ciy610.


A trade-off between dry season survival longevity and wet season high net reproduction can explain the persistence of Anopheles mosquitoes.

Magombedze G, Ferguson NM, Ghani AC.

Parasit Vectors. 2018 Nov 3;11(1):576. doi: 10.1186/s13071-018-3158-0.


Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1208-1219. doi: 10.1164/rccm.201711-2333OC.


Ceftazidime-avibactam has potent sterilizing activity against highly drug-resistant tuberculosis.

Deshpande D, Srivastava S, Chapagain M, Magombedze G, Martin KR, Cirrincione KN, Lee PS, Koeuth T, Dheda K, Gumbo T.

Sci Adv. 2017 Aug 30;3(8):e1701102. doi: 10.1126/sciadv.1701102. eCollection 2017 Aug.


Systematic Review and Meta-analyses of the Effect of Chemotherapy on Pulmonary Mycobacterium abscessus Outcomes and Disease Recurrence.

Pasipanodya JG, Ogbonna D, Ferro BE, Magombedze G, Srivastava S, Deshpande D, Gumbo T.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01206-17. doi: 10.1128/AAC.01206-17. Print 2017 Nov.


Linezolid Dose That Maximizes Sterilizing Effect While Minimizing Toxicity and Resistance Emergence for Tuberculosis.

Srivastava S, Magombedze G, Koeuth T, Sherman C, Pasipanodya JG, Raj P, Wakeland E, Deshpande D, Gumbo T.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00751-17. doi: 10.1128/AAC.00751-17. Print 2017 Aug.


Can Immune Response Mechanisms Explain the Fecal Shedding Patterns of Cattle Infected with Mycobacterium avium Subspecies paratuberculosis?

Magombedze G, Eda S, Koets A.

PLoS One. 2016 Jan 25;11(1):e0146844. doi: 10.1371/journal.pone.0146844. eCollection 2016.


Predicting the Role of IL-10 in the Regulation of the Adaptive Immune Responses in Mycobacterium avium Subsp. paratuberculosis Infections Using Mathematical Models.

Magombedze G, Eda S, Stabel J.

PLoS One. 2015 Nov 30;10(11):e0141539. doi: 10.1371/journal.pone.0141539. eCollection 2015.


Exploring the benefits of antibody immune response in HIV-1 infection using a discrete model.

Showa SP, Nyabadza F, Hove-Musekwa SD, Magombedze G.

Math Med Biol. 2016 Jun;33(2):189-210. doi: 10.1093/imammb/dqv014. Epub 2015 Apr 21.


A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection.

Showa SP, Nyabadza F, Hove-Musekwa SD, Magombedze G.

BMC Res Notes. 2014 Oct 20;7:737. doi: 10.1186/1756-0500-7-737.


A theoretical mathematical assessment of the effectiveness of coartemether in the treatment of Plasmodium falciparum malaria infection.

Kamangira B, Nyamugure P, Magombedze G.

Math Biosci. 2014 Oct;256:28-41. doi: 10.1016/j.mbs.2014.07.010. Epub 2014 Aug 10.


Evaluation [corrected] of the "Iceberg Phenomenon" in Johne's disease through mathematical modelling.

Magombedze G, Ngonghala CN, Lanzas C.

PLoS One. 2013 Oct 22;8(10):e76636. doi: 10.1371/journal.pone.0076636. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/44f299df-fbe6-4ed2-b802-1616e2cb36ee. Magombedze, Gesgam [corrected to Magombedze, Gesham].


Cellular and population plasticity of helper CD4(+) T cell responses.

Magombedze G, Reddy PB, Eda S, Ganusov VV.

Front Physiol. 2013 Aug 16;4:206. doi: 10.3389/fphys.2013.00206. eCollection 2013.


Latent Tuberculosis: Models, Computational Efforts and the Pathogen's Regulatory Mechanisms during Dormancy.

Magombedze G, Dowdy D, Mulder N.

Front Bioeng Biotechnol. 2013 Aug 27;1:4. eCollection 2013. Review.


Understanding TB latency using computational and dynamic modelling procedures.

Magombedze G, Mulder N.

Infect Genet Evol. 2013 Jan;13:267-83. doi: 10.1016/j.meegid.2012.09.017. Epub 2012 Nov 10.


A mathematical representation of the development of Mycobacterium tuberculosis active, latent and dormant stages.

Magombedze G, Mulder N.

J Theor Biol. 2012 Jan 7;292:44-59. doi: 10.1016/j.jtbi.2011.09.025. Epub 2011 Sep 29.


Modelling within host parasite dynamics of schistosomiasis.

Chiyaka ET, Magombedze G, Mutimbu L.

Comput Math Methods Med. 2010 Sep;11(3):255-80. doi: 10.1080/17486701003614336.


Mathematical modelling of immune regulation of type 1 diabetes.

Magombedze G, Nduru P, Bhunu CP, Mushayabasa S.

Biosystems. 2010 Nov-Dec;102(2-3):88-98. doi: 10.1016/j.biosystems.2010.07.018. Epub 2010 Aug 11.


Mathematical analysis of a two strain HIV/AIDS model with antiretroviral treatment.

Bhunu CP, Garira W, Magombedze G.

Acta Biotheor. 2009 Sep;57(3):361-81. doi: 10.1007/s10441-009-9080-2. Epub 2009 Apr 9.


Modelling the effects of pre-exposure and post-exposure vaccines in tuberculosis control.

Bhunu CP, Garira W, Mukandavire Z, Magombedze G.

J Theor Biol. 2008 Oct 7;254(3):633-49. doi: 10.1016/j.jtbi.2008.06.023. Epub 2008 Jul 1.


Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs.

Magombedze G, Garira W, Mwenje E.

Math Biosci Eng. 2006 Oct;3(4):661-82.

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